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1.发明授权Saccharomyces cerevisiae yeast strain with functional expression of a Glut transporter 有权具有Glut转运蛋白功能性表达的酿酒酵母菌株公开(公告)号：US07052900B2
公开(公告)日：2006-05-30
申请号：US10067449
申请日：2002-02-05
摘要： The invention relates to a strain of the yeast Saccharomyces cerevisiae which, owing to deletion of the genomic sequences, no longer synthesizes hexose transporters and, as a consequence, can no longer grow on substrates with hexoses as the only carbon source, and whose ability of growing on a substrate with a hexose as the only carbon source is restored when it expresses a GLUT4 gene.
摘要翻译： 本发明涉及酵母酿酒酵母菌株，其由于基因组序列的缺失而不再合成己糖转运蛋白，因此不能再以己糖作为唯一的碳源在底物上生长，并且其能力 生长在具有己糖的底物上，当其表达GLUT4基因时，唯一的碳源被还原。
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公开(公告)号：US4918007A
公开(公告)日：1990-04-17
申请号：US917066
申请日：1986-10-08
CPC分类号： C07K14/36 , C12N15/76 , C07K2319/00 , Y10S435/886
摘要： A tandem arrangement of two promoters which are each active in Streptomyces is provided. The tandem arrangement provides a considerable increase in protein expression.
摘要翻译： 提供了两种在链霉菌中活跃的启动子的串联排列。 串联排列提供了蛋白质表达的显着增加。
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3.发明申请Saccharomyces cerevisiae yeast strain with functional expression of a GLUT transporter 有权具有葡萄糖转运蛋白功能性表达的酿酒酵母菌株公开(公告)号：US20060275319A1
公开(公告)日：2006-12-07
申请号：US11399990
申请日：2006-04-07
摘要： The invention relates to a strain of the yeast Saccharomyces cerevisiae which, owing to deletion of the genomic sequences, no longer synthesizes hexose transporters and, as a consequence, can no longer grow on substrates with hexoses as the only carbon source, and whose ability of growing on a substrate with a hexose as the only carbon source is restored when it expresses a GLUT4 gene.
摘要翻译： 本发明涉及酵母酿酒酵母菌株，其由于基因组序列的缺失而不再合成己糖转运蛋白，因此不能再以己糖作为唯一的碳源在底物上生长，并且其能力 生长在具有己糖的底物上，当其表达GLUT4基因时，唯一的碳源被还原。
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公开(公告)号：US5667991A
公开(公告)日：1997-09-16
申请号：US524677
申请日：1995-09-08
IPC分类号： A23L3/3526 , A61K38/00 , A61P31/04 , C07H21/04 , C07K7/56 , C07K14/195 , C07K14/315 , C07K14/32 , C07K14/36 , C12N1/21 , C12N15/09 , C12N15/11 , C12N15/31 , C12N15/63 , C12N15/74 , C12N15/75 , C12N15/76 , C12P1/04 , C12P21/02 , C12P21/04 , C12R1/07 , C12R1/46 , C12R1/465 , C12P21/06 , C07H19/00 , C12N1/20
摘要： The present invention refers in particular to the structural gene sequence of the peptide antibiotic mersacidin. Sequencing revealed that premersacidin consists of an unusually long 48 amino acid leader sequence and a 20 amino acid propeptide part (Seq. ID No:1) which is modified during biosynthesis to the mature lantibiotic.
摘要翻译： 本发明特别涉及肽抗生素美沙他的结构基因序列。 测序表明，预杀菌素由异常长的48个氨基酸的前导序列和20个氨基酸的前肽部分（Seq.ID No：1）组成，其在生物合成期间被修饰为成熟的羊毛硫抗生素。
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公开(公告)号：US06649369B2
公开(公告)日：2003-11-18
申请号：US10118010
申请日：2002-04-09
IPC分类号： C12P3500
摘要： The present invention relates to a process for delaying the deactivation of glutaryl amidase during enzyme catalysis. The enzyme catalyst is, after maximum conversion of the substrate, separated off by filtration and can be reused in a subsequent reaction batch. In each reaction cycle, the enzyme catalyst loses activity. The inactivation of the enzyme catalyst can be delayed by bringing it into contact with a thiol during the reaction.
