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    Chimeric chains for receptor-associated signal transduction pathways
    3.
    发明授权
    Chimeric chains for receptor-associated signal transduction pathways 失效
    用于受体相关信号转导途径的嵌合链

    公开(公告)号：US06319494B1

    公开(公告)日：2001-11-20

    申请号：US08479737

    申请日：1995-06-07

    申请人： Daniel J. Capon ,  Arthur Weiss ,  Brian A. Irving ,  Margo R. Roberts ,  Krisztina Zsebo

    发明人： Daniel J. Capon ,  Arthur Weiss ,  Brian A. Irving ,  Margo R. Roberts ,  Krisztina Zsebo

    IPC分类号： C12N1500

    CPC分类号： C07K14/70514 ,  C07K14/7051 ,  C07K14/70535 ,  C07K2319/00

    摘要： Chimeric proteins and DNA encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to a ligand in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathway. The extracellular domain and cytoplasmic domain are not naturally found together. Binding of ligand to the extracellular domain results in transduction of a signal and activation of a signaling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signalling pathway. A wide variety of extracellular domains may be employed as receptors, where such domains may be naturally occurring or synthetic. The chimeric DNA may be used to modify lymphocytes as well as hematopoietic stem cells as precursors to a number of important cell types.

    摘要翻译： 提供嵌合蛋白和编码嵌合蛋白的DNA，其中嵌合蛋白的特征在于能够以非MHC限制性方式结合配体的细胞外结构域，能够激活信号通路的跨膜结构域和胞质结构域。 细胞外结构域和细胞质结构域不是天生地共同发现的。 配体与细胞外结构域的结合导致信号的转导和信号通路在细胞中的激活，由此可诱导细胞进行与信号通路相关的各种功能。 可以使用多种细胞外结构域作为受体，其中这些结构域可以是天然存在的或合成的。 嵌合DNA可用于修饰淋巴细胞以及造血干细胞作为许多重要细胞类型的前体。

    Chimeric receptor molecules for delivery of co-stimulatory signals
    4.
    发明授权
    Chimeric receptor molecules for delivery of co-stimulatory signals 失效
    用于传递共刺激信号的嵌合受体分子

    公开(公告)号：US5712149A

    公开(公告)日：1998-01-27

    申请号：US383749

    申请日：1995-02-03

    申请人： Margo R. Roberts

    发明人： Margo R. Roberts

    IPC分类号： A61K38/00 ,  C07K14/55 ,  C07K14/705 ,  C07K14/725 ,  C07K14/73 ,  C07K19/00 ,  C12N15/62

    CPC分类号： C07K14/70507 ,  C07K14/55 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/70514 ,  C07K14/70521 ,  C07K14/70528 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention is directed to novel chimeric co-stimulatory receptor proteins and DNA sequences encoding these proteins. The chimeric receptors comprise at least three domains in a single chain molecule: an extracellular ligand binding domain, a transmembrane domain and a cytoplasmic co-stimulatory effector function signaling domain that acts synergistically with an effector function signal in the host cell. Novel hybrid co-stimulatory receptor proteins include a second cytoplasmic effector function signaling domain. The invention further relates to expression cassettes containing the nucleic acids encoding the novel chimeric receptors, to host cells expressing the novel chimeric receptors and to methods of using the receptors to co-stimulate effector functions in the cells and for using cells expressing the receptors for treatment of cancer, disease and viral infections.

    摘要翻译： 本发明涉及新型嵌合共刺激受体蛋白和编码这些蛋白的DNA序列。 嵌合受体在单链分子中包含至少三个结构域：细胞外配体结合结构域，跨膜结构域和与宿主细胞中的效应子功能信号协同作用的细胞质共刺激效应子功能信号结构域。 新型杂合共刺激受体蛋白包括第二细胞质效应子功能信号结构域。 本发明还涉及含有编码新型嵌合受体的核酸，表达新型嵌合受体的宿主细胞的表达盒以及使用受体共同刺激细胞中的效应子功能并使用表达受体的细胞进行治疗的方法 的癌症，疾病和病毒感染。

