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公开(公告)号：US20140235554A1
公开(公告)日：2014-08-21
申请号：US14179034
申请日：2014-02-12
申请人： Brian Lawrence , Jon St. Germain
发明人： Brian Lawrence , Jon St. Germain
IPC分类号： A61K38/17 , A61K47/26 , A61K45/06 , C07K14/435 , A61K31/728
CPC分类号： A61K38/1767 , A61K9/0048 , A61K31/728 , A61K45/06 , A61K47/26 , A61K47/36 , C07K14/43586
摘要： An ophthalmic composition is described for the treatment of dry eye syndrome in a human or mammal. The composition comprises an aqueous solution including an effective amount of silk protein. The aqueous solution comprises from about 0.01% by weight to about 30% by weight of the silk protein. In one embodiment, the silk protein may be fibroin. A method of treating an eye having an ocular surface is also described. The method comprises providing an ophthalmic composition comprising an aqueous solution including an effective amount of silk protein, and administering the ophthalmic composition topically to the ocular surface.
摘要翻译： 描述了用于治疗人或哺乳动物的干眼综合征的眼用组合物。 组合物包含含有有效量的丝蛋白的水溶液。 该水溶液占丝蛋白质的约0.01重量％至约30重量％。 在一个实施方案中，丝蛋白可以是丝心蛋白。 还描述了一种治疗具有眼表面的眼睛的方法。 该方法包括提供一种眼用组合物，其包含含有有效量的丝蛋白的水溶液，并将眼用组合物局部施用于眼表面。
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公开(公告)号：US20090062824A1
公开(公告)日：2009-03-05
申请号：US12229343
申请日：2008-08-22
IPC分类号： A61B17/122
CPC分类号： A61F5/005 , A61B2017/00818 , A61B2017/00876 , A61F2/0018 , A61F2/0036 , A61F5/0066 , A61F2210/009
摘要： A structure that can be used as a gastric band (and that may also have other uses as an implant elsewhere in a patient) includes a plurality of magnetic elements in a serial array that can be implanted so that the array extends in a circumferential direction around the patient's stomach (or other body tissue structure in the patient). Circumferentially adjacent magnetic elements magnetically attract one another to apply radial pressure to the tissue structure encompassed by the array, but those elements can also move apart in response to sufficient outward pressure from the encompassed tissue structure and/or the contents of (e.g., food in) that tissue structure. When used as a gastric band, the device can provide resistance to excessive food intake, which can help promote weight loss.
摘要翻译： 可以用作胃带（并且还可以作为其他用途在医院其他地方的其他用途）的结构包括可以植入的串联阵列中的多个磁性元件，使得阵列沿圆周方向延伸 患者的胃（或患者的其他身体组织结构）。 周向相邻的磁性元件相互磁吸引，以向阵列所包围的组织结构施加径向压力，但是这些元件也可以响应于来自包围的组织结构的足够的向外压力和/或（例如， ）组织结构。 当用作胃带时，该装置可以提供抵抗过量食物摄取，这可以帮助促进减肥。
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公开(公告)号：US20180344444A1
公开(公告)日：2018-12-06
申请号：US15883044
申请日：2018-01-29
申请人： Jon ST. GERMAIN
发明人： Jon ST. GERMAIN
摘要： Sphincter reinforcement devices are described. Sphincter reinforcement devices may be configured to be placed at least partially around a bodily passage at or near a sphincter. In one embodiment, a sphincter reinforcement device may comprise a ring including a tubular structure. The ring may be expandable. The tubular structure may be hollow. The tubular structure may have a first end and a second end. The first end may be configured to be coupled to the second end. The tubular structure may include a braided material.
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公开(公告)号：US6120522A
公开(公告)日：2000-09-19
申请号：US141209
申请日：1998-08-27
CPC分类号： A61F2/95 , A61F2/0095 , A61F2/91 , A61F2002/011 , A61F2002/3008 , A61F2002/30448 , A61F2002/9665 , A61F2220/005 , A61F2250/0098
摘要： The present invention provides a self-expanding stent delivery system comprising a catheter, a self-expanding stent having a plurality of interconnected expansion cells therein and concentrically arranged around the catheter near the distal end of the catheter, a retractable sheath for covering the stent constructed and arranged for retraction to release the stent to self-expand, and a stent holder abutting the stent for holding the stent in place until the retractable sheath is fully retracted. During retraction of the retractable cover, the stent holder prevents the stent from substantially moving longitudinally until the retractable sheath has been completely removed from the stent.
