公开(公告)号：US08847151B2

公开(公告)日：2014-09-30

申请号：US12946084

申请日：2010-11-15

申请人： John Vandermey ,  Alexandre Loboda

发明人： John Vandermey ,  Alexandre Loboda

IPC分类号： H01J49/02 ,  H01J49/42 ,  H01F19/04

CPC分类号： H01J49/022 ,  H01F19/04 ,  H01J49/422 ,  H04B2203/5483 ,  H04B2203/5491

摘要： An apparatus and method for coupling RF and AC signals to provide power to a multipole in a mass spectrometer is provided. A first circuit comprises: an RF power source for providing difference mode power to the multipole via the RF signal; at least one inductor for forming at least one resonant LC circuit with the multipole for providing voltage gain for the RF signal; and a transformer, comprising a secondary tap, the transformer connected in parallel to the RF power source and further connected to the at least one inductor such that the signals injected into the secondary tap are communicated to the at least one resonant LC circuit. A second circuit comprises: an AC power source for providing common mode power to the multipole via the AC signal, an output from the second circuit connected to the secondary tap such that the common mode power is injected into the first circuit and the multipole can be operated in common mode and difference mode simultaneously; and at least one inductor for forming a resonant LC circuit with the multipole via the transformer, to provide voltage gain for the AC signal.

摘要翻译： 提供了一种用于耦合RF和AC信号以在质谱仪中为多极提供功率的装置和方法。 第一电路包括：RF电源，用于经由RF信号向多极提供差模功率; 至少一个电感器，用于与用于为RF信号提供电压增益的多极形成至少一个谐振LC电路; 以及变压器，包括二次抽头，所述变压器并联连接到所述RF电源并进一步连接到所述至少一个电感器，使得注入到所述次级抽头中的信号被传送到所述至少一个谐振LC电路。 第二电路包括：AC电源，用于经由AC信号向多极提供共模功率，来自连接到次级抽头的第二电路的输出，使得共模功率注入到第一电路中，并且多极可以是 同时工作在共模和差模; 以及用于通过变压器与多极形成谐振LC电路的至少一个电感器，以为AC信号提供电压增益。

公开(公告)号：US20110278917A1

公开(公告)日：2011-11-17

申请号：US12946084

申请日：2010-11-15

申请人： John Vandermey ,  Alexandre Loboda

发明人： John Vandermey ,  Alexandre Loboda

IPC分类号： H02J3/00

CPC分类号： H01J49/022 ,  H01F19/04 ,  H01J49/422 ,  H04B2203/5483 ,  H04B2203/5491

摘要： An apparatus and method for coupling RF and AC signals to provide power to a multipole in a mass spectrometer is provided. A first circuit comprises: an RF power source for providing difference mode power to the multipole via the RF signal; at least one inductor for forming at least one resonant LC circuit with the multipole for providing voltage gain for the RF signal; and a transformer, comprising a secondary tap, the transformer connected in parallel to the RF power source and further connected to the at least one inductor such that the signals injected into the secondary tap are communicated to the at least one resonant LC circuit. A second circuit comprises: an AC power source for providing common mode power to the multipole via the AC signal, an output from the second circuit connected to the secondary tap such that the common mode power is injected into the first circuit and the multipole can be operated in common mode and difference mode simultaneously; and at least one inductor for forming a resonant LC circuit with the multipole via the transformer, to provide voltage gain for the AC signal.

摘要翻译： 提供了一种用于耦合RF和AC信号以在质谱仪中为多极提供功率的装置和方法。 第一电路包括：RF电源，用于经由RF信号向多极提供差模功率; 至少一个电感器，用于与用于为RF信号提供电压增益的多极形成至少一个谐振LC电路; 以及变压器，包括二次抽头，所述变压器并联连接到所述RF电源并进一步连接到所述至少一个电感器，使得注入到所述次级抽头中的信号被传送到所述至少一个谐振LC电路。 第二电路包括：AC电源，用于经由AC信号向多极提供共模功率，来自连接到次级抽头的第二电路的输出，使得共模功率注入到第一电路中，并且多极可以是 同时工作在共模和差模; 以及用于通过变压器与多极形成谐振LC电路的至少一个电感器，以为AC信号提供电压增益。

