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公开(公告)号：US08546384B2
公开(公告)日：2013-10-01
申请号：US13547196
申请日：2012-07-12
IPC分类号： A61K31/535
CPC分类号： C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
摘要： Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.
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2.发明申请公开(公告)号：US20090181927A1
公开(公告)日：2009-07-16
申请号：US12407481
申请日：2009-03-19
IPC分类号： A61K31/435 , A61K31/727 , A61K31/337 , A61K31/4355
CPC分类号： C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
摘要： Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.
摘要翻译： 萘二甲酰亚胺化合物用于组织结合和蛋白质交联应用。 当活化剂如400-500nm吸收范围的光激活时，萘酰亚胺化合物形成化学反应性物质，其将蛋白质交联，将结缔组织结合在一起，并将组织和其他生物材料结合在一起。 萘二甲酰亚胺标记的生物分子，例如萘二甲酰亚胺标记的壳聚糖，也能够粘合组织而不随后直接照射接触的组织区域。 萘二甲酰亚胺化合物可以用于组织或动脉修复，血管成形术后扩张的动脉壁的稳定化，将药剂束紧到组织表面以提供局部药物递送，以及将皮肤护理产品，防晒剂和化妆品化学粘合到皮肤上。
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公开(公告)号：US09884121B2
公开(公告)日：2018-02-06
申请号：US14978512
申请日：2015-12-22
IPC分类号： A61K47/36 , A61K31/407 , A61K31/5575 , A61K31/573 , A61K47/48 , A61K8/73 , A61K9/00 , A61L24/08 , A61L27/20 , C08B37/08 , C08L5/08 , A61K47/61
CPC分类号： A61K47/36 , A61K9/0014 , A61K9/0048 , A61K31/407 , A61K31/5575 , A61K31/573 , A61K47/61 , A61L24/08 , A61L27/20 , A61L2300/404 , A61L2430/16 , C08B37/003 , C08L5/08
摘要： Biomaterials are disclosed having unique properties that make it a useful material in adhesives, local drug delivery applications and as filler or bulking material. The biomaterials are strong, safe and easily used as a surgical adhesive. Treated chitosan, modified chitosan or modified and treated chitosan compositions are disclosed displaying strengths suitable for general surgical applications. The materials can be used as a drug delivery vehicle which allows for the localization of the delivered drug as well as a programmable tether which allows for the release of the drug on a timed basis or in response to a physiological state such as the release of proteolytic enzymes. The materials of this invention can also be modified and treated to optimize the retention of water, thereby serving as a useful filler or bulking material.
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4.发明授权公开(公告)号：US08242114B2
公开(公告)日：2012-08-14
申请号：US12407481
申请日：2009-03-19
IPC分类号： A61K31/55
CPC分类号： C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
摘要： Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.
摘要翻译： 萘二甲酰亚胺化合物用于组织结合和蛋白质交联应用。 当活化剂如400-500nm吸收范围的光激活时，萘酰亚胺化合物形成化学反应性物质，其将蛋白质交联，将结缔组织结合在一起，并将组织和其他生物材料结合在一起。 萘二甲酰亚胺标记的生物分子，例如萘二甲酰亚胺标记的壳聚糖，也能够粘合组织而不随后直接照射接触的组织区域。 萘二甲酰亚胺化合物可以用于组织或动脉修复，血管成形术后扩张的动脉壁的稳定化，将药剂束紧到组织表面以提供局部药物递送，以及将皮肤护理产品，防晒剂和化妆品化学粘合到皮肤上。
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公开(公告)号：US20080207561A1
公开(公告)日：2008-08-28
申请号：US12023977
申请日：2008-01-31
申请人： Ronald E. Utecht , Kaia L. Kloster , Therese M. Downey , Barbara R. Haberer , Patrick D. Youso , James N. Chang
发明人： Ronald E. Utecht , Kaia L. Kloster , Therese M. Downey , Barbara R. Haberer , Patrick D. Youso , James N. Chang
IPC分类号： A61K47/48
CPC分类号： A61K47/36 , A61K9/0014 , A61K9/0048 , A61K31/407 , A61K31/5575 , A61K31/573 , A61K47/61 , A61L24/08 , A61L27/20 , A61L2300/404 , A61L2430/16 , C08B37/003 , C08L5/08
摘要： A novel biomaterial is disclosed having unique properties that make it useful in ocular drug delivery applications, where the drugs selected from the group consisting of a prostaglandin, a prostamide, a non-steroidal anti-inflammatory drug (NSAID), and a corticosteroid, and mixtures, derivatives, salts and esters thereof.
