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公开(公告)号：US09163618B2
公开(公告)日：2015-10-20
申请号：US13530931
申请日：2012-06-22
CPC分类号： F04B11/0075 , F04B23/06 , G01N30/32 , G01N30/34 , G01N2030/326 , Y10T137/0352 , Y10T137/7722 , G01N2030/342 , B01D15/40
摘要： An apparatus, system, and process of converting a standard, high performance liquid chromatography (HPLC) flow path to a flow path suitable for supercritical fluid chromatography (SFC) are described. This reversible technique is applied to a variety of flow configurations including binary, high pressure solvent mixing systems and quaternary, low pressure solvent mixing systems than can be conventionally operated or automated. The technique is generally applied to the fields of supercritical fluid chromatography and high pressure liquid chromatography, but users skilled in the art will find utility for any flow system where pressurization components must be periodically applied to and removed from both ends of a flow stream in an automated manner.
摘要翻译： 描述了将标准的高效液相色谱（HPLC）流动路径转换到适用于超临界流体色谱（SFC）的流动路径的装置，系统和方法。 这种可逆技术应用于各种流动配置，包括二元，高压溶剂混合系统和四级，低压溶剂混合系统，比常规操作或自动化。 该技术通常应用于超临界流体色谱和高压液相色谱领域，但是本领域技术人员将发现对于任何流动系统都将发挥效用，其中加压组分必须周期性地施加到流动流的两端并从其中移除 自动化方式。
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公开(公告)号：US07905133B2
公开(公告)日：2011-03-15
申请号：US12152785
申请日：2008-05-16
CPC分类号： G01N30/84 , B01D15/40 , G01N30/10 , G01N30/7233 , G01N2030/8429 , Y10T137/87249
摘要： A splitter for a pressurized primary flowstream of a mobile phase is provided. The splitter comprises a first splitting stage that divides the primary flowstream between a major split flowstream and a minor split flowstream by means of a first and a second restrictive flow element; a first dilution stage that combines a dilution flow source with the minor split flowstream to create a diluted minor flowstream; a second splitting stage that divides the diluted minor flowstream between a secondary major diluted flowstream and a secondary minor diluted flowstream by means of a third restrictive element in the secondary minor diluted flow stream; and a second dilution stage wherein a conditioning flow source conditions the secondary minor diluted flow stream after the third restrictive element prior to outlet of the secondary minor diluted flowstream from the splitter.
摘要翻译： 提供了用于流动相的加压初级流动流的分流器。 分流器包括第一分流段，其通过第一和第二限制流动元件在主分流流和小分流流之间划分主流流; 第一稀释阶段，其将稀释流动源与次要分流流动相结合以产生稀释的次要流动流; 第二分裂阶段，通过次级次要稀释流动流中的第三限制性元素将稀释的次要流动流在次级主要稀释流动流和次要次要稀释流动流之间分配; 以及第二稀释阶段，其中调节流动源在来自分离器的次要次要稀释流动流出口之前，在第三限制元件之后对次级稀释流量进行调节。
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公开(公告)号：US06656354B2
公开(公告)日：2003-12-02
申请号：US10066955
申请日：2002-02-04
申请人： Terry A. Berger , Kimber D. Fogelman , L. Thompson Staats, III , Mark Nickerson , Paul F. Bente, III , Kenneth J. Klein
发明人： Terry A. Berger , Kimber D. Fogelman , L. Thompson Staats, III , Mark Nickerson , Paul F. Bente, III , Kenneth J. Klein
IPC分类号： B01D1508
CPC分类号： B01D15/247 , B01D11/0203 , B01D15/40 , G01N1/405 , G01N30/24 , G01N30/82
摘要： A fractionated sample collection process and device having at least one pressurized chamber used to gather and store liquid samples generated from a flow stream containing a mixture of highly compressed gas, compressible liquid, or supercritical fluid and a relatively incompressible liquid. A bank of multiple collection chambers is secured together in a frame to form a cassette unit. Each collection chamber may house a replaceable liner such as a test tube vial, to hold a fractionated liquid phase sample. After filling with sample, a collection chamber is returned to a clean state and ready for refilling with a new sample by manually or automatically replacing the liner.
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公开(公告)号：US06576125B2
公开(公告)日：2003-06-10
申请号：US09931238
申请日：2001-08-17
IPC分类号： B01D1508
CPC分类号： B01D15/166 , B01D15/14 , B01D15/40 , G01N30/02 , G01N30/22 , G01N30/34 , G01N30/36 , G01N2030/324 , G01N2030/347 , G01N30/16
摘要： An improved method of introducing sample into a low-pressure flow stream of a high-pressure chromatography system to improve efficiency and significantly shorten the time of the separation process through a chromatography column is described. The method comprises injecting samples in a modifier liquid flow stream upstream of a mixing column that combines two independent flow streams of a liquid modifier with a highly compressed solvating fluid. Focusing can be controlled at the column head by changing the ratios of the two flow streams. Total flow may also be adjusted to speed the application of the sample onto the column during injection. The method improves the timing and efficiency of a supercritical fluid chromatography system and can reduce the amount of modifier added to the mobile phase flow stream.
