公开(公告)号：US20230016479A1

公开(公告)日：2023-01-19

申请号：US17784740

申请日：2020-12-14

申请人： Jeong Chan RA ,  R Bio CO., Ltd. ,  NATURECELL CO., LTD.

发明人： Jeong Chan RA ,  Eun-Young KIM

IPC分类号： C12N5/0775 ,  A61K35/28 ,  A61P35/00

摘要： The present invention relates to a method for preparing oncolytic virus-containing mesenchymal stem cells having improved cell viability, a method for storing the oncolytic virus-containing stem cells produced by the method, and a cell therapeutic agent for cancer treatment containing the oncolytic virus-containing stem cells produced by the method. More particularly, an oncolytic virus is introduced into mesenchymal stem cells, followed by treatment with aspirin, so that the infection efficiency of the oncolytic virus may be increased, the replication time of the virus may be prolonged, and lysis of the stem cells by the virus may be prevented, thereby improving the viability and survival period of the stem cells and preparing anticancer stem cells having excellent activity. The anticancer stem cell therapeutic agent produced in this way is maintained at high viability during cold storage due to aspirin treatment, and thus is very useful medically and industrially.

公开(公告)号：US20150072421A1

公开(公告)日：2015-03-12

申请号：US14395170

申请日：2013-04-17

申请人： Jeong Chan RA ,  K-STEMCELL CO., LTD.

发明人： Jeong Chan Ra ,  Sung Keun Kang ,  Il Seob Shin

IPC分类号： C12N5/0775

CPC分类号： C12N5/0667 ,  C12N2500/14 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/33 ,  C12N2501/39

摘要： The present invention relates to a method for preparing stem cells having a size suitable for intravascular administration, and preferably to a method for preparing stem cells with a diameter ranging from 11-16 μm. Additionally, the present invention relates to media composition for preparing stem cells having a size suitable for intravascular administration. According to the present invention, stem cells having a size suitable for intravascular administration can be prepared such that stem cells administered into a vein can stably reach a target tissue, and thus can more efficiently increase efficacy displaying activity, thereby innovatively enhancing the efficacy of cell therapy using stem cells.

摘要翻译： 本发明涉及一种制备适合血管内给药的干细胞的方法，优选涉及制备直径为11-16μm的干细胞的方法。 另外，本发明涉及用于制备适合于血管内施用的尺寸的干细胞的培养基组合物。 根据本发明，可以制备适合于血管内给药的尺寸的干细胞，使得施用于静脉的干细胞可以稳定地达到目标组织，从而可以更有效地提高功效显示活性，从而创新地提高细胞的功效 使用干细胞治疗。

公开(公告)号：US20110144039A1

公开(公告)日：2011-06-16

申请号：US12774761

申请日：2010-05-06

申请人： Jeong Chan RA ,  Young Ho KIM ,  Dong Hwan SOHN

发明人： Jeong Chan RA ,  Young Ho KIM ,  Dong Hwan SOHN

IPC分类号： A61K31/12 ,  C07C49/248 ,  C07H15/18 ,  A61K31/7028 ,  A61P29/00 ,  A61P31/00 ,  A61P9/10 ,  A61P9/12 ,  A61P35/00 ,  A61P25/00 ,  A61P17/02 ,  A61P37/00 ,  A61P3/10 ,  A61P39/06 ,  A61P1/16

CPC分类号： A61K36/185 ,  A61K31/12 ,  A61K31/7028

摘要： The present invention relates to antioxidative and hepatoprotective compositions, and more particularly to antioxidative and hepatoprotective compositions comprising diarylheptanoid compounds from Alnus japonica. The diarylheptanoid compounds from Alnus japonica include a compound selected from the group consisting of alusenone 1a, alusenone 1b, hirsutenone, hirsutanonol, oregonin, alnuside A, alnuside B, rubranoside B and rubranoside C. The antioxidative and hepatoprotective compositions have excellent antioxidative and hepatoprotective activities while having no side effects, and thus are useful for the prevention and treatment of oxidation-associated diseases and liver diseases.