公开(公告)号：US20110057095A1

公开(公告)日：2011-03-10

申请号：US12873408

申请日：2010-09-01

申请人： Alexandre Loboda

发明人： Alexandre Loboda

IPC分类号： H01J49/40

CPC分类号： H01J49/4215 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/40

摘要： A method and mass spectrometer for filtering ions are provided. The mass spectrometer generally comprises an ion guide, a quadrupole mass filter, a collision cell and a time of flight (ToF) detector, and is enabled to transmit an ion beam through to the ToF detector. The mass spectrometer is operated in MS mode, such that ions in the ion beam remain substantially unfragmented, the quadrupole mass filter operating at a pressure substantially lower than in either of the ion guide and the collision cell. The quadrupole mass filter is operated in a bandpass mode such that ions outside of a range of interest are filtered from the ion beam, leaving ions inside the range of interest in the ion beam. The ions inside the range of interest are analyzed at the ToF detector.

摘要翻译： 提供了用于过滤离子的方法和质谱仪。 质谱仪通常包括离子导向器，四极质量过滤器，碰撞池和飞行时间（ToF）检测器，并且能够将离子束传输到ToF检测器。 质谱仪以MS模式操作，使得离子束中的离子保持基本上未分片，四极质量过滤器在基本上低于任一种离子导向器和碰撞池中的压力下操作。 四极质量过滤器以带通模式操作，使得离离子束以外的离子之外的离子从离子束中过滤，使离子留在离子束中的感兴趣范围内。 在ToF检测器处分析感兴趣范围内的离子。

公开(公告)号：US20070057178A1

公开(公告)日：2007-03-15

申请号：US11222971

申请日：2005-09-12

申请人： Igor Chernushevich ,  Alexandre Loboda ,  Bruce Thomson ,  Andrew Krutchinsky

发明人： Igor Chernushevich ,  Alexandre Loboda ,  Bruce Thomson ,  Andrew Krutchinsky

IPC分类号： H01J49/06

CPC分类号： H01J49/063 ,  H01J49/107

摘要： A multi-device interface for use in mass spectrometry for interfacing one or more ion sources to one or more downstream devices. The multi-device interface comprises three or more multipole rod sets configured as either an input rod set or an output rod set depending on potentials applied to the multipole rod sets. The multipole rod sets configured as an input rod set are connectable to the one or more ion sources for receiving generated ions therefrom and sending the ions to at least one multipole rod set configured as an output multipole rod set. The output multipole rod sets are connectable to a downstream device for sending the generated ions thereto. At least two of the multipole rod sets are configured as input rod sets or at least two of the multipole rod sets are configured as output rod sets.

摘要翻译： 用于质谱法的多器件界面，用于将一个或多个离子源连接到一个或多个下游装置。 多器件接口包括三个或更多个多极杆组，其被配置为根据施加到多极杆组的电位的输入杆组或输出杆组。 配置为输入杆组的多极棒组可连接到一个或多个离子源，用于从其接收生成的离子，并将离子发送到被配置为输出多极棒组的至少一个多极棒组。 输出多极杆组可连接到用于将产生的离子发送到其的下游装置。 多极杆组中的至少两个被配置为输入杆组，或者至少两个多极杆组被配置为输出杆组。

公开(公告)号：US20060169891A1

公开(公告)日：2006-08-03

申请号：US11315788

申请日：2005-12-22

申请人： Bruce Collings ,  Thomas Covey ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bradley Schneider ,  Bruce Thomson

发明人： Bruce Collings ,  Thomas Covey ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bradley Schneider ,  Bruce Thomson

IPC分类号： B01D59/44

CPC分类号： H01J49/067 ,  H01J49/063

摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, at least one ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.

