公开(公告)号：US07005136B2

公开(公告)日：2006-02-28

申请号：US10112554

申请日：2002-03-29

Applicant: Aruna Nathan ,  Mora C. Melican ,  Kelly R. Brown ,  Mark C. Zimmerman

Inventor： Aruna Nathan ,  Mora C. Melican ,  Kelly R. Brown ,  Mark C. Zimmerman

IPC: A61F2/00

CPC classification number: A61L27/18 ,  A61L27/48 ,  A61L2400/06 ,  A61L2430/02 ,  C08L89/00

Abstract: The present invention is directed to bone replacement devices and compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry.

公开(公告)号：US06306424B1

公开(公告)日：2001-10-23

申请号：US09469118

申请日：1999-12-21

Applicant: Murty N. Vyakarnam ,  Mark C. Zimmerman ,  Angelo George Scopelianos ,  Iksoo Chun ,  Mora C. Melican ,  Clairene A. Bazilio ,  Mark B. Roller ,  David V. Gorky

Inventor： Murty N. Vyakarnam ,  Mark C. Zimmerman ,  Angelo George Scopelianos ,  Iksoo Chun ,  Mora C. Melican ,  Clairene A. Bazilio ,  Mark B. Roller ,  David V. Gorky

IPC: A61F200

CPC classification number: A61L27/3852 ,  A61F2/06 ,  A61F2/28 ,  A61F2/30756 ,  A61F2002/30004 ,  A61F2002/30011 ,  A61F2002/30014 ,  A61F2002/30018 ,  A61F2002/30032 ,  A61F2002/30062 ,  A61F2002/30677 ,  A61F2002/30766 ,  A61F2002/30784 ,  A61F2002/3092 ,  A61F2210/0004 ,  A61F2250/0014 ,  A61F2250/0018 ,  A61F2250/0023 ,  A61F2250/0029 ,  A61F2250/003 ,  A61F2250/0067 ,  A61L27/18 ,  A61L27/3817 ,  A61L27/3843 ,  A61L27/56 ,  A61L31/06 ,  A61L31/146 ,  Y10S514/945 ,  Y10T428/24132 ,  Y10T428/24149 ,  Y10T428/24165 ,  Y10T428/24322 ,  Y10T428/24793 ,  Y10T428/249953 ,  Y10T428/249955 ,  Y10T428/249958 ,  Y10T428/249986 ,  Y10T428/268 ,  Y10T428/31786 ,  C08L67/04

Abstract: The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.

Abstract translation: 本专利描述了一种生物相容性复合材料，其由连接到通过一个或多个方向具有组成和/或微结构的梯度的三维相互连接的开孔多孔泡沫的第一纤维层制成。 这些复合材料可以由可吸收和生物相容性聚合物的混合物制成。 这些生物相容性复合材料特别适用于组织工程应用，可以设计为模拟组织转变或界面区域。

公开(公告)号：US08366787B2

公开(公告)日：2013-02-05

申请号：US10172347

申请日：2002-06-14

Applicant: Laura Jean Brown ,  Iksoo Chun ,  Sridevi Dhanaraj ,  Prasanna Malaviya ,  Mora C. Melican ,  Alireza Rezania ,  Li Zhang

Inventor： Laura Jean Brown ,  Iksoo Chun ,  Sridevi Dhanaraj ,  Prasanna Malaviya ,  Mora C. Melican ,  Alireza Rezania ,  Li Zhang

IPC: A61F2/02

CPC classification number: A61F2/0063 ,  A61B2017/0495 ,  A61F2/08 ,  A61L27/18 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3641 ,  A61L27/3683 ,  A61L27/40 ,  C08L67/04

Abstract: A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a three-dimensional synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the three-dimensional synthetic portion comprises a foam or a three-dimensional mesh, textile, or felt.

