公开(公告)号：US08287725B2

公开(公告)日：2012-10-16

申请号：US12308052

申请日：2007-06-04

申请人： Leif Sörnmo ,  Kristian Solem ,  Bo Olde

发明人： Leif Sörnmo ,  Kristian Solem ,  Bo Olde

IPC分类号： B01D61/12 ,  A61B5/024

CPC分类号： A61B5/14551 ,  A61B5/021 ,  A61B5/02116 ,  A61M1/3639 ,  A61M2205/18 ,  A61M2205/50 ,  A61M2230/30

摘要： The invention relates to prediction of a rapid symptomatic drop in a subject's blood pressure, e.g. during a medical treatment or when operating an aircraft. To this aim, a pulse shape parameter (Pps) with respect to a peripheral body part (105) of the subject (P) is registered by means of a pulse oximetry instrument (110) adapted to detect light response variations in blood vessels. An initial pulse magnitude measure is calculated based on a pulse shape parameter (Pps) received at a first instance. During a measurement period subsequent to the first instance, a respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (Pps). It is further investigated, for each pulse magnitude measure in the measurement period, whether or not the measure fulfills a decision criterion relative to the initial pulse magnitude measure. An alarm triggering signal (α) is generated if the decision criterion is found to be fulfilled.

摘要翻译： 本发明涉及预测受试者血压中快速有症状的下降，例如， 在治疗期间或在操作飞行器时。 为此目的，通过适于检测血管中的光反应变化的脉搏血氧仪（110）来记录相对于被检体（P）的外周身体部分（105）的脉搏形状参数（Pps）。 基于在一次接收的脉冲形状参数（Pps）来计算初始脉冲幅度测量。 在第一次之后的测量周期期间，基于接收的脉冲形状参数（Pps）的数量来计算相应的脉冲幅度测量。 对于测量周期中的每个脉冲幅度测量，进一步研究测量是否满足相对于初始脉冲幅度测量的判定标准。 如果发现满足判定标准，则产生报警触发信号（α）。

公开(公告)号：US08311619B2

公开(公告)日：2012-11-13

申请号：US12066478

申请日：2006-08-10

申请人： Leif Sörnmo ,  Kristian Solem

发明人： Leif Sörnmo ,  Kristian Solem

IPC分类号： A61B5/04 ,  A61B5/02

CPC分类号： A61B5/746 ,  A61B5/0402 ,  A61B5/0452 ,  A61B5/7203 ,  A61B5/7264 ,  A61M1/30

摘要： A cardiac-activity based prediction of a rapid drop in a patient's blood pressure during extracorporeal blood treatment is disclosed. A proposed alarm apparatus includes a primary beat morphology analysis unit bank of secondary analysis units and an alarm generating unit. The primary beat morphology analysis unit discriminates heart beats in a received basic electrocardiogram signal, classifies each beat into one out of at least two different beat categories, and associates each segment of the signal with relevant event-type data. The event-type data and the basic electrocardiogram signal together form an enhanced electrocardiogram signal, based upon which the primary beat morphology analysis unit determines whether one or more secondary signal analyses should be performed. Depending on the enhanced electrocardiogram signal's properties, the bank of secondary analysis units performs none, one or more of up to at least two different types of secondary analyses, and for each analysis performed produces a respective test signal. The alarm generating unit receives the test signals, and triggers an alarm signal indicative of an estimated rapid blood pressure decrease, if at least one alarm criterion is fulfilled.

摘要翻译： 公开了一种基于心脏活动的预测体外血液治疗期间患者血压迅速下降的预测。 所提出的报警装置包括二次分析单元的主拍形态分析单元组和报警发生单元。 主要搏动形态分析单元鉴别接收到的基本心电图信号中的心跳，将每个节拍分为至少两个不同节拍类别中的一个，并且将每个信号段与相关的事件类型数据相关联。 事件类型数据和基本心电图信号一起形成增强的心电图信号，基于该心电图信号，初步搏动形态分析单元确定是否应执行一个或多个次要信号分析。 根据增强的心电图信号的性质，二次分析单元组不执行至多两种不同类型的辅助分析中的一个或多个，并且对于执行的每个分析，都产生相应的测试信号。 如果满足至少一个报警标准，则报警发生单元接收测试信号，并触发指示估计的快速血压下降的报警信号。

