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1.发明授权
公开(公告)号：US4876188A
公开(公告)日：1989-10-24
申请号：US932442
申请日：1986-11-18
CPC分类号： G01N33/723 , Y10S436/808 , Y10S436/811 , Y10S436/815 , Y10S436/825
摘要： Methods of preparing glucitollysinehemoglobin from a sample of glucohemoglobin containing stable and labile glucohemoglobins and for assaying for the presence of stable glucohemoglobin are disclosed, as is a diagnostic assay system useful for carrying out the methods.
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公开(公告)号：US5169937A
公开(公告)日：1992-12-08
申请号：US426306
申请日：1989-10-24
IPC分类号： G01N33/72
CPC分类号： G01N33/723
摘要： Methods of preparing glucitollysine-hemoglobin from a sample of glucohemoglobin containing stable and labile glucohemoglobins and for assaying for the presence of stable glucohemoglobin are disclosed, as is a diagnostic assay system useful for carrying out the methods.
摘要翻译： 公开了从含有稳定和不稳定的葡糖血红蛋白的葡糖血红蛋白样品中测定稳定的葡糖血红蛋白的方法制备葡糖糖苷血红蛋白的方法，以及用于实施该方法的诊断测定系统。
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3.发明授权Polypeptide analogs of apolipoprotein E, diagnostic systems and methods using the analogs 失效载脂蛋白E的多肽类似物，诊断系统和使用类似物的方法
公开(公告)号：US5473039A
公开(公告)日：1995-12-05
申请号：US805193
申请日：1991-12-09
申请人： Cheryl A. Dyer , Linda K. Curtiss , Richard Smith
发明人： Cheryl A. Dyer , Linda K. Curtiss , Richard Smith
CPC分类号： C07K16/18 , C07K14/775 , A61K38/00
摘要： The present invention contemplates a multimeric polypeptide capable of mimicking the ability of apo E to induce differentiated cellular function. The repeating unit of the polypeptide has an amino acid residue sequence corresponding to that represented by the formula LRXLRKRLLX. Also contemplated is a method for treating hypercholesterolemia in a patient, which method comprises administering to the patient an LDL plasma concentration-reducing amount of the polypeptide. Described as well, is the use of the polypeptide in preparing diagnostic antibodies, and their use in diagnostic systems and methods for detecting apo E antigens in vascular body fluids.
摘要翻译： 本发明考虑了能够模拟载脂蛋白E诱导分化的细胞功能的能力的多聚体多肽。 多肽的重复单元具有与由式LRXLRKRLLX表示的氨基酸残基相对应的氨基酸残基。 还考虑了用于治疗患者的高胆固醇血症的方法，该方法包括向患者施用LDL血浆浓度降低量的多肽。 还描述了多肽在制备诊断抗体中的用途，以及它们在用于检测血管体液中的载脂蛋白E抗原的诊断系统和方法中的用途。
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公开(公告)号：US5182364A
公开(公告)日：1993-01-26
申请号：US485158
申请日：1990-02-26
申请人： Cheryl A. Dyer , Linda K. Curtiss , Richard Smith
发明人： Cheryl A. Dyer , Linda K. Curtiss , Richard Smith
IPC分类号： A61K38/00 , C07K14/775 , C07K16/18
CPC分类号： C07K14/775 , C07K16/18 , A61K38/00
摘要： The present invention contemplates a method for treating hypercholesterolemia in a patient, which method comprises administering to the patient an LDL plasma concentration-reducing amount of a multimeric polypeptide capable of binding the LDL receptor. THe repeating unit of the polypeptide has an amino acid residue sequence corresponding to that represented by the formula LRKLRKRLLRDADDL.
摘要翻译： 本发明涉及用于治疗患者的高胆固醇血症的方法，该方法包括向患者施用LDL血浆浓度降低量的能够结合LDL受体的多聚体多肽。 所述多肽的重复单元具有对应于由式LRKLRKRLLRDADDL表示的氨基酸残基序列。
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公开(公告)号：US5177189A
公开(公告)日：1993-01-05
申请号：US395732
申请日：1989-08-18
申请人： Cheryl A. Dyer , Linda K. Curtiss , Richard Smith
发明人： Cheryl A. Dyer , Linda K. Curtiss , Richard Smith
IPC分类号： A61K38/00 , C07K14/775 , C07K16/18
CPC分类号： C07K16/18 , C07K14/775 , A61K38/00
摘要： The present invention contemplates a multimeric polypeptide capable of mimicking the ability of Apo E in regulating lymphocyte proliferation and ovarian androgen synthesis. The polypeptide has an amino acid residue sequence represented by the formula ##STR1##
摘要翻译： 本发明考虑了能够模拟Apo E调节淋巴细胞增殖和卵巢雄激素合成的能力的多聚体多肽。 该多肽具有由式NH2-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu- Leu-Arg-Asp-Ala-Asp-Asp-Leu- Leu-Arg-Lys- Leu-Arg-Lys-Arg-Leu- Leu-Arg-Asp-Ala-Asp-Asp-Leu-COOH。
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6.发明授权Diagnostic systems and methods using polypeptide analogs of apolipoprotein E 失效诊断系统和使用APOPOOPOPTETE E的多肽类似物的方法
公开(公告)号：US5168045A
公开(公告)日：1992-12-01
申请号：US540363
申请日：1990-06-18
申请人： Cheryl A. Dyer , Linda K. Curtiss , Richard Smith
发明人： Cheryl A. Dyer , Linda K. Curtiss , Richard Smith
IPC分类号： A61K38/00 , A61K38/04 , A61K39/395 , A61P3/06 , A61P7/00 , A61P37/06 , C07K7/08 , C07K14/775 , C07K16/00 , C07K16/18 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53
CPC分类号： C07K16/18 , C07K14/775 , A61K38/00
摘要： Apo E polypeptides capable of mimicking apolipoprotein E are described that are useful to prepare diagnostic antibodies, and for use in diagnostic systems and methods for detecting apo E antigens in vascular body fluids.
