利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

28 条记录 (耗时 0.019 秒)

    Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion
    4.
    发明授权
    Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion 有权
    用丁胺改性的可生物降解阳离子聚（丙烯富马酸酯 - 共 - 乙二醇）共聚物水凝胶的合成和表征，增强细胞粘附

    公开(公告)号：US07629388B2

    公开(公告)日：2009-12-08

    申请号：US10300202

    申请日：2002-11-20

    申请人： Antonios G. Mikos ,  Kazuhiro Tanahashi

    发明人： Antonios G. Mikos ,  Kazuhiro Tanahashi

    IPC分类号： A67K47/00 ,  A01N25/00

    CPC分类号： A61K47/60

    摘要： A cross-linkable monomer comprises a fumaric acid functional group having a first end and a second end, a first spacer group affixed to said first end and comprising at least repeating unit, a first terminal group affixed to said first spacer group, a second spacer group affixed to said second end and comprising at least one ethylene glycol repeating unit, and a second terminal group affixed to said second spacer group. A hydrogel formed by cross-linking the present monomer and a method for making the monomer. A method for forming a hydrogel, comprises the steps of a) synthesizing a copolymer of poly(propylene fumarate) (PPF) and poly(ethylene glycol (PEG) so as to produce P(PF-co-EG), b) synthesizing a PEG-tethered fumarate (PEGF), c) coupling agmatine sulfate to the PEGF to produce PEGF modified with agmatine (Agm-PEGF), and d) cross-linking the P(PF-co-EG) from step a) with Agm-PEGF from step c).

    摘要翻译： 可交联单体包括具有第一末端和第二末端的富马酸官能团，第一间隔基团固定在所述第一末端并且包含至少重复单元，固定到所述第一间隔基团的第一末端基团，第二间隔基团 固定在所述第二端并且包含至少一个乙二醇重复单元的基团和固定到所述第二间隔基团上的第二末端基团。 通过交联本发明单体形成的水凝胶和制备该单体的方法。 一种形成水凝胶的方法，包括以下步骤：a）合成聚（丙烯酸富马酸酯）（PPF）和聚（乙二醇（PEG））以产生P（PF-co-EG）的共聚物，b） PEG连接的富马酸酯（PEGF），c）将硫酸胍加到PEGF上以产生用胍丁胺（Agm-PEGF）修饰的PEGF，和d）将来自步骤a）的P（PF-co-EG）与Agm- 来自步骤c）的PEGF。

    BIODEGRADABLE PARTICLE, VASCULAR EMBOLIZATION MATERIAL AND METHOD FOR PRODUCING BIODEGRADABLE PARTICLES
    6.
    发明申请
    BIODEGRADABLE PARTICLE, VASCULAR EMBOLIZATION MATERIAL AND METHOD FOR PRODUCING BIODEGRADABLE PARTICLES 有权
    生物可降解颗粒，生物可降解颗粒的血管形成材料和方法

    公开(公告)号：US20140018505A1

    公开(公告)日：2014-01-16

    申请号：US14008194

    申请日：2012-03-29

    申请人： Masaki Fujita ,  Megumi Nakanishi ,  Yoshitake Takahashi ,  Yasufumi Yamamura ,  Kazuhiro Tanahashi

    发明人： Masaki Fujita ,  Megumi Nakanishi ,  Yoshitake Takahashi ,  Yasufumi Yamamura ,  Kazuhiro Tanahashi

    IPC分类号： A61L24/04 ,  A61L24/00

    CPC分类号： A61L24/046 ,  A61L24/0042 ,  A61L31/06 ,  A61L31/148 ,  A61L2430/36 ,  C08G63/08 ,  C08G63/664 ,  C08J3/28 ,  C08J2367/04 ,  C08L67/04

    摘要： A biodegradable particle including a block copolymer produced by copolymerization of a biodegradable copolymer having a structure composed of hydroxycarboxylic acid a1, whose homopolymer produced by homopolymerization has a glass transition point of not less than 40° C. and hydroxycarboxylic acid a2, whose homopolymer produced by homopolymerization has a glass transition point of not more than −40° C.; a water-soluble polymer comprising a functional group selected from the group consisting of a hydroxyl group, amino group and carboxylic acid group at each of both ends; and a polyvalent compound comprising 2 or more functional groups each selected from the group consisting of a hydroxyl group, amino group and carboxylic acid group; wherein a ratio of mass of said structure composed of hydroxycarboxylic acid a2 to mass of said biodegradable copolymer is 30 to 90% by mass.