摘要翻译： 在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。 入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。 一旦形成，具有预定横截面以至基本上径向限制超音速自由射流膨胀的至少一个离子导向器可以将离子聚焦以透过真空室。 这有效地改善离子源和质量分析器之间的离子传递。

公开(公告)号：US20060151692A1

公开(公告)日：2006-07-13

申请号：US11032376

申请日：2005-01-10

申请人： Bruce Collings ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bruce Thomson

发明人： Bruce Collings ,  Mircea Guna ,  Hassan Javaheri ,  Alexandre Loboda ,  Bruce Thomson

IPC分类号： B01D59/44

CPC分类号： H01J49/04 ,  H01J49/062

摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, an ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.

摘要翻译： 在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。 入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。 一旦形成，具有预定横截面以基本上径向限制超音速自由射流膨胀的离子导向器可将离子聚焦以透过真空室。 这有效地改善离子源和质量分析器之间的离子传递。

公开(公告)号：US08785845B2

公开(公告)日：2014-07-22

申请号：US13017709

申请日：2011-01-31

申请人： Alexandre Loboda

发明人： Alexandre Loboda

IPC分类号： H01J49/02 ,  H01J49/40 ,  G01T1/17

CPC分类号： H01J49/025 ,  G01T1/17 ,  H01J49/0027 ,  H01J49/40

摘要： Dual TDC-ADC detection systems for time of flight mass spectrometry are disclosed herein. Detection systems based upon TDC generally provide higher timing resolution as opposed to detection systems based upon ADC. However, ADC generally provides increased dynamic range over TDC. By combining TDC and ADC into a tandem detector, and adjusting performance parameters of the respective converter types, the dynamic range of the dual TDC-ADC detection can be extended beyond what either detector type could have achieved individually. Composite time of flight mass spectra can be generated by aggregating individual mass spectra acquired from multiple time-of-flight extractions, and selecting the number of time-of-flight extractions to ensure overlap between the ADC and TDC dynamic ranges in the dual TDC-ADC detector system.

摘要翻译： 本文公开了用于飞行时间质谱的双TDC-ADC检测系统。 与基于ADC的检测系统相反，基于TDC的检测系统通常提供更高的定时分辨率。 然而，ADC通常提供比TDC更大的动态范围。 通过将TDC和ADC组合成串联检测器，并调整各种转换器类型的性能参数，双TDC-ADC检测的动态范围可以扩展到单独检测器类型之外。 复合飞行时间质谱可以通过聚合从多次飞行时间提取获得的单个质谱，并选择飞行时间提取次数，以确保双TDC中ADC和TDC动态范围之间的重叠， ADC检测器系统。

公开(公告)号：US07495213B2

公开(公告)日：2009-02-24

申请号：US11689742

申请日：2007-03-22

申请人： Alexandre Loboda

发明人： Alexandre Loboda

IPC分类号： H01J49/34 ,  H01J49/40

CPC分类号： H01J49/4225 ,  H01J49/0095

摘要： There is provided a linear ion trap having an ion guide and a method of operating same. The ion guide has a first end and a second end. The method involves a) providing a first group of ions within the ion guide; b) providing a second group of ions within the ion guide, the second group of ions being opposite in polarity to the first group of ions; c) providing an RF drive voltage to the ion guide to radially confine the first group of ions and the second group of ions in the ion guide; d) providing a gas flow of an inert gas in a first axial direction away from the first end of the ion guide and toward a middle of the ion guide to repel both the first group of ions and the second group of ions from the first end of the ion guide; and, e) providing a trapping region barrier for repelling both the first group of ions and the second group of ions away from the second end of the ion guide. The gas flow in the first axial direction and the trapping region barrier together define a main trapping region for trapping both the first group of ions and the second group of ions.

