公开(公告)号：US20060253100A1

公开(公告)日：2006-11-09

申请号：US11460012

申请日：2006-07-26

申请人： Eric Burright ,  Lisa Shafer ,  Bill McKay ,  John Zanella

发明人： Eric Burright ,  Lisa Shafer ,  Bill McKay ,  John Zanella

IPC分类号： A61M31/00 ,  A61K31/00 ,  A61M37/00 ,  A01N61/00

CPC分类号： A61K31/4168 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/1647 ,  A61K31/00 ,  A61K31/185 ,  A61K31/192 ,  A61K31/352 ,  A61K31/366 ,  A61K31/381 ,  A61K31/401 ,  A61K31/4402 ,  A61K31/498 ,  A61M5/14244 ,  A61M5/14276 ,  A61M37/0069 ,  G01N2800/2842

摘要： Disclosed herein are systems and methods for contributing to the local treatment of pain. More specifically, the disclosed systems and methods contribute to the local treatment pain by inhibiting the NFκB family of transcription factors.

摘要翻译： 本文公开了用于促进疼痛的局部治疗的系统和方法。 更具体地，所公开的系统和方法通过抑制NFkappaB家族的转录因子而有助于局部治疗疼痛。

公开(公告)号：US20050075701A1

公开(公告)日：2005-04-07

申请号：US10820677

申请日：2004-04-08

申请人： Lisa Shafer

发明人： Lisa Shafer

IPC分类号： A61N1/32 ,  A61N1/34 ,  A61N1/36 ,  A61N1/18

CPC分类号： A61N1/36017 ,  A61B5/4041 ,  A61B5/41 ,  A61B5/412 ,  A61B5/416 ,  A61N1/0553 ,  A61N1/0558 ,  A61N1/326 ,  A61N1/36021 ,  A61N1/3605 ,  A61N1/36071 ,  A61N1/36114

摘要： Stimulation of one or more neurons of the sympathetic nervous system, including the splenic nerve, to attenuate an immune response, including an inflammatory immune response, is discussed. Devices and systems to stimulate the sympathetic nervous system to attenuate an immune response are also discussed. Devices discussed include pulse generators and drug pumps. Systems are described as optionally having one or more sensors and operator instructions. In specific examples, stimulation of the splenic nerve of pigs with a pulse generator is shown to be safe and effective in attenuating a lipopolysaccharide-induced immune response.

摘要翻译： 讨论了一种或多种交感神经系统的神经元刺激，包括脾神经，以减轻免疫应答，包括炎性免疫应答。 还讨论了刺激交感神经系统以减轻免疫应答的装置和系统。 所讨论的设备包括脉冲发生器和药物泵。 系统被描述为可选地具有一个或多个传感器和操作者指令。 在具体实例中，用脉冲发生器刺激猪的脾神经被证明在减轻脂多糖诱导的免疫应答中是安全和有效的。

公开(公告)号：US20120040318A1

公开(公告)日：2012-02-16

申请号：US12806345

申请日：2010-08-11

申请人： Michelle Lisa Shafer

发明人： Michelle Lisa Shafer

IPC分类号： G09B23/28

CPC分类号： G09B19/00 ,  G09B23/28

摘要： A medico-legal template process, created by the Medical—Nursing community, that audio-visually demonstrates actual injury and trauma of a patient physically, functionally, mentally, emotionally and psychologically, and it's impact on altering that patient's pre-morbid/baseline activities of daily living, and relationships, both short and long term. The audio-visual record is a patient focused, neutral, medical and nursing assessment and analysis application for the discovery, mediation and litigation components of personal injury and medical malpractice law, and other applicable fields of study. This material is unique and original in that it applies the Nursing Process to the Clinical Forensic Video, it is created by the Medical-Nursing community for the Legal community, and it creates a neutral position within Plaintiff and Defense litigation.

