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1.发明申请VACCINES AND IMMUNOPOTENTIATING COMPOSITIONS AND METHODS FOR MAKING AND USING THEM 审中-公开疫苗和免疫组合物及其制备和使用方法公开(公告)号：US20140134202A1
公开(公告)日：2014-05-15
申请号：US13324887
申请日：2011-12-13
CPC分类号： A61K39/12 , A61K39/02 , A61K2039/5258 , A61K2039/55555 , A61K2039/6075 , C07K14/005 , C07K14/62 , C07K2319/00 , C07K2319/21 , C12N7/00 , C12N2760/10122 , C12N2770/24222 , C12N2770/26022 , C12N2770/26023
摘要： An immunopotentiating composition comprising a papaya mosaic virus (PapMV), or a virus-like particle (VLP) derived from PapMV coat protein, which is capable of functioning as an adjuvant and thus potentiating an immune response in an animal is provided. The immunopotentiating composition can further comprise an immunogen, which can be fused or otherwise linked to the VLP, or not linked to the VLP. The immunopotentiating composition is capable of potentiating a humoral and/or a cellular response in the animal and is suitable for use as an adjuvant or vaccine. Methods of potentiating an immune response in an animal comprising administering to the animal an immunopotentiating composition are also provided have application in both human and veterinary medicine.
摘要翻译： 提供了包含番木瓜花叶病毒（PapMV）或衍生自PapMV外壳蛋白的病毒样颗粒（VLP）的免疫增强组合物，其能够起到佐剂的作用，从而增强动物的免疫应答。 免疫增强组合物还可以包含免疫原，其可以融合或以其它方式连接到VLP，或不与VLP连接。 免疫增强组合物能够增强动物体液和/或细胞应答，并且适合用作佐剂或疫苗。 增强动物免疫应答的方法包括向动物施用免疫增强组合物也可应用于人和兽药。
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2.发明授权Vaccines and immunopotentiating compositions and methods for making and using them 有权疫苗和免疫增强组合物和制备和使用它们的方法公开(公告)号：US09339535B2
公开(公告)日：2016-05-17
申请号：US13324887
申请日：2011-12-13
CPC分类号： A61K39/12 , A61K39/02 , A61K2039/5258 , A61K2039/55555 , A61K2039/6075 , C07K14/005 , C07K14/62 , C07K2319/00 , C07K2319/21 , C12N7/00 , C12N2760/10122 , C12N2770/24222 , C12N2770/26022 , C12N2770/26023
摘要： An immunopotentiating composition comprising a papaya mosaic virus (PapMV), or a virus-like particle (VLP) derived from PapMV coat protein, which is capable of functioning as an adjuvant and thus potentiating an immune response in an animal is provided. The immunopotentiating composition can further comprise an immunogen, which can be fused or otherwise linked to the VLP, or not linked to the VLP. The immunopotentiating composition is capable of potentiating a humoral and/or a cellular response in the animal and is suitable for use as an adjuvant or vaccine. Methods of potentiating an immune response in an animal comprising administering to the animal an immunopotentiating composition are also provided have application in both human and veterinary medicine.
摘要翻译： 提供了包含番木瓜花叶病毒（PapMV）或衍生自PapMV外壳蛋白的病毒样颗粒（VLP）的免疫增强组合物，其能够起到佐剂的作用，从而增强动物的免疫应答。 免疫增强组合物还可以包含免疫原，其可以融合或以其它方式连接到VLP，或不与VLP连接。 免疫增强组合物能够增强动物体液和/或细胞应答，并且适合用作佐剂或疫苗。 增强动物免疫应答的方法包括向动物施用免疫增强组合物也可应用于人和兽药。
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3.发明申请Compositions Comprising Salmonella Porins and Uses Thereof as Adjuvants and Vaccines 审中-公开组成包括沙门氏菌和其用途作为佐剂和疫苗公开(公告)号：US20110189231A1
公开(公告)日：2011-08-04
申请号：US12999989
申请日：2009-06-17
IPC分类号： A61K39/145 , A61K39/39 , A61P37/04 , A61P31/16
CPC分类号： A61K39/39 , A61K39/0275 , A61K39/04 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/55516 , A61K2039/58 , A61K2039/70 , C12N2760/16134 , C12N2760/16234 , Y02A50/482 , Y02A50/484
摘要： Adjuvants comprising OmpC porin, OmpF porin, or a combination thereof, are provided. The adjuvants can be administered to a subject in combination with antigenic material in order to potentiate the immunogenic effect of the antigenic material. Also provided are products comprising antigenic material in combination with OmpC and/or OmpF, including products comprising a pre-formulated vaccine in combination with OmpC and/or OmpF. Further provided is the use of OmpC and/or OmpF to improve the effect of a pre-formulated vaccine.
摘要翻译： 提供了包含OmpC孔蛋白，OmpF孔蛋白或其组合的佐剂。 佐剂可以与抗原物质组合施用于受试者，以增强抗原物质的免疫原性作用。 还提供了包含与OmpC和/或OmpF组合的抗原物质的产品，包括与OmpC和/或OmpF组合的预配制疫苗的产品。 还提供了使用OmpC和/或OmpF来改善预配制疫苗的效果。
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