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公开(公告)号：US20230130686A1
公开(公告)日：2023-04-27
申请号：US17509229
申请日：2021-10-25
摘要： A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
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公开(公告)号：US11634766B2
公开(公告)日：2023-04-25
申请号：US16782044
申请日：2020-02-04
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： Jason Daniel Buenrostro , Sai Ma , Aviv Regev
IPC分类号： C12Q1/68 , C12Q1/6874 , C12N15/10 , C12Q1/6853
摘要： Provided herein include methods and compositions for analyzing nucleic acid in individual cells. In some embodiments, the methods herein include generating, within individual cells, fragmented cellular genomic DNA and cDNA copies of cellular RNA molecules, barcoding the fragmented genomic DNA and the cDNA within each cell such that the genomic DNA and the cDNA from the same cell receive the same unique barcode sequence, isolating the barcoded genomic DNA and cDNA, and characterizing one or more features of the individual cells based, at least in part, on sequencing of the isolated barcoded genomic DNA and the cDNA.
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公开(公告)号：US20230121232A1
公开(公告)日：2023-04-20
申请号：US17979195
申请日：2022-11-02
发明人： Phillip A. Sharp , Dig Mahat
IPC分类号： C12Q1/6869 , C12Q1/6855 , C12Q1/686
摘要： The present disclosure relates to a method of sequencing nascent RNA in a cell. In some embodiments, the nascent RNA is conjugated to DNA using copper-catalyzed azide-alkyne cycloaddition (CuAAC). Methods of the present disclosure can be used to generate genomic libraries of a cell and measure gene expression and enhancer and/or super-enhancer activity.
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公开(公告)号：US11632764B1
公开(公告)日：2023-04-18
申请号：US16880377
申请日：2020-05-21
发明人： Rachel E. Learned
摘要： In some embodiments, a method for mitigating interference in a channel having multiple users includes: receiving a plurality of signals from a plurality of antenna elements, the received signals comprised of one or more interfering signals and a signal of interest (SOI); for each of the one or more interfering signals, beamforming the received signals to enhance the interfering signal, generating an estimate of the interfering signal, and adjusting the estimated interfering signal to undo the effects of beamforming; and subtracting each of the estimated interfering signals from each of the received signals to generate a plurality of interference-mitigated received signals.
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公开(公告)号：US11626227B2
公开(公告)日：2023-04-11
申请号：US16907741
申请日：2020-06-22
摘要： Using the Meissner effect in superconductors, demonstrated here is the capability to create an arbitrarily high magnetic flux density (also sometimes referred to as “flux squeezing”). This technique has immediate applications for numerous technologies. For example, it allows the generation of very large magnetic fields (e.g., exceeding 1 Tesla) for nuclear magnetic resonance (NMR), magnetic resonance imaging (MRI), the generation of controlled magnetic fields for advanced superconducting quantum computing devices, and/or the like. The magnetic field concentration/increased flux density approaches can be applied to both static magnetic fields (i.e., direct current (DC) magnetic fields) and time-varying magnetic fields (i.e., alternating current (AC) magnetic fields) up to microwave frequencies.
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6.发明授权公开(公告)号：US11625487B2
公开(公告)日：2023-04-11
申请号：US16256267
申请日：2019-01-24
发明人： Pin-Yu Chen , Sijia Liu , Akhilan Boopathy , Tsui-Wei Weng , Luca Daniel
摘要： A certification method, system, and computer program product include certifying an adversarial robustness of a convolutional neural network by deriving an analytic solution for a neural network output using an efficient upper bound and an efficient lower bound on an activation function and applying the analytic solution in computing a certified robustness.
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公开(公告)号：US11617817B2
公开(公告)日：2023-04-04
申请号：US16589768
申请日：2019-10-01
发明人： Christopher S. Chen , Jan D. Baranski , Ritika Chaturvedi , Michael T. Yang , Kelly Stevens , Sangeeta Bhatia
摘要： The present disclosure provides patterned biomaterials having organized cords and extracellular matrix embedded in a 3D scaffold. According, the present disclosure provides compositions and applications for patterned biomaterials. Pre-patterning of these biomaterials can lead to enhanced integration of these materials into host organisms, providing a strategy for enhancing the viability of engineered tissues by promoting vascularization.
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公开(公告)号：US20230097465A1
公开(公告)日：2023-03-30
申请号：US17911270
申请日：2021-03-25
摘要： Structures and methods enable emergency or rapid shutdown of an energized no-insulation (NI) superconducting magnet, without damage due to thermal effects of a quench. A resistive bypass wire is coupled between electrical terminals of the magnet coil, and does not pass significant current during normal magnet operation. When rapid shutdown is required, the bypass wire is cooled below its critical temperature, adding a superconducting current path in parallel with the magnet coil. A portion of the coil is then heated above its critical temperature, interrupting current flow through the coil. Hot spots near the coil leads are mitigated through the use of a conductive structure, such as copper cladding, that carries away excess heat due to the quench. This heat may be deposited in a resistive matrix, such as a steel plate, over a duration of seconds and without compromising other magnet design parameters.
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公开(公告)号：US11614643B2
公开(公告)日：2023-03-28
申请号：US16876477
申请日：2020-05-18
摘要： A reflective spatial light modulator (SLM) made of an electro-optic material in a one-sided Fabry-Perot resonator can provide phase and/or amplitude modulation with fine spatial resolution at speeds over a Gigahertz. The light is confined laterally within the electro-optic material/resonator layer stack with microlenses, index perturbations, or by patterning the layer stack into a two-dimensional (2D) array of vertically oriented micropillars. Alternatively, a photonic crystal guided mode resonator can vertically and laterally confine the resonant mode. In phase-only modulation mode, each SLM pixel can produce a π phase shift under a bias voltage below 10 V, while maintaining nearly constant reflection amplitude. This high-speed SLM can be used in a wide range of new applications, from fully tunable metasurfaces to optical computing accelerators, high-speed interconnects, true 2D phased array beam steering, beam forming, or quantum computing with cold atom arrays.
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公开(公告)号：US11611423B2
公开(公告)日：2023-03-21
申请号：US17186894
申请日：2021-02-26
发明人： Kenneth E. Kolodziej
摘要： A system for canceling signal interference (SI) includes a transceiver configured to concurrently transmit signals and receive signals within a single frequency band, which causes signal interference between the transmitted and received signals. The SI canceller is configured to use a set of cancellation coefficients to generate a cancellation signal to mitigate the SI. The system is configured to iteratively change the cancellation coefficients by a step factor to produce tuned cancellation coefficients. The step factor is determined by a cancellation error gradient and one or more of: a tunable coefficient step aggressiveness factor; and a time-based forgetting factor; and cause the SI canceller to cancel the SI using the tuned cancellation coefficients.
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