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1.发明申请Materials and Methods for the Detection, Prevention and Treatment of Autoimmune Disease 审中-公开自身免疫性疾病的检测，预防和治疗的材料与方法公开(公告)号：US20100178652A1
公开(公告)日：2010-07-15
申请号：US12522155
申请日：2008-01-07
Applicant: Sally A. Litherland , Marcia McDuffie , Laurence Morel , Federica Seydel , Erin Garrigan , Nicole S. Belkin , Bryan Stutevoss , Michael J. Clare-Salzler , Mark A. Atkinson , Clive Henry Wasserfall , Ammon B. Peck , Abdolreza Davoodi-Semiromi
Inventor： Sally A. Litherland , Marcia McDuffie , Laurence Morel , Federica Seydel , Erin Garrigan , Nicole S. Belkin , Bryan Stutevoss , Michael J. Clare-Salzler , Mark A. Atkinson , Clive Henry Wasserfall , Ammon B. Peck , Abdolreza Davoodi-Semiromi
IPC: C12Q1/68
CPC classification number: G01N33/6893 , G01N2333/4706 , G01N2800/042 , G01N2800/046 , G01N2800/101 , G01N2800/102 , G01N2800/104 , G01N2800/52
Abstract: The subject invention provides materials and methods for the detection, prevention, and treatment of diabetes and other autoimmune conditions.
Abstract translation: 本发明提供了用于检测，预防和治疗糖尿病和其它自身免疫病症的材料和方法。
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公开(公告)号：US20120183513A1
公开(公告)日：2012-07-19
申请号：US13144028
申请日：2010-02-18
Applicant: Josef Neu , Graciela Liliana Lorca , Eric W. Triplett , Mark A. Atkinson , Desmond A. Schatz
Inventor： Josef Neu , Graciela Liliana Lorca , Eric W. Triplett , Mark A. Atkinson , Desmond A. Schatz
CPC classification number: A61K35/747 , A23C9/1234 , A23C19/0323 , A23G9/363 , A23L33/135 , A23V2002/00 , A23Y2220/43 , A23Y2220/71 , A61K2035/115 , C12N1/20 , A23V2200/328 , A23V2200/3204
Abstract: Isolated Lactobacillus strains are useful in preventing or delaying the development of Type 1 Diabetes (T1D). A probiotic composition comprising the Lactobacillus strains and use of the composition in T1D prevention are provided.
Abstract translation: 分离的乳杆菌菌株可用于预防或延缓1型糖尿病（T1D）的发展。 提供了包含乳杆菌菌株的益生菌组合物和预防T1D中组合物的用途。
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3.发明申请RAAV VECTOR-BASED COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF MAMMALIAN DISEASES 审中-公开基于RAAV VECTOR的组合物和预防和治疗马马里兰病的方法公开(公告)号：US20090111766A1
公开(公告)日：2009-04-30
申请号：US12139840
申请日：2008-06-16
Applicant: Mark A. Atkinson , Terence R. Flotte , Sihong Song , Scott A. Loiler
Inventor： Mark A. Atkinson , Terence R. Flotte , Sihong Song , Scott A. Loiler
IPC: A61K31/7088 , C12N15/00
CPC classification number: C12N15/86 , A61K48/005 , C07K14/52 , C07K14/8121 , C12N2750/14143 , C12N2830/008 , C12N2830/42 , C12N2830/48 , C12N2830/85 , C12N2840/203
Abstract: Disclosed are recombinant adeno-associated viral (rAAV) vector compositions that are expressed in selected mammalian cells, such as pancreatic islets cells, and that encode one or more mammalian serpin or cytokine polypeptides having therapeutic efficacy in the amelioration, treatment and/or prevention of interleukin deficiencies, such as for example diabetes, and related diseases of the pancreas. Also disclosed are methods and compositions for preventing diabetes in a mammal, reducing the rate of disease progression, and ameliorating the symptoms of diabetes in humans at risk for developing such conditions.
