公开(公告)号：US09636447B2

公开(公告)日：2017-05-02

申请号：US14234527

申请日：2012-06-20

申请人： Bo Olde ,  Kristian Solem ,  Mattias Holmer ,  Jan Sternby

发明人： Bo Olde ,  Kristian Solem ,  Mattias Holmer ,  Jan Sternby

IPC分类号： A61B5/02 ,  A61M1/36 ,  B01D61/30 ,  B01D61/32 ,  G01L19/00 ,  A61B5/021 ,  A61B5/00

CPC分类号： A61M1/3607 ,  A61B5/02108 ,  A61B5/6866 ,  A61B5/7217 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3621 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M2205/3331 ,  A61M2205/3368 ,  A61M2205/50 ,  B01D61/30 ,  B01D61/32 ,  G01L19/00

摘要： A device removes first pulses in a pressure signal of a pressure sensor which is arranged in a fluid containing system to detect the first pulses, which originate from a first pulse generator, and second pulses, which originate from a second pulse generator. The first pulse generator operates in a sequence of pulse cycles, each pulse cycle resulting in at least one first pulse. The device repetitively obtains a current data sample, calculates a corresponding reference value and subtracts the reference value from the current data sample. The reference value is calculated as a function of other data sample(s) in the same pressure signal. The fluid containing system may include an extracorporeal blood flow circuit, e.g. as part of a dialysis machine, and a cardiovascular system of a human patient.

公开(公告)号：US09427513B2

公开(公告)日：2016-08-30

申请号：US14129087

申请日：2012-05-23

申请人： Mattias Holmer ,  Bo Olde ,  Kristian Solem

发明人： Mattias Holmer ,  Bo Olde ,  Kristian Solem

IPC分类号： A61M37/00 ,  A61M1/36 ,  G01N19/00

CPC分类号： A61M1/367 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2205/13 ,  A61M2205/3331 ,  A61M2205/3351 ,  G01N19/00

摘要： A device monitors a blood path from a blood vessel access of a human subject through an extracorporeal blood processing apparatus and back to the blood vessel access. A pumping device in the blood path is operable to pump blood through the blood path from the blood withdrawal device to the blood return device. The monitoring device obtains pressure data from a pressure sensor arranged upstream of the pumping device in the blood path, and processes the pressure data for detection of a disruption of the blood path downstream of the pumping device, e.g. caused by VND (Venous Needle Dislodgement). The disruption is detected by evaluating presence/absence of cross-talk pulses at the pressure sensor, where the cross-talk pulses originate from one or more pulse generators in the extracorporeal blood processing apparatus and have propagated on a propagation path in a direction downstream of the pumping device through the blood return device, the blood vessel access and the blood withdrawal device to the pressure sensor.

摘要翻译： 一种装置通过体外血液处理装置监测来自人体受试者的血管通路的血液通路并返回到血管通路。 血液路径中的抽吸装置可操作以将血液通过血液通道从血液提取装置泵送到血液返回装置。 监测装置从布置在血液路径中的泵送装置上游的压力传感器获取压力数据，并处理用于检测泵送装置下游的血液路径破裂的压力数据，例如， 由VND引起的（静脉针脱落）。 通过评估压力传感器处的串扰脉冲的存在/不存在来检测中断，其中串扰脉冲源自体外血液处理设备中的一个或多个脉冲发生器，并且在传播路径上沿着下游的方向传播 泵送装置通过血液回流装置，血管通路和取血装置到压力传感器。

公开(公告)号：US20140298891A1

公开(公告)日：2014-10-09

申请号：US14129087

申请日：2012-05-23

申请人： Mattias Holmer ,  Bo Olde ,  Kristian Solem

发明人： Mattias Holmer ,  Bo Olde ,  Kristian Solem

IPC分类号： A61M1/36 ,  G01N19/00

CPC分类号： A61M1/367 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2205/13 ,  A61M2205/3331 ,  A61M2205/3351 ,  G01N19/00

摘要： A device monitors a blood path from a blood vessel access of a human subject through an extracorporeal blood processing apparatus and back to the blood vessel access. A pumping device in the blood path is operable to pump blood through the blood path from the blood withdrawal device to the blood return device. The monitoring device obtains pressure data from a pressure sensor arranged upstream of the pumping device in the blood path, and processes the pressure data for detection of a disruption of the blood path downstream of the pumping device, e.g. caused by VND (Venous Needle Dislodgement). The disruption is detected by evaluating presence/absence of cross-talk pulses at the pressure sensor, where the cross-talk pulses originate from one or more pulse generators in the extracorporeal blood processing apparatus and have propagated on a propagation path in a direction downstream of the pumping device through the blood return device, the blood vessel access and the blood withdrawal device to the pressure sensor.