Abstract translation: 提供了用于软组织附着，加强和/或重建的生物假体装置。 该装置包括天然存在的细胞外基质部分和三维合成部分。 在所示实施例中，天然存在的细胞外基质部分包括小肠粘膜下层，并且三维合成部分包括泡沫或三维网，织物或毡。

公开(公告)号：US07192604B2

公开(公告)日：2007-03-20

申请号：US10020021

申请日：2001-12-07

Applicant: Kelly R. Brown ,  Iksoo Chun ,  Joseph J. Hammer ,  Victor F. Janas ,  Jennifer Mandanas ,  Mora C Melican ,  Alireza Rezania ,  Mark C. Zimmerman

Inventor： Kelly R. Brown ,  Iksoo Chun ,  Joseph J. Hammer ,  Victor F. Janas ,  Jennifer Mandanas ,  Mora C Melican ,  Alireza Rezania ,  Mark C. Zimmerman

IPC: A61K9/70 ,  A61L15/64

CPC classification number: A61L27/58 ,  A61L27/48 ,  C08L67/04

Abstract: An implantable biodegradable device is disclosed containing a fibrous matrix, the fibrous matrix being constructed from fibers A and fibers B, wherein fibers A biodegrade faster than fibers B, fibers A and fibers B are present in relative amounts and are organized such that the fibrous matrix is provided with properties useful in repair and/or regeneration of mammalian tissue.

Abstract translation: 公开了一种可植入的可生物降解的装置，其包含纤维基质，该纤维基质由纤维A和纤维B构成，其中纤维A比纤维B，纤维A和纤维B生物降解得更快，并以组织使纤维基质 具有可用于哺乳动物组织的修复和/或再生的性质。

公开(公告)号：US07160333B2

公开(公告)日：2007-01-09

申请号：US10656345

申请日：2003-09-05

Applicant: Pamela L. Plouhar ,  Prasanna Malaviya ,  Joe W. Ferguson ,  Mora C. Melican

Inventor： Pamela L. Plouhar ,  Prasanna Malaviya ,  Joe W. Ferguson ,  Mora C. Melican

IPC: A61F2/02

CPC classification number: A61L27/3683 ,  A61F2/0063 ,  A61F2/08 ,  A61L27/18 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3641 ,  A61L27/40 ,  C08L67/04

Abstract: Bioprosthetic devices for soft tissue attachment, reinforcement, or construction are provided. The devices comprise a sheet of naturally occurring extracellular matrix and a sheet of synthetic mesh coupled to the naturally occurring extracellular matrix portion.

Abstract translation: 提供了用于软组织附着，加强或构造的生物假体装置。 该装置包括一片天然存在的细胞外基质和与天然存在的细胞外基质部分相连的一片合成网。

公开(公告)号：US06787179B2

公开(公告)日：2004-09-07

申请号：US09897657

申请日：2001-06-29

Applicant: Debra A. Timm ,  Henry K. Hui ,  Mark B. Roller ,  Mora C. Melican ,  Syed Hossainy

Inventor： Debra A. Timm ,  Henry K. Hui ,  Mark B. Roller ,  Mora C. Melican ,  Syed Hossainy

IPC: A61L2700

CPC classification number: A61L27/34 ,  A61L2/14 ,  A61L29/085 ,  A61L31/10 ,  A61M25/0009 ,  A61M25/0045

Abstract: The invention provides a method for single-step surface modification, grafting and sterilization for bio-active coating on materials and biomaterials used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombogenic and biocompatible surfaces. Other relevant device examples may include heparin or urokinase coated stents to reduce clotting and restenosis, dental or ophthamological implants. These materials may be comprised of a variety of polymeric compositions such as, polyurethane, polyester, polytetrafluoroethylene, polyethylene, polymethylmethacrylate, polyHEMA, polyvinyl alcohol, polysiloxanes, polylactic or glycolic acids, polycaprolactone, etc. The substrates can also be metal, ceramics or biologically derived materials.