摘要翻译： 本发明涉及抗氧化和保肝组合物，更具体地涉及包含来自Al粳的二芳基庚糖类化合物的抗氧化和肝保护组合物。 来自Al粳的二芳基庚酸类化合物包括选自由以下组成的组中的化合物：阿杜塞酮1a，阿杜塞酮1b，多环烯酮，海藻多酚，oregonin，alnuside A，alnuside B，rubranoside B和rubranoside C.抗氧化和肝保护组合物具有优异的抗氧化和保肝活性 同时没有副作用，因此可用于预防和治疗氧化相关疾病和肝脏疾病。

公开(公告)号：US20110124740A1

公开(公告)日：2011-05-26

申请号：US12996314

申请日：2009-06-04

申请人： Jeong Chan Ra ,  Young Ho Kim ,  Hyuk Joon Kwon ,  Huu Tung Nguyen

发明人： Jeong Chan Ra ,  Young Ho Kim ,  Hyuk Joon Kwon ,  Huu Tung Nguyen

IPC分类号： A61K31/12 ,  C07C49/223 ,  A61P31/12 ,  A61P31/16

CPC分类号： C07C49/248 ,  A61K31/12 ,  C07B2200/07 ,  C07C49/245

摘要： The present invention relates to a diaryl hepatonoid-based compound of formula (1) having viral inhibitory activity; its pharmaceutically acceptable salt; or a hydrate, a solvate or a prodrug of any of the foregoing, and a pharmaceutical composition containing the same, and the use thereof therapeutic agents. The diaryl hepatonoid-based compound has an excellent effect of inhibiting viral activity, and thus will be useful as therapeutic agents against virus-related diseases.

摘要翻译： 本发明涉及具有病毒抑制活性的式（1）的二芳基肝素类化合物; 其药学上可接受的盐; 或上述任何一种的水合物，溶剂合物或前药，以及含有该水合物，溶剂合物或前药的药物组合物及其用途。 二芳基肝素类化合物具有优异的抑制病毒活性的效果，因此可用作抗病毒相关疾病的治疗剂。

公开(公告)号：US20110098239A1

公开(公告)日：2011-04-28

申请号：US12996321

申请日：2009-06-04

申请人： Jeong Chan Ra ,  Young Ho Kim ,  Hyuk Joon Kwon ,  Huu Tung Nguyen

发明人： Jeong Chan Ra ,  Young Ho Kim ,  Hyuk Joon Kwon ,  Huu Tung Nguyen

IPC分类号： A61K31/7034 ,  C07H15/18 ,  A61P31/16

CPC分类号： C07D309/10

摘要： The present invention relates to a diaryl hepatonoid-based compound of formula (1) having viral inhibitory activity; its pharmaceutically acceptable salt; or a hydrate, a solvate or a prodrug of any of the foregoing, and a pharmaceutical composition comprising the same, and the use thereof therapeutic agents. The diaryl hepatonoid-based compounds according to present invention have an excellent effect of inhibiting viral activity, and thus will be useful as therapeutic agents against virus-related diseases.

摘要翻译： 本发明涉及具有病毒抑制活性的式（1）的二芳基肝素类化合物; 其药学上可接受的盐; 或上述任何一种的水合物，溶剂合物或前药，以及包含其的药物组合物及其治疗剂的用途。 本发明的二芳基肝素类化合物具有优异的抑制病毒活性的效果，因此可用作抗病毒相关疾病的治疗剂。