摘要翻译： 描述了能够模拟载脂蛋白E的Apo E多肽，其可用于制备诊断抗体，并且用于诊断系统和用于检测血管体液中的载脂蛋白E抗原的方法。
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7.发明授权Diagnostic assay for the presence of apolipoproteins associated with plasma high density lipoproteins 失效与血浆高密度脂蛋白相关的载脂蛋白的存在的诊断测定
公开(公告)号：US4677057A
公开(公告)日：1987-06-30
申请号：US710038
申请日：1985-03-11
IPC分类号： G01N33/53 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/18 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/92 , G01N33/543
CPC分类号： G01N33/92 , C07K16/18 , G01N2800/044 , Y10S435/948 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S530/808 , Y10S530/809 , Y10S530/864
摘要： Monoclonal receptors that immunologically bind to human apolipoprotein A molecules, particularly apo-A-I and apo-A-II, are described as are their methods of use and articles of manufacture containing them.
摘要翻译： 与人载脂蛋白A分子，特别是载脂蛋白A-I和载脂蛋白A-II免疫结合的单克隆受体，被描述为它们的使用方法和含有它们的制品。
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公开(公告)号：US5055396A
公开(公告)日：1991-10-08
申请号：US116248
申请日：1987-11-02
申请人： Linda K. Curtiss , Richard S. Smith
发明人： Linda K. Curtiss , Richard S. Smith
IPC分类号： G01N33/53 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/775 , C07K16/00 , C07K16/18 , C07K19/00 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： C07K16/18 , Y10S435/81 , Y10S436/808 , Y10S530/806
摘要： The present invention describes a monoclonal antibody that is directed against an Apo AI/HLD epitope whose expression is substantially unaffected by deamidation. Also disclosed is a polypeptide capable of immunologically mimicking an Apo AI/HLD epitope whose expression is substantially unaffected by deamidation. Diagnostic systems and methods for determining the amount of Apo AI in a vascular fluid sample using a disclosed monoclonal antibody and/or a disclosed polypeptide are also described.
摘要翻译： 本发明描述了针对Apo AI / HLD表位的单克隆抗体，其表达基本上不受脱酰胺作用的影响。 还公开了能够免疫模拟Apo AI / HLD表位的多肽，其表达基本上不受脱酰胺的影响。 还描述了使用公开的单克隆抗体和/或所公开的多肽来测定血管液样品中Apo AI的量的诊断系统和方法。
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9.发明授权Apolipoprotein B-specific monoclonal antibodies produced by two novel hybridomas 失效由两种新型杂交瘤产生的载脂蛋白B特异性单克隆抗体
公开(公告)号：US5460947A
公开(公告)日：1995-10-24
申请号：US219963
申请日：1994-03-30
IPC分类号： G01N33/53 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/18 , C07K19/00 , C12N5/10 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/531
CPC分类号： C07K16/18 , C07K2317/77
摘要： Two hybridomas that produce receptors containing antibody combining sites that immunoreact with apolipoprotein B-100 are disclosed as are uses for the receptors, compositions and diagnostic systems that include the receptors.
摘要翻译： 公开了产生含有与载脂蛋白B-100免疫反应的抗体结合位点的受体的两个杂交瘤作为包括受体的受体，组合物和诊断系统的用途。
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10.发明授权Nonnatural apolipoprotein B-100 peptides and apolipoprotein B-100-apolipoprotein A-I fusion peptides 失效非天然载脂蛋白B-100肽和载脂蛋白B-100载脂蛋白A-I融合肽
公开(公告)号：US5408038A
公开(公告)日：1995-04-18
申请号：US959946
申请日：1992-10-08
CPC分类号： C07K14/775 , A61K38/00 , C07K2319/00 , C07K2319/40
摘要： Methods and compositions are described for determining the level of low density lipoproteins (LDL) in plasma. Native apoprotein B-100 (apo B-100) present in LDL particles is immunologically mimicked by a polypeptide of the invention. A polypeptide includes an amino acid residue sequence corresponding to a pan epitope region of the target apoprotein. A preferred polypeptide is a fusion protein that simultaneously mimics native apo B-100 and native apo A-I. Improved assay systems and methods for determining HDL and LDL levels in a body fluid sample are also described.
摘要翻译： 描述了用于确定血浆中低密度脂蛋白（LDL）水平的方法和组合物。 LDL颗粒中存在的天然载脂蛋白B-100（载脂蛋白B-100）由本发明的多肽免疫模拟。 多肽包括对应于目标载脂蛋白的泛表位区域的氨基酸残基序列。 优选的多肽是同时模拟天然载脂蛋白B-100和天然载脂蛋白A-I的融合蛋白。 还描述了用于测定体液样品中HDL和LDL水平的改进的测定系统和方法。
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