摘要翻译： 描述了将样品引入高压色谱系统的低压流动流以提高效率并显着缩短通过色谱柱的分离过程的时间的改进方法。 该方法包括将样品注入混合塔上游的改性剂液流流中，该混合塔将液体改性剂的两个独立流动流与高度压缩的溶剂化流体相结合。 可以通过改变两个流动流的比例来在柱头处控制聚焦。 也可以调整总流量以加速样品在注射期间在柱上的应用。 该方法提高了超临界流体色谱系统的时间和效率，并且可以减少添加到流动相流动流中的改性剂的量。
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公开(公告)号：US06558540B2
公开(公告)日：2003-05-06
申请号：US09917210
申请日：2001-07-30
申请人： Terry A. Berger , Kimber D. Fogelman , L. Thompson Staats, III , Mark Nickerson , Paul F. Bente, III
发明人： Terry A. Berger , Kimber D. Fogelman , L. Thompson Staats, III , Mark Nickerson , Paul F. Bente, III
IPC分类号： B01D1508
CPC分类号： B01D11/0203 , B01D15/247 , B01D15/40 , G01N1/405 , G01N30/24 , G01N30/82
摘要： An efficient and safe method and apparatus for collecting exhaust gasses in an open-air sample collection container in a supercritical fluid chromatography system is claimed. The invention uses a vacuum force to evacuate the gaseous phase and vapors separated from liquid mobile phase in a sample collection device. The invention is portable to use on a series of collection containers, such as test tubes or wells in a titration place. Embodiments are claimed for capture of gasses and vapors either internally or externally to a collection container. The invention removes the gasses from the collection container that are then safely vented to a waste collector, thereby creating a safer environment for the laboratory and properly removing and disposing potentially hazardous chemicals instead of venting these chemicals into the environment.
摘要翻译： 一种用于在超临界流体色谱系统中的露天样品收集容器中收集废气的有效和安全的方法和装置。 本发明使用真空力来抽空样品收集装置中的气相和与液体流动相分离的蒸汽。 本发明便携式用于一系列收集容器，例如滴定处的试管或孔。 要求用于在收集容器的内部或外部捕集气体和蒸气的实施例。 本发明从收集容器中除去气体，然后将其安全地排放到废物收集器，从而为实验室创造更安全的环境，并适当地去除和处置潜在的危险化学品，而不是将这些化学物质排放到环境中。
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6.发明授权公开(公告)号：US06428702B1
公开(公告)日：2002-08-06
申请号：US09918435
申请日：2001-08-01
IPC分类号： B01D1100
摘要： An improved method and apparatus for safely introducing sample into a flow stream of a supercritical fluid chromatography system is described. The sample injection method improves safety of injection by eliminating the risk of injecting sample into a high-pressure system containing liquids and gasses at or near supercritical ranges. The method improves the efficiency and significantly shortens the time of the injection process by using a check valve placed between a fill port on an injection valve and sample port where sample is injected by a syringe. After sample injection from a sample loop into a high-pressure flow stream, an injection valve is reset to receive a subsequent sample. High-pressure flow stream mixtures become trapped within the sample loop when the valve is reset. The check valve prevents the mixtures from expanding into the sample port and blowing out a syringe and flow stream mixtures from the fill lines. The trapped flow stream mixtures are directed to a waste port where they are safely contained. The technique can be applied equally as effective to preparatory SFC as well as to analytical SFC systems.
摘要翻译： 描述了用于将样品安全地引入超临界流体色谱系统的流动流的改进的方法和装置。 样品注射方法通过消除在超临界范围内或附近含有液体和气体的高压系统中注入样品的风险，提高了注射的安全性。 该方法通过使用放置在注射阀上的填充口和通过注射器注射样品的样品端口的样品端口之间的止回阀来提高效率并显着缩短注射过程的时间。 从样品回路进样到高压流动流中后，重新注入进样阀以接收随后的样品。 当阀门复位时，高压流动流混合物将被捕获在样品回路内。 止回阀防止混合物膨胀到样品端口，吹出注射器并从填充线流出混合物。 被捕获的流动流混合物被引导到废物端口，在那里它们被安全地包含。 该技术可以同样适用于预备性证监会以及分析SFC系统。
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公开(公告)号：US5363707A
公开(公告)日：1994-11-15
申请号：US877909
申请日：1992-05-01
CPC分类号： G01N30/06 , G01N2001/2229
摘要： Methods and apparatus for collecting gasses from the sample headspace of a sealed sample container are disclosed. The gasses in the sample headspace are withdrawn by inserting a probe into the sample headspace and permitting the gasses to flow into an external headspace. The probe is then disconnected from the sample to seal the external headspace and the external headspace is then connected to an analytical instrument such as a gas chromatograph to permit the sample gasses to be transferred out of the external headspace and into the instrument. The step of transferring the gasses is preferably accomplished by connecting a source of carrier gas to an inlet port of the external headspace and sweeping the sample gasses from the external headspace. In certain preferred embodiments of the present invention, vibration is used to promote the formation of sample gasses either by vibrating the sample container itself or by moving the sample container relative to a stop to vibrate a septum which seals the sample container in certain embodiments. In these embodiments, the agitation created by such vibrations increases the rate of outgassing from the sample to the sample headspace. Also, in certain embodiments, the external headspace includes a flexible portion that is vibrated to agitate the external headspace and thereby promote uniform dispersion of sample gasses throughout the headspace.