摘要翻译： 由医疗护理社区创建的医疗法律模板过程，视听在身体，功能，精神，情感和心理上表现出患者的实际伤害和创伤，并且对改变患者病前/基线活动的影响 的日常生活，以及短期和长期的关系。 视听记录是针对人身伤害和医疗事故法以及其他适用学科领域的发现，调解和诉讼部分的患者重点，中立，医疗和护理评估与分析申请。 这种材料是独一无二的，因为它将护理流程应用于临床法医视频，由医疗护理社区为法律界创建，并在原告和辩护诉讼中创造了中立的地位。

公开(公告)号：US07999060B2

公开(公告)日：2011-08-16

申请号：US11928274

申请日：2007-10-30

申请人： Warren Ronk ,  Lisa Shafer

发明人： Warren Ronk ,  Lisa Shafer

IPC分类号： C08G73/00

CPC分类号： C08G73/10 ,  C08G73/101 ,  C08G73/1014 ,  C08G73/12 ,  C08L79/08 ,  C08L2205/02 ,  C08L2666/20

摘要： A tailorable polyimide prepolymer blend comprising an end group component, a dianhydride component, and a diamine component. The dianhydride component includes at least 3,4,3′,4′-benzophenonetetracarboxylic dianhydride (BTDA), derivatives thereof, or combinations thereof, and 3,4,3′,4′-biphenyltetracarboxylic dianhydride (BPDA), derivatives thereof, or combinations thereof. The diamine component includes at least 1,3-phenylenediamine (mPDA), derivatives thereof, or combinations thereof; 1,4-phenylenediamine (pPDA), derivatives thereof, or combinations thereof; bis amino phenoxy benzene (APB), derivatives thereof, and combinations thereof; and optionally, 4,4′-(1,3-phenylene-bis(1-methylethylidene)bisaniline (Bis-M), derivatives thereof, and combinations thereof. A cured polyimide matrix has a glass transition temperature of at least about 450° F. (232° C.). An article formed from the tailorable polyimide prepolymer blend may be a powder, a neat resin, a coating material, a film, an adhesive, a fiber, a composite, a laminate, a prepreg, a part, and combinations thereof.

摘要翻译： 包含端基组分，二酐组分和二胺组分的可调节的聚酰亚胺预聚物共混物。 二酐组分包括至少3,4,3'，4'-二苯甲酮四羧酸二酐（BTDA），其衍生物或其组合，和3,4,3'，4'-联苯四羧酸二酐（BPDA），其衍生物或 其组合。 二胺组分包括至少1,3-苯二胺（mPDA），其衍生物或其组合; 1,4-苯二胺（pPDA），其衍生物或其组合; 双氨基苯氧基苯（APB），其衍生物及其组合; 和任选的4,4' - （1,3-亚苯基 - 双（1-甲基亚乙基）双苯胺（Bis-M），其衍生物及其组合。固化的聚酰亚胺基质的玻璃化转变温度至少为约450° F.（232℃）由可调节聚酰亚胺预聚物共混物形成的制品可以是粉末，纯树脂，涂料，膜，粘合剂，纤维，复合材料，层压材料，预浸料， 部分及其组合。

公开(公告)号：US20050119712A1

公开(公告)日：2005-06-02

申请号：US11000856

申请日：2004-12-01

申请人： Lisa Shafer

发明人： Lisa Shafer

IPC分类号： A61K38/18 ,  A61K38/19 ,  A61K38/30 ,  A61N1/32 ,  A61N1/36 ,  A61N1/20

CPC分类号： A61K38/18 ,  A61K35/545 ,  A61K38/185 ,  A61K38/19 ,  A61N1/326 ,  A61N1/36082

摘要： Devices and methods for treating diseases associated with loss of neuronal function are described. The methods are designed to promote proliferation, differentiation, migration, or integration of endogenous progenitor stem cells of the central nervous system (CNS). A therapy, such as an electrical signal or a stem cell enhancing agent, or a combination of therapies, is applied to a CNS region containing endogenous stem cells or a CNS region where the endogenous stem cells are predicted to migrate and eventually reside, or a combination thereof.

摘要翻译： 描述了用于治疗与神经元功能丧失相关的疾病的装置和方法。 这些方法旨在促进中枢神经系统（CNS）的内源祖细胞的增殖，分化，迁移或整合。 例如电信号或干细胞增强剂或治疗组合的治疗被应用于含有内源性干细胞或CNS区域的CNS区域，其中内源性干细胞被预测迁移并最终存在， 的组合。

公开(公告)号：US20070276443A1

公开(公告)日：2007-11-29

申请号：US11835808

申请日：2007-08-08

申请人： Lisa SHAFER ,  Steve LaPORTE ,  James KEOGH ,  Michael HILL ,  Matthew BONNER

发明人： Lisa SHAFER ,  Steve LaPORTE ,  James KEOGH ,  Michael HILL ,  Matthew BONNER

IPC分类号： A61N1/00

CPC分类号： A61N1/39 ,  A61N1/36114 ,  A61N1/362 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/3684 ,  A61N1/385 ,  A61N1/3956

摘要： A method of performing a medical procedure is provided. The medical procedure includes stimulation of a patient's heart while stimulating a nerve of the patient in order to modulate the patient's inflammatory process. More particularly, the medical procedure includes pacing the ventricles of the patient's heart while stimulating the vagal nerve of the patient. Systems and devices for performing the medical procedure are also provided.

