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1.发明申请Heparin-insensitive Method for Determining Direct Coagulation Factor Inhibitors 有权用于确定直接凝血因子抑制剂的肝素不敏感方法公开(公告)号：US20120202232A1
公开(公告)日：2012-08-09
申请号：US13366746
申请日：2012-02-06
Applicant: Konrad Braun , Wolfgang KLEIN , Norbert Zander , Michael Timme
Inventor： Konrad Braun , Wolfgang KLEIN , Norbert Zander , Michael Timme
IPC: C12Q1/56
CPC classification number: G01N33/86 , C12Q1/56 , G01N2500/02
Abstract: The invention is in the field of coagulation diagnostics and relates to a heparin-insensitive method for determining direct coagulation factor inhibitors in a sample, in particular direct thrombin and factor Xa inhibitors.
Abstract translation: 本发明在凝血诊断领域，涉及用于确定样品中直接凝血因子抑制剂的肝素不敏感方法，特别是直接凝血酶和因子Xa抑制剂。
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公开(公告)号：US20100158932A1
公开(公告)日：2010-06-24
申请号：US12591303
申请日：2009-11-16
Applicant: Stefan Teigelkamp , Konrad Braun
Inventor： Stefan Teigelkamp , Konrad Braun
CPC classification number: C12N9/6429 , C07K16/40 , C12Y304/21005
Abstract: The invention relates to antibodies directed against F1+2, to the preparation and use thereof, especially in therapy and diagnosis. The antibodies bind to an epitope on the N-terminal half of the F2 fragment of prothrombin.
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公开(公告)号：US06372423B1
公开(公告)日：2002-04-16
申请号：US09588497
申请日：2000-06-07
Applicant: Konrad Braun
Inventor： Konrad Braun
IPC: A01N102
CPC classification number: G01N33/96 , A61K35/19 , G01N2496/05
Abstract: The present invention relates to preparations of functionally active platelets and to a process for stabilizing these functionally active platelets by means of freeze-drying. In particular, a lyophilized or reconstituted platelet composition containing an anticoagulant, a cake forming agent, and an inhibitor of platelet function is disclosed.
Abstract translation: 本发明涉及功能活性血小板的制剂和通过冷冻干燥来稳定这些功能活性血小板的方法。 特别地，公开了含有抗凝血剂，成饼剂和血小板功能抑制剂的冻干或重构的血小板组合物。
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4.发明授权Reagent for the determination of ristocetin cofactor (v.Willebrand factor) 失效用于测定瑞斯托菌素辅因子的试剂（v.Willebrand因子）
公开(公告)号：US4510126A
公开(公告)日：1985-04-09
申请号：US430748
申请日：1982-09-30
Applicant: Peter Fuhge , Konrad Braun , Udo Becker
Inventor： Peter Fuhge , Konrad Braun , Udo Becker
CPC classification number: G01N33/86 , C12Q1/56 , G01N2333/755 , Y10T436/101666
Abstract: An agent for determining ristocetin cofactor (v.Willebrand factor) is described, which contains platelets which have been treated with a tanning agent, with a protease inhibitor and, optionally, with a dye-stuff, and ristocetin A.
Abstract translation: 描述了一种用于测定瑞斯托菌素辅因子（v.Willebrand因子）的试剂，其包含已经用鞣剂处理的血小板，具有蛋白酶抑制剂，任选地含有染料和瑞斯他汀A.
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公开(公告)号：US4404134A
公开(公告)日：1983-09-13
申请号：US352954
申请日：1982-02-26
Applicant: Udo Becker , Konrad Braun , Norbert Heimburger
Inventor： Udo Becker , Konrad Braun , Norbert Heimburger
IPC: A61K8/96 , A61K8/24 , A61K8/44 , A61K8/65 , A61K8/72 , A61K38/00 , A61K38/16 , A61K38/17 , A61L15/32 , A61L15/42 , A61L26/00 , A61P7/04 , A61P17/00 , A61Q19/00 , C07K14/745 , C07K14/755 , C07K14/78 , C12N9/10 , D01F4/00 , G01N33/50 , G01N33/86 , C07G7/00
CPC classification number: C12N9/1044 , A61K8/65 , A61L15/325 , A61L15/425 , A61L26/0033 , A61Q19/00 , C07K14/755 , C07K14/78 , G01N33/86 , A61K38/00 , G01N2333/755 , G01N2333/78 , G01N2333/9108 , G01N2333/91085
Abstract: Process for the manufacture of a collagen solution and its use for the manufacture of collagen fibrillae for adsorbing coagulation factors, as diagnostic agent, for the manufacture of a collagen sponge and for use in a cosmetic preparation.
Abstract translation: 用于制造胶原溶液的方法及其用于制造用于吸收凝血因子的胶原原纤维的用途，作为诊断剂，用于制造胶原海绵并用于化妆品制剂。
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Patent Agency Ranking
6.发明授权Heparin-insensitive method for determining direct coagulation factor inhibitors 有权用于确定直接凝血因子抑制剂的肝素不敏感方法公开(公告)号：US08685636B2
公开(公告)日：2014-04-01
申请号：US13366746
申请日：2012-02-06
Applicant: Konrad Braun , Wolfgang Klein , Norbert Zander , Michael Timme
Inventor： Konrad Braun , Wolfgang Klein , Norbert Zander , Michael Timme
CPC classification number: G01N33/86 , C12Q1/56 , G01N2500/02
Abstract: The invention is in the field of coagulation diagnostics and relates to a heparin-insensitive method for determining direct coagulation factor inhibitors in a sample, in particular direct thrombin and factor Xa inhibitors.