公开(公告)号：US08060190B2

公开(公告)日：2011-11-15

申请号：US11662480

申请日：2005-09-12

申请人： Leif Sörnmo ,  Kristian Solem

发明人： Leif Sörnmo ,  Kristian Solem

IPC分类号： A61B5/0402

CPC分类号： A61B5/02405 ,  A61B5/021 ,  A61B5/0468 ,  A61M1/16 ,  A61M1/3639 ,  A61M2205/18 ,  A61M2205/50 ,  A61M2230/04

摘要： The invention relates to cardiac-activity based prediction of a rapid drop in a patient's blood pressure during hemodialysis. A proposed alarm apparatus includes an input interface, primary and secondary analysis units and an alarm-generating unit. An electrocardiogram signal (HECG) of the patient is received via the input interface by the primary analysis unit, which in response thereto produces a heart-rate-variability signal (PHRV). The secondary analysis unit determines an intensity of ectopic beats (PEBC) based on the electrocardiogram signal (HECG). The alarm-generating unit investigates whether the intensity of ectopic beats (PEBC) is relatively low or relatively high. In case of a relatively low intensity, the unit triggers an alarm signal (α) indicative of an estimated rapid blood pressure decrease if the heart-rate-variability signal (PHRV) fulfills a first alarm criterion. In case of a relatively high intensity, however, the unit triggers the alarm signal (α) if the intensity of the ectopic beats (PEBC) fulfills a second alarm criterion.

摘要翻译： 本发明涉及基于心脏活动的预测血液透析期间患者血压的快速下降。 所提出的报警装置包括输入接口，主要和次要分析单元以及报警发生单元。 通过主分析单元经由输入接口接收患者的心电图信号（HECG），主要分析单元响应于此产生心率变异信号（PHRV）。 二次分析单元基于心电图信号（HECG）确定异位搏动（PEBC）的强度。 报警机构调查异位搏动（PEBC）的强度是否相对较低或相对较高。 在强度相对较低的情况下，如果心率变异信号（PHRV）满足第一警报标准，则该单元触发指示估计的快速血压降低的报警信号（α）。 然而，在强度相对较高的情况下，如果异位搏动（PEBC）的强度达到第二警报标准，则该单元触发报警信号（α）。

公开(公告)号：US09636447B2

公开(公告)日：2017-05-02

申请号：US14234527

申请日：2012-06-20

申请人： Bo Olde ,  Kristian Solem ,  Mattias Holmer ,  Jan Sternby

发明人： Bo Olde ,  Kristian Solem ,  Mattias Holmer ,  Jan Sternby

IPC分类号： A61B5/02 ,  A61M1/36 ,  B01D61/30 ,  B01D61/32 ,  G01L19/00 ,  A61B5/021 ,  A61B5/00

CPC分类号： A61M1/3607 ,  A61B5/02108 ,  A61B5/6866 ,  A61B5/7217 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3621 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M2205/3331 ,  A61M2205/3368 ,  A61M2205/50 ,  B01D61/30 ,  B01D61/32 ,  G01L19/00

摘要： A device removes first pulses in a pressure signal of a pressure sensor which is arranged in a fluid containing system to detect the first pulses, which originate from a first pulse generator, and second pulses, which originate from a second pulse generator. The first pulse generator operates in a sequence of pulse cycles, each pulse cycle resulting in at least one first pulse. The device repetitively obtains a current data sample, calculates a corresponding reference value and subtracts the reference value from the current data sample. The reference value is calculated as a function of other data sample(s) in the same pressure signal. The fluid containing system may include an extracorporeal blood flow circuit, e.g. as part of a dialysis machine, and a cardiovascular system of a human patient.