Abstract translation: 本发明提供了用于医疗装置（例如导管，组织工程支架或药物递送载体材料）中的材料和生物材料上的生物活性涂层的单步表面改性，接枝和灭菌的方法。 这可以包括可以从改进的抗血栓形成和生物相容性表面受益的任何医疗装置或植入物。 其他相关装置实例可包括用于减少凝血和再狭窄的肝素或尿激酶涂层的支架，牙科或眼科植入物。 这些材料可以由多种聚合物组合物，如聚氨酯，聚酯，聚四氟乙烯，聚乙烯，聚甲基丙烯酸甲酯，聚乙烯醇，聚乙烯醇，聚硅氧烷，聚乳酸或乙醇酸，聚己内酯等组成。基材也可以是金属，陶瓷或生物学 衍生材料。

公开(公告)号：US06638312B2

公开(公告)日：2003-10-28

申请号：US09918116

申请日：2001-07-30

Applicant: Pamela L. Plouhar ,  Prasanna Malaviya ,  Joe W. Ferguson ,  Mora C. Melican

Inventor： Pamela L. Plouhar ,  Prasanna Malaviya ,  Joe W. Ferguson ,  Mora C. Melican

IPC: A61F202

CPC classification number: A61L27/3683 ,  A61F2/0063 ,  A61F2/08 ,  A61L27/18 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3641 ,  A61L27/40 ,  C08L67/04

Abstract: A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the synthetic portion comprises one or more rows of fibers or mesh positioned between layers of the small intestine submucosa.

公开(公告)号：US07914808B2

公开(公告)日：2011-03-29

申请号：US10195341

申请日：2002-07-15

Applicant: Prasanna Malaviya ,  Mora C. Melican ,  Alireza Rezania ,  Iksoo Chun

Inventor： Prasanna Malaviya ,  Mora C. Melican ,  Alireza Rezania ,  Iksoo Chun

IPC: A61F2/00

CPC classification number: A61L27/3691 ,  A61B17/0401 ,  A61B17/06166 ,  A61B17/064 ,  A61B17/0642 ,  A61B2017/00004 ,  A61B2017/0475 ,  A61B2017/06057 ,  A61B2017/0646 ,  A61F2/0063 ,  A61F2/08 ,  A61F2/0811 ,  A61F2/28 ,  A61F2/30749 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/30965 ,  A61F2/3872 ,  A61F2/442 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/30032 ,  A61F2002/30062 ,  A61F2002/30131 ,  A61F2002/30153 ,  A61F2002/30199 ,  A61F2002/3021 ,  A61F2002/30217 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30233 ,  A61F2002/30261 ,  A61F2002/30281 ,  A61F2002/30293 ,  A61F2002/30294 ,  A61F2002/30429 ,  A61F2002/30611 ,  A61F2002/30677 ,  A61F2002/30678 ,  A61F2002/30751 ,  A61F2002/30764 ,  A61F2002/30766 ,  A61F2002/30785 ,  A61F2002/30841 ,  A61F2002/30848 ,  A61F2002/30878 ,  A61F2002/30891 ,  A61F2002/30892 ,  A61F2002/30914 ,  A61F2002/30957 ,  A61F2002/3096 ,  A61F2002/30971 ,  A61F2002/30975 ,  A61F2210/0004 ,  A61F2220/0025 ,  A61F2230/0013 ,  A61F2230/0019 ,  A61F2230/0063 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2230/0086 ,  A61F2230/0091 ,  A61F2240/001 ,  A61F2240/004 ,  A61F2250/003 ,  A61F2250/0063 ,  A61F2250/0067 ,  A61F2310/00365 ,  A61L27/18 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3683 ,  A61L27/56 ,  A61L31/005 ,  A61L2430/06 ,  C08L67/04

Abstract: Methods of making a hybrid biologic/synthetic scaffold for repairing damaged or diseased tissue are provided. The methods include the step of suspending pieces of an extracellular matrix material in a liquid to form a slurry, and coating a synthetic mat with the slurry, or mixing or layering the slurry with a synthetic polymer solution. The liquid is subsequently driven off so as to form a foam. Porous implantable scaffolds fabricated by such a method are also disclosed.