Abstract translation: 本发明在凝血诊断领域，涉及用于确定样品中直接凝血因子抑制剂的肝素不敏感方法，特别是直接凝血酶和因子Xa抑制剂。
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7.发明授权Antibodies directed against prothrombin fragment F1+2, the preparation and use thereof 有权针对凝血酶原片段F1 + 2的抗体，其制备和应用公开(公告)号：US08063180B2
公开(公告)日：2011-11-22
申请号：US12591303
申请日：2009-11-16
Applicant: Stefan Teigelkamp , Konrad Braun
Inventor： Stefan Teigelkamp , Konrad Braun
IPC: C07K7/06
CPC classification number: C12N9/6429 , C07K16/40 , C12Y304/21005
Abstract: The invention relates to antibodies directed against F1+2, to the preparation and use thereof, especially in therapy and diagnosis. The antibodies bind to an epitope on the N-terminal half of the F2 fragment of prothrombin.
Abstract translation: 本发明涉及针对F1 + 2的抗体，其制备和应用，特别是在治疗和诊断中。 抗体结合凝血酶原F2片段的N末端一半上的表位。
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8.发明授权Process for the preparation of factor VIII:C-deficient plasma, and a deficient plasma obtained in this way 失效因子VIII的制备方法：C缺乏血浆，以及以这种方式获得的缺血性血浆
公开(公告)号：US5021243A
公开(公告)日：1991-06-04
申请号：US164486
申请日：1988-03-04
Applicant: Udo Becker , Norbert Heimburger , Konrad Braun
Inventor： Udo Becker , Norbert Heimburger , Konrad Braun
IPC: G01N33/48 , A61K35/16 , A61K38/00 , C07K14/755 , G01N33/53
CPC classification number: C07K14/755 , A61K35/16 , A61K38/00
Abstract: A process for the preparation of a factor VIII:C-deficient plasma is made available, in which a starting plasma is consecutively treated with antibodies against von Willebrand factor and antibodies against factor VIII:Ag. The deficient plasma prepared in this way contains less than 0.5% residual activity of factor VIII:C.
Abstract translation: 制备VIII因子：缺血性血浆的方法是可获得的，其中起始血浆通过抗血管性血友病因子抗体和针对因子VIII：Ag的抗体连续治疗。 以这种方式制备的缺陷血浆含有少于0.5％的因子VIII的残留活性：C。
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公开(公告)号：US4331766A
公开(公告)日：1982-05-25
申请号：US169842
申请日：1980-07-17
Applicant: Udo Becker , Konrad Braun , Norbert Heimburger
Inventor： Udo Becker , Konrad Braun , Norbert Heimburger
IPC: A61K8/96 , A61K8/24 , A61K8/44 , A61K8/65 , A61K8/72 , A61K38/00 , A61K38/16 , A61K38/17 , A61L15/32 , A61L15/42 , A61L26/00 , A61P7/04 , A61P17/00 , A61Q19/00 , C07K14/745 , C07K14/755 , C07K14/78 , C12N9/10 , D01F4/00 , G01N33/50 , G01N33/86 , C07G17/00
CPC classification number: C12N9/1044 , A61K8/65 , A61L15/325 , A61L15/425 , A61L26/0033 , A61Q19/00 , C07K14/755 , C07K14/78 , G01N33/86 , A61K38/00 , G01N2333/755 , G01N2333/78 , G01N2333/9108 , G01N2333/91085
Abstract: Process for the manufacture of a collagen solution and its use for the manufacture of collagen fibrillae for adsorbing coagulation factors, as diagnostic agent, for the manufacture of a collagen sponge and for use in a cosmetic preparation.
Abstract translation: 用于制造胶原溶液的方法及其用于制造用于吸收凝血因子的胶原原纤维的用途，作为诊断剂，用于制造胶原海绵并用于化妆品制剂。
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10.发明授权Antibodies directed against prothrombin fragment F1+2, the preparation and use thereof 有权针对凝血酶原片段F1 + 2的抗体，其制备和应用公开(公告)号：US07795403B2
公开(公告)日：2010-09-14
申请号：US10992351
申请日：2004-11-19
Applicant: Stefan Teigelkamp , Konrad Braun
Inventor： Stefan Teigelkamp , Konrad Braun
IPC: C07K16/00
CPC classification number: C12N9/6429 , C07K16/40 , C12Y304/21005
Abstract: The invention relates to antibodies directed against F1+2, to the preparation and use thereof, especially in therapy and diagnosis. The antibodies bind to an epitope on the N-terminal half of the F2 fragment of prothrombin.
Abstract translation: 本发明涉及针对F1 + 2的抗体，其制备和应用，特别是在治疗和诊断中。 抗体结合凝血酶原F2片段的N末端一半上的表位。
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