公开(公告)号：US20070248680A1

公开(公告)日：2007-10-25

申请号：US11660282

申请日：2006-02-08

申请人： Liping Tang

发明人： Liping Tang

IPC分类号： A61K9/14 ,  A61P31/00

CPC分类号： G01N33/5308 ,  A61K9/14 ,  A61K9/167

摘要： The present invention provides for compositions and methods for recognizing toxins in a host. The composition comprising a particle of less than 100 micrometers in diameter having a tag in direct contact with a portion of the particle, the particle comprising a biodegradable polymer and the portion of the particle in contact with the tag selected from the group consisting of acrylic acid, 2-hydroxyethyl acrylate, 2-acrylamido-2-methyl-1-propanesulfonic acid, allylamine, carboxyl group, hydroxyl group, sulfonic group, aldehyde group, and amine group, wherein the tag is selected from the group consisting of drug, antibody, ligand, antigen, protein, peptide, counter-ligand moiety, fatty acid moiety, and carbohydrate moiety, and wherein one or more particles are introduced into the host having toxins and the one or more particle recognize the toxins.

摘要翻译： 本发明提供用于识别宿主中的毒素的组合物和方法。 所述组合物包含直径小于100微米的颗粒，其具有与颗粒的一部分直接接触的标签，所述颗粒包含可生物降解的聚合物，并且所述颗粒部分与所述标签接触，所述标签选自丙烯酸 ，丙烯酸2-羟基乙酯，2-丙烯酰胺基-2-甲基-1-丙磺酸，烯丙胺，羧基，羟基，磺酸基，醛基和胺基，其中标签选自药物，抗体 ，配体，抗原，蛋白质，肽，反配体部分，脂肪酸部分和碳水化合物部分，并且其中将一种或多种颗粒引入具有毒素的宿主中，并且所述一种或多种颗粒识别毒素。

公开(公告)号：US20060040892A1

公开(公告)日：2006-02-23

申请号：US10980125

申请日：2004-11-03

申请人： Zhibing Hu ,  Xiaohu Xia ,  Liping Tang

发明人： Zhibing Hu ,  Xiaohu Xia ,  Liping Tang

IPC分类号： A61K31/728 ,  C08B37/00

CPC分类号： C08B37/0072 ,  B82Y30/00 ,  C08J3/12 ,  C08J3/243 ,  C08J2305/08

摘要： A method for synthesizing uniformly sized hyaluronic acid (“HA”) particles that are substantially free from oil and surfactant contaminants. The method comprises crosslinking HA chains with 1-ethyl-3-(3-dimethlyaminopropyl) carbodiimide hydrochloride (“EDAC”) and adipic acid dihydrazide in a water/acetone mixture.

公开(公告)号：US12055925B2

公开(公告)日：2024-08-06

申请号：US17523996

申请日：2021-11-11

申请人： Yougang Xiang ,  Liping Tang

发明人： Yougang Xiang

IPC分类号： G01B3/18 ,  G05B23/02 ,  G06Q30/018

CPC分类号： G05B23/0221 ,  G01B3/18 ,  G06Q30/018

摘要： A measuring instrument and a method of remote quantity value transfer/traceability are provided. The measuring instrument includes a central processing component, a local quantity value transfer/traceability component connected to the central processing component, a remote quantity value transfer/traceability component connected to the central processing component and a remote communication component connected to the central processing component; a metrological grade of the remote quantity value transfer/traceability component is greater than or equal to that of the local quantity value transfer/traceability component; the remote quantity value transfer/traceability component is configured to perform quantity value transfer/traceability to the local quantity value transfer/traceability component by using one of the in-machine metrological standard and the remote high-grade metrological standard provided from the remote quantity value transfer/traceability component. The method of remote quantity value transfer/traceability can be achieved to make the quantity value transfer/traceability of the measuring instrument very convenient, simple and less costly.

公开(公告)号：US20050014255A1

公开(公告)日：2005-01-20

申请号：US10857443

申请日：2004-05-27

申请人： Liping Tang ,  Robert Hansen

发明人： Liping Tang ,  Robert Hansen

IPC分类号： A61K35/12 ,  A61K35/15 ,  A61K35/30 ,  A61K35/32 ,  A61K35/34 ,  A61K35/35 ,  A61K35/545 ,  C12N5/074 ,  A61K45/00 ,  C12N5/08 ,  A61M31/00

CPC分类号： A61K35/15 ,  A61K35/30 ,  A61K35/32 ,  A61K35/34 ,  A61K35/35 ,  A61K35/545 ,  C12N5/0607 ,  C12N2506/03

摘要： Methods for accumulating, recruiting and retrieving stem cells from a body cavity space of an adult mammal are disclosed, in addition to compositions and cells in accordance with the present invention. In accordance with another aspect of the present invention, a method of obtaining a new source of stem cells is provided by implanting a foreign object in a body cavity space of a mammal and collecting those stem cells resulting from implantation. Further in accordance with the present invention, a method for providing to a subject in need thereof one or more stem cells of the present invention is identified by retrieving stem cells for a body cavity space of a mammal after implanting a foreign object, manipulating the stem cells and introducing the stem cells into the subject in need thereof.