Abstract translation: 提供了用于修复损伤或患病组织的混合生物/合成支架的方法。 所述方法包括将细胞外基质材料块悬浮在液体中以形成浆料，并用浆料涂覆合成垫，或者用合成聚合物溶液混合或分层浆料的步骤。 随后将液体排出以形成泡沫。 还公开了通过这种方法制造的多孔可植入支架。

公开(公告)号：US07674408B2

公开(公告)日：2010-03-09

申请号：US11230220

申请日：2005-09-19

Applicant: Kelly R. Brown ,  Mora C. Melican ,  Iksoo Chun

Inventor： Kelly R. Brown ,  Mora C. Melican ,  Iksoo Chun

IPC: C08J9/26

CPC classification number: A61L31/146 ,  A61F2/0077 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/30767 ,  A61F2002/0086 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30199 ,  A61F2002/30677 ,  A61F2002/30762 ,  A61F2002/30766 ,  A61F2002/30785 ,  A61F2002/30787 ,  A61F2002/3093 ,  A61F2002/4648 ,  A61F2210/0004 ,  A61F2230/0063 ,  A61F2250/0067 ,  A61L27/18 ,  A61L27/56 ,  A61L31/06 ,  C08L67/04

Abstract: The present invention provides a biomedical, biocompatible, polymeric foam scaffold suitable for use in the repair and regeneration of tissue and which contains located therein a network of, branched channels that are effective to encourage and facilitate vascularization and tissue growth within the scaffold and to methods for making such biomedical scaffolds.

Abstract translation: 本发明提供了适用于组织修复和再生的生物医学，生物相容的聚合物泡沫支架，其包含有效促进和促进支架内的血管形成和组织生长以及方法的分支通道网络 用于制造这样的生物医学支架。

公开(公告)号：US07112417B2

公开(公告)日：2006-09-26

申请号：US09938364

申请日：2001-08-24

Applicant: Murty N. Vyakarnam ,  Mark C. Zimmerman ,  Angelo George Scopelianos ,  Iksoo Chun ,  Mora C. Melican ,  Clairene A. Bazilio ,  Mark B. Roller ,  David V. Gorky

Inventor： Murty N. Vyakarnam ,  Mark C. Zimmerman ,  Angelo George Scopelianos ,  Iksoo Chun ,  Mora C. Melican ,  Clairene A. Bazilio ,  Mark B. Roller ,  David V. Gorky

IPC: C12P1/00 ,  A01N63/00 ,  A61F2/00 ,  B32B5/14

CPC classification number: A61L27/3852 ,  A61F2/06 ,  A61F2/28 ,  A61F2/30756 ,  A61F2002/30004 ,  A61F2002/30011 ,  A61F2002/30014 ,  A61F2002/30018 ,  A61F2002/30032 ,  A61F2002/30062 ,  A61F2002/30677 ,  A61F2002/30766 ,  A61F2002/30784 ,  A61F2002/3092 ,  A61F2210/0004 ,  A61F2250/0014 ,  A61F2250/0018 ,  A61F2250/0023 ,  A61F2250/0029 ,  A61F2250/003 ,  A61F2250/0067 ,  A61L27/18 ,  A61L27/3817 ,  A61L27/3843 ,  A61L27/56 ,  A61L31/06 ,  A61L31/146 ,  Y10S514/945 ,  Y10T428/24132 ,  Y10T428/24149 ,  Y10T428/24165 ,  Y10T428/24322 ,  Y10T428/24793 ,  Y10T428/249953 ,  Y10T428/249955 ,  Y10T428/249958 ,  Y10T428/249986 ,  Y10T428/268 ,  Y10T428/31786 ,  C08L67/04

Abstract: The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.