摘要翻译： 提供了一种执行医疗程序的方法。 医疗过程包括刺激患者的心脏同时刺激患者的神经以调节患者的炎症过程。 更具体地，医疗过程包括在刺激患者的迷走神经的同时起搏患者心脏的心室。 还提供用于执行医疗程序的系统和设备。

公开(公告)号：US20060189564A1

公开(公告)日：2006-08-24

申请号：US11388891

申请日：2006-03-24

申请人： Eric Burright ,  Rodolfo Padua ,  Peter Schroeder ,  Jennifer Christianson ,  Lisa Shafer

发明人： Eric Burright ,  Rodolfo Padua ,  Peter Schroeder ,  Jennifer Christianson ,  Lisa Shafer

IPC分类号： A61K48/00

CPC分类号： C12N15/1136 ,  A61K31/70 ,  A61K31/713 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  G01N2800/2842

摘要： Disclosed herein are methods and sequences used to treat pain. Specifically, the methods and sequences include locally administering nucleic acid molecules that suppress the expression of amino acid sequences that encode for pro-inflammatory cytokines and their receptors to treat acute or neuropathic pain associated with sciatica.

摘要翻译： 本文公开了用于治疗疼痛的方法和序列。 具体地，所述方法和序列包括局部施用抑制编码促炎细胞因子及其受体的氨基酸序列的表达以治疗与坐骨神经痛相关的急性或神经性疼痛的核酸分子。

公开(公告)号：US20050180974A1

公开(公告)日：2005-08-18

申请号：US10972177

申请日：2004-10-22

申请人： Lisa Shafer

发明人： Lisa Shafer

IPC分类号： A61B20060101 ,  A61K9/22 ,  A61K39/395 ,  A61M5/142 ,  A61M5/172 ,  A61M39/02 ,  C07K16/24 ,  G01N33/53

CPC分类号： A61K38/02 ,  A61K38/1709 ,  A61K38/206 ,  A61K38/2066 ,  A61K2039/505 ,  A61M5/14276 ,  A61M5/1723 ,  A61M25/00 ,  A61M39/0208 ,  A61M2205/04 ,  A61M2210/0693 ,  C07K16/241 ,  G01N33/6863 ,  G01N33/6896 ,  G01N33/743 ,  G01N33/948 ,  G01N2333/54 ,  G01N2500/00

摘要： Methods and devices to attenuate tumor necrosis factor (TNF) and other pro-inflammatory mediators in the CNS to treat neurological, neurodegenerative, neuropsychiatric disorders, and brain injury are described. More particularly, TNF blocking agents that target TNF-receptor interactions and the effects of downstream secreted cytokines associated with an inflammatory cascade are described. Such TNF blocking agents are administered directly to the brain by, for example, intraparenchymal administration, intracerebroventricular administration, or administration into a cerebral artery. Devices described include therapy delivery devices comprising a reservoir capable of housing a TNF blocking agent and a catheter operably coupled to the device and adapted to deliver the TNF blocking agent to a target site within a subject.

摘要翻译： 描述了减轻CNS中的肿瘤坏死因子（TNF）和其他促炎介质以治疗神经系统，神经变性，神经精神障碍和脑损伤的方法和装置。 更具体地，描述了靶向TNF受体相互作用的TNF阻断剂以及与炎性级联相关的下游分泌的细胞因子的作用。 这种TNF阻断剂通过例如实质内施用，脑室内给药或施用于大脑动脉直接施用于脑。 描述的装置包括治疗递送装置，其包括能够容纳TNF阻断剂的储存器和可操作地耦合到该装置并适于将TNF阻断剂输送到受试者内的靶位点的导管。