摘要翻译： 除了根据本发明的组合物和细胞外，还公开了从成年哺乳动物的体腔空间积累，募集和回收干细胞的方法。 根据本发明的另一方面，通过将异物植入哺乳动物的体腔空间并收集由植入产生的干细胞来提供获得新的干细胞来源的方法。 此外，根据本发明，通过在植入异物后检索哺乳动物的体腔空间的干细胞来鉴定本发明的一个或多个干细胞的需要的受试者的方法，操纵茎 并将干细胞导入需要的受试者。

公开(公告)号：US20220066433A1

公开(公告)日：2022-03-03

申请号：US17523996

申请日：2021-11-11

申请人： YOUGANG XIANG ,  LIPING TANG

发明人： YOUGANG XIANG

IPC分类号： G05B23/02 ,  G06Q30/00 ,  G01B3/18

摘要： A measuring instrument and a method of remote quantity value transfer/traceability are provided. The measuring instrument includes a central processing component, a local quantity value transfer/traceability component connected to the central processing component, a remote quantity value transfer/traceability component connected to the central processing component and a remote communication component connected to the central processing component; a metrological grade of the remote quantity value transfer/traceability component is greater than or equal to that of the local quantity value transfer/traceability component; the remote quantity value transfer/traceability component is configured to perform quantity value transfer/traceability to the local quantity value transfer/traceability component by using one of the in-machine metrological standard and the remote high-grade metrological standard provided from the remote quantity value transfer/traceability component. The method of remote quantity value transfer/traceability can be achieved to make the quantity value transfer/traceability of the measuring instrument very convenient, simple and less costly.

公开(公告)号：US20140356974A1

公开(公告)日：2014-12-04

申请号：US13905520

申请日：2013-05-30

申请人： Wen-Jing Hu ,  Liping Tang

发明人： Wen-Jing Hu ,  Liping Tang

IPC分类号： G01N33/84 ,  A61B5/1455 ,  A61K49/00 ,  G01N31/22 ,  A61B5/145

CPC分类号： G01N33/84 ,  A61B5/0071 ,  A61B5/14539 ,  A61B5/1455 ,  A61K49/0032 ,  G01N31/221

摘要： A pH detectable coating. The pH detectable coating includes a pH insensitive fluorescent dye and a pH sensitive fluorescent dye. The pH insensitive fluorescent dye and the pH sensitive fluorescent dye are attached to a surface. The ratio of the fluorescent intensity of the pH insensitive fluorescent dye to the fluorescent intensity of the pH sensitive fluorescent dye varies according to the pH of an environment into which the surface is placed.

摘要翻译： 可检测pH的涂层。 pH可检测的涂层包括pH不敏感的荧光染料和pH敏感的荧光染料。 pH不敏感荧光染料和pH敏感荧光染料附着在表面上。 pH不敏感荧光染料的荧光强度与pH敏感荧光染料的荧光强度的比率根据放置表面的环境的pH而变化。

公开(公告)号：US20050084456A1

公开(公告)日：2005-04-21

申请号：US10690466

申请日：2003-10-21

申请人： Liping Tang ,  Sheng Zhang ,  Hong Weng

发明人： Liping Tang ,  Sheng Zhang ,  Hong Weng

IPC分类号： A61K9/51 ,  A61K47/48 ,  A61K48/00 ,  C12N15/88 ,  A61L9/04 ,  A61K9/14 ,  C12N15/87

CPC分类号： A61K9/5138 ,  A61K9/5161 ,  A61K47/6865 ,  A61K47/6935 ,  A61K47/6939 ,  A61K48/0075 ,  A61K49/0043 ,  A61K49/0093 ,  C12N15/88

摘要： The present invention provides functionalized particles and methods for delivering said particles capable of crossing a physiologic barrier and exerting an effect. In one embodiment, the present invention provides a method of delivering a particle to a mammal comprising the steps of contacting a functionalized particle with a tag and introducing the functionalized and tagged particle to a mammal, wherein the functionalized portion of the particle is selected from the group consisting of acrylic acid, 2-hydroxyethyl acrylate, 2-acrylamido-2-methyl-1-propanesulfonic acid, allylamine, carboxyl group, hydroxyl group, sulfonic group, aldehyde and amine group. The particle is a biodegradable or nodegradable polymer and less than 1.0 mm in diameter.

