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    METHOD FOR MANUFACTURING STEM CELL HAVING APPROPRIATE SIZE FOR INTRAVASCULAR ADMINISTRATION
    1.
    发明申请
    METHOD FOR MANUFACTURING STEM CELL HAVING APPROPRIATE SIZE FOR INTRAVASCULAR ADMINISTRATION 有权

    公开(公告)号：US20210040453A1

    公开(公告)日：2021-02-11

    申请号：US17080128

    申请日：2020-10-26

    申请人： JEONG CHAN RA ,  K-STEMCELL CO., LTD.

    发明人： Jeong Chan RA ,  Sung Keun KANG ,  Il Seob SHIN

    IPC分类号： C12N5/0775

    摘要： The present invention relates to a method for preparing stem cells having a size suitable for intravascular administration, and preferably to a method for preparing stem cells with a diameter ranging from 11-16 μm. Additionally, the present invention relates to media composition for preparing stem cells having a size suitable for intravascular administration. According to the present invention, stem cells having a size suitable for intravascular administration can be prepared such that stem cells administered into a vein can stably reach a target tissue, and thus can more efficiently increase efficacy displaying activity, thereby innovatively enhancing the efficacy of cell therapy using stem cells.

    METHOD FOR MANUFACTURING STEM CELL HAVING APPROPRIATE SIZE FOR INTRAVASCULAR ADMINISTRATION
    2.
    发明申请
    METHOD FOR MANUFACTURING STEM CELL HAVING APPROPRIATE SIZE FOR INTRAVASCULAR ADMINISTRATION 审中-公开
    用于制造具有适当尺寸用于静脉内给药的干细胞的方法

    公开(公告)号：US20150072421A1

    公开(公告)日：2015-03-12

    申请号：US14395170

    申请日：2013-04-17

    申请人： Jeong Chan RA ,  K-STEMCELL CO., LTD.

    发明人： Jeong Chan Ra ,  Sung Keun Kang ,  Il Seob Shin

    IPC分类号： C12N5/0775

    CPC分类号： C12N5/0667 ,  C12N2500/14 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/33 ,  C12N2501/39

    摘要： The present invention relates to a method for preparing stem cells having a size suitable for intravascular administration, and preferably to a method for preparing stem cells with a diameter ranging from 11-16 μm. Additionally, the present invention relates to media composition for preparing stem cells having a size suitable for intravascular administration. According to the present invention, stem cells having a size suitable for intravascular administration can be prepared such that stem cells administered into a vein can stably reach a target tissue, and thus can more efficiently increase efficacy displaying activity, thereby innovatively enhancing the efficacy of cell therapy using stem cells.

    摘要翻译： 本发明涉及一种制备适合血管内给药的干细胞的方法，优选涉及制备直径为11-16μm的干细胞的方法。 另外，本发明涉及用于制备适合于血管内施用的尺寸的干细胞的培养基组合物。 根据本发明，可以制备适合于血管内给药的尺寸的干细胞，使得施用于静脉的干细胞可以稳定地达到目标组织，从而可以更有效地提高功效显示活性，从而创新地提高细胞的功效 使用干细胞治疗。

    MEDIUM COMPOSITION FOR REJUVENATING STEM CELLS
    3.
    发明申请
    MEDIUM COMPOSITION FOR REJUVENATING STEM CELLS 有权
    用于重建干细胞的中间组合物

    公开(公告)号：US20140322811A1

    公开(公告)日：2014-10-30

    申请号：US14360621

    申请日：2012-12-03

    申请人： K-STEMCELL CO., LTD.

    发明人： Sung Keun Kang ,  Jeong Chan Ra ,  Hyeong Geun Park ,  Hang Young Lee

    IPC分类号： C12N5/0775

    CPC分类号： C12N5/0667 ,  C12N2500/90 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/33 ,  C12N2501/39

    摘要： The present invention relates to a medium composition for transforming stem cells from an aged person into young stem cells, and more particularly to a medium composition for culturing stem cells, which is used to rejuvenate stem cells from an aged person so as to have characteristics similar to those of the stem cells of young people, and to a method for rejuvenating stem cells, which comprises culturing stem cells from an aged person in the medium composition. According to the present invention, even mesenchymal stem cells collected from over 60 years old patients can be transformed into young mesenchymal stem cells having high differentiation ability, high telomerase activity, and high ability to express stem cell markers. Thus, the present invention can significantly increase the efficacy of cell therapy employing mesenchymal stem cells.

    摘要翻译： 本发明涉及一种用于将老年人干细胞转化为年轻干细胞的培养基组合物，更具体地涉及用于培养干细胞的培养基组合物，其用于使来自老年人的干细胞恢复活力，以具有相似的特征 对于年轻人的干细胞的那些，以及用于培养干细胞的方法，其包括在培养基组合物中培养来自老年人的干细胞。 根据本发明，即使从60多岁的患者收集的间充质干细胞也可以转化为具有高分化能力，高端粒酶活性，高表达干细胞标记能力的年轻间充质干细胞。 因此，本发明可以显着增加使用间充质干细胞的细胞疗法的功效。

    METHOD AND COMPOSITION FOR PREVENTING STEM CELL DISRUPTION AND AGGREGATION
    6.
    发明申请
    METHOD AND COMPOSITION FOR PREVENTING STEM CELL DISRUPTION AND AGGREGATION 有权
    用于预防干细胞破坏和聚集的方法和组合物

    公开(公告)号：US20150118194A1

    公开(公告)日：2015-04-30

    申请号：US14394402

    申请日：2013-04-15

    申请人： Jeong Chan RA ,  K-STEMCELL CO., LTD.