    摘要翻译： 包含由具有由均聚产生的均聚物的羟基羧酸a1构成的结构的生物降解性共聚物的共聚制得的嵌段共聚物的玻璃化转变温度为40℃以上的生物降解性粒子和羟基羧酸a2，其均聚物由 均聚反应玻璃化转变温度不高于-40℃。 在两端各自包含选自羟基，氨基和羧酸基的官能团的水溶性聚合物; 和包含2个以上选自羟基，氨基和羧酸基的官能团的多价化合物; 其中由羟基羧酸a2构成的所述结构的质量与所述生物降解性共聚物的质量之比为30〜90质量％。

    BIODEGRADABLE PARTICLE AND METHOD FOR PRODUCING THE SAME
    8.
    发明申请
    BIODEGRADABLE PARTICLE AND METHOD FOR PRODUCING THE SAME 审中-公开
    生物可降解颗粒及其生产方法

    公开(公告)号：US20120156302A1

    公开(公告)日：2012-06-21

    申请号：US13402851

    申请日：2012-02-22

    申请人： Kazuhiro TANAHASHI ,  Megumi Nakanishi

    发明人： Kazuhiro TANAHASHI ,  Megumi Nakanishi

    IPC分类号： A61K9/14 ,  A61K47/34

    CPC分类号： A61L31/148 ,  A61K9/0019 ,  A61K9/14 ,  A61L24/0042 ,  A61L24/046 ,  A61L31/06 ,  A61L2430/36 ,  C08J3/12 ,  C08J2367/04 ,  C08L67/04 ,  C08L71/02 ,  C08L2666/22

    摘要： The present invention aims to provide a biodegradable particle capable of being molded without an aggregation or cohesion of the particles, capable of being carried or injected without clogging by an aggregation in a micro diameter tube such as of a catheter, needle or syringe mainly used in pharmaceutical and medical applications of which inner diameter is smaller than the particle size or in a blood vessel and capable of being smoothly degraded in a specified period of time so that degraded component can finally be absorbed or discharged in vitro. As means for solving the problem, the present invention provides a biodegradable particle characterized in that a compressive modulus of the particle in water saturated state is 10 MPa or less.

    摘要翻译： 本发明的目的在于提供一种可生物降解的颗粒，其能够在没有颗粒聚集或内聚的情况下模制，能够被携带或注入，而不会在主要用于 其内径小于粒径或在血管中的能够在规定时间内顺利降解的药物和医疗应用，使得降解的成分最终能够在体外被吸收或排出。 作为解决问题的手段，本发明提供一种生物降解性粒子，其特征在于，水饱和状态下的粒子的压缩弹性模量为10MPa以下。

    FRACTIONATION APPARATUS
    10.
    发明申请
    FRACTIONATION APPARATUS 审中-公开
    分类装置

    公开(公告)号：US20110009503A1

    公开(公告)日：2011-01-13

    申请号：US12834666

    申请日：2010-07-12

    申请人： Kazuhiro TANAHASHI ,  Hiroshi Takahashi ,  Hiroyuki Sugaya ,  Shigehisa Wada

    发明人： Kazuhiro TANAHASHI ,  Hiroshi Takahashi ,  Hiroyuki Sugaya ,  Shigehisa Wada

    IPC分类号： C08J5/22 ,  C08J3/28

    CPC分类号： C07K1/22

    摘要： The present invention discloses a fractionation device used for proteins and/or peptides, which has any of the following features:1) At least one portion of a substrate surface with which proteins or the like are made in contact has an amount of adsorption of bovine serum albumin of 50 ng/cm2 or less with respect to the substrate surface, when a bovine serum albumin solution is made in contact therewith. 2) At least one portion of a substrate surface with which proteins or the like are made in contact has an amount of adsorption of human β2-microglobulin of 3 ng/cm2 or less with respect to the substrate surface, when a protein aqueous solution consisting of human β2-microglobulin and bovine serum albumin is made in contact with the substrate surface. 3) The fractionation device is provided with: a means for supplying a solution containing proteins or the like; a means for separating proteins or the like from the solution; and a means for concentrating proteins or the like in the solution, and in the fractionation device, at least one portion of the substrate surface with which proteins or the like are made in contact is subjected to a grafting process by using a hydrophilic polymer. By using the above-mentioned device, it becomes possible to reduce non-peculiar adsorption of protein onto the substrate, and consequently to easily provide a sample from which proteins having high-molecular weights have been removed, and which is advantageously used for an analysis.

    摘要翻译： 本发明公开了一种用于蛋白质和/或肽的分级装置，其具有以下特征：1）与蛋白质等接触的底物表面的至少一部分具有牛的吸附量 当与其接触的牛血清白蛋白溶液时，相对于底物表面的血清白蛋白为50ng / cm 2以下。 2）当与蛋白质接触的基底表面的至少一部分相对于底物表面具有3ng / cm 2以下的人和2μg微球蛋白的吸附量，当蛋白质水溶液 由人类和微生物组织的2-微球蛋白和牛血清白蛋白组成的溶液与底物表面接触。 3）分离装置设有：用于供给含有蛋白质等的溶液的装置; 用于从溶液中分离蛋白质等的方法; 以及用于将蛋白质等浓缩在溶液中的方法，并且在分级装置中，通过使用亲水性聚合物对与蛋白质等接触的基底表面的至少一部分进行接枝处理。 通过使用上述装置，可以减少蛋白质在基质上的非特异性吸附，从而容易地提供已经除去高分子量蛋白质的样品，并且有利地用于分析 。