公开(公告)号：US08975309B2

公开(公告)日：2015-03-10

申请号：US12998077

申请日：2009-09-14

申请人： Maria Stromme ,  Albert Mihranyan

发明人： Maria Stromme ,  Albert Mihranyan

IPC分类号： A61F2/00 ,  C08F220/12 ,  C08F220/18 ,  C08F16/06 ,  A61K9/00 ,  C08F218/08 ,  A61K47/34 ,  A61L27/52 ,  A61K9/06 ,  A61L27/16 ,  A61K9/19 ,  A61K9/70 ,  C08J5/18 ,  C08F220/06 ,  C08F220/56

CPC分类号： A61L27/16 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/0031 ,  A61K9/006 ,  A61K9/0065 ,  A61K9/06 ,  A61K9/19 ,  A61K9/7007 ,  A61K47/34 ,  A61L27/52 ,  C08F8/12 ,  C08F218/08 ,  C08F220/06 ,  C08F220/56 ,  C08J5/18 ,  C08L29/04

摘要： A cryogel-forming vinyl alcohol co-polymer is operable to form a cryogel, i.e., a hydrogel formed by crytropic gelation, in an aqueous solution at a concentration of less than about 10% by weight, in the absence of a chemical cross-linking agent and in the absence of an emulsifier. In one embodiment, a vinyl alcohol co-polymer cryogel comprises at least about 75% by weight water and a vinyl alcohol co-polymer, wherein the vinyl alcohol co-polymer is operable to form a cryogel in an aqueous solution at a concentration of less than about 10% by weight, in the absence of a chemical cross-linking agent and in the absence of an emulsifier. In another embodiment, a vinyl alcohol co-polymer cryogel comprises at least about 75% by weight water and a vinyl alcohol co-polymer comprising a saponified product of a vinyl acetate co-polymer formed from at least about 80% by weight of vinyl acetate monomer, and (i) at least about 3% by weight of acrylamide monomer or a mixture of acrylamide monomer and acrylic acid monomer, or (ii) at least about 5% by weight acrylic acid monomer. The vinyl acetate co-polymer, vinyl alcohol co-polymer and vinyl alcohol co-polymer cryogel may be formed according to particular methods, and the vinyl alcohol co-polymer cryogels may be used in various applications including biomedical implants and thin films and for delivery of therapeutic or cosmetic agents.

摘要翻译： 低温凝胶形成乙烯醇共聚物可操作以在不存在化学交联的情况下，以小于约10重量％的浓度在水溶液中形成冷冻凝胶，即通过热溶胶凝胶形成的水凝胶 并且在不存在乳化剂的情况下。 在一个实施方案中，乙烯醇共聚物冷冻凝胶包含至少约75重量％的水和乙烯醇共聚物，其中乙烯醇共聚物可操作以在浓度较低的水溶液中形成冷冻凝胶 在不存在化学交联剂的条件下和在不存在乳化剂的条件下进行。 在另一个实施方案中，乙烯醇共聚物冷冻凝胶包含至少约75重量％的水和包含由至少约80重量％的乙酸乙烯酯形成的乙酸乙烯酯共聚物的皂化产物的乙烯醇共聚物 单体，和（i）至少约3重量％的丙烯酰胺单体或丙烯酰胺单体和丙烯酸单体的混合物，或（ii）至少约5重量％的丙烯酸单体。 可以根据具体方法形成乙酸乙烯酯共聚物，乙烯醇共聚物和乙烯醇共聚物冷冻凝胶，并且乙烯醇共聚物冷冻凝胶可用于各种应用，包括生物医学植入物和薄膜并用于递送 的治疗或化妆品。

公开(公告)号：US20110230567A1

公开(公告)日：2011-09-22

申请号：US12998077

申请日：2009-09-14

申请人： Maria Stromme ,  Albert Mihranyan

发明人： Maria Stromme ,  Albert Mihranyan

IPC分类号： A61K47/30 ,  C08F16/06 ,  C08F2/22 ,  C08L29/04 ,  C08J3/075 ,  C08J9/28 ,  C08L89/00 ,  A61L27/16

CPC分类号： A61L27/16 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/0031 ,  A61K9/006 ,  A61K9/0065 ,  A61K9/06 ,  A61K9/19 ,  A61K9/7007 ,  A61K47/34 ,  A61L27/52 ,  C08F8/12 ,  C08F218/08 ,  C08F220/06 ,  C08F220/56 ,  C08J5/18 ,  C08L29/04