公开(公告)号：US09289545B2

公开(公告)日：2016-03-22

申请号：US13519148

申请日：2010-12-22

申请人： Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby ,  Anders Wieslander

发明人： Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby ,  Anders Wieslander

IPC分类号： A61M1/30 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/00 ,  A61M1/36

CPC分类号： A61M1/3656 ,  A61B5/02125 ,  A61B5/0215 ,  A61B5/02405 ,  A61B5/4836 ,  A61M1/30 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3653 ,  A61M1/3659 ,  A61M2205/3331 ,  A61M2205/6018

摘要： A control system (23) is arranged to control the operation of an apparatus (200) for extracorporeal blood treatment. The apparatus (200) comprises an extracorporeal blood circuit (20) and a connection system (C) for connecting the blood circuit (20) to the vascular system of a patient. The blood circuit (20) comprises a blood processing device (6), and at least one pumping device (3). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit (20) to pump blood from the vascular system via the connection system (C) through the blood processing device (6) and back to the vascular system via the connection system (C). The control system (23) is operable to obtain measurement data from at least one energy transfer sensor (40) arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit (20). The control system (23) is configured to, in the pre-treatment mode, process the measurement data for identification of a characteristic change indicating a connection of the blood circuit (20) to the vascular system of the patient, and, upon such identification, take dedicated action. The action may involve activating at least part of a patient protection system and/or enabling entry into the blood treatment mode. The control system may be included in an apparatus (200) for blood treatment, such as a dialysis machine.

摘要翻译： 控制系统（23）被布置成控制用于体外血液处理的装置（200）的操作。 装置（200）包括用于将血液回路（20）连接到患者血管系统的体外血液回路（20）和连接系统（C）。 血液回路（20）包括血液处理装置（6）和至少一个泵送装置（3）。 控制系统可操作以在预处理模式和血液处理模式之间切换。 血液处理模式包括操作血液回路（20），以经由连接系统（C）从血管系统通过血液处理装置（6）泵送血液，并通过连接系统（C）返回血管系统。 控制系统（23）可操作以从至少一个能量传递传感器（40）获得测量数据，所述能量传递传感器（40）布置成感测患者和连接系统（C）之间或患者与血液回路（20）之间的能量传递， 。 控制系统（23）被配置为在预处理模式下处理用于识别指示血液回路（20）与患者的血管系统的连接的特征变化的测量数据，并且在这种识别 ，采取专门的行动。 该动作可以涉及激活患者保护系统的至少一部分和/或使得能够进入血液处理模式。 控制系统可以包括在用于血液处理的装置（200）中，例如透析机。

公开(公告)号：US20130096402A1

公开(公告)日：2013-04-18

申请号：US13519067

申请日：2010-12-22

申请人： Bo Olde ,  Kristian Solem

发明人： Bo Olde ,  Kristian Solem

IPC分类号： A61B5/00 ,  A61M1/30 ,  A61B5/0205

CPC分类号： A61B5/4836 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/02108 ,  A61B5/02416 ,  A61B5/053 ,  A61M1/30 ,  A61M1/36 ,  A61M2230/30

摘要： A monitoring arrangement 100 is configured to predict a rapid syruptomatic drop in a subject's blood pressure, e.g. during a medical treatment or when operating aircraft. To this aim, a pulse shape parameter (pps) with respect to a peripheral body part (105) of the subject (P) is repeatedly registered by means of a pulse oximetry instrument (110) adapted to detect light response variations in blood vessels. A respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (pps), and a statistical dispersion measure is calculated based on the thus-calculated pulse magnitude measure. It is investigated whether or not the statistical dispersion measure fulfils a decision criterion relative to a reference measure. An output signal (α) is generated if the decision criterion is found to be fulfilled.

