公开(公告)号：US20100007877A1

公开(公告)日：2010-01-14

申请号：US12319817

申请日：2009-01-12

申请人： E. Neil Lewis ,  Linda K. Yarlott ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Linda K. Yarlott ,  Kenneth S. Haber

IPC分类号： G01J3/28

CPC分类号： G01J3/42 ,  G01J3/10 ,  G01N21/3563 ,  G01N2021/3133

摘要： Spectrometers and spectrometric measurement methods are disclosed. These employ narrow-band sources positioned in a circular array to perform spectrometric measurements that can employ Hadamard sequences.

摘要翻译： 公开了光谱仪和光谱测量方法。 这些采用位于圆形阵列中的窄带源进行可采用Hadamard序列的光谱测量。

公开(公告)号：US20080130001A1

公开(公告)日：2008-06-05

申请号：US10996189

申请日：2004-11-22

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01N21/25

CPC分类号： G01J3/51 ,  G01J3/2823 ,  G01J3/44 ,  G01J2003/1217 ,  G01J2003/1243

摘要： An imaging optical instrument for acquiring images of a sample area is disclosed. The instrument includes a spatial detector with aligned detector elements and a variable filter having filter characteristics that vary in at least one direction and are located in an optical path between the sample area and the spatial detector. An actuator is operatively connected between the variable filter and the spatial detector and is operative to move the variable filter along the direction in which the filter characteristics vary.

摘要翻译： 公开了一种用于获取样本区域的图像的成像光学仪器。 仪器包括具有对准的检测器元件的空间检测器和具有在至少一个方向上变化并且位于样品区域和空间检测器之间的光路中的滤波器特性的可变滤波器。 致动器可操作地连接在可变滤波器和空间检测器之间，并且可操作以沿着滤波器特性变化的方向移动可变滤波器。

公开(公告)号：US20110238327A1

公开(公告)日：2011-09-29

申请号：US13008884

申请日：2011-01-18

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01J3/44 ,  G01J3/28 ,  G06F17/18

CPC分类号： G01N21/85 ,  B01F9/00 ,  G01J3/0218 ,  G01J3/0294 ,  G01J3/453 ,  G01N21/31

摘要： In one general aspect, a spectroscopic method is disclosed. This method includes acquiring a plurality of separate spectral measurements at different locations on a sample and evaluating results of the measurements based on one or more predetermined test criteria. Information from measurements made at the different locations is categorized based on results of the step of evaluating, and results are reported that include information from both the step of acquiring and the step of categorizing.

摘要翻译： 在一般的方面，公开了一种光谱方法。 该方法包括在样本上的不同位置获取多个单独的光谱测量值，并基于一个或多个预定测试标准评估测量结果。 来自不同地点的测量信息根据评估步骤的结果进行分类，报告结果包括获取步骤和分类步骤的信息。

公开(公告)号：US08004662B2

公开(公告)日：2011-08-23

申请号：US11265796

申请日：2005-10-17

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01N21/00

CPC分类号： A61K31/00 ,  G01N21/9508 ,  G01N33/15

摘要： A method of obtaining information about a heterogeneous pharmaceutical mixture is disclosed. This method involves applying an image enhancement agent, such as a stain, to the mixture. An image of the mixture can then be obtained, and information about a distribution of components of the mixture in the image can also be obtained based on spatial information derived from the application of the image enhancement agent.

摘要翻译： 公开了获得有关异质药物混合物的信息的方法。 该方法包括将诸如污渍的图像增强剂施加到混合物。 然后可以获得混合物的图像，并且还可以基于从图像增强剂的应用导出的空间信息来获得关于图像中混合物的分量分布的信息。

公开(公告)号：US08842266B2

公开(公告)日：2014-09-23

申请号：US13216038

申请日：2011-08-23

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01N21/00 ,  G01N21/95 ,  A61K31/00 ,  G01N33/15

CPC分类号： A61K31/00 ,  G01N21/9508 ,  G01N33/15

摘要： A method of obtaining information about a heterogeneous pharmaceutical mixture is disclosed. This method involves applying an image enhancement agent, such as a stain, to the mixture. An image of the mixture can then be obtained, and information about a distribution of components of the mixture in the image can also be obtained based on spatial information derived from the application of the image enhancement agent.

摘要翻译： 公开了获得有关异质药物混合物的信息的方法。 该方法包括将诸如污渍的图像增强剂施加到混合物。 然后可以获得混合物的图像，并且还可以基于从图像增强剂的应用导出的空间信息来获得关于图像中混合物的分量分布的信息。

公开(公告)号：US20120197541A1

公开(公告)日：2012-08-02

申请号：US13216038

申请日：2011-08-23

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01J3/44 ,  G06F19/00 ,  G01J3/00

CPC分类号： A61K31/00 ,  G01N21/9508 ,  G01N33/15

摘要： A method of obtaining information about a heterogeneous pharmaceutical mixture is disclosed. This method involves applying an image enhancement agent, such as a stain, to the mixture. An image of the mixture can then be obtained, and information about a distribution of components of the mixture in the image can also be obtained based on spatial information derived from the application of the image enhancement agent.

