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    Heterocyclic Sulfonamide Derivatives As Inhibitors Of Factor Xa
    2.
    发明申请
    Heterocyclic Sulfonamide Derivatives As Inhibitors Of Factor Xa 审中-公开
    杂环磺酰胺衍生物作为因子Xa的抑制剂

    公开(公告)号：US20080221063A1

    公开(公告)日：2008-09-11

    申请号：US11994847

    申请日：2006-07-05

    Applicant: Christer Alstermark ,  Kjell Andersson ,  Ulf Fahlander ,  Kenneth Granberg

    Inventor： Christer Alstermark ,  Kjell Andersson ,  Ulf Fahlander ,  Kenneth Granberg

    IPC: A61K31/715 ,  C07D403/14 ,  A61K31/501

    CPC classification number: C07D401/14

    Abstract: The invention relates to heterocyclic derivatives of formula (I), Chemical formula should be inserted here. Please see paper copy wherein R1 is hydrogen or C1-3alkyl; R2 is selected from hydroxy, C1-5alkyl, carboxy, cyano, tetrazolyl, N—C1-5alkyltetrazolyl, oxazolyl, C1-5oxazolyl, isoxazolyl, C1-5 isoxazolyl, hydroxyC1-5alkyl, carboxy C1-5alkyl, C1-5alkoxyoxo C1-5alkyl, carbamoyl, C1-5alkylcarbamoyl, di(C1-5alkyl)carbamoyl, C1-5alkylcarbamoyl C1-4alkyl, hydroxy C1-5alkylcarbamoyl, C1-5alkoxy C1-5alkylcarbamoyl; —C1-5alkyl-Y1, —COOCHR17R18 and —CONR17R18; and R3 is hydrogen or halogen; or a pharmaceutically acceptable salt thereof, said compounds possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the compounds, to their use, to pharmaceutical compositions comprising them, to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect, and to combinations comprising them.

    Abstract translation: 本发明涉及式（I）的杂环衍生物，其中应插入化学式。 请参见其中R 1是氢或C 1-3烷基的纸副本; R 2选自羟基，C 1-5烷基，羧基，氰基，四唑基，NC 1-5烷基四唑基，恶唑基， 1〜5个恶唑基，异恶唑基，C 1〜5个异恶唑基，羟基C 1-5烷基，羧基C 1-5 烷基，C 1-5烷氧基氧基C 1-5烷基，氨基甲酰基，C 1-5烷基氨基甲酰基，二（C 1） -5个烷基）氨基甲酰基，C 1-5烷基氨基甲酰基C 1-4烷基，羟基C 1-5烷基氨基甲酰基，C 1-5烷氧基C 1-5烷基氨基甲酰基; -C 1-5烷基-Y 1，-COOCHR 17 R 18和-CONR 17 R＆lt; 18＆gt;; R 3是氢或卤素; 或其药学上可接受的盐，所述化合物具有抗血栓形成和抗凝血性质，因此可用于治疗人或动物的方法。 本发明还涉及制备化合物，其用途，包含它们的药物组合物在制备用于产生抗血栓形成或抗凝血作用的药物中的用途，以及包含它们的组合的方法。

    Heterocyclic Sulfonamide Derivatives as Inhibitors of Factor Xa
    3.
    发明申请
    Heterocyclic Sulfonamide Derivatives as Inhibitors of Factor Xa 审中-公开

    公开(公告)号：US20080214495A1

    公开(公告)日：2008-09-04

    申请号：US11994846

    申请日：2006-07-05

    Applicant: Christer Alstermark ,  Kosrat Amin ,  Kjell Andersson ,  Yantao Chen ,  Ulf Fahlander ,  Kevin Michael Foote ,  Kenneth Granberg ,  Daniel Hovdal

    Inventor： Christer Alstermark ,  Kosrat Amin ,  Kjell Andersson ,  Yantao Chen ,  Ulf Fahlander ,  Kevin Michael Foote ,  Kenneth Granberg ,  Daniel Hovdal