摘要翻译： 提供了具有离子导向器的线性离子阱和其操作方法。 离子导向件具有第一端和第二端。 该方法包括：a）在离子导向器内提供第一组离子; b）在所述离子导向器内提供第二组离子，所述第二组离子极性与所述第一组离子相反; c）向所述离子导向器提供RF驱动电压以将所述第一组离子和所述第二组离子径向地限制在所述离子导向器中; d）提供惰性气体在远离离子导向器的第一端的第一轴向方向上并朝向离子导向器的中间的气流，以从第一端排斥第一组离子和第二组离子 的离子导向器; 以及e）提供俘获区域屏障，用于排斥所述第一组离子和所述第二组离子离开所述离子导向件的第二端。 第一轴向的气流和俘获区势垒一起限定用于俘获第一组离子和第二组离子的主捕集区。

公开(公告)号：US20070110628A1

公开(公告)日：2007-05-17

申请号：US10555784

申请日：2004-05-28

申请人： Alexandre Loboda

发明人： Alexandre Loboda

IPC分类号： B01L3/02

CPC分类号： B01L3/0265 ,  B01L3/0268 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0439 ,  B01L2400/0487 ,  B01L2400/0666 ,  G01N30/10 ,  G01N30/6095 ,  G01N30/7233 ,  G01N30/84 ,  G01N35/1016 ,  G01N2030/385 ,  G01N2030/8411 ,  G01N2030/8417 ,  G01N2030/8464 ,  G01N2030/847 ,  G01N2035/1034 ,  H01J49/00

摘要： An apparatus and method for dispensing low volumes of an analyte solution. The apparatus comprises: (a) a receiver defining an ejection cavity and an outlet downstream of and in fluid communication with the ejection cavity; (b) first and second fluid conduits coupled to the receiver and defining respective first and second fluid flow paths in fluid communication with the ejection cavity; (c) an analyte generating apparatus operatively coupled to the first fluid conduit and operable to deliver analyte solution along the first fluid flow path to the ejection cavity; and (d) a dispensing mechanism operatively coupled to the second fluid conduit and operable to deliver a fluid buffer along the second fluid flow path into the ejection cavity to displace analyte solution present therein through the outlet. The method involves filling the ejection cavity with an analyte solution at a selected rate and injecting a fluid buffer into the injection cavity to displace the analyte solution through the outlet.

摘要翻译： 用于分配低体积分析物溶液的装置和方法。 所述装置包括：（a）接收器，其限定出射腔和与所述喷射腔流体连通的下游出口; （b）第一和第二流体管道，其耦合到所述接收器并且限定与所述喷射腔流体连通的相应的第一和第二流体流动路径; （c）分析物产生装置，其可操作地耦合到所述第一流体导管并且可操作以将分析物溶液沿着所述第一流体流动路径输送到所述喷射腔; 和（d）分配机构，其可操作地耦合到所述第二流体导管并且可操作以沿着所述第二流体流动路径将流体缓冲器输送到所述喷射腔中，以通过所述出口移动其中存在的分析物溶液。 该方法包括以选定的速率向分析物溶液填充喷射腔，并将流体缓冲液注射到注射腔中以通过出口移动分析物溶液。

公开(公告)号：US20050247872A1

公开(公告)日：2005-11-10

申请号：US11122034

申请日：2005-05-05

申请人： Alexandre Loboda ,  Igor Chernushhevich

发明人： Alexandre Loboda ,  Igor Chernushhevich

IPC分类号： H01J49/00 ,  H01J49/02 ,  H01J49/16 ,  H01J49/26 ,  H01J49/40 ,  H01J49/42

CPC分类号： H01J49/401 ,  H01J49/062

摘要： An ion guide 24 for a mass spectrometer 30 including means for ejecting ions of different mass-to-charge ratios from the ion guide towards a detector or other object or device. The ejecting means causes the ions to be ejected in a desired sequence. The ions travel at different rates according to their mass-to-charge ratios, so that they arrive at a desired point in space in a desired sequence, for example in a detector 56 of a mass spectrometer at substantially the same time.

摘要翻译： 用于质谱仪30的离子导向器24包括用于从离子导向器朝向检测器或其它物体或装置喷射不同质荷比的离子的装置。 喷射装置使得以期望的顺序喷射离子。 离子以不同的速率根据它们的质荷比而行进，使得它们以所需的顺序到达空间中的期望点，例如在质谱仪的基本上同时的检测器56中。