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    Papaya Mosaic Virus-Based Vaccines for Influenza
    2.
    发明申请
    Papaya Mosaic Virus-Based Vaccines for Influenza 审中-公开
    木瓜花叶病毒型流感疫苗

    公开(公告)号：US20100111996A1

    公开(公告)日：2010-05-06

    申请号：US12515265

    申请日：2007-11-15

    申请人： Denis Leclerc

    发明人： Denis Leclerc

    IPC分类号： A61K39/295 ,  C07K14/11 ,  C07H21/04 ,  A61P37/04 ,  A61P31/16

    CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/55516 ,  A61K2039/6075 ,  A61K2039/64 ,  C07K14/005 ,  C07K2319/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/00022 ,  C12N2770/00023 ,  C12N2770/00043

    摘要： An antigen-presenting system (APS) comprising one or more antigens in combination with a papaya mosaic virus (PapMV) or a virus like particle (VLP) derived from papaya mosaic virus is provided. Specifically an APS comprising one or more influenza virus antigens is provided. The APS can be used, for example, as a vaccine against influenza. The one or more antigens comprised by the APS can be conjugated to a coat protein of the PapMV or PaPMV VLP, or they may be non-conjugated (i.e. separate from the PapMV or PapMV VLP). Conjugation can be, for example, by genetic fusion with the coat protein, or binding via covalent, non-covalent or affinity means.

    摘要翻译： 提供了包含与番木瓜花叶病毒（PapMV）或源自番木瓜花叶病毒的病毒样颗粒（VLP））组合的一种或多种抗原的抗原呈递系统（APS）。 具体地提供了包含一种或多种流感病毒抗原的APS。 APS可以用作例如针对流感的疫苗。 由APS包含的一种或多种抗原可以与PapMV或PaPMV VLP的外壳蛋白缀合，或者它们可以是非共轭的（即与PapMV或PapMV VLP分离）。 缀合可以是例如通过与外壳蛋白的遗传融合，或通过共价，非共价或亲和手段结合。

    Saturable light absorber structure and a device incorporating the structure for regenerating a wavelength division multiplexed signal
    4.
    发明授权
    Saturable light absorber structure and a device incorporating the structure for regenerating a wavelength division multiplexed signal 失效
    可饱和光吸收体结构和结合有再生波分复用信号的结构的装置

    公开(公告)号：US07158725B2

    公开(公告)日：2007-01-02

    申请号：US10207887

    申请日：2002-07-31

    申请人： Alexandre Shen ,  Denis Leclerc

    发明人： Alexandre Shen ,  Denis Leclerc

    IPC分类号： H04B10/16 ,  H04J14/02

    CPC分类号： G02F1/3523 ,  B82Y20/00 ,  G02B2006/12126 ,  G02F1/01725 ,  G02F2203/15

    摘要： The invention relates to a saturable light absorber adapted to receive different focused spectral components, wherein the structure of said saturable light absorber comprises microcavities integrated into a substrate and each associated with a respective one of said spectral components, each microcavity comprising a saturable absorber layer delimited by a top reflector and a bottom reflector and being disposed and having dimensions such that it receives only the focused spectral component associated with it.

    摘要翻译： 本发明涉及适于接收不同聚焦光谱分量的可饱和光吸收体，其中所述可饱和光吸收体的结构包括集成到衬底中的每一个与相应的所述光谱分量相关联的微腔，每个微腔包括限定的饱和吸收层 通过顶部反射器和底部反射器设置并具有使其仅接收与其相关联的聚焦光谱分量的尺寸。

    Positive feedback device for processing an optical signal
    7.
    发明授权
    Positive feedback device for processing an optical signal 失效
    用于处理光信号的正反馈装置

    公开(公告)号：US5265111A

    公开(公告)日：1993-11-23

    申请号：US841710

    申请日：1992-02-26

    申请人： Jose Chesnoy ,  Jean-Michel Gabriagues ,  Denis Leclerc

    发明人： Jose Chesnoy ,  Jean-Michel Gabriagues ,  Denis Leclerc

    IPC分类号： H04B10/04 ,  G02F3/02 ,  H01S5/06 ,  H01S5/062 ,  H01S5/068 ,  H04B10/06 ,  H04B10/14 ,  H01S3/10

    CPC分类号： H01S5/068 ,  H01S5/0601 ,  G02F3/026 ,  H01S5/06223

    摘要： A photodiode (26) receives an optical input signal (P1) and an internal optical signal (P2) and supplies in response thereto an internal electrical signal (I2), which in turn controls a laser (4) which effects amplification and supplies the internal optical signal and an output signal (P3). The feedback loop formed by this photodiode and laser leads to a strong non-linearity in the variation of the output signal as a function of the input signal. The invention is useful especially in optical fiber telecommunications systems.