    IPC: A61K31/501 ,  C07D401/14 ,  A61K31/497 ,  A61K31/496 ,  A61K31/397 ,  A61P9/00

    CPC classification number: C07D409/14 ,  C07D401/04 ,  C07D401/14

    Abstract: The invention relates to compounds of formula (I), wherein R1 and R3 are independently selected from carbon and nitrogen; R2 is oxo or thioxo; n is 0, 1 or 2; each R10 is independently selected from hydrogen and C1-3alkyl; R4 and R5 are each selected from carbon and nitrogen, wherein at least one of R4 and R5 is nitrogen; R6 is hydrogen or oxo; R7 is an aliphatic, partially saturated or aromatic carbocyclic ring, said carbocyclic ring having 0, 1 or 2 hetero nitrogen; m is 0, 1 or 2; each R11 is independently selected from hydrogen, hydroxy, oxo, C1-5alkyl, carboxy, hydroxyC1-5alkyl, carboxyC1-5alkyl, C1-5alkoxy-oxoC1-5alkyl, carbamoyl, C1-5alkylcarbamoyl, di (C1-5 alkyl)carbamoyl, carbamoylC1-4alkyl,C1-5alkylcarbamoylC1-4alkyl, di(C1-5alkyl)carbamoylC1-4alkyl, hydroxyC1-5alkylcarbamoyl, C1-5 alkoxyC1-5alkylcarbamoyl, hydroxyC1-5alkylcarbamoylC1-4alkyl, C1-5alkoxyC1-5 alkylcarbamoylC1-4 alkyl, CONR80(CH2)xS(O)pR90, CONH(CH2)qNR100R100, —C1-5 alkyl-Y1, —COOCHR170R180 and —CON R170R180; R8 is a bond, C1-4alkylene or C2-6alkenylene; R9 is an aromatic ring system having 0, 1 or 2 hetero atoms; wherein R9 is substituted by 0 or 1 halogen; or a pharmaceutically acceptable salt thereof, said compounds possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the compounds, to their use, to pharmaceutical compositions comprising them, to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect, and to combinations comprising them.

    Jointing system
    7.
    发明授权
    Jointing system 失效
    接合系统

    公开(公告)号：US6029416A

    公开(公告)日：2000-02-29

    申请号：US875270

    申请日：1997-07-18

    Applicant: Kjell Andersson

    Inventor： Kjell Andersson

    IPC: E04F15/02 ,  E04B1/61 ,  E04F15/04 ,  E04B5/00

    CPC classification number: E04B1/6133 ,  E04F15/04 ,  E04F2201/08 ,  Y10T403/7016

    Abstract: In a system for jointing together of adjacent pieces of flooring material by means of grooves (3) and tongues (4), at least one of the opposing surfaces on the tongues (4) and the grooves (3) of the pieces display flocked surface portions (10-13). The flocked surface portions (10-13) extend along the tongues (4) and/or the grooves (3) and cover substantially their entire length. The fiber length (9) of the flocked surface portions (10-13) exceeds the difference between the width of the grooves (3) and the thickness of the tongues (4).

    Abstract translation: PCT No.PCT / SE96 / 01537第 371日期1997年7月18日 102（e）日期1997年7月18日PCT 1995年12月19日PCT PCT。 第WO96 / 23942号公报 日期：1996年8月8日在通过槽（3）和舌片（4）将邻接的地板材料块接合在一起的系统中，舌部（4）和沟槽（3）中的至少一个相对表面 片展示植绒表面部分（10-13）。 植绒表面部分（10-13）沿着舌片（4）和/或凹槽（3）延伸并且基本上覆盖其整个长度。 植绒表面部分（10-13）的纤维长度（9）超过槽（3）的宽度和舌部（4）的厚度之差。

    Silica sols and use of the sols
    8.
    发明授权
    Silica sols and use of the sols 失效
    二氧化硅溶胶和溶胶的使用

    公开(公告)号：US5603805A

    公开(公告)日：1997-02-18

    申请号：US379630

    申请日：1995-02-03

    Applicant: Kjell Andersson ,  Bo Larsson ,  Erik Lindgren

    Inventor： Kjell Andersson ,  Bo Larsson ,  Erik Lindgren

    IPC: C01B33/14 ,  C01B33/143 ,  C01B33/146 ,  C01B33/149 ,  D21F11/00 ,  D21H17/13 ,  D21H17/37 ,  D21H17/45 ,  D21H17/67 ,  D21H17/68 ,  D21H21/10

    CPC classification number: D21H17/68 ,  C01B33/143 ,  C01B33/149 ,  D21H17/375 ,  D21H17/45

    Abstract: Silica sols with a high content of microgel and particles with a specific surface area within the range 300 to 700 m.sup.2 /g, preferably 400 to 650 m.sup.2 /g. The sols can be prepared by acidification or a water glass solution and alkalization at a certain dry content, alternatively to a certain pH. The sols are particularly suitable for use as additives in papermaking in combination with cationic polymers and especially in combination with cationic acrylamide based polymers.