摘要翻译： 公开了从密封样品容器的样品顶部空间收集气体的方法和装置。 通过将探针插入样品顶部空间并允许气体流入外部顶部空间来取出样品顶部空间中的气体。 然后将探头与样品断开以密封外部顶部空间，然后将外部顶部空间连接到诸如气相色谱仪的分析仪器，以允许样品气体从外部顶部空间转移到仪器中。 传送气体的步骤优选通过将载气源连接到外部顶部空间的入口并且从外部顶部空间扫掠样品气体来实现。 在本发明的某些优选实施例中，振动用于通过振动样品容器本身或通过相对于止动器移动样品容器来振动样品气体的形成，以振动在某些实施方案中密封样品容器的隔膜。 在这些实施例中，由这种振动产生的搅动增加了从样品到样品顶部空间的放气速率。 此外，在某些实施例中，外部顶部空间包括振动的柔性部分，以搅拌外部顶部空间，从而促使样品气体均匀分散在整个顶部空间中。
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公开(公告)号：US07964029B2
公开(公告)日：2011-06-21
申请号：US11487581
申请日：2006-07-17
IPC分类号： B01D50/00
CPC分类号： B01D11/0203 , B01D11/0403 , B01D11/0407 , B01D11/0484 , B01D15/40 , B01D19/0021 , B01D19/0052 , Y10T137/3003 , G01N30/80
摘要： A device and process for separating liquid and gas phases in a flowstream containing a liquefied gas or supercritical fluid under pressure mixed with a liquid. A splitter vessel separates the liquid from gas phases and transfers liquid to a collection container while conducting the gas phase out of the splitter. Separation of liquid phase out of the flowstream is provided without additional pressure schemes or solvent extractions imposed on the stream.
摘要翻译： 一种用于在含有与液体混合的压力下的液化气体或超临界流体的流动流中分离液相和气相的装置和方法。 分流器容器将液体与气相分离，并将液体转移到收集容器，同时将气相从分离器中排出。 没有额外的压力方案或施加在流上的溶剂萃取提供从流动流中分离出液相。
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公开(公告)号：US20110113962A1
公开(公告)日：2011-05-19
申请号：US13009291
申请日：2011-01-19
IPC分类号： B01D19/00
CPC分类号： B01D11/0203 , B01D11/0403 , B01D11/0407 , B01D11/0484 , B01D15/40 , B01D19/0021 , B01D19/0052 , Y10T137/3003 , G01N30/80
摘要： A device and process for separating liquid and gas phases in a flowstream containing a liquefied gas or supercritical fluid under pressure mixed with a liquid. A splitter vessel separates the liquid from gas phases and transfers liquid to a collection container while conducting the gas phase out of the splitter. Separation of liquid phase out of the flowstream is provided without additional pressure schemes or solvent extractions imposed on the stream.
摘要翻译： 一种用于在含有与液体混合的压力下的液化气体或超临界流体的流动流中分离液相和气相的装置和方法。 分流器容器将液体与气相分离，并将液体转移到收集容器，同时将气相从分离器中排出。 没有额外的压力方案或施加在流上的溶剂萃取提供从流动流中分离出液相。
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公开(公告)号：US07670487B2
公开(公告)日：2010-03-02
申请号：US11490498
申请日：2006-07-21
IPC分类号： B01D15/08
CPC分类号： G05D16/202 , B01D15/163 , G01N30/32 , Y10T137/0396 , Y10T137/2278
摘要： A depressurization process for a packed separation column is provided where the column system experiences a rapid and/or severe drop in pressure that could potentially damage column components. The process provides a safe de-pressurization of the column on the outlet side by decreasing the outlet pressure in controlled steps while allowing the inlet pressure of the column time to lower after each decreased step.
摘要翻译： 提供了一种用于填充分离塔的减压方法，其中塔系统经历可能损坏塔组分的快速和/或严重的压力下降。 该方法通过在受控的步骤中降低出口压力，同时允许柱子的入口压力在每个降低的步骤之后降低，从而在出口侧对柱进行安全的降压。
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