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    Alpha-galactosyl ceramide analogs and their use as immunotherapies
    5.
    发明授权
    Alpha-galactosyl ceramide analogs and their use as immunotherapies 有权
    α-半乳糖基神经酰胺类似物及其作为免疫治疗的用途

    公开(公告)号：US07928077B2

    公开(公告)日：2011-04-19

    申请号：US12218082

    申请日：2008-07-11

    申请人： Chi-Huey Wong ,  Alice Yu ,  Ya-Jen Chang ,  Kun-Hsien Lin ,  Jung-Tung Hung

    发明人： Chi-Huey Wong ,  Alice Yu ,  Ya-Jen Chang ,  Kun-Hsien Lin ,  Jung-Tung Hung

    IPC分类号： A61K31/7032 ,  C07H15/18

    CPC分类号： C07H15/18 ,  A61K31/7034 ,  A61K39/0011 ,  A61K2039/57 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/48

    摘要： The present disclosure relates to synthetic alpha-galactosyl ceramide (α-GalCer) analogs, and their use as immunotherapies. In one aspect. a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1: or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.

    摘要翻译： 本公开涉及合成的α-半乳糖神经酰胺（α-GalCer）类似物，以及它们作为免疫治疗的用途。 在一个方面 在受试者中激活细胞因子应答的方法包括向受试者施用有效量的化合物，其中受试者具有包括细胞群的适应性免疫系统，所述群体包括至少一种淋巴细胞和至少一种抗原 - 呈递细胞，并且其中所述化合物由式1的结构表示：或其药学上可接受的盐; 在化合物和抗原呈递细胞之间形成复合物，其中复合物的形成导致淋巴细胞上受体的活化; 并激活淋巴细胞以产生细胞因子反应。

    GLOBO H AND RELATED ANTI-CANCER VACCINES WITH NOVEL GLYCOLIPID ADJUVANTS
    6.
    发明申请
    GLOBO H AND RELATED ANTI-CANCER VACCINES WITH NOVEL GLYCOLIPID ADJUVANTS 有权
    GLOBO H和相关的抗癌药物与新型甘露醇辅剂

    公开(公告)号：US20100136042A1

    公开(公告)日：2010-06-03

    申请号：US12537129

    申请日：2009-08-06

    申请人： Chi-Huey Wong ,  Chung-Yi Wu ,  Alice Yu ,  John Yu

    发明人： Chi-Huey Wong ,  Chung-Yi Wu ,  Alice Yu ,  John Yu

    IPC分类号： A61K39/385 ,  A61P35/04

    CPC分类号： A61K39/0011 ,  A61K2039/55511 ,  A61K2039/6037 ,  A61K2039/6081 ,  A61K2039/627 ,  C12N15/1137 ,  C12N2310/14

    摘要： Immunogenic compositions, cancer vaccines and methods for treating cancer are provided. Compositions comprising: (a) a glycan such as Globo H or an immunogenic fragment thereof, wherein the glycan is conjugated with a carrier protein by a linker such as para-nitrophenyl; and (b) an adjuvant comprising glycolipid capable of binding CD1d on a dendritic cell, such as an α-galactosyl-ceramide derivative, wherein the immunogenic composition induces an immune response that induces a higher relative level of IgG isotype antibodies as compared to IgM isotype antibodies, are provided. Immunogenic compositions comprising the carrier protein diphtheria toxin cross-reacting material 197 (DT-CRM197) and the adjuvant C34 are provided. Antibodies generated by immunogenic compositions disclosed herein further neutralize at least one of the antigens Globo H, stage-specific embryonic antigen-3 (SSEA-3) and stage-specific embryonic antigen-4 (SSEA-4). Therapeutics against breast cancer stem cells comprising immunogenic compositions comprising Globo H, SSEA-3 or SSEA-4 conjugated with DT-CRM197.

    摘要翻译： 提供免疫原性组合物，癌症疫苗和治疗癌症的方法。 组合物，其包含：（a）聚糖如Globo H或其免疫原性片段，其中所述聚糖通过诸如对硝基苯基之类的接头与载体蛋白缀合; 和（b）包含能够结合树突状细胞上的CD1d的糖脂如α-半乳糖基 - 神经酰胺衍生物的佐剂，其中所述免疫原性组合物诱导与IgM同种型相比诱导更高相对水平的IgG同种型抗体的免疫应答 抗体。 提供了包含载体蛋白质白喉毒素交叉反应材料197（DT-CRM197）和佐剂C34的免疫原性组合物。 由本文公开的免疫原性组合物产生的抗体进一步中和至少一种抗原Globo H，阶段特异性胚胎抗原-3（SSEA-3）和阶段特异性胚胎抗原-4（SSEA-4）。 包括含有与DT-CRM197缀合的Globo H，SSEA-3或SSEA-4的免疫原性组合物的乳腺癌干细胞的治疗剂。

    Alpha-galactosyl ceramide analogs and their use as immunotherapies
    7.
    发明申请
    Alpha-galactosyl ceramide analogs and their use as immunotherapies 有权
    α-半乳糖基神经酰胺类似物及其作为免疫治疗的用途

    公开(公告)号：US20100008954A1

    公开(公告)日：2010-01-14

    申请号：US12218082

    申请日：2008-07-11

    申请人： Chi-Huey Wong ,  Alice Yu ,  Ya-Jen Chang ,  Kun-Hsien Lin ,  Jung-Tung Hung

    发明人： Chi-Huey Wong ,  Alice Yu ,  Ya-Jen Chang ,  Kun-Hsien Lin ,  Jung-Tung Hung

    IPC分类号： A61K39/02 ,  A61K31/7034 ,  C07H15/18 ,  A61K39/00

    CPC分类号： C07H15/18 ,  A61K31/7034 ,  A61K39/0011 ,  A61K2039/57 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/48

    摘要： The present disclosure relates to synthetic alpha-galactosyl ceramide (α-GalCer) analogs, and their use as immunotherapies. In one aspect. a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1: or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.