摘要翻译： 一种装置通过体外血液处理装置监测来自人体受试者的血管通路的血液通路并返回到血管通路。 血液路径中的抽吸装置可操作以将血液通过血液通道从血液提取装置泵送到血液返回装置。 监测装置从布置在血液路径中的泵送装置上游的压力传感器获取压力数据，并处理用于检测泵送装置下游的血液路径破裂的压力数据，例如， 由VND引起的（静脉针脱落）。 通过评估压力传感器处的串扰脉冲的存在/不存在来检测中断，其中串扰脉冲源自体外血液处理设备中的一个或多个脉冲发生器，并且在传播路径上沿着下游的方向传播 泵送装置通过血液回流装置，血管通路和取血装置到压力传感器。

公开(公告)号：US20140231319A1

公开(公告)日：2014-08-21

申请号：US14234527

申请日：2012-06-20

申请人： Bo Olde ,  Kristian Solem ,  Mattias Holmer ,  Jan Sternby

发明人： Bo Olde ,  Kristian Solem ,  Mattias Holmer ,  Jan Sternby

IPC分类号： A61M1/36 ,  G01L19/00

CPC分类号： A61M1/3607 ,  A61B5/02108 ,  A61B5/6866 ,  A61B5/7217 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3621 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M2205/3331 ,  A61M2205/3368 ,  A61M2205/50 ,  B01D61/30 ,  B01D61/32 ,  G01L19/00

摘要： A device removes first pulses in a pressure signal of a pressure sensor which is arranged in a fluid containing system to detect the first pulses, which originate from a first pulse generator, and second pulses, which originate from a second pulse generator. The first pulse generator operates in a sequence of pulse cycles, each pulse cycle resulting in at least one first pulse. The device repetitively obtains a current data sample, calculates a corresponding reference value and subtracts the reference value from the current data sample. The reference value is calculated as a function of other data sample(s) in the same pressure signal. The fluid containing system may include an extracorporeal blood flow circuit, e.g. as part of a dialysis machine, and a cardiovascular system of a human patient.

摘要翻译： 装置去除压力传感器的压力信号中的第一脉冲，该压力传感器布置在流体容纳系统中，以检测源自第一脉冲发生器的第一脉冲和来自第二脉冲发生器的第二脉冲。 第一脉冲发生器以脉冲周期的顺序操作，每个脉冲周期产生至少一个第一脉冲。 设备重复获取当前数据样本，计算相应的参考值，并从当前数据样本中减去参考值。 参考值根据相同压力信号中其他数据采样的函数计算。 流体容纳系统可以包括体外血流回路，例如， 作为透析机的一部分，以及人类患者的心血管系统。

公开(公告)号：US09442036B2

公开(公告)日：2016-09-13

申请号：US13001314

申请日：2009-06-26

申请人： Martin Furmanski ,  Anders Roslund ,  Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby

发明人： Martin Furmanski ,  Anders Roslund ,  Bo Olde ,  Kristian Solem ,  Thomas Hertz ,  Jan Sternby

IPC分类号： G01L27/00 ,  G01N33/49 ,  G01M3/28 ,  A61M1/36

CPC分类号： G01M3/2846 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  G01L27/002 ,  G01M3/2815 ,  G01N33/49

摘要： A method of monitoring the integrity of a fluid connection between first and second fluid containing systems based on at least one time-dependent measurement signal from a pressure sensor in the first fluid containing system. The pressure sensor detects first pulses originating from a first pulse generator in the first fluid containing system and second pulses originating from a second pulse generator in the second fluid containing system. A parameter value representing a distribution of signal values within a time window is calculated by analyzing the measurement signal in the time domain and/or by using information on the timing of the second pulses in the measurement signal. The parameter value may be calculated as a statistical dispersion measure of the signal values, or from matching the signal to a predicted temporal signal profile of the second pulse. The integrity of the fluid connection is determined from the parameter value.

摘要翻译： 基于来自第一流体容纳系统中的压力传感器的至少一个与时间相关的测量信号来监测第一和第二流体容纳系统之间的流体连接的完整性的方法。 压力传感器检测来自第一流体容纳系统中的第一脉冲发生器的第一脉冲和源自第二流体容纳系统中的第二脉冲发生器的第二脉冲。 通过在时域中分析测量信号和/或通过使用关于测量信号中的第二脉冲的定时的信息来计算表示时间窗内的信号值分布的参数值。 可以将参数值计算为信号值的统计色散测量值，或者将信号与第二脉冲的预测时间信号分布匹配。 根据参数值确定流体连接的完整性。