    Chimeric receptor molecules for delivery of co-stimulatory signals
    5.
    发明授权
    Chimeric receptor molecules for delivery of co-stimulatory signals 失效
    用于传递共刺激信号的嵌合受体分子

    公开(公告)号：US5686281A

    公开(公告)日：1997-11-11

    申请号：US455860

    申请日：1995-05-31

    申请人： Margo R. Roberts

    发明人： Margo R. Roberts

    IPC分类号： A61K38/00 ,  C07K14/55 ,  C07K14/705 ,  C07K14/725 ,  C07K14/73 ,  C12N15/62

    CPC分类号： C07K14/70507 ,  C07K14/55 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/70514 ,  C07K14/70521 ,  C07K14/70528 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention is directed to novel chimeric co-stimulatory receptor proteins and DNA sequences encoding these proteins. The chimeric receptors comprise at least three domains in a single chain molecule: an extracellular ligand binding domain, a transmembrane domain and a cytoplasmic co-stimulatory effector function signaling domain that acts synergistically with an effector function signal in the host cell. Novel hybrid co-stimulatory receptor proteins include a second cytoplasmic effector function signaling domain. The invention further relates to expression cassettes containing the nucleic acids encoding the novel chimeric receptors, to host cells expressing the novel chimeric receptors and to methods of using the receptors to co-stimulate effector functions in the cells and for using cells expressing the receptors for treatment of cancer, disease and viral infections.

    摘要翻译： 本发明涉及新型嵌合共刺激受体蛋白和编码这些蛋白的DNA序列。 嵌合受体在单链分子中包含至少三个结构域：细胞外配体结合结构域，跨膜结构域和与宿主细胞中的效应子功能信号协同作用的细胞质共刺激效应子功能信号结构域。 新型杂合共刺激受体蛋白包括第二细胞质效应子功能信号结构域。 本发明还涉及含有编码新型嵌合受体的核酸，表达新型嵌合受体的宿主细胞的表达盒以及使用受体共同刺激细胞中的效应子功能并使用表达该受体的细胞进行治疗的方法 的癌症，疾病和病毒感染。

    Chimeric chains for receptor-associated signal transduction pathways
    9.
    发明授权
    Chimeric chains for receptor-associated signal transduction pathways 失效
    用于受体相关信号转导途径的嵌合链

    公开(公告)号：US06407221B1

    公开(公告)日：2002-06-18

    申请号：US08475442

    申请日：1995-06-07

    申请人： Daniel J. Capon ,  Arthur Weiss ,  Brian A. Irving ,  Margo R. Roberts ,  Krisztina Zsebo

    发明人： Daniel J. Capon ,  Arthur Weiss ,  Brian A. Irving ,  Margo R. Roberts ,  Krisztina Zsebo

    IPC分类号： C07H2104

    CPC分类号： C07K14/70514 ,  C07K14/7051 ,  C07K14/70535 ,  C07K2319/00

    摘要： Chimeric proteins and DNA encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to a ligand in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathway. The extracellular domain and cytoplasmic domain are not naturally found together. Binding of ligand to the extracellular domain results in transduction of a signal and activation of a signaling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signalling pathway. A wide variety of extracellular domains may be employed as receptors, where such domains may be naturally occurring or synthetic. The chimeric DNA may be used to modify lymphocytes as well as hematopoietic stem cells as precursors to a number of important cell types.

    摘要翻译： 提供嵌合蛋白和编码嵌合蛋白的DNA，其中嵌合蛋白的特征在于能够以非MHC限制性方式结合配体的细胞外结构域，能够激活信号通路的跨膜结构域和胞质结构域。 细胞外结构域和细胞质结构域不是天生地共同发现的。 配体与细胞外结构域的结合导致信号的转导和信号通路在细胞中的激活，由此可诱导细胞进行与信号通路相关的各种功能。 可以使用多种细胞外结构域作为受体，其中这些结构域可以是天然存在的或合成的。 嵌合DNA可用于修饰淋巴细胞以及造血干细胞作为许多重要细胞类型的前体。