摘要翻译： 本发明提供功能化颗粒和递送所述能够穿过生理屏障并发挥作用的颗粒的方法。 在一个实施方案中，本发明提供了向哺乳动物递送颗粒的方法，包括使官能化颗粒与标签接触并将官能化和标记的颗粒引入哺乳动物的步骤，其中所述颗粒的官能化部分选自 丙烯酸，丙烯酸2-羟基乙酯，2-丙烯酰胺基-2-甲基-1-丙磺酸，烯丙胺，羧基，羟基，磺酸基，醛和胺基组成的组。 颗粒是可生物降解或可分级的聚合物，直径小于1.0mm。

公开(公告)号：US07601704B2

公开(公告)日：2009-10-13

申请号：US10980125

申请日：2004-11-03

申请人： Zhibing Hu ,  Xiaohu Xia ,  Liping Tang

发明人： Zhibing Hu ,  Xiaohu Xia ,  Liping Tang

IPC分类号： A61K31/728 ,  C08B37/00

CPC分类号： C08B37/0072 ,  B82Y30/00 ,  C08J3/12 ,  C08J3/243 ,  C08J2305/08

摘要： A method for synthesizing uniformly sized hyaluronic acid (“HA”) particles that are substantially free from oil and surfactant contaminants. The method comprises crosslinking HA chains with 1-ethyl-3-(3-dimethlyaminopropyl) carbodiimide hydrochloride (“EDAC”) and adipic acid dihydrazide in a water/acetone mixture.

摘要翻译： 用于合成基本上不含油和表面活性剂污染物的均匀尺寸的透明质酸（“HA”）颗粒的方法。 该方法包括在水/丙酮混合物中将1-乙基-3-（3-二甲氨基丙基）碳二亚胺盐酸盐（“EDAC”）和己二酸二酰肼交联HA链。

公开(公告)号：US20050084513A1

公开(公告)日：2005-04-21

申请号：US10896376

申请日：2004-07-21

申请人： Liping Tang

发明人： Liping Tang

IPC分类号： A61K9/51 ,  A61K47/48 ,  A61K48/00 ,  C12N15/88 ,  A61F2/00 ,  A61K9/14

CPC分类号： A61L27/28 ,  A61K9/5138 ,  A61K9/5161 ,  A61K47/6937 ,  A61K47/6957 ,  A61K48/0075 ,  A61L2400/12 ,  C12N15/88

摘要： A coating for an implant surface comprising one or more nanoparticles of less than or equal to 500 nanometers and an implant surface capable of receiving the nanoparticles, the implant selected from the group consisting of metal, carbon, graphite, polymer, protein, nucleic acid, microorganisms, hydrogel, liquid, porous and polymer blend particles, and combinations thereof. The coating promotes characteristics on the implant surface such as reducing protein unfolding, preventing inflammatory and fibrotic cell accumulation, reducing the number of such cell attachment sites and preventing other adverse biological reactions. The coating may be applied on any material via physical and/or chemical binding. The coating may further comprise a surfactant and may include a tag, adsorbed, absorbed or incorporated onto the nanoparticle. The coating on an implant surface is used for purposes that may be cosmetic, therapeutic, preventative, reconstructive, monitoring and replacement. The coating may also be used for in vitro purposes.

摘要翻译： 一种用于植入物表面的涂层，其包含小于或等于500纳米的一种或多种纳米颗粒和能够接收纳米颗粒的植入物表面，所述植入物选自金属，碳，石墨，聚合物，蛋白质，核酸， 微生物，水凝胶，液体，多孔和聚合物共混物颗粒及其组合。 涂层促进植入物表面的特征，例如减少蛋白质展开，预防炎症和纤维细胞积聚，减少这种细胞附着位点的数量并防止其它不利的生物反应。 涂层可以通过物理和/或化学结合施加在任何材料上。 涂层可以进一步包含表面活性剂，并且可以包括吸附，吸收或掺入到纳米颗粒上的标签。 植入物表面上的涂层用于可能是美容，治疗，预防，重建，监测和替换的目的。 涂层也可用于体外目的。