摘要翻译： 公开了一种新颖的生物材料，其具有使其可用于眼药物递送应用的独特性质，其中选自前列腺素，前列腺酰胺，非甾体抗炎药（NSAID）和皮质类固醇的药物和 其混合物，衍生物，盐和酯。
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公开(公告)号：US09855337B2
公开(公告)日：2018-01-02
申请号：US12023963
申请日：2008-01-31
IPC分类号： A61B17/03 , A61K47/36 , C07H5/06 , C07K19/00 , C08L5/08 , C09J105/08 , A61K9/00 , A61L24/08 , C08B37/08 , A61K31/407 , A61K31/5575 , A61K31/573 , A61L27/20 , A61K47/61
CPC分类号： A61K47/36 , A61K9/0014 , A61K9/0048 , A61K31/407 , A61K31/5575 , A61K31/573 , A61K47/61 , A61L24/08 , A61L27/20 , A61L2300/404 , A61L2430/16 , C08B37/003 , C08L5/08
摘要： Biomaterials are disclosed having unique properties that make it a useful material in adhesives, local drug delivery applications and as filler or bulking material. The biomaterials are strong, safe and easily used as a surgical adhesive. Treated chitosan, modified chitosan or modified and treated chitosan compositions are disclosed displaying strengths suitable for general surgical applications. The materials can be used as a drug delivery vehicle which allows for the localization of the delivered drug as well as a programmable tether which allows for the release of the drug on a timed basis or in response to a physiological state such as the release of proteolytic enzymes. The materials of this invention can also be modified and treated to optimize the retention of water, thereby serving as a useful filler or bulking material.
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7.发明授权公开(公告)号：US07514399B2
公开(公告)日：2009-04-07
申请号：US10982197
申请日：2004-11-05
IPC分类号： A01N37/18 , A01N43/04 , A61K38/00 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08H1/00 , C07H5/04 , C07H5/06 , C08B37/00 , C08B37/08
CPC分类号： C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
摘要： Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.
摘要翻译： 萘二甲酰亚胺化合物用于组织结合和蛋白质交联应用。 当活化剂如400-500nm吸收范围的光激活时，萘酰亚胺化合物形成化学反应性物质，其将蛋白质交联，将结缔组织结合在一起，并将组织和其他生物材料结合在一起。 萘二甲酰亚胺标记的生物分子，例如萘二甲酰亚胺标记的壳聚糖，也能够粘合组织而不随后直接照射接触的组织区域。 萘二甲酰亚胺化合物可以用于组织或动脉修复，血管成形术后扩张的动脉壁的稳定化，将药剂束紧到组织表面以提供局部药物递送，以及将皮肤护理产品，防晒剂和化妆品化学粘合到皮肤上。
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公开(公告)号：US20080200948A1
公开(公告)日：2008-08-21
申请号：US12023963
申请日：2008-01-31
CPC分类号： A61K47/36 , A61K9/0014 , A61K9/0048 , A61K31/407 , A61K31/5575 , A61K31/573 , A61K47/61 , A61L24/08 , A61L27/20 , A61L2300/404 , A61L2430/16 , C08B37/003 , C08L5/08
摘要： Novel biomaterials are disclosed having unique properties that make it a useful material in adhesives, local drug delivery applications and as filler or bulking material. The biomaterials are strong, safe and easily used as a surgical adhesive. Treated chitosan, modified chitosan or modified and treated chitosan compositions are disclosed displaying strengths suitable for general surgical applications. The materials can be used as a drug delivery vehicle which allows for the localization of the delivered drug as well as a programmable tether which allows for the release of the drug on a timed basis or in response to a physiological state such as the release of proteolytic enzymes. The materials of this invention can also be modified and treated to optimize the retention of water, thereby serving as a useful filler or bulking material.