公开(公告)号：US09289544B2

公开(公告)日：2016-03-22

申请号：US13519146

申请日：2010-12-22

申请人： Bo Olde ,  Kristian Solem

发明人： Bo Olde ,  Kristian Solem

IPC分类号： A61M1/30 ,  A61M1/36 ,  A61M5/168

CPC分类号： A61M1/30 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M5/16859 ,  A61M2205/13 ,  A61M2205/3331 ,  A61M2230/04

摘要： A device is arranged to detect a configuration of withdrawal and return devices (1, 14, 111, 112, 211, 212, 702, 703, 802, 803) coupling an extracorporeal blood flow circuit (20) to a cardiovascular system of a subject. The device comprises a signal processor (29), which is configured to receive a primary measurement signal obtained by a primary pressure sensor (4a, 4b, 4c) in the extracorporeal blood flow circuit (20). The device is further configured to process the primary measurement signal for extraction of primary pressure data originating from a subject pulse generator (3′) in the cardiovascular system or extracorporeal blood flow circuit (20), the primary pressure data comprising at least a part of a first pulse from the subject pulse generator (3′). The device is also configured to calculate a parameter value from the primary pressure data and to determine the configuration based at least partly on the parameter value.

摘要翻译： 一种装置被布置成检测将体外血流回路（20）耦合到对象的心血管系统的撤回和返回装置（1,14,111,112,211,212,702,702,802,803）的构造 。 该装置包括信号处理器（29），其被配置为接收由体外血流回路（20）中的一次压力传感器（4a，4b，4c）获得的主测量信号。 该装置还被配置为处理主要测量信号以提取源自心血管系统或体外血流回路（20）中的受检者脉冲发生器（3'）的主要压力数据，所述主要压力数据包括至少一部分 来自对象脉冲发生器（3'）的第一脉冲。 该装置还被配置为从主压力数据计算参数值，并且至少部分地基于参数值来确定配置。

公开(公告)号：US20130274570A9

公开(公告)日：2013-10-17

申请号：US13519067

申请日：2010-12-22

申请人： Bo Olde ,  Kristian Solem

发明人： Bo Olde ,  Kristian Solem

IPC分类号： A61B5/00 ,  A61M1/30 ,  A61B5/0205

CPC分类号： A61B5/4836 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/02108 ,  A61B5/02416 ,  A61B5/053 ,  A61M1/30 ,  A61M1/36 ,  A61M2230/30

摘要： A monitoring arrangement 100 is configured to predict a rapid syruptomatic drop in a subject's blood pressure, e.g. during a medical treatment or when operating aircraft. To this aim, a pulse shape parameter (pps) with respect to a peripheral body part (105) of the subject (P) is repeatedly registered by means of a pulse oximetry instrument (110) adapted to detect light response variations in blood vessels. A respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (pps), and a statistical dispersion measure is calculated based on the thus-calculated pulse magnitude measure. It is investigated whether or not the statistical dispersion measure fulfils a decision criterion relative to a reference measure. An output signal (α) is generated if the decision criterion is found to be fulfilled.

摘要翻译： 监测装置100被配置为预测受试者的血压中的快速糖尿病下降。 在医疗或运营飞机时。 为此目的，相对于被检体（P）的周边主体部分（105）的脉冲形状参数（pps）通过适于检测血管中的光反应变化的脉搏血氧仪（110）重复记录。 基于接收的脉冲形状参数（pps）中的每一个来计算相应的脉冲幅度测量，并且基于由此计算的脉冲幅度测量值来计算统计色散测量。 调查统计色散测量是否满足参考测量的决策标准。 如果发现满足判定标准，则产生输出信号（α）。

公开(公告)号：US20130204174A1

公开(公告)日：2013-08-08

申请号：US13519248

申请日：2010-12-22

申请人： Bo Olde ,  Kristian Solem

发明人： Bo Olde ,  Kristian Solem

IPC分类号： G01N11/02

CPC分类号： G01N11/02 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3661 ,  A61M5/16859 ,  A61M2205/13 ,  A61M2205/15 ,  A61M2205/3331 ,  A61M2230/04

摘要： A device is configured to detect a fault condition in a fluid connection system between a first (e.g. extracorporeal blood circuit) and second (e.g. vascular system of a patient) fluid containing systems. The first and second fluid containing systems comprise a first and second pulse generator, respectively. A pressure sensor is arranged in the first fluid containing system to detect pulses originating from the first and second pulse generator. The device operates according to a detection method, by generating a time-dependent monitoring signal based on measurement data obtained from said at least one pressure sensor, such that the monitoring signal at least comprises one or more first pulses; processing (42) the monitoring signal to calculate a parameter value which is indicative of the shape of at least part of a first pulse in the monitoring signal, and evaluating (44) the parameter value for detection of the fault condition.