摘要： A cryogel-forming vinyl alcohol co-polymer is operable to form a cryogel, i.e., a hydrogel formed by crytropic gelation, in an aqueous solution at a concentration of less than about 10% by weight, in the absence of a chemical cross-linking agent and in the absence of an emulsifier. In one embodiment, a vinyl alcohol co-polymer cryogel comprises at least about 75% by weight water and a vinyl alcohol co-polymer, wherein the vinyl alcohol co-polymer is operable to form a cryogel in an aqueous solution at a concentration of less than about 10% by weight, in the absence of a chemical cross-linking agent and in the absence of an emulsifier. In another embodiment, a vinyl alcohol co-polymer cryogel comprises at least abut 75% by weight water and a vinyl alcohol co-polymer comprising a saponified product of a vinyl acetate co- polymer formed from at least about 80% by weight of vinyl acetate monomer, and (i) at least about 3% by weight of acrylamide monomer or a mixture of acrylamide monomer and acrylic acid monomer, or (ii) at least about 5% by weight acrylic acid monomer. The vinyl acetate co- polymer, vinyl alcohol co-polymer and vinyl alcohol co-polymer cryogel may be formed according to particular methods, and the vinyl alcohol co-polymer cryogels may be used in various applications including biomedical implants and thin films and for delivery of therapeutic or cosmetic agents.

摘要翻译： 低温凝胶形成乙烯醇共聚物可操作以在不存在化学交联的情况下，以小于约10重量％的浓度在水溶液中形成冷冻凝胶，即通过热溶胶凝胶形成的水凝胶 并且在不存在乳化剂的情况下。 在一个实施方案中，乙烯醇共聚物冷冻凝胶包含至少约75重量％的水和乙烯醇共聚物，其中乙烯醇共聚物可操作以在浓度较低的水溶液中形成冷冻凝胶 在不存在化学交联剂的条件下和在不存在乳化剂的条件下进行。 在另一个实施方案中，乙烯醇共聚物冷冻凝胶包含至少约75重量％的水和包含由至少约80重量％的乙酸乙烯酯形成的乙酸乙烯酯共聚物的皂化产物的乙烯醇共聚物 单体，和（i）至少约3重量％的丙烯酰胺单体或丙烯酰胺单体和丙烯酸单体的混合物，或（ii）至少约5重量％的丙烯酸单体。 可以根据具体方法形成乙酸乙烯酯共聚物，乙烯醇共聚物和乙烯醇共聚物冷冻凝胶，并且乙烯醇共聚物冷冻凝胶可用于各种应用，包括生物医学植入物和薄膜并用于递送 的治疗或化妆品。

公开(公告)号：US20080132456A1

公开(公告)日：2008-06-05

申请号：US11792217

申请日：2005-12-09

申请人： Ragnar Ek ,  Maria Stromme ,  Albert Mihranyan

发明人： Ragnar Ek ,  Maria Stromme ,  Albert Mihranyan

IPC分类号： A61K31/7048 ,  A61K47/38 ,  A61K31/21 ,  A61K31/435 ,  A61K31/551 ,  A61K31/19 ,  A61K31/164 ,  A61K31/515 ,  A61K31/43 ,  A61K31/352

CPC分类号： A61K47/38 ,  A61K9/1652 ,  A61K9/2054 ,  A61K31/616

摘要： A pharmaceutical composition comprises a pharmaceutically effective amount of an active ingredient and low crystallinity cellulose having a crystallinity index of less than about 75% as measured by X-ray diffraction. The compositions advantageously may be provided in tablet form or granulate form and provide good stability against moisture degradation.

摘要翻译： 药物组合物包含药学有效量的通过X射线衍射测量的结晶度指数小于约75％的活性成分和低结晶度纤维素。 组合物有利地可以片剂形式或颗粒形式提供，并提供对水分降解的良好稳定性。