公开(公告)号：US20110106466A1

公开(公告)日：2011-05-05

申请号：US13001314

申请日：2009-06-26

申请人： Martin Furmanski ,  Anders Roslund ,  Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby

发明人： Martin Furmanski ,  Anders Roslund ,  Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby

IPC分类号： G01M3/28 ,  A61M1/14

CPC分类号： G01M3/2846 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  G01L27/002 ,  G01M3/2815 ,  G01N33/49

摘要： A surveillance device monitors the integrity of a fluid connection between first and second fluid containing systems based on at least one time-dependent measurement signal from a pressure sensor in the first fluid containing system. The first fluid containing system comprises a first pulse generator, and the second fluid containing system comprises a second pulse generator. The pressure sensor is arranged to detect first pulses originating from the first pulse generator and second pulses originating from the second pulse generator. The integrity of the fluid connection is determined based on the presence of second pulses in the measurement signal. The second pulses may be detected by analysing the measurement signal in the time domain and/or by using timing information indicative of the timing of the second pulses in said at least one measurement signal. The analysis may be based on a parameter value that represents a distribution of signal values within a time window of the measurement signal. The parameter value may be calculated as a statistical dispersion measure of the signal values, or may result from a matching of the signal values within the time window to a predicted temporal signal profile of a second pulse. The fluid connection may be established between a human blood system and an extracorporeal blood flow circuit.

摘要翻译： 监视装置基于来自第一流体容纳系统中的压力传感器的至少一个与时间相关的测量信号监测第一和第二流体容纳系统之间的流体连接的完整性。 第一流体容纳系统包括第一脉冲发生器，并且第二流体容纳系统包括第二脉冲发生器。 压力传感器被布置成检测源自第一脉冲发生器的第一脉冲和来自第二脉冲发生器的第二脉冲。 基于测量信号中第二个脉冲的存在来确定流体连接的完整性。 可以通过在时域中分析测量信号和/或通过使用指示所述至少一个测量信号中的第二脉冲的定时的定时信息来检测第二脉冲。 分析可以基于表示测量信号的时间窗内的信号值分布的参数值。 参数值可以被计算为信号值的统计色散测量值，或者可以由时间窗口内的信号值与第二脉冲的预测时间信号曲线的匹配产生。 可以在人体血液系统和体外血液回路之间建立流体连接。

公开(公告)号：US09427513B2

公开(公告)日：2016-08-30

申请号：US14129087

申请日：2012-05-23

申请人： Mattias Holmer ,  Bo Olde ,  Kristian Solem

发明人： Mattias Holmer ,  Bo Olde ,  Kristian Solem

IPC分类号： A61M37/00 ,  A61M1/36 ,  G01N19/00

CPC分类号： A61M1/367 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2205/13 ,  A61M2205/3331 ,  A61M2205/3351 ,  G01N19/00

摘要： A device monitors a blood path from a blood vessel access of a human subject through an extracorporeal blood processing apparatus and back to the blood vessel access. A pumping device in the blood path is operable to pump blood through the blood path from the blood withdrawal device to the blood return device. The monitoring device obtains pressure data from a pressure sensor arranged upstream of the pumping device in the blood path, and processes the pressure data for detection of a disruption of the blood path downstream of the pumping device, e.g. caused by VND (Venous Needle Dislodgement). The disruption is detected by evaluating presence/absence of cross-talk pulses at the pressure sensor, where the cross-talk pulses originate from one or more pulse generators in the extracorporeal blood processing apparatus and have propagated on a propagation path in a direction downstream of the pumping device through the blood return device, the blood vessel access and the blood withdrawal device to the pressure sensor.

摘要翻译： 一种装置通过体外血液处理装置监测来自人体受试者的血管通路的血液通路并返回到血管通路。 血液路径中的抽吸装置可操作以将血液通过血液通道从血液提取装置泵送到血液返回装置。 监测装置从布置在血液路径中的泵送装置上游的压力传感器获取压力数据，并处理用于检测泵送装置下游的血液路径破裂的压力数据，例如， 由VND引起的（静脉针脱落）。 通过评估压力传感器处的串扰脉冲的存在/不存在来检测中断，其中串扰脉冲源自体外血液处理设备中的一个或多个脉冲发生器，并且在传播路径上沿着下游的方向传播 泵送装置通过血液回流装置，血管通路和取血装置到压力传感器。