摘要翻译： 设备被配置为检测流体连接系统中的第一（例如体外血液回路）和第二（例如患者的血管系统）流体容纳系统之间的故障状况。 第一和第二流体容纳系统分别包括第一和第二脉冲发生器。 压力传感器布置在第一流体容纳系统中以检测源自第一和第二脉冲发生器的脉冲。 该装置根据检测方法，通过基于从所述至少一个压力传感器获得的测量数据产生与时间相关的监视信号，使得监视信号至少包括一个或多个第一脉冲; 处理（42）监视信号以计算指示监视信号中的第一脉冲的至少一部分的形状的参数值，并评估（44）用于检测故障状况的参数值。

公开(公告)号：US20130150766A1

公开(公告)日：2013-06-13

申请号：US13519146

申请日：2010-12-22

申请人： Bo Olde ,  Kristian Solem

发明人： Bo Olde ,  Kristian Solem

IPC分类号： A61M1/30

CPC分类号： A61M1/30 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M5/16859 ,  A61M2205/13 ,  A61M2205/3331 ,  A61M2230/04

摘要： A device is arranged to detect a configuration of withdrawal and return devices (1, 14, 111, 112, 211, 212, 702, 703, 802, 803) coupling an extracorporeal blood flow circuit (20) to a cardiovascular system of a subject. The device comprises a signal processor (29), which is configured to receive a primary measurement signal obtained by a primary pressure sensor (4a, 4b, 4c) in the extracorporeal blood flow circuit (20). The device is further configured to process the primary measurement signal for extraction of primary pressure data originating from a subject pulse generator (3′) in the cardiovascular system or extracorporeal blood flow circuit (20), the primary pressure data comprising at least a part of a first pulse from the subject pulse generator (3′). The device is also configured to calculate a parameter value from the primary pressure data and to determine the configuration based at least partly on the parameter value.

摘要翻译： 一种装置被布置成检测将体外血流回路（20）耦合到对象的心血管系统的撤回和返回装置（1,14,111,112,211,212,702,702,802,803）的构造 。 该装置包括信号处理器（29），其被配置为接收由体外血流回路（20）中的一次压力传感器（4a，4b，4c）获得的主测量信号。 该装置还被配置为处理主要测量信号以提取源自心血管系统或体外血流回路（20）中的受检者脉冲发生器（3'）的主要压力数据，所述主要压力数据包括至少一部分 来自对象脉冲发生器（3'）的第一脉冲。 该装置还被配置为从主压力数据计算参数值，并且至少部分地基于参数值来确定配置。

公开(公告)号：US20130023776A1

公开(公告)日：2013-01-24

申请号：US13519532

申请日：2010-12-22

申请人： Bo Olde ,  Kristian Solem

发明人： Bo Olde ,  Kristian Solem

IPC分类号： A61B5/024 ,  A61B5/0215

摘要： A device is configured to monitor a cardiovascular property of a subject. The device obtains measurement data from a primary pressure wave sensor arranged to detect pressure waves in an extracorporeal fluid circuit in fluid communication with the cardiovascular system of the subject. The device has a signal processor configured to generate a time-dependent monitoring signal based on the measurement data, such that the monitoring signal comprises a sequence of heart pulses, wherein each heart pulse represents a pressure wave originating from a heart beat in the subject; determine beat classification data for each heart pulse in the monitoring signal; and calculate, based at least partly on the beat classification data, a parameter value indicative of the cardiovascular property. The beat classification data may distinguish between heart pulses originating from normal heart beats and heart pulses originating from ectopic heart beats. The cardiovascular property may be an arterial status of the cardiovascular system, a degree of calcification in the cardiovascular system, a status of a blood vessel access used for connecting the extracorporeal fluid circuit to the cardiovascular system, a heart rate variability, a heart rate, a heart rate turbulence, an ectopic beat count, or an origin of ectopic beats. The device may be attached to or part of a dialysis machine.

摘要翻译： 设备被配置为监测受试者的心血管性质。 该装置从一次压力波传感器获得测量数据，其被布置成检测体液流体回路中与受试者的心血管系统流体连通的压力波。 该装置具有信号处理器，其被配置为基于测量数据产生与时间相关的监视信号，使得监视信号包括心脏脉冲序列，其中每个心脏脉搏表示源自受试者的心跳的压力波; 确定监测信号中每个心脏脉搏的搏动分类数据; 并且至少部分地基于节拍分类数据计算指示心血管特性的参数值。 节拍分类数据可以区分源自正常心跳的心脏脉搏和源自异位心跳的心脏脉冲。 心血管功能可以是心血管系统的动脉状态，心血管系统中的钙化程度，用于将体外流体回路连接到心血管系统的血管通路的状态，心率变异性，心率， 心率湍流，异位搏动计数或异位搏动的来源。 该装置可以附接到透析机或透析机的一部分。