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公开(公告)号：US20110288023A1
公开(公告)日：2011-11-24
申请号：US12961378
申请日：2010-12-06
Applicant: Daniel T. Kamei , Bert J. Lao , Wen-Lin P. Tsai , Foad Mashayekhi , Edward A. Pham , Anne B. Mason
Inventor： Daniel T. Kamei , Bert J. Lao , Wen-Lin P. Tsai , Foad Mashayekhi , Edward A. Pham , Anne B. Mason
CPC classification number: C07K14/79 , A61K47/6415 , A61K47/644
Abstract: The invention provides modified Transferrin (Tf) molecules and conjugates of the Tf molecules with a therapeutic agent. The invention also provides methods of treating cancer wherein the therapeutic agents are chemotherapeutic agents. The modified Tf molecules improve the delivery of the conjugated agent to a target tissue. In some embodiments, the modified Tf molecule has a mutation which decreases the release of bound iron from a Tf complex. The complex can also contain, for instance, a carbonate, oxalate, or other anion to stabilize the Tf iron complex.
Abstract translation: 本发明提供修饰的转铁蛋白（Tf）分子和Tf分子的缀合物与治疗剂。 本发明还提供了治疗癌症的方法，其中治疗剂是化学治疗剂。 修饰的Tf分子改善了共轭剂向靶组织的递送。 在一些实施方案中，经修饰的Tf分子具有降低来自Tf复合物的结合铁释放的突变。 络合物还可以含有例如碳酸盐，草酸盐或其它阴离子以稳定Tf铁络合物。
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公开(公告)号：US06870495B1
公开(公告)日：2005-03-22
申请号：US10779748
申请日：2004-02-18
Applicant: Ali E. Zadeh , Lin P. Ang
Inventor： Ali E. Zadeh , Lin P. Ang
CPC classification number: H03M1/1245 , H03M1/002 , H03M1/0695 , H03M1/442
Abstract: A pipelined analog-to-digital converter features an amplifier block that includes a switching network to implement a double sampling and double conversion principle of operation. The amplifier block utilizes both phases of a clock for sampling and conversion. Additionally, each stage of the analog-to-digital converter is associated with two independent processing blocks. The analog-to-digital converter can achieve double throughput for approximately the same level of power consumption. Alternatively, throughput may be maintained, but the gain-bandwidth of the amplifier block may be reduced by half, thereby halving the DC bias current consumed by the amplifier. Additionally, the output signal of the amplifier itself is not reset to a common mode voltage.
Abstract translation: 流水线模数转换器具有放大器块，其包括交换网络以实现双采样和双转换操作原理。 放大器模块利用时钟的两相进行采样和转换。 此外，模数转换器的每个级与两个独立的处理块相关联。 模数转换器可以在大致相同的功耗水平下实现双通道吞吐量。 或者，可以保持吞吐量，但是放大器块的增益带宽可以减少一半，从而将放大器消耗的DC偏置电流减半。 此外，放大器本身的输出信号不会复位到共模电压。
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公开(公告)号：US06558159B2
公开(公告)日：2003-05-06
申请号：US10155411
申请日：2002-05-24
Applicant: Lin P. Bollwahn , Douglas A. Jackson , James W. Angell
Inventor： Lin P. Bollwahn , Douglas A. Jackson , James W. Angell
IPC: B65D138
CPC classification number: C21D9/0025
Abstract: A container (10) for holding parts during a heat treating process. The container includes a bottom plate (14), end walls (20 and 22), sidewalls (30 and 32) and dividers (40, 42 and 44) which are connected together using a tab and slot construction to form an egg crate structure. The construction of the container reduces the effects of the heat treating process on the container. The guide cradle (58) in the compartment (12) of the container supports the cylinder head in the compartment and reduces the movement of the cylinder head during the heat treating process. The positioners (60) on the top portion (58A) of the guide cradle guides the cylinder head into the guide cradle and into the compartment. The bottom portion (58B) of the guide cradle supports the cylinder head above the bottom plate.