公开(公告)号：US20100196329A1

公开(公告)日：2010-08-05

申请号：US12601809

申请日：2008-05-09

申请人： Jeong Chan Ra ,  Hae Jung Han ,  Hang Young Lee ,  Hyo Eun Kim

发明人： Jeong Chan Ra ,  Hae Jung Han ,  Hang Young Lee ,  Hyo Eun Kim

IPC分类号： A61K35/12 ,  A61P7/00

CPC分类号： A61K31/10 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/10 ,  A61K31/198 ,  A61K35/28 ,  A61K38/38 ,  A61K45/06 ,  A61K47/02 ,  A61K47/183 ,  A61K47/20 ,  A61K47/26 ,  A61K47/42 ,  A61K2300/00

摘要： Disclosed herein is a cell therapeutic composition for treating ischemic limb diseases, more specifically, disclosed is a cell therapeutic composition for treating ischemic diseases, which contains adipose tissue-derived mesenchymal stem cells and sucrose or mannose as an excipient. The composition induces angiogenesis around closed blood vessels in the ischemic limb lesions, and thus is useful to treat ischemic diseases.

摘要翻译： 本文公开了一种用于治疗缺血性肢体疾病的细胞治疗组合物，更具体地，公开了一种用于治疗缺血性疾病的细胞治疗组合物，其包含脂肪组织来源的间充质干细胞和蔗糖或甘露糖作为赋形剂。 该组合物在缺血性肢体损伤中诱导闭合血管周围的血管生成，因此可用于治疗缺血性疾病。

公开(公告)号：US20080113034A1

公开(公告)日：2008-05-15

申请号：US11791598

申请日：2005-06-13

申请人： Jeong Chan Ra ,  Hyeong Geun Park ,  Kyung Sun Kang

发明人： Jeong Chan Ra ,  Hyeong Geun Park ,  Kyung Sun Kang

IPC分类号： A61K36/8962 ,  A61K36/254 ,  A61K36/282 ,  A61K36/31 ,  A61K36/48 ,  A61K36/28 ,  A61K35/32

CPC分类号： A23K50/30 ,  A23K10/30 ,  A23K20/10 ,  A23K50/10

摘要： The present invention relates to a composition for promoting the growth of animals, comprising extracts of Artemisia capillaris thunberg., Acanthopanax and garlic, as well as a feed composition comprising the same. The composition for promoting the growth of animals shows the excellent effect of promoting the secretion of growth hormone. Particularly, when the feed composition comprising the animal growth-promoting composition is administered to livestock animals, it will show the excellent effects of body weight gain, meat quality improvement and milk production increase in the livestock animals.

摘要翻译： 本发明涉及一种用于促进动物生长的组合物，其包含青蒿提取物，刺五加和大蒜，以及包含该组合物的饲料组合物。 用于促进动物生长的组合物显示促进生长激素分泌的优异效果。 特别地，当将包含动物生长促进组合物的饲料组合物施用于家畜时，将显示家畜中体重增加，肉质量改善和产奶量增加的优异效果。

公开(公告)号：US20160081917A1

公开(公告)日：2016-03-24

申请号：US14890585

申请日：2014-02-06

申请人： Jeong-Chan RA ,  K-STEMCELL CO., LTD

发明人： Jeong-Chan Ra ,  Sung Keun Kang ,  Jung Youn Jo

IPC分类号： A61K9/00 ,  C12N5/0775 ,  A61K35/28

CPC分类号： A61K9/0019 ,  A61K35/28 ,  A61K47/46 ,  C12N5/0667 ,  C12N2500/38 ,  C12N2500/44 ,  C12N2501/06 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2501/91 ,  C12N2501/999 ,  C12N2509/00

摘要： The present invention relates to a stem cell composition for intravenous administration, which contains stem cells at a concentration of 1×107 to 5×108 cells/ml, in which the stem cells have a diameter of 10-20 μm and are present as single cells. The stem cell composition according to the present invention is suitable for intravenous administration, and enables the stem cells to securely reach a target tissue after intravascular administration so as to exhibit their activity in the target tissue. Thus, it can significantly increase the therapeutic effects of the stem cells.