Abstract translation: 公开了在选定的哺乳动物细胞例如胰岛细胞中表达的重组腺相关病毒（rAAV）载体组合物，并编码一种或多种在改善，治疗和/或预防或治疗中具有治疗功效的哺乳动物丝氨酸蛋白酶抑制剂或细胞因子多肽 白细胞介素缺乏症，例如糖尿病和胰腺相关疾病。 还公开了用于预防哺乳动物中的糖尿病，降低疾病进展速率和改善患有发展这种病症风险的人的糖尿病症状的方法和组合物。
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4.发明授权Methods and compositions for the early detection and treatment of insulin dependent diabetes mellitus 失效用于早期检测和治疗胰岛素依赖性糖尿病的方法和组合物
公开(公告)号：US5645998A
公开(公告)日：1997-07-08
申请号：US242689
申请日：1994-05-13
Applicant: Mark A. Atkinson , Noel K. Maclaren
Inventor： Mark A. Atkinson , Noel K. Maclaren
IPC: A61K38/00 , A61K39/00 , A61K47/48 , C07K14/72 , C07K16/40 , C07K19/00 , C12N9/88 , C12N15/88 , G01N33/564 , G01N33/573 , G01N33/68 , G01N33/74
CPC classification number: A61K47/48238 , A61K47/48646 , C07K14/72 , C07K16/40 , C07K19/00 , C12N15/88 , C12N9/88 , G01N33/564 , G01N33/573 , G01N33/6893 , G01N33/74 , A61K38/00 , A61K39/00 , G01N2800/042 , Y10S435/811 , Y10S436/811
Abstract: The subject invention concerns a process for the early detection of insulin dependent diabetes (IDD). The process described here enables the detection of the onset of IDD before clinical symptoms appear. The process involves the detection, in a sample of biological fluid, of an autoantibody which is highly specific to individuals who will later develop the clinical manifestations of IDD. Novel treatments for the prevention of IDD are also described.
Abstract translation: 本发明涉及早期检测胰岛素依赖型糖尿病（IDD）的方法。 这里描述的过程能够在出现临床症状之前检测IDD的发作。 该过程涉及在生物流体样品中检测对随后发展IDD的临床表现的个体高度特异性的自身抗体。 还描述了防治IDD的新型治疗方法。
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公开(公告)号：US10022440B2
公开(公告)日：2018-07-17
申请号：US14117122
申请日：2012-06-25
Applicant: Clive Henry Wasserfall , Mark A. Atkinson , Benjamin George Keselowsky , Young Mee Yoon
Abstract: The present invention provides materials and methods for modulating an immune response. In one embodiment, the present invention provides an initial artificial lymph-node homing environment, and a simultaneous, or subsequent, artificial spleen environment leading to the resolution of the activated immune responses. In one specific embodiment, the present invention can be used to prevent and/or treat pathogenic infection, cancer, allergenic reactions, and/or unwanted immune or auto-immune responses.
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Patent Agency Ranking
公开(公告)号：US09474773B2
公开(公告)日：2016-10-25
申请号：US13144028
申请日：2010-02-18
Applicant: Josef Neu , Graciela Liliana Lorca , Eric W. Triplett , Mark A. Atkinson , Desmond A. Schatz
Inventor： Josef Neu , Graciela Liliana Lorca , Eric W. Triplett , Mark A. Atkinson , Desmond A. Schatz
IPC: A61K35/74 , C12N1/20 , A61P3/10 , A61K35/747 , A23C9/123 , A23C19/032 , A23G9/36 , A23L1/30 , A61K35/00
CPC classification number: A61K35/747 , A23C9/1234 , A23C19/0323 , A23G9/363 , A23L33/135 , A23V2002/00 , A23Y2220/43 , A23Y2220/71 , A61K2035/115 , C12N1/20 , A23V2200/328 , A23V2200/3204
Abstract: Isolated Lactobacillus strains are useful in preventing or delaying the development of Type 1 Diabetes (T1D). A probiotic composition comprising the Lactobacillus strains and use of the composition in T1D prevention are provided.
Abstract translation: 分离的乳杆菌菌株可用于预防或延缓1型糖尿病（T1D）的发展。 提供了包含乳杆菌菌株的益生菌组合物和预防T1D中组合物的用途。
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公开(公告)号：US08758761B2
公开(公告)日：2014-06-24
申请号：US12680614
申请日：2008-09-30
Applicant: Mark A. Atkinson , Scott Eisenbeis , Donna Armentano , Abraham Scaria , Tracey Lodie
Inventor： Mark A. Atkinson , Scott Eisenbeis , Donna Armentano , Abraham Scaria , Tracey Lodie
CPC classification number: A61K39/39541 , A61K31/436 , A61K35/28 , A61K38/193 , A61K38/26 , A61K45/06 , A61K2300/00
Abstract: In accordance with the subject invention, combination therapies can be used to modulate a patient's immune response in order to prevent, delay and/or reverse type 1 diabetes.