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公开(公告)号：US3830069A
公开(公告)日：1974-08-20
申请号：US38414173
申请日：1973-07-30
Applicant: LIN P
Inventor： LIN P
Abstract: Trenches are formed around the periphery of the area intended to be reinforced. Openings are then drilled from the surface, such openings being in rows, and selected rows being of different depths. By using freezer points the soil is then frozen solid. There is next formed a series of spaced channels extending through unfrozen soil from one trench to the opposite trench and after being excavated the channels are filled with hardenable material such as concrete. The sections which are adjacent to these hardenable sections may be then thawed and excavated and thereafter filled with hardenable material to form a complete mat the surface of which is adapted for sustaining soil loads and the weight of any structure thereon. The trenches are then filled with soil or hardenable material.
Abstract translation: 沟槽围绕着要加固的区域的周边形成。 然后从表面钻出开口，这样的开口是行，并且所选择的行具有不同的深度。 通过使用冷冻点，土壤然后冷冻固体。 接下来形成了一系列间隔开的通道，其通过未冷冻的土壤从一个沟槽延伸到相对的沟槽，并且在被挖掘之后，通道充满可硬化材料如混凝土。 然后将与这些可硬化部分相邻的部分解冻和挖掘，然后用可硬化材料填充以形成完整的垫，其表面适于维持土壤载荷和其上的任何结构的重量。 然后用土壤或可硬化材料填充沟槽。
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Patent Agency Ranking
公开(公告)号：US4292755A
公开(公告)日：1981-10-06
申请号：US60785
申请日：1979-07-25
Applicant: Lin P. Houn
Inventor： Lin P. Houn
CPC classification number: A63H18/002
Abstract: This invention relates to an air-floating saucer toy, comprising a housing, of which the main dynamic elements including saucer, air pump, electric motor, speed-reducing device, pneumatic tube and batteries are carried. The saucer is driven to float along a circular slot in the housing by the pneumatic discharge from the air pump through an injection nozzle at the outer end of the pneumatic tube, which travels in a circular path below the slot, the saucer thereby moving along an orbit corresponding with the slot and in the same direction as the end of the tube.
Abstract translation: 本发明涉及一种浮动碟形玩具，包括壳体，其中承载了主要的动态元件包括碟，气泵，电动马达，减速装置，气动管和电池。 通过从空气泵的气动排出通过气动管的外端处的注射喷嘴在托架中沿着圆形槽浮动，碟形盘沿着槽的下方的圆形路径行进，从而沿着 对应于槽的轨道和与管的端部相同的方向。
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公开(公告)号：US3781408A
公开(公告)日：1973-12-25
申请号：US3781408D
申请日：1972-03-16
Applicant: LIN P
Inventor： LIN P
CPC classification number: B01D53/8609 , F23J15/006
Abstract: COMBUSTION GASSES FROM FUEL-BURNING FURNACES ARE TREATED TO SEPARATE SOLID PARTICLES SUCH AS FLY ASH AND TO OXIDIZE THE SULFUR DIOXIDE GAS (SO2) CONTAINED THEREIN TO SULFUR TRIOXIDE (SO3). THE SO3 IS REACTED WITH EXCESS LIME (CAO) TO FORM CALCIUM SULFATE (CASO4). THE CASO4, UNSPENT LIME PARTICLES, SOME OF WHICH HAVE CRACKED OUTER SHELLS OF CASO4, AND COLLECTED FLY ASH ARE PACKAGED DRY AND USED IN APPROPRIATELY BLENDED FORM TOGETHER WITH CEMENT AND SAND, GRAVEL, OR ROCK TO FROM CONSTRUCTION MATERIALS, THE AVERAGE PERCENTAGE OF CASO4 THEREIN BEING REGULATED TO CONTROL THE SETTING TIME OF THE CEMENT. THE PROPORTION OF THE EXCESS LIME IS AUTOMATICALLY REGULATED BY PROCESS-CONTROL DEVICES WHICH CONTINUOUSLY MONITOR AND CONTROL THE REACTION APPLYING THE PARAMETERS OF FUEL COMPOSITIONS, AND SULFUR OXIDE LEVEL IN THE COMBUSTION GASSES.