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公开(公告)号：US5830743A
公开(公告)日：1998-11-03
申请号：US312675
申请日：1994-09-28
CPC分类号： C12N9/80
摘要： The gene encoding glutarylacylase (GA) contained in the plasmid pCM 145 (DSM 6409) permits the expression of GA in E. coli in high yields.
摘要翻译： 质粒pCM 145（DSM 6409）中所含的编码戊二酰基化酶（GA）的基因允许以高产率在大肠杆菌中表达GA。
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7.发明授权
公开(公告)号：US5766881A
公开(公告)日：1998-06-16
申请号：US544087
申请日：1995-10-17
申请人： Werner Aretz , Ulrich Holst , Klaus Peter Koller
发明人： Werner Aretz , Ulrich Holst , Klaus Peter Koller
IPC分类号： C12N15/09 , C07H21/04 , C12N9/80 , C12N15/31 , C12N15/72 , C12R1/19 , C12P21/02 , C12N15/56 , C12N15/70
摘要： Improved, induction-free process for the recombinant preparation of glutarylamidase. The invention relates to a recombinant process for preparing glutarylamidase (GA), wherein the GA gene is expressed constitutively from an expression vector. In certain embodiments, the promoter for constitutively expressing the GA gene is a trc promoter or a trc-equivalent promoter which does not have any repressor or has a non-functional repressor.
摘要翻译： 改进的无诱导的戊二酰胺酶重组制备方法。 本发明涉及一种制备戊二酰胺酶（GA）的重组方法，其中GA基因从表达载体中组成型表达。 在某些实施方案中，用于组成型表达GA基因的启动子是不具有任何阻遏物或具有非功能性阻遏物的trc启动子或trc等效启动子。
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8.发明授权Clostripain catalyzed hydrolysis of preproinsulin analogs into corresponding insulins 失效梭菌素催化前胰岛素类似物水解成相应的胰岛素
公开(公告)号：US5728543A
公开(公告)日：1998-03-17
申请号：US291060
申请日：1994-08-08
摘要： A process is described to specifically hydrolyze the amino acid chain of preproinsulin analogs to give the corresponding insulins. The hydrolysis is catalyzed by clostripain and, if necessary, carboxypeptidase B.
摘要翻译： 描述了一种方法来特异性水解前胰岛素类似物的氨基酸链，得到相应的胰岛素。 水解由clostripain催化，如果需要，羧肽酶B.
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9.发明授权Saccharomyces cerevisiae yeast strain with functional expression of a GLUT transporter gene 有权具有GLUT转运蛋白基因功能性表达的酿酒酵母菌株公开(公告)号：US08574909B2
公开(公告)日：2013-11-05
申请号：US11399990
申请日：2006-04-07
摘要： The invention relates to a strain of the yeast Saccharomyces cerevisiae which, owing to deletion of the genomic sequences, no longer synthesizes hexose transporters and, as a consequence, can no longer grow on substrates with hexoses as the only carbon source, and whose ability of growing on a substrate with a hexose as the only carbon source is restored when it expresses a GLUT4 gene.
摘要翻译： 本发明涉及酵母酿酒酵母菌株，其由于基因组序列的缺失而不再合成己糖转运蛋白，因此不能再以己糖作为唯一的碳源在底物上生长，并且其能力 生长在具有己糖的底物上，当其表达GLUT4基因时，唯一的碳源被还原。
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公开(公告)号：US06468750B1
公开(公告)日：2002-10-22
申请号：US09561989
申请日：2000-05-02
申请人： Klaus-Peter Koller
发明人： Klaus-Peter Koller
IPC分类号： C12Q168
CPC分类号： C07K14/4738 , Y10S435/81
摘要： The invention relates to the cell regulation factor TTO 20, DNA coding therefor, its preparation and use, antibodies binding to TTO 20 and the use of DNA coding for TTO 20 and an antibody binding to TTO 20 for use in a diagnostic kit for the detection of inflammatory disorders, in particular rheumatoid arthritis.
摘要翻译： 本发明涉及细胞调节因子TTO 20，其编码的DNA，其制备和用途，与TTO20结合的抗体以及编码TTO 20的DNA的使用以及与TTO20结合的抗体用于检测用诊断试剂盒 的炎症性疾病，特别是类风湿性关节炎。
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