摘要翻译： 公开了获得有关异质药物混合物的信息的方法。 该方法包括将诸如污渍的图像增强剂施加到混合物。 然后可以获得混合物的图像，并且还可以基于从图像增强剂的应用导出的空间信息来获得关于图像中混合物的分量分布的信息。

公开(公告)号：US07864316B2

公开(公告)日：2011-01-04

申请号：US11986548

申请日：2007-11-20

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01J3/28

CPC分类号： G01J3/06 ,  B01F9/04 ,  B01F15/00207 ,  B01F15/00214 ,  B01F2215/0032 ,  G01J3/0218 ,  G01J3/42 ,  G01N21/03 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/85 ,  G01N21/9508 ,  G01N2021/3595 ,  G01N2021/8592

摘要： In one general aspect, a spectroscopic method for monitoring heterogeneity of a sample is disclosed. In this method, sampled spectroscopic measurements are acquired over a range of different micro locations in a macro-sample of the sample. This step is repeated for micro-locations in further macro-samples of the sample, and a statistical measure of chemical heterogeneity is derived from the acquisitions. In another general aspect, differently sized samples are acquired, and a statistical measure of chemical heterogeneity is derived from these acquisitions.

摘要翻译： 在一般的方面，公开了一种用于监测样品异质性的光谱方法。 在该方法中，在样本的宏观样本中的不同微位置的范围上获取采样的光谱测量。 对于样品的其他宏观样品中的微位置重复此步骤，并且从采集中得出化学异质性的统计量度。 在另一个一般方面，获得不同大小的样品，并且从这些获取中得出化学异质性的统计量度。

公开(公告)号：US20080032412A1

公开(公告)日：2008-02-07

申请号：US11499390

申请日：2006-08-04

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01N21/00

CPC分类号： G01N21/6428 ,  G01N21/3563 ,  G01N21/6456 ,  G01N21/65 ,  G01N21/78 ,  G01N21/9508 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/7773 ,  G01N2021/7786

摘要： A method for obtaining information about a heterogeneous pharmaceutical mixture is disclosed. The method includes beginning to apply an image enhancement agent to the mixture. A plurality of images of the mixture can then be obtained over time, with at least one image being obtained after the step of beginning to apply an image enhancement agent. This allows information to be derived about a distribution of components of the mixture, based on differences between spatial information in different images.

摘要翻译： 公开了一种获取有关异质药物混合物的信息的方法。 该方法包括开始向混合物施加图像增强剂。 然后可以随着时间获得混合物的多个图像，其中在开始施加图像增强剂的步骤之后获得至少一个图像。 这允许基于不同图像中的空间信息的差异来获得关于混合物的分量的分布的信息。

公开(公告)号：US20140002662A1

公开(公告)日：2014-01-02

申请号：US13841721

申请日：2013-03-15

申请人： E. Neil Lewis ,  John McCaffrey ,  Kenneth S. Haber ,  Peter Bennett ,  Gerald Sando ,  Tomasz Sadowski

发明人： E. Neil Lewis ,  John McCaffrey ,  Kenneth S. Haber ,  Peter Bennett ,  Gerald Sando ,  Tomasz Sadowski

IPC分类号： G01N15/06

CPC分类号： G01N15/0612 ,  G01N15/1459 ,  G01N15/1463 ,  G01N2015/1043 ,  G01N2015/1493 ,  G01N2015/1497

摘要： In one general aspect, a particle characterization method is disclosed that includes suspending particles in a fluid, causing them to flow past a two-dimensional array detector, and illuminating them as they do so. The method also includes acquiring images of the particles as they flow past the two-dimensional array detector in the fluid, and applying a particle characterization function to the images for at least some of the suspended particles.

摘要翻译： 在一个一般方面，公开了一种颗粒表征方法，其包括将颗粒悬浮在流体中，使得它们流过二维阵列检测器，并照它们这样做。 该方法还包括当粒子流过流体中的二维阵列检测器时获取粒子的图像，以及对至少一些悬浮粒子的图像应用粒子表征功能。

公开(公告)号：US08456633B2

公开(公告)日：2013-06-04

申请号：US12387643

申请日：2009-05-05

申请人： E. Neil Lewis ,  Kenneth S. Haber

发明人： E. Neil Lewis ,  Kenneth S. Haber

IPC分类号： G01N21/25

CPC分类号： G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/26 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/42 ,  G01J3/51 ,  G01N21/31 ,  G01N21/65 ,  G01N2021/651

摘要： Spectrometric apparatus that include an array of detector elements and exhibits a number of capabilities is disclosed. The elements can be responsive to incident radiation to produce an output signal that includes information from the incident radiation. A spectrally selective element can be located in an optical path between the radiation source and the array, with an analysis module responsive to the output signal operative to analyze spatial distribution of spectral information received by the array. The apparatus can also correct for differences in intensity and spectral variability for spectral image signals and/or compare the spectral image signals with a pattern in spatial-spectral coordinate space. Detector elements can be responsive to scattering, and spatial information in their output can be analyzed.