    发明人： Jeong Chan Ra ,  Sung Keun Kang ,  Il Seob Shin

    IPC分类号： A61K35/28 ,  C12N5/0775 ,  A61K31/616

    CPC分类号： A61K35/28 ,  A61K31/616 ,  C12N5/0667 ,  C12N2500/30 ,  C12N2501/71 ,  C12N2501/999

    摘要： There is provided a method for preventing disruption and aggregation of stem cells. In addition, there is provided a stem cell composition for intravascular administration, in which stem cells are suspended in a solution containing aspirin. Further, there is provided a composition for preventing disruption or aggregation of stem cells, in which stem cells are suspended in a solution containing aspirin.According to the present invention, disruption and aggregation of cells may be prevented during transport or storage, such that the administered stem cells may stably reach the target tissue and exhibit the activity thereof in a more efficient manner, thereby remarkably increasing the effect of cell therapy using stem cells.

    摘要翻译： 提供了一种防止干细胞破裂和聚集的方法。 此外，提供了用于血管内给药的干细胞组合物，其中将干细胞悬浮于含有阿司匹林的溶液中。 此外，提供了用于预防干细胞的破坏或聚集的组合物，其中干细胞悬浮于含有阿司匹林的溶液中。 根据本发明，在运输或储存期间可以防止细胞的破裂和聚集，使得所施用的干细胞可以以更有效的方式稳定地到达靶组织并显示其活性，从而显着增加细胞治疗的作用 使用干细胞。

    Method for manufacturing stem cell having appropriate size for intravascular administration
    7.
    发明授权
    Method for manufacturing stem cell having appropriate size for intravascular administration 有权

    公开(公告)号：US10815459B2

    公开(公告)日：2020-10-27

    申请号：US14395170

    申请日：2013-04-17

    申请人： K-STEMCELL CO., LTD. ,  Jeong Chan Ra

    发明人： Jeong Chan Ra ,  Sung Keun Kang ,  Il Seob Shin

    IPC分类号： C12N5/0775

    摘要： The present invention relates to a method for preparing stem cells having a size suitable for intravascular administration, and preferably to a method for preparing stem cells with a diameter ranging from 11-16 μm. Additionally, the present invention relates to media composition for preparing stem cells having a size suitable for intravascular administration. According to the present invention, stem cells having a size suitable for intravascular administration can be prepared such that stem cells administered into a vein can stably reach a target tissue, and thus can more efficiently increase efficacy displaying activity, thereby innovatively enhancing the efficacy of cell therapy using stem cells.

    CANCER DIAGNOSIS METHOD USING RESPIRATORY GAS
    9.
    发明申请
    CANCER DIAGNOSIS METHOD USING RESPIRATORY GAS 有权
    使用呼吸气的癌症诊断方法

    公开(公告)号：US20150351662A1

    公开(公告)日：2015-12-10

    申请号：US14758176

    申请日：2013-12-19

    申请人： Jeong-Chan RA ,  K-STEMCELL CO., LTD.

    发明人： Jeong-Chan RA ,  Soo Hyun KIM

    IPC分类号： A61B5/08

    CPC分类号： A61B5/082 ,  G01N30/7206 ,  G01N33/0047 ,  G01N33/57488 ,  G01N2030/8804 ,  G01N2030/884 ,  G01N2033/4975

    摘要： A method for diagnosing cancer, comprises detecting volatile organic compounds (VOCs) contained specifically in exhaled breath of cancer patients, and more particularly, to a method for providing information for cancer diagnosis, which comprises a step of measuring whether ionized fragments of cancer-specific VOCs, which have molecular weights of (i) 69, (ii) 131 and (iii) 181, are present in exhaled breath gas collected from patients suspected of having cancer. Cancer can be early diagnosed with high sensitivity in a non-invasive manner by use of exhaled breath sampled from cancer patients. Thus, the cancer diagnosis method can diagnose cancer in a more cost-effective and rapid manner compared to conventional cancer diagnosis methods.

    摘要翻译： 一种诊断癌症的方法，包括检测癌症患者的呼出气体中特别包含的挥发性有机化合物（VOC），更具体地，涉及用于提供癌症诊断信息的方法，其包括测量癌症特异性的电离片段 存在分子量为（i）69，（ii）131和（iii）181）的VOC存在于从疑似患有癌症的患者收集的呼出呼吸气体中。 可以通过使用从癌症患者取样的呼出呼吸，以非侵入性的方式将癌症早期诊断为高灵敏度。 因此，与常规癌症诊断方法相比，癌症诊断方法可以以更具成本效益和更快速的方式诊断癌症。