Abstract translation: 根据本发明，组合疗法可用于调节患者的免疫应答，以防止，延迟和/或逆转1型糖尿病。
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公开(公告)号：US20120077709A1
公开(公告)日：2012-03-29
申请号：US13245287
申请日：2011-09-26
Applicant: Tamir M. Ellis , Alba Esther Morales , Mark A. Atkinson , Clive H. Wasserfall
Inventor： Tamir M. Ellis , Alba Esther Morales , Mark A. Atkinson , Clive H. Wasserfall
IPC: C40B30/10 , G01N33/566
CPC classification number: G01N33/6863 , G01N33/564 , G01N33/6893 , G01N33/74 , G01N33/92 , G01N2800/042 , G06F19/00 , Y10S436/811 , Y10T436/145555 , Y10T436/24
Abstract: Biomarkers that are diagnostic of type 1 diabetes, type 2 diabetes and/or diabetic disorder are identified. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of type 1 diabetes, type 2 diabetes and/or diabetic disorder. An analysis includes the parameters of matching for BMI and Tanner stage. Receiver-operator characteristic (ROC) curves were established to assess association of the biomarkers with a disease.
Abstract translation: 鉴定出1型糖尿病，2型糖尿病和/或糖尿病病症诊断的生物标志物。 本发明的不同生物标志物的检测也是1型糖尿病，2型糖尿病和/或糖尿病病症的严重程度的诊断。 分析包括BMI和Tanner阶段的匹配参数。 建立了受体 - 运营人特征（ROC）曲线，以评估生物标志物与疾病的关联。
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公开(公告)号：US20100120629A1
公开(公告)日：2010-05-13
申请号：US12689102
申请日：2010-01-18
Applicant: Tamir M. Ellis , Alba Esther Morales , Mark A. Atkinson , Clive H. Wasserfall
Inventor： Tamir M. Ellis , Alba Esther Morales , Mark A. Atkinson , Clive H. Wasserfall
CPC classification number: G01N33/6863 , G01N33/564 , G01N33/6893 , G01N33/74 , G01N33/92 , G01N2800/042 , Y10S436/811 , Y10T436/145555 , Y10T436/24
Abstract: Biomarkers that are diagnostic of type 1 diabetes, type 2 diabetes and/or diabetic disorder are identified. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of type 1 diabetes, type 2 diabetes and/or diabetic disorder. An analysis includes the parameters of matching for BMI and Tanner stage. Receiver-operator characteristic (ROC) curves were established to assess association of the biomarkers with a disease.
Abstract translation: 鉴定出1型糖尿病，2型糖尿病和/或糖尿病病症诊断的生物标志物。 本发明的不同生物标志物的检测也是1型糖尿病，2型糖尿病和/或糖尿病病症的严重程度的诊断。 分析包括BMI和Tanner阶段的匹配参数。 建立了受体 - 运营人特征（ROC）曲线，以评估生物标志物与疾病的关联。
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公开(公告)号：US07648825B2
公开(公告)日：2010-01-19
申请号：US10873101
申请日：2004-06-21
Applicant: Tamir M. Ellis , Alba Esther Morales , Mark A. Atkinson , Clive H. Wasserfall
Inventor： Tamir M. Ellis , Alba Esther Morales , Mark A. Atkinson , Clive H. Wasserfall
IPC: G01N33/74 , G01N24/08 , G01N33/543
CPC classification number: G01N33/6863 , G01N33/564 , G01N33/6893 , G01N33/74 , G01N33/92 , G01N2800/042 , G06F19/00 , Y10S436/811 , Y10T436/145555 , Y10T436/24
Abstract: Biomarkers that are diagnostic of type 1 diabetes, type 2 diabetes and/or diabetic disorder are identified. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of type 1 diabetes, type 2 diabetes and/or diabetic disorder. An analysis includes the parameters of matching for BMI and Tanner stage. Receiver-operator characteristic (ROC) curves were established to assess association of the biomarkers with a disease.
Abstract translation: 鉴定出1型糖尿病，2型糖尿病和/或糖尿病病症诊断的生物标志物。 本发明的不同生物标志物的检测也是1型糖尿病，2型糖尿病和/或糖尿病病症的严重程度的诊断。 分析包括BMI和Tanner阶段的匹配参数。 建立了受体 - 运营人特征（ROC）曲线，以评估生物标志物与疾病的关联。
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