摘要翻译： 本发明提供了一种自扩张支架输送系统，其包括导管，其中具有多个相互连接的膨胀细胞的自扩张支架，并且在导管的远端附近围绕导管同心布置，用于覆盖支架的伸缩护套 并且布置成用于缩回以释放支架以自扩张，并且支架支架邻接支架以将支架保持在适当位置，直到可伸缩护套完全缩回。 在缩回可缩回的盖子期间，支架支架防止支架基本上纵向移动，直到伸缩护套已从支架完全移除。
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公开(公告)号：US08715157B2
公开(公告)日：2014-05-06
申请号：US12229343
申请日：2008-08-22
CPC分类号： A61F5/005 , A61B2017/00818 , A61B2017/00876 , A61F2/0018 , A61F2/0036 , A61F5/0066 , A61F2210/009
摘要： A structure that can be used as a gastric band (and that may also have other uses as an implant elsewhere in a patient) includes a plurality of magnetic elements in a serial array that can be implanted so that the array extends in a circumferential direction around the patient's stomach (or other body tissue structure in the patient). Circumferentially adjacent magnetic elements magnetically attract one another to apply radial pressure to the tissue structure encompassed by the array, but those elements can also move apart in response to sufficient outward pressure from the encompassed tissue structure and/or the contents of (e.g., food in) that tissue structure. When used as a gastric band, the device can provide resistance to excessive food intake, which can help promote weight loss.
摘要翻译： 可以用作胃带（并且还可以作为其他用途在医院其他地方的其他用途）的结构包括可以植入的串联阵列中的多个磁性元件，使得阵列沿圆周方向延伸 患者的胃（或患者的其他身体组织结构）。 周向相邻的磁性元件相互磁吸引，以向阵列所包围的组织结构施加径向压力，但是这些元件也可以响应于来自包围的组织结构的足够的向外压力和/或（例如， ）组织结构。 当用作胃带时，该装置可以提供抵抗过量食物摄取，这可以帮助促进减肥。
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6.发明申请公开(公告)号：US20110098731A1
公开(公告)日：2011-04-28
申请号：US12902207
申请日：2010-10-12
IPC分类号： A61B17/00
CPC分类号： A61F2/0018 , A61B17/12009 , A61B2017/00805 , A61B2017/00827 , A61B2017/00876 , A61F2/0036 , A61F2002/044 , A61F2210/009
摘要： A prosthesis for implanting in a patient may include an elongated, laterally flexible structure having first and second end portions that are spaced from one another along a length of the elongated structure. First and second magnetic structures may be respectively secured to the first and second end portions. The first and second magnetic structures may magnetically attract one another when brought into proximity with one another. This magnetic attraction can facilitate achieving desired final relative positioning and/or alignment of the magnetic structures. Thereafter, this magnetic attraction can keep (or help to keep) the end portions of the prosthesis proximate to one another, thereby forming the prosthesis into a desired closed ring shape.
摘要翻译： 用于植入患者体内的假体可以包括细长的横向柔性结构，其具有沿细长结构的长度彼此间隔开的第一和第二端部。 第一和第二磁性结构可以分别固定到第一和第二端部。 当彼此接近时，第一和第二磁性结构可以磁性吸引。 这种磁吸引可以有助于实现磁性结构的期望的最终相对定位和/或对准。 此后，该磁性吸引物可以保持（或有助于保持）假体的端部彼此靠近，从而将假体形成为期望的闭环形状。
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公开(公告)号：US20070233232A1
公开(公告)日：2007-10-04
申请号：US11395196
申请日：2006-03-31
申请人： Jon St. Germain , Daniel Adams
发明人： Jon St. Germain , Daniel Adams
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/852 , A61F2/915 , A61F2/95 , A61F2002/91541 , A61F2002/91558 , A61F2002/91591 , A61F2002/9665 , A61F2230/0054 , A61F2250/0063 , A61F2250/0071
摘要： The present invention is a vascular stent comprising a cylindrical wall radially expandable from a compressed state to an expanded state and including a plurality of cells. At least one cell includes a first primary member having a first restrainer member and a second primary member having a second restrainer member. When the cylindrical wall is in the expanded state, the first and second primary members are located a greater distance from each other than when the cylindrical wall is in the compressed state. The first and second restrainer members join to maintain the cylindrical wall in the compressed state. An expansion force applied to the cylindrical wall causes the first and second restrainer members to separate, thereby freeing the cylindrical wall to expand from the compressed state to the expanded state.