    Abstract translation: PCT No.PCT / SE93 / 00663 Sec。 371日期：1995年2月3日 102（e）日期1995年2月3日PCT提交1993年8月11日PCT公布。 公开号WO94 / 05596 日期1994年3月17日硅溶胶具有高含量的微凝胶和颗粒，比表面积在300-700m2 / g，优选400-650m2 / g的范围内。 溶胶可以通过酸化或水玻璃溶液制备，并以一定的干含量，或者一定的pH值碱化。 该溶胶特别适用于与阳离子聚合物结合使用的造纸添加剂，特别是与阳离子丙烯酰胺基聚合物组合使用。

    Method of printing a glass pane with a decorative coating reaching the peripheral face of the glass pane
    9.
    发明授权
    Method of printing a glass pane with a decorative coating reaching the peripheral face of the glass pane 失效
    将具有装饰涂层的玻璃板印刷到达玻璃板的周边面的方法

    公开(公告)号：US5250321A

    公开(公告)日：1993-10-05

    申请号：US851795

    申请日：1992-03-16

    Applicant: Kjell Andersson ,  Carl Liden ,  Raimo Eronen ,  Hans Ohlenforst ,  Dieter Hahn ,  Jean-Pierre Lacoste

    Inventor： Kjell Andersson ,  Carl Liden ,  Raimo Eronen ,  Hans Ohlenforst ,  Dieter Hahn ,  Jean-Pierre Lacoste

    IPC: C03C17/32 ,  B41F15/08 ,  B41M1/12 ,  B41M1/34 ,  B60J1/02 ,  C03C17/00 ,  B05D5/06

    CPC classification number: C03C17/002 ,  B41M1/12 ,  B41M1/34 ,  B60J1/02

    Abstract: In a method of making a glazing pane (1), printed with a decorative frame (15), in which the decorative frame (15) extends right to the peripheral surface (6) of the glass pane (1) independently of edge tolerances of the glass panes and of positioning tolerances of the glass pane and of the printing tools during the printing operation, a profiled strand (13), which extends the surface of the glass pane (1) beyond its peripheral face (6) is integrally formed immediately adjoining the peripheral face (6). The decorative frame (15) is printed on beyond the peripheral edge of the glass pane (1) and onto the profiled strand (13). After the printing ink has dried, the profiled strand (13) is removed from the glass pane (1).

    Abstract translation: 在制造装饰框架（15）的玻璃窗（1）的方法中，其中装饰框架（15）直接延伸到玻璃板（1）的周面（6），独立于边缘公差 在打印操作期间玻璃板和印刷工具的玻璃板和定位公差，使玻璃板（1）的表面延伸超过其外表面（6）的成型股线（13）立即一体地形成 邻接周边面（6）。 装饰框架（15）印刷在玻璃板（1）的周边边缘上并且被印刷到成型股线（13）上。 在印刷油墨干燥后，从玻璃板（1）中取出成型股（13）。

    Method for determining the specific fuel consumption of an internal combustion engine and apparatus therefor
    10.
    发明授权
    Method for determining the specific fuel consumption of an internal combustion engine and apparatus therefor 失效
    用于确定内燃机的特定燃料消耗的方法及其装置

    公开(公告)号：US5006994A

    公开(公告)日：1991-04-09

    申请号：US340227

    申请日：1989-04-19

    Applicant: Kjell Andersson ,  Lennart Eriksson

    Inventor： Kjell Andersson ,  Lennart Eriksson

    IPC: G01F9/00

    CPC classification number: G01F9/003

    Abstract: The invention relates to a method and an apparatus for determining the specific fuel consumption of an internal combustion engine by measuring the change in weight of a pot containing fuel for consumption by the engine during a specific, selectable time. The apparatus for performing this method includes a data acquisition system equipped with a number of measuring points. Sensors at the measuring points feed, through the data acquisition system, signals representing the change in weight of the fuel pot, the speed of the engine and the torque of the engine into a computer. The computer is programmed for measuring at constant speed and constant torque, within selectable tolerances, and for measurement during a specific, selectable period of time. The method of the invention permits the use of statistical methods to assure reliable and accurate measurement results with the shortest possible measurement period, while providing high flexibility in interfacing with an operator or central computer system.

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