    摘要翻译： 本公开涉及合成的α-半乳糖神经酰胺（α-GalCer）类似物，以及它们作为免疫治疗的用途。 在一个方面 在受试者中激活细胞因子应答的方法包括向受试者施用有效量的化合物，其中受试者具有包括细胞群的适应性免疫系统，所述群体包括至少一种淋巴细胞和至少一种抗原 - 呈递细胞，并且其中所述化合物由式1的结构表示：或其药学上可接受的盐; 在化合物和抗原呈递细胞之间形成复合物，其中复合物的形成导致淋巴细胞上受体的活化; 并激活淋巴细胞以产生细胞因子反应。

    Alpha-galactosyl ceramide analogs and their use as immunotherapies
    8.
    发明申请
    Alpha-galactosyl ceramide analogs and their use as immunotherapies 审中-公开
    α-半乳糖基神经酰胺类似物及其作为免疫治疗的用途

    公开(公告)号：US20080260774A1

    公开(公告)日：2008-10-23

    申请号：US12082751

    申请日：2008-04-14

    申请人： Chi-Huey Wong ,  Alice Yu ,  Ya-Jen Chang

    发明人： Chi-Huey Wong ,  Alice Yu ,  Ya-Jen Chang

    IPC分类号： A61K39/00 ,  A61K31/35 ,  C07D315/00 ,  A61P37/00

    CPC分类号： C07H15/26 ,  A61K8/68 ,  A61K2800/91 ,  A61Q17/005 ,  C07H15/06 ,  C07H15/18

    摘要： The present disclosure relates to synthetic alpha-galactosyl ceramide (α-GalCer) analogs, and their use as immunotherapies. In one aspect, a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1: wherein, n is 0 to 25; X is selected from O and S; R1 is selected from H, CH3, and phenyl, where phenyl is optionally substituted with H, OH, OCH3, F, CF3, phenyl, phenyl-F, C1-C6 alkyl, or C2-C6 branched alkyl; R2 is selected from OH and H; R3 is selected from C1-C15 alkyl, and phenyl, where phenyl is optionally substituted with H, OH, OCH3, F, CF3, phenyl, C1-C6 alkyl, or C2-C6 branched alkyl; R4 is selected from OH, OSO3H, OSO3Na, and OSO3K; and R5 is selected from CH2OH and CO2H; or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.

    摘要翻译： 本公开涉及合成的α-半乳糖神经酰胺（α-GalCer）类似物，以及它们作为免疫治疗的用途。 一方面，在受试者中激活细胞因子应答的方法包括向受试者施用有效量的化合物，其中所述受试者具有包括细胞群的适应性免疫系统，所述群体包括至少一种淋巴细胞，并且在 至少一种抗原呈递细胞，并且其中所述化合物由式1的结构表示：其中n为0至25; X选自O和S; R 1选自H，CH 3和苯基，其中苯基任选被H，OH，OCH 3，F，CF 苯基，苯基-F，C 1 -C 6烷基或C 2 -C 6亚烷基 >支链烷基; R 2选自OH和H; R 3选自C 1 -C 15烷基和苯基，其中苯基任选被H，OH，OCH 3取代， 3，F，CF 3，苯基，C 1 -C 6烷基或C 2 H 2 -C 6 -C 6支链烷基; R 4选自OH，OSO 3 H，OSO 3 Na和OSO 3 K; 和R 5选自CH 2 OH和CO 2 H; 或其药学上可接受的盐; 在化合物和抗原呈递细胞之间形成复合物，其中复合物的形成导致淋巴细胞上受体的活化; 并激活淋巴细胞以产生细胞因子反应。

    Anti-Viral Effect of an Extract of Ganoderma Lucidum
    9.
    发明申请
    Anti-Viral Effect of an Extract of Ganoderma Lucidum 审中-公开
    灵芝提取物的抗病毒作用

    公开(公告)号：US20080214442A1

    公开(公告)日：2008-09-04

    申请号：US11859729

    申请日：2007-09-21

    申请人： Alice Yu ,  Chi-Huey Wong ,  Jia Tsrong Jan ,  Y.-S. Edmond Cheng

    发明人： Alice Yu ,  Chi-Huey Wong ,  Jia Tsrong Jan ,  Y.-S. Edmond Cheng

    IPC分类号： A61K38/16 ,  C07K14/00 ,  A61P31/12

    CPC分类号： C07K2/00 ,  A61K36/074 ,  A61K38/00

    摘要： Compositions and methods for the treatment viral infections in organisms, particularly flu virus. The methods and compositions of the disclosure involve the administration to mammals and immune cells of a fucose-containing glycoprotein fraction from Reishi. An extract of G. lucidum induces immune responses that are shown to induce increase survivability in mice injected with lethal does of influenza virus. The effect is increased when the G. lucidum extract is dosed prior to injection of the lethal dose of influenza virus.

    摘要翻译： 用于治疗生物体中的病毒感染的组合物和方法，特别是流感病毒。 本公开的方法和组合物涉及向来自Reishi的含岩藻糖的糖蛋白部分的哺乳动物和免疫细胞施用。 灵芝的提取物诱导免疫应答，显示其在注射致死性流感病毒的小鼠中诱导增加的存活能力。 当在注射致死剂量的流感病毒之前配制灵芝提取物时，效果增加。