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公开(公告)号：US4268978A
公开(公告)日：1981-05-26
申请号：US050632
申请日：1979-06-21
Applicant: Lin P. Houn
Inventor： Lin P. Houn
Abstract: The present invention relates to an automatic sound-emitted self-learning toy characterized by effectively emitting the sound "YES" while the selected answer card coincides with the question card on the base sheet, and "NO" while the two are not in accordance with each other. The answer card, question card and basic sheet are provided with a magnet, when the corresponding magnets are located so as to be attracted to each other, the tape recorder within the rear body connected to the mechanism under the basic sheet will selectively emit the sounds "YES" or "NO" so that children may learn calculation while playing the toy.
Abstract translation: 本发明涉及一种自动发声自学习玩具，其特征在于当选择的答录卡与基片上的问题卡一致时，有效地发出声音“是”，而两者不符合 彼此。 答案卡，问题卡和基本纸都设置有磁体，当相应的磁体位于彼此被吸引时，连接到基板下方的机构的后体内的磁带记录器将选择性地发出声音 “是”或“否”，以便孩子玩玩具时学习计算。
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公开(公告)号：US3855125A
公开(公告)日：1974-12-17
申请号：US30514872
申请日：1972-11-09
Applicant: LIN P
Inventor： LIN P
CPC classification number: C02F5/00 , C02F1/281 , C02F1/66 , Y10S210/906
Abstract: A solid pollution control product consists of a core material of lime, surrounded by a cracked shell of either calcium sulfate or calcium carbonate. The materials are referred to by coined terms as ''''Linfans'''' and ''''Linveins,'''' respectively. Both of these materials are particularly suitable for neutralizing acids in industrial wastes, removal of phosphates, and turbidity in wastewater by additions as a solid or in slurry form to wastewater. In one embodiment of the invention, the ''''Linveins,'''' I utilize the material as a water softening agent.
Abstract translation: 固体污染控制产品由石灰的核心材料组成，被硫酸钙或碳酸钙的裂化壳包围。 这些材料分别被称为“Linfans”和“Linveins”。
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公开(公告)号：US20090181048A1
公开(公告)日：2009-07-16
申请号：US12134922
申请日：2008-06-06
Applicant: Daniel T. Kamei , Bert J. Lao , Wen-Lin P. Tsai , Foad Mashayekhi , Edward A. Pham , Anne B. Mason
Inventor： Daniel T. Kamei , Bert J. Lao , Wen-Lin P. Tsai , Foad Mashayekhi , Edward A. Pham , Anne B. Mason
CPC classification number: C07K14/79
Abstract: The present invention provides transferrin (Tf) conjugates of anti-cancer agents with increased cellular association and increased cellular internalization. The present invention also provides methods of treating cancer comprising administration of a Tf conjugate with increased cellular association to a subject with cancer. The present invention additionally provides methods of making, as well as screening for, Tf conjugates with increased cellular association or cellular internalization. The present invention also provides Tf conjugates with increased cellular association and internalization for delivering nucleic acids to cancer cells.
Abstract translation: 本发明提供抗癌剂的转铁蛋白（Tf）缀合物与增加的细胞缔合和增加的细胞内化。 本发明还提供了治疗癌症的方法，其包括向患有癌症的受试者施用具有增加的细胞结合的Tf缀合物。 本发明另外提供了制备和筛选具有增加的细胞缔合或细胞内化的Tf缀合物的方法。 本发明还提供了具有增加的细胞结合和内源化的Tf缀合物，用于将核酸递送至癌细胞。
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