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    Activation specific inhibitors of nf-kb and method of treating inflammatory processes in cardio-vascular diseases
    2.
    发明申请
    Activation specific inhibitors of nf-kb and method of treating inflammatory processes in cardio-vascular diseases 审中-公开
    nf-kb的活化特异性抑制剂和治疗心血管疾病中的炎症过程的方法

    公开(公告)号：US20060194819A1

    公开(公告)日：2006-08-31

    申请号：US10551143

    申请日：2004-03-26

    申请人： Götz Munch ,  Hans-Peter Holthoff ,  Martin Ungerer ,  Bernd Kramer ,  Matthias Dormeyer

    发明人： Götz Munch ,  Hans-Peter Holthoff ,  Martin Ungerer ,  Bernd Kramer ,  Matthias Dormeyer

    IPC分类号： A61K31/519 ,  C07D498/02

    CPC分类号： A61K31/519

    摘要： A 5H-Thiazolo[3,2]pyrimidine derivative or a salt thereof for use as a medicine, which is represented by the following formula (A): wherein R represents an optionally substituted phenyl or pyridyl group; R4 represents a hydroxyl group, an amino group, a straight chain or branched alkoxy group, a straight chain or branched alkyl group, a cycloalkyloxy group, an alkylamino group, a cycloalkylamino group, a dialkylamino group, R5 represents a hydrogen atom, a straight chain or branched alkyl group, R6 and R7, which may be the same or different represent a hydrogen atom, a halogen atom, a straight chain or branched alkyl group, a straight chain or branched alkoxy group, a straight chain or branched alkenyl group, a cycloalkyl group, an aryl group, X, Y, and Z which may be same or different represent a hydrogen atom, a halogen atom, a carboxyl group a nitro group, a cyano group, an alkyl group, an alkoxy group or an acyl group.

    摘要翻译： 用作药物的5H-噻唑并[3,2]嘧啶衍生物或其盐，其由下式（A）表示：其中R表示任选取代的苯基或吡啶基; R4表示羟基，氨基，直链或支链烷氧基，直链或支链烷基，环烷基氧基，烷基氨基，环烷基氨基，二烷基氨基，R 5 >表示氢原子，直链或支链烷基，R 6和R 7可以相同或不同，表示氢原子，卤素原子， 直链或支链烷基，直链或支链烷氧基，直链或支链烯基，环烷基，芳基，X，Y和Z可以相同或不同，表示氢原子， 卤素原子，羧基，硝基，氰基，烷基，烷氧基或酰基。