摘要翻译： 本发明涉及用于静脉内给药的干细胞组合物，其含有浓度为1×10 7至5×10 8个细胞/ ml的干细胞，其中干细胞具有10-20μm的直径并以单一形式存在 细胞。 根据本发明的干细胞组合物适用于静脉内施用，并且使得干细胞能够在血管内给药之后牢固地到达靶组织，以便在靶组织中表现出其活性。 因此，它可以显着增加干细胞的治疗效果。

公开(公告)号：US20120276044A1

公开(公告)日：2012-11-01

申请号：US13502898

申请日：2010-10-25

申请人： Jeong Chan Ra ,  Sung Keun Kang ,  Sun Jin Baek

发明人： Jeong Chan Ra ,  Sung Keun Kang ,  Sun Jin Baek

IPC分类号： A61K35/12 ,  A61K38/19

CPC分类号： C12N5/0667 ,  A61K35/12 ,  C12N2501/21

摘要： The present invention relates to the ability of adipose tissue-derived adult stem cells to migrate, and more particularly to the novel use of adipose tissue-derived adult stem cells primed with a specific chemokine or growth factor and their specific secretory products, which more effectively migrate to a disease site in vivo. The inventive composition containing either adipose-derived adult stem cells or adipose tissue-derived adult stem cells primed with a specific chemokine or growth factor can be administered by a simple method such as intravenous administration and are able to induce the targeting of the stem cells to a disease site. Thus, the composition is useful as a cell therapeutic agent.

摘要翻译： 本发明涉及脂肪组织衍生的成体干细胞迁移的能力，更具体地涉及用特定趋化因子或生长因子及其特异性分泌产物引发的脂肪组织衍生的成体干细胞的新用途，其更有效地 在体内迁移到疾病部位。 含有脂肪来源的成体干细胞或用特定趋化因子或生长因子引发的脂肪组织衍生的成体干细胞的本发明组合物可以通过简单的方法如静脉内施用来施用，并且能够诱导干细胞靶向 一个疾病部位。 因此，该组合物可用作细胞治疗剂。

公开(公告)号：US20120263685A1

公开(公告)日：2012-10-18

申请号：US13500764

申请日：2010-04-07

申请人： Jeong Chan RA ,  Sung Keun KANG ,  Sang Kyu WOO ,  Hwa Young YOUN ,  Hee Woo LEE ,  Kyoung Won SEO

发明人： Jeong Chan RA ,  Sung Keun KANG ,  Sang Kyu WOO ,  Hwa Young YOUN ,  Hee Woo LEE ,  Kyoung Won SEO

IPC分类号： A61K35/12 ,  A61K38/18 ,  C12N5/0775 ,  A61P35/02 ,  A61P35/00 ,  A61K38/39 ,  A61K38/19 ,  C12N5/074 ,  C12N5/0789

CPC分类号： A61K35/28

摘要： The present invention relates to a composition for preventing or treating cancer, which contains one or more selected from the group consisting of human adult stem cells and their secretory products, and to a method of preventing or treating cancer using the same. Particularly, the invention relates to the use of adult stem cells that exhibit the effect of preventing or treating cancer by activating the immune system. The human adult stem cells of the invention are administered by a simple method such as intravenous injection and are highly valuable as a cell therapeutic agent for treating various cancer (tumor) diseases. Thus, the adult stem cells will be highly useful in anticancer studies.

摘要翻译： 本发明涉及一种预防或治疗癌症的组合物，其含有选自人成体干细胞及其分泌产物的一种或多种，​​以及使用其的预防或治疗癌症的方法。 特别地，本发明涉及通过激活免疫系统表现出预防或治疗癌症的效果的成体干细胞的用途。 本发明的人成体干细胞通过静脉注射等简单的方法给药，作为治疗各种癌症（肿瘤）疾病的细胞治疗剂是非常有价值的。 因此，成体干细胞在抗癌研究中将是非常有用的。