    摘要翻译： 光电二极管（26）接收光输入信号（P1）和内部光信号（P2），并响应于内部电信号（I2）供应光电输入信号（I2），内部电信号（I2）进而控制实现放大的内部激光器（4） 光信号和输出信号（P3）。 由该光电二极管和激光器形成的反馈环路作为输入信号的函数导致输出信号变化的强非线性。 本发明特别适用于光纤通信系统。

    Condition control system, device and process for message transmission
    8.
    发明授权
    Condition control system, device and process for message transmission 有权
    条件控制系统，消息传输的设备和过程

    公开(公告)号：US08117253B2

    公开(公告)日：2012-02-14

    申请号：US11574977

    申请日：2007-03-02

    申请人： Julien Robinson ,  Mathieu Boussard ,  Denis Leclerc ,  Fabien Bataille ,  Abdelkrim Hebbar ,  Bruno Mongazon-Cazavet

    发明人： Julien Robinson ,  Mathieu Boussard ,  Denis Leclerc ,  Fabien Bataille ,  Abdelkrim Hebbar ,  Bruno Mongazon-Cazavet

    IPC分类号： G06F15/16 ,  H04W4/00 ,  H04Q9/00 ,  G06Q10/00

    CPC分类号： G06Q50/22 ,  H04L51/14 ,  H04W4/12

    摘要： The invention concerns in particular a system comprising: a first terminal (1); a second terminal (21 or 22 or 23); at least a first messaging system (31 or 32 or 33) able to transmit, to the second terminal, at least the message body of a message (10) from the first terminal; at least one device (4) controlling at least one condition (11), at least once, the said control device allowing the first messaging system to transmit to the second terminal at least the message body of the said message if the condition control result is positive, the said control device preventing the first messaging system from transmitting to the second terminal at least the message body of the said message if the condition control is negative, at least during the time for which the condition control result remains negative; at least one data server (51 or 52 or 53 or 54) external to the control device; at least one link providing communication through the Internet between on the hand the external server, or at least one of the external servers, and on the other hand the control device, the condition control device being designed to: store a message sent by the first terminal; receive at least one item of information from at least one external server; at least partially perform the condition control relating to the said message stored by means of the information received from the external server.

    摘要翻译： 本发明尤其涉及一种系统，包括：第一终端（1）; 第二终端（21或22或23）; 至少第一消息系统（31或32或33）能够从所述第一终端向所述第二终端至少传送消息（10）的消息主体; 至少一个设备（4）控制至少一个条件（11）至少一次所述控制设备，允许所述第一消息系统至少将所述消息的消息体发送到所述第二终端，如果所述条件控制结果是 肯定的是，至少在条件控制结果保持为负的时间内，如果条件控制是否定的，则所述控制设备防止第一消息传送系统至少向所述消息的消息体发送至第二终端; 在所述控制设备外部的至少一个数据服务器（51或52或53或54）; 至少一个链路，通过互联网提供在外部服务器或外部服务器之间的至少一个上的通信，另一方面，控制设备，条件控制设备被设计为：存储由第一 终奌站; 从至少一个外部服务器接收至少一个信息项; 至少部分地通过从外部服务器接收的信息来执行与所述消息有关的条件控制。

    Method of manufacturing an integrated optical component comprising a thick waveguide coupled to a thin waveguide
    10.
    发明授权
    Method of manufacturing an integrated optical component comprising a thick waveguide coupled to a thin waveguide 有权
    制造集成光学部件的方法，其包括耦合到薄波导的厚波导

    公开(公告)号：US6040246A

    公开(公告)日：2000-03-21

    申请号：US148480

    申请日：1998-09-08

    申请人： Leon Goldstein ,  Denis Leclerc ,  Beatrice Dagens

    发明人： Leon Goldstein ,  Denis Leclerc ,  Beatrice Dagens

    IPC分类号： G02B6/12 ,  G02B6/122 ,  G02B6/26 ,  H01S5/026 ,  H01L21/02 ,  G02B6/13 ,  G02B6/136 ,  H01L21/20 ,  H01L21/3065

    CPC分类号： G02B6/26 ,  G02B6/12004 ,  G02B6/1228 ,  H01S5/026

    摘要： To form an integrated optical component comprising a thick waveguide coupled to a thin waveguide, the method consists in:depositing a first guiding layer of said thick waveguide on a substrate;locally etching said first guiding layer over a portion allocated both to a coupling interface and to the thin waveguide;depositing a second guiding layer on the first guiding layer and on the locally etched portion so as to form said thick waveguide in a manner such that it has a maximum thickness in a first zone, a graded-thickness section in a second zone, and a reduced-thickness section in a third zone;locally etching the second guiding layer over a portion of the third zone, said portion being allocated to the thin waveguide; anddepositing a third guiding layer in said portion of said third zone so as to form said thin waveguide.

    摘要翻译： 为了形成包括耦合到薄波导的厚波导的集成光学部件，该方法包括：在衬底上沉积所述厚波导的第一引导层; 在分配给耦合接口和薄波导的部分上局部蚀刻所述第一引导层; 在第一引导层和局部蚀刻部分上沉积第二引导层，以便形成所述厚波导，使得其在第一区域具有最大厚度，在第二区域中具有最大厚度，在第二区域中具有渐变厚度部分， 第三区的厚度减薄部分; 在第三区域的一部分上局部蚀刻第二引导层，所述部分被分配给薄波导; 以及在所述第三区的所述部分中沉积第三引导层以形成所述薄波导。