公开(公告)号：US20130150766A1

公开(公告)日：2013-06-13

申请号：US13519146

申请日：2010-12-22

申请人： Bo Olde ,  Kristian Solem

发明人： Bo Olde ,  Kristian Solem

IPC分类号： A61M1/30

CPC分类号： A61M1/30 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M5/16859 ,  A61M2205/13 ,  A61M2205/3331 ,  A61M2230/04

摘要： A device is arranged to detect a configuration of withdrawal and return devices (1, 14, 111, 112, 211, 212, 702, 703, 802, 803) coupling an extracorporeal blood flow circuit (20) to a cardiovascular system of a subject. The device comprises a signal processor (29), which is configured to receive a primary measurement signal obtained by a primary pressure sensor (4a, 4b, 4c) in the extracorporeal blood flow circuit (20). The device is further configured to process the primary measurement signal for extraction of primary pressure data originating from a subject pulse generator (3′) in the cardiovascular system or extracorporeal blood flow circuit (20), the primary pressure data comprising at least a part of a first pulse from the subject pulse generator (3′). The device is also configured to calculate a parameter value from the primary pressure data and to determine the configuration based at least partly on the parameter value.

摘要翻译： 一种装置被布置成检测将体外血流回路（20）耦合到对象的心血管系统的撤回和返回装置（1,14,111,112,211,212,702,702,802,803）的构造 。 该装置包括信号处理器（29），其被配置为接收由体外血流回路（20）中的一次压力传感器（4a，4b，4c）获得的主测量信号。 该装置还被配置为处理主要测量信号以提取源自心血管系统或体外血流回路（20）中的受检者脉冲发生器（3'）的主要压力数据，所述主要压力数据包括至少一部分 来自对象脉冲发生器（3'）的第一脉冲。 该装置还被配置为从主压力数据计算参数值，并且至少部分地基于参数值来确定配置。

公开(公告)号：US20130023776A1

公开(公告)日：2013-01-24

申请号：US13519532

申请日：2010-12-22

申请人： Bo Olde ,  Kristian Solem

发明人： Bo Olde ,  Kristian Solem

IPC分类号： A61B5/024 ,  A61B5/0215

摘要： A device is configured to monitor a cardiovascular property of a subject. The device obtains measurement data from a primary pressure wave sensor arranged to detect pressure waves in an extracorporeal fluid circuit in fluid communication with the cardiovascular system of the subject. The device has a signal processor configured to generate a time-dependent monitoring signal based on the measurement data, such that the monitoring signal comprises a sequence of heart pulses, wherein each heart pulse represents a pressure wave originating from a heart beat in the subject; determine beat classification data for each heart pulse in the monitoring signal; and calculate, based at least partly on the beat classification data, a parameter value indicative of the cardiovascular property. The beat classification data may distinguish between heart pulses originating from normal heart beats and heart pulses originating from ectopic heart beats. The cardiovascular property may be an arterial status of the cardiovascular system, a degree of calcification in the cardiovascular system, a status of a blood vessel access used for connecting the extracorporeal fluid circuit to the cardiovascular system, a heart rate variability, a heart rate, a heart rate turbulence, an ectopic beat count, or an origin of ectopic beats. The device may be attached to or part of a dialysis machine.

摘要翻译： 设备被配置为监测受试者的心血管性质。 该装置从一次压力波传感器获得测量数据，其被布置成检测体液流体回路中与受试者的心血管系统流体连通的压力波。 该装置具有信号处理器，其被配置为基于测量数据产生与时间相关的监视信号，使得监视信号包括心脏脉冲序列，其中每个心脏脉搏表示源自受试者的心跳的压力波; 确定监测信号中每个心脏脉搏的搏动分类数据; 并且至少部分地基于节拍分类数据计算指示心血管特性的参数值。 节拍分类数据可以区分源自正常心跳的心脏脉搏和源自异位心跳的心脏脉冲。 心血管功能可以是心血管系统的动脉状态，心血管系统中的钙化程度，用于将体外流体回路连接到心血管系统的血管通路的状态，心率变异性，心率， 心率湍流，异位搏动计数或异位搏动的来源。 该装置可以附接到透析机或透析机的一部分。