公开(公告)号：US20050123526A1

公开(公告)日：2005-06-09

申请号：US11001200

申请日：2004-12-01

申请人： Lisa Shafer

发明人： Lisa Shafer

IPC分类号： A61K48/00 ,  A61N1/18 ,  A61N1/32 ,  A61N1/36

CPC分类号： A61N1/326 ,  A61N1/36082

摘要： Devices and methods for treating diseases associated with loss of neuronal function by cell replacement therapy are described. The methods are designed to promote proliferation, differentiation, migration, or integration of exogenous stem cells transplanted into the central nervous system (CNS). A therapy, such as an electrical signal or a stem cell enhancing agent, or a combination of therapies, is applied to a CNS region having damaged neuronal tissues, into which region exogenous stem cells are transplanted. A therapy may also be applied to a second region of the CNS to which neurons from the damaged CNS region are expected to project. The exogenous stem cells may be transfected with an electrically responsive genetic construct comprising an electrically responsive promoter and a target gene. Expression of the target gene, which may encode a gene product that promotes proliferation, differentiation, migration, or integration of the exogenous stem cell, may be closely controlled by application of an electrical signal.

摘要翻译： 描述了通过细胞置换治疗治疗与神经元功能丧失相关的疾病的装置和方法。 这些方法旨在促进移植到中枢神经系统（CNS）中的外源性干细胞的增殖，分化，迁移或整合。 将诸如电信号或干细胞增强剂或治疗组合的治疗应用于具有损伤的神经元组织的CNS区域，在其中移植了外源性干细胞。 还可以将治疗应用于CNS区域受损的CNS区域的第二区域。 可以用包含电响应性启动子和靶基因的电响应基因构建体转染外源性干细胞。 可以通过施加电信号来密切控制可能编码促进外源性干细胞的增殖，分化，迁移或整合的基因产物的靶基因的表达。

公开(公告)号：US20080108781A1

公开(公告)日：2008-05-08

申请号：US11928274

申请日：2007-10-30

申请人： Warren Ronk ,  Lisa Shafer

发明人： Warren Ronk ,  Lisa Shafer

IPC分类号： C08G73/12

CPC分类号： C08G73/10 ,  C08G73/101 ,  C08G73/1014 ,  C08G73/12 ,  C08L79/08 ,  C08L2205/02 ,  C08L2666/20

摘要： A tailorable polyimide prepolymer blend comprising an end group component, a dianhydride component, and a diamine component. The dianhydride component includes at least 3,4,3′,4′-benzophenonetetracarboxylic dianhydride (BTDA), derivatives thereof, or combinations thereof, and 3,4,3′,4′-biphenyltetracarboxylic dianhydride (BPDA), derivatives thereof, or combinations thereof. The diamine component includes at least 1,3-phenylenediamine (mPDA), derivatives thereof, or combinations thereof, 1,4-phenylenediamine (pPDA), derivatives thereof, or combinations thereof, bis amino phenoxy benzene (APB), derivatives thereof, and combinations thereof, and optionally, 4,4′-(1,3-phenylene-bis(1-methylethylidene) bisaniline (Bis-M), derivatives thereof, and combinations thereof. A cured polyimide matrix has a glass transition temperature of at least about 450° F. (232° C.). An article formed from the tailorable polyimide prepolymer blend may be a powder, a neat resin, a coating material, a film, an adhesive, a fiber, a composite, a laminate, a prepreg, a part, and combinations thereof.

摘要翻译： 包含端基组分，二酐组分和二胺组分的可调节的聚酰亚胺预聚物共混物。 二酐组分包括至少3,4,3'，4'-二苯甲酮四羧酸二酐（BTDA），其衍生物或其组合，和3,4,3'，4'-联苯四羧酸二酐（BPDA），其衍生物或 其组合。 二胺组分包括至少1,3-苯二胺（mPDA），其衍生物或其组合，1,4-苯二胺（pPDA），其衍生物或其组合，双氨基苯氧基苯（APB），其衍生物和 其组合，和任选的4,4' - （1,3-亚苯基 - 双（1-甲基亚乙基）双苯胺（Bis-M），其衍生物及其组合。固化的聚酰亚胺基体的玻璃化转变温度至少为 由可调节的聚酰亚胺预聚物共混物形成的制品可以是粉末，纯树脂，涂料，膜，粘合剂，纤维，复合材料，层压材料， 预浸料，部件及其组合。