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公开(公告)号：US5645982A
公开(公告)日：1997-07-08
申请号：US109305
申请日：1993-08-19
CPC分类号： G01N33/5088 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N2333/16 , Y10S435/974
摘要： The invention provides methods for screening agents for potential anti-viral effects by assessing the ability of the agents to suppress viral replication and/or pathology in thymic cells grown in thymic organ culture in vitro. Also provided are methods to study viral pathology and infectivity.
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2.发明授权Chimeric immunocompromised mammal comprosing vascularized fetal organ tissue 失效嵌合免疫受损的哺乳动物压缩血管化的胎儿器官组织
公开(公告)号：US5639939A
公开(公告)日：1997-06-17
申请号：US205053
申请日：1994-03-01
IPC分类号： A01K67/027 , C07K16/00 , A61K49/00
CPC分类号： C07K16/00 , A01K67/0271 , C12N2517/00
摘要： Xenogeneic tissue is introduced into an immunocompromised host for interacting with agents and using such interaction for evaluating efficacy of drugs and vaccines, producing xenogeneic monoclonal antibodies, evaluating the effect of the various agents on specific tissues and the like. Particularly, drugs can be evaluated for their efficacy against a wide variety of pathogens which infect xenogeneic tissue, agents can be evaluated for their effect on the xenogeneic immune system and monoclonal antibodies to a predetermined epitope may be produced.
摘要翻译： 将异种组织引入免疫受损的宿主中与试剂相互作用，并使用这种相互作用来评价药物和疫苗的功效，产生异种单克隆抗体，评估各种试剂对特定组织等的影响。 特别地，可以评估药物对于感染异种组织的各种病原体的功效，可以评价药物对异种免疫系统的作用，并且可以产生预定表位的单克隆抗体。
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公开(公告)号：US5476997A
公开(公告)日：1995-12-19
申请号：US245250
申请日：1994-05-17
IPC分类号： A01K67/027 , C12N15/85 , A61K35/00
CPC分类号： A01K67/0271 , C12N15/8509 , A01K2217/05 , A01K2267/025 , A01K2267/0381 , C12N2517/00
摘要： A human hematopoietic system is provided in an immunocompromised mammalian host, where the hematopoietic system is functional for extended periods of time. Particularly, human fetal liver tissue and human fetal thymus is introduced into an appropriate site of a young immunocompromised mouse at a site supplied with a vascular system, whereby the fetal tissue results in novel formation of functional human bone marrow tissue.
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公开(公告)号：US5612018A
公开(公告)日：1997-03-18
申请号：US183178
申请日：1994-01-18
IPC分类号： A01K67/027 , A61K49/00 , C12N15/85
CPC分类号： A61K49/0004 , A01K67/0271 , C12N2517/00
摘要： A method is provided for screening compounds for the ability to supress thymocyte depletion in thymuses of HIV-infected individuals, particularly enhancing the CD4.sup.+ -expressing population as compared to an untreated individual. Particularly, drugs are provided which allow for this result, cyclosporine A being exemplary.
摘要翻译： 提供了一种筛选化合物以抑制HIV感染个体的胸腺中胸腺细胞消耗的能力的方法，特别是与未处理的个体相比增强了CD4 +表达的群体。 特别地，提供了允许该结果的药物，环孢菌素A是示例性的。
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5.发明授权
公开(公告)号：US5601975A
公开(公告)日：1997-02-11
申请号：US466420
申请日：1995-06-06
CPC分类号： G01N33/5088 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N2333/16 , Y10S435/974
摘要： The invention provides methods for screening agents for potential anti-viral effects by assessing the ability of the agents to suppress viral replication and/or pathology in thymic cells grown in thymic organ culture in vitro. Also provided are methods to study viral pathology and infectivity.