摘要翻译： 公开了具有独特性质的新型生物材料，使其成为粘合剂，局部药物递送应用和填料或膨胀材料中的有用材料。 生物材料坚固，安全，易于用作手术粘合剂。 公开了处理的壳聚糖，改性壳聚糖或经改性和处理的壳聚糖组合物，显示出适用于一般手术应用的强度。 这些材料可以用作药物递送载体，其允许递送的药物的定位以及允许在定时基础上或响应于生理状态（例如蛋白水解的释放）释放药物的可编程系链 酶。 本发明的材料也可以进行改性和处理以优化水的保留，从而用作有用的填料或膨胀材料。
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公开(公告)号：US20160175449A1
公开(公告)日：2016-06-23
申请号：US14978512
申请日：2015-12-22
IPC分类号： A61K47/36 , A61K9/00 , A61L27/20 , A61K31/5575 , A61K47/48 , A61K31/407 , A61K31/573 , A61K8/73 , A61L24/08
CPC分类号： A61K47/36 , A61K9/0014 , A61K9/0048 , A61K31/407 , A61K31/5575 , A61K31/573 , A61K47/61 , A61L24/08 , A61L27/20 , A61L2300/404 , A61L2430/16 , C08B37/003 , C08L5/08
摘要： Novel biomaterials are disclosed having unique properties that make it a useful material in adhesives, local drug delivery applications and as filler or bulking material. The biomaterials are strong, safe and easily used as a surgical adhesive. Treated chitosan, modified chitosan or modified and treated chitosan compositions are disclosed displaying strengths suitable for general surgical applications. The materials can be used as a drug delivery vehicle which allows for the localization of the delivered drug as well as a programmable tether which allows for the release of the drug on a timed basis or in response to a physiological state such as the release of proteolytic enzymes. The materials of this invention can also be modified and treated to optimize the retention of water, thereby serving as a useful filler or bulking material.
摘要翻译： 公开了具有独特性质的新型生物材料，使其成为粘合剂，局部药物递送应用和填料或膨胀材料中的有用材料。 生物材料坚固，安全，易于用作手术粘合剂。 公开了处理的壳聚糖，改性壳聚糖或经改性和处理的壳聚糖组合物，显示出适用于一般手术应用的强度。 这些材料可以用作药物递送载体，其允许递送的药物的定位以及允许在定时基础上或响应于生理状态（例如蛋白水解的释放）释放药物的可编程系链 酶。 本发明的材料也可以进行改性和处理以优化水的保留，从而用作有用的填料或膨胀材料。
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10.发明授权公开(公告)号：US08741270B2
公开(公告)日：2014-06-03
申请号：US13772510
申请日：2013-02-21
CPC分类号： C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
摘要： Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.
摘要翻译： 萘二甲酰亚胺化合物用于组织结合和蛋白质交联应用。 当活化剂如400-500nm吸收范围的光激活时，萘酰亚胺化合物形成化学反应性物质，其将蛋白质交联，将结缔组织结合在一起，并将组织和其他生物材料结合在一起。 萘二甲酰亚胺标记的生物分子，例如萘二甲酰亚胺标记的壳聚糖，也能够粘合组织而不随后直接照射接触的组织区域。 萘二甲酰亚胺化合物可以用于组织或动脉修复，血管成形术后扩张的动脉壁的稳定化，将药剂束紧到组织表面以提供局部药物递送，以及将皮肤护理产品，防晒剂和化妆品化学粘合到皮肤上。
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