摘要翻译： 本发明是一种血管支架，其包括从压缩状态向膨胀状态径向扩张并包括多个细胞的圆柱形壁。 至少一个电池包括具有第一限制器构件的第一主构件和具有第二限制构件的第二主构件。 当圆柱形壁处于膨胀状态时，与圆柱形壁处于压缩状态相比，第一和第二主要构件彼此相距较大。 第一和第二限制件连接以将圆筒壁保持在压缩状态。 施加到圆筒壁上的膨胀力使得第一和第二限制构件分离，从而使圆柱形壁从压缩状态膨胀到膨胀状态。
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公开(公告)号：US20050159640A1
公开(公告)日：2005-07-21
申请号：US11042642
申请日：2005-01-24
申请人： Denise Barbut , Peter Keith , Steven Berhow , Jon St. Germain
发明人： Denise Barbut , Peter Keith , Steven Berhow , Jon St. Germain
IPC分类号： A61B5/0215 , A61B17/00 , A61B17/12 , A61B17/22 , A61F2/06 , A61M25/00 , A61M25/06 , A61N1/362
CPC分类号： A61B17/12045 , A61B5/0215 , A61B5/4076 , A61B6/481 , A61B17/12036 , A61B17/12109 , A61B17/12136 , A61B17/12145 , A61B17/1219 , A61B2017/22054 , A61B2090/3966 , A61F7/12 , A61F2002/068 , A61F2007/126 , A61M25/00 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/0069 , A61M25/0074 , A61M25/008 , A61M25/0082 , A61M25/0147 , A61M25/0662 , A61M25/1011 , A61M2025/0002 , A61M2025/0034 , A61M2025/0073 , A61M2025/0081 , A61M2025/1052 , A61M2210/127 , A61M2230/005 , A61M2230/30
摘要： Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.
摘要翻译： 为全脑或局灶性脑缺血患者提供局部主动脉阻塞用于脑灌注增强的方法。 或者，所述方法可用于部分阻塞主动脉血流以调节脊髓以在腹主动脉瘤修复之前分泌神经保护剂。 容器的部分阻塞可以通过包括细长导管和远侧安装的可扩张构件的装置来实现。 可膨胀构件可以包括一个或两个气囊。 诸如血管成形术，支架或粥样斑块切除术导管的其它医疗装置可以在可扩张构件的远端插入以提供治疗干预。
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9.发明申请Partial aortic occlusion devices and methods for cerebral perfusion augmentation 有权局部主动脉闭塞装置和脑灌注增强的方法公开(公告)号：US20050124849A1
公开(公告)日：2005-06-09
申请号：US11042639
申请日：2005-01-24
申请人： Denise Barbut , Peter Keith , Steven Berhow , Jon St. Germain
发明人： Denise Barbut , Peter Keith , Steven Berhow , Jon St. Germain
IPC分类号： A61B5/0215 , A61B17/00 , A61B17/12 , A61B17/22 , A61F2/06 , A61M25/00 , A61M25/06 , A61N1/362 , A61M31/00
CPC分类号： A61B17/12045 , A61B5/0215 , A61B5/4076 , A61B6/481 , A61B17/12036 , A61B17/12109 , A61B17/12136 , A61B17/12145 , A61B17/1219 , A61B2017/22054 , A61B2090/3966 , A61F7/12 , A61F2002/068 , A61F2007/126 , A61M25/00 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/0069 , A61M25/0074 , A61M25/008 , A61M25/0082 , A61M25/0147 , A61M25/0662 , A61M25/1011 , A61M2025/0002 , A61M2025/0034 , A61M2025/0073 , A61M2025/0081 , A61M2025/1052 , A61M2210/127 , A61M2230/005 , A61M2230/30
摘要： Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.
摘要翻译： 为全脑或局灶性脑缺血患者提供局部主动脉阻塞用于脑灌注增强的方法。 或者，所述方法可用于部分阻塞主动脉血流以调节脊髓以在腹主动脉瘤修复之前分泌神经保护剂。 容器的部分阻塞可以通过包括细长导管和远侧安装的可扩张构件的装置来实现。 可膨胀构件可以包括一个或两个气囊。 诸如血管成形术，支架或粥样斑块切除术导管的其它医疗装置可以在可扩张构件的远端插入以提供治疗干预。
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公开(公告)号：US06478814B2
公开(公告)日：2002-11-12
申请号：US09407836
申请日：1999-09-28
IPC分类号： A61F206
CPC分类号： A61F2/958 , A61F2002/9583 , A61F2002/9665 , A61F2250/0029
摘要： A stent delivery system which has a catheter including an inflatable portion. A stent being disposed about the inflatable portion of the catheter, the stent having a contracted state and an expanded state. A pair of stent retaining sleeves which are partially composed of PTFE, each sleeve having a first end portion overlying a respective end of the stent, each sleeve having a second end portion respectively attached to the catheter, the sleeves retaining the stent to the catheter when the stent is in the contracted state, the stent being freed from the sleeves when the stent is placed in the expanded state. The sleeves being placed on the stent by heat shrinking. The inflatable portion of the balloon optionally having stepped compliant characteristics.
摘要翻译： 一种支架输送系统，其具有包括可充气部分的导管。 支架围绕导管的可充气部分设置，支架具有收缩状态和膨胀状态。 一对支架保持套管，其部分地由PTFE组成，每个套管具有覆盖在支架的相应端部上的第一端部部分，每个套筒具有分别附接到导管的第二端部，套管将支架保持在导管上， 支架处于收缩状态，当支架置于膨胀状态时，支架从套筒中脱离。 袖子通过热收缩放置在支架上。 气囊的可充气部分可选地具有阶梯顺应特性。
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