摘要翻译： 本发明通过评估试剂在体外在胸腺器官培养物中生长的胸腺细胞中抑制病毒复制和/或病理学的能力来提供用于筛选潜在抗病毒作用的方法。 还提供了研究病毒病理学和感染性的方法。
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公开(公告)号：US5643551A
公开(公告)日：1997-07-01
申请号：US329679
申请日：1994-10-26
IPC分类号： A01K67/027 , A61K35/12 , A61K49/00 , C12N5/06 , C12Q1/02 , G01N33/48 , A01N57/00 , A61K38/00 , C12N5/00 , C12N15/06
CPC分类号： A01K67/0271 , A61K49/0008 , Y10S424/90
摘要： A method for initiating metastasis of human tumor cells under experimental conditions is provided. Immunocompromised non-human mammals having a viable, xenogeneic organ or tissue are used as a host for human tumor cells. The cells are introduced into the chimeric animal after the solid tissue is implanted and are then able to grow and metastasize as they would in situ. Therapeutic regimens may be evaluated in this system to determine efficacy against metastatic processes.
摘要翻译： 提供了一种在实验条件下启动人肿瘤细胞转移的方法。 具有活的异种器官或组织的免疫受损的非人哺乳动物用作人肿瘤细胞的宿主。 在植入固体组织后，将细胞导入嵌合动物体内，然后能像原位一样生长和转移。 可以在该系统中评估治疗方案以确定对转移过程的功效。
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公开(公告)号：US5633426A
公开(公告)日：1997-05-27
申请号：US194717
申请日：1994-02-10
IPC分类号： A01K67/027 , A61K49/00 , A61K48/00
CPC分类号： A01K67/0271
摘要： Chimeric immunocompromised hosts are provided, comprising human bone marrow of at least 4 weeks from the time of implantation. The bone marrow is found to assume the normal population of bone marrow except for erythrocytes. The bone marrow may be used to study the effect of various agents on the proliferation and differentiation of hematopoietic cells.
摘要翻译： 提供嵌合的免疫受损宿主，其包含从植入起始至少4周的人骨髓。 除了红细胞外，发现骨髓假定正常骨髓群体。 骨髓可用于研究各种药剂对造血细胞增殖和分化的影响。
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公开(公告)号：US5625127A
公开(公告)日：1997-04-29
申请号：US434706
申请日：1995-05-04
IPC分类号： A01K67/027 , C12N15/85 , A61K35/00
CPC分类号： A01K67/0271 , C12N15/8509 , A01K2217/05 , A01K2267/025 , A01K2267/0381 , C12N2517/00
摘要： A human hematopoietic system is provided in an immunocompromised mammalian host, where the hematopoietic system is functional for extended periods of time. Particularly, human fetal liver tissue and human fetal thymus is introduced into an appropriate site of a young immunocompromised mouse at a site supplied with a vascular system, whereby the fetal tissue results in novel formation of functional human bone marrow tissue.
摘要翻译： 在免疫受损的哺乳动物宿主中提供人类造血系统，其中造血系统在延长的时间段内起作用。 特别地，在供应有血管系统的部位将人胎肝组织和人胎儿胸腺引入幼年免疫受损小鼠的适当部位，由此胎儿组织导致功能性人骨髓组织的新形成。
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公开(公告)号：US5411749A
公开(公告)日：1995-05-02
申请号：US996831
申请日：1992-12-23
IPC分类号： A01K67/027 , A61K35/00 , A61K39/00 , C07K16/00 , C12N5/08 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12P21/08 , C12R1/91 , A61K49/00
CPC分类号： A01K67/0271 , C07K16/00
摘要： Human lymphoid tissue is introduced into an immunocompromised host to provide opportunities to investigate the effect of stimuli on the human immune system and obtain information and products from the stimulus. Particularly, methodology is provided for the production of human monoclonal antibodies by introducing lymphoid tissue into an immunocompromised host, stimulating the B-lymphocytes with an appropriate immunogen, harvesting the tissue and immortalizing and/or cloning the B-lymphocytes under conditions to obtain a stable supply of monoclonal antibodies.
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