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公开(公告)号：US6057102A
公开(公告)日：2000-05-02
申请号：US907468
申请日：1997-08-08
申请人： Nathaniel R. Landau , Richard A. Koup , Rong Liu , William Paxton
发明人： Nathaniel R. Landau , Richard A. Koup , Rong Liu , William Paxton
IPC分类号： C07K14/715 , C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/703 , C07K14/7158 , A01K2217/05 , C12Q2600/156
摘要： Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the .beta.-chemokines RANTES, MIP-1.alpha., and MIP-1.beta.. It has also been found that individuals who are homozygous for a mutation of the CKR-5 receptor are resistent to HIV infection; in vitro infection requires a 1000-fold higher dose of HIV than normal cells. The mutation results in complete suppression of CKR-5 expression.
摘要翻译： HIV-1进入靶细胞需要细胞表面CD4以及额外的宿主细胞辅因子。 最近鉴定了一种在转化的T细胞系中适应生长的病毒感染所需的辅因子，并命名为fusin。 然而，Fusin不促进被认为是体内关键致病菌株的巨噬细胞 - 嗜性病毒的进入。 现在已经确定，由HIV-1的初级巨噬细胞 - 热带菌株的包膜糖蛋白引入的主要辅助因子是CC-CKR5，β-chemokines RANTES，MIP-1α和MIP-1β的受体 。 还发现对CKR-5受体的突变是纯合的个体对HIV感染是抗性的; 体外感染需要比正常细胞高1000倍的HIV。 突变导致CKR-5表达的完全抑制。
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2.发明授权G-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof 失效与巨噬细胞营养性HIV相关的G-偶联受体及其诊断和治疗用途
公开(公告)号：US5939320A
公开(公告)日：1999-08-17
申请号：US666020
申请日：1996-06-19
IPC分类号： C07K14/715 , C12N15/85 , G01N33/50 , G01N33/569 , C12N5/06 , C12N5/08 , C12N5/10
CPC分类号： G01N33/502 , C07K14/7158 , C12N15/8509 , G01N33/5008 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5055 , G01N33/5091 , G01N33/56988 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/30 , A01K2227/105 , A01K2267/02 , A01K2267/0337 , A01K2267/0393
摘要： Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the .beta.-chemokines RANTES, MIP-1.alpha., and MIP-1.beta..
摘要翻译： HIV-1进入靶细胞需要细胞表面CD4以及额外的宿主细胞辅因子。 最近鉴定了一种在转化的T细胞系中适应生长的病毒感染所需的辅因子，并命名为fusin。 然而，Fusin不促进被认为是体内关键致病菌株的巨噬细胞 - 嗜性病毒的进入。 现在已经确定，由HIV-1的初级巨噬细胞 - 热带菌株的包膜糖蛋白引入的主要辅助因子是CC-CKR5，β-chemokines RANTES，MIP-1α和MIP-1β的受体 。
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公开(公告)号：US20130183334A1
公开(公告)日：2013-07-18
申请号：US13743877
申请日：2013-01-17
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , C12N7/00 , C12N15/86 , C12N2740/16034 , C12N2740/16041 , C12N2740/16045 , C12N2740/16052 , C12N2740/16134 , C12N2740/16234
摘要： The compositions and methods described herein relate to lentiviral vectors that can be used to generate virions/viruses that exhibit enhanced infectivity with respect to monocyte-derived macrophages (MDM) and dendritic cells (MDDC). Such compositions and methods further relate to production of virions/viruses that can be used as components of vaccines that effectively stimulate innate immune responses. In a particular embodiment, compositions and methods described herein relate to production of virions/viruses that can be used as components of human immunodeficiency-1 (HIV-1) vaccines administered to stimulate innate immune responses to HIV-1.
摘要翻译： 本文所述的组合物和方法涉及可用于产生相对于单核细胞衍生的巨噬细胞（MDM）和树突状细胞（MDDC）表现出增强的感染性的病毒粒子/病毒的慢病毒载体。 这样的组合物和方法还涉及可用作有效刺激先天免疫应答的疫苗的组分的病毒粒子/病毒的产生。 在一个具体实施方案中，本文所述的组合物和方法涉及可用作被用于刺激对HIV-1的先天免疫应答的人类免疫缺陷-1（HIV-1）疫苗的组分的病毒粒子/病毒的产生。
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4.发明授权Methods of identifying g-couple receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof 有权识别与巨噬细胞营养型HIV相关的g-偶合受体的方法及其诊断和治疗用途公开(公告)号：US07129055B2
公开(公告)日：2006-10-31
申请号：US09734221
申请日：2000-12-11
IPC分类号： C01N33/53 , C01N33/533 , C12N15/00 , C12N15/48 , C12N15/07 , C12N15/09 , C12N5/28 , C07K16/28
CPC分类号： G01N33/56988 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2217/30 , A01K2227/105 , A01K2267/0337 , C07K14/7158 , C12N15/8509 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5055 , G01N33/5091
摘要： Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the β-chemokines RANTES, MIP-1α, and MIP-1β.
摘要翻译： HIV-1进入靶细胞需要细胞表面CD4以及额外的宿主细胞辅因子。 最近鉴定了一种在转化的T细胞系中适应生长的病毒感染所需的辅因子，并命名为fusin。 然而，Fusin不促进被认为是体内关键致病菌株的巨噬细胞 - 嗜性病毒的进入。 现在已经确定，由HIV-1的初级巨噬细胞 - 嗜热菌株的包膜糖蛋白介导的进入的主要辅助因子是CC-CKR5，β-趋化因子RANTES，MIP-1α和MIP-1β的受体。
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5.发明授权Methods of identifying g-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof 失效鉴定与巨噬细胞营养型HIV相关的g-偶联受体的方法及其诊断和治疗用途公开(公告)号：US06258527B1
公开(公告)日：2001-07-10
申请号：US08861105
申请日：1997-05-21
IPC分类号： C12Q170
CPC分类号： G01N33/56988 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2217/30 , A01K2227/105 , A01K2267/0337 , C07K14/7158 , C12N15/8509 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5055 , G01N33/5091
摘要： Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the &bgr;-chemokines RANTES, MIP-1&agr;, and MIP-1&bgr;.
摘要翻译： HIV-1进入靶细胞需要细胞表面CD4以及额外的宿主细胞辅因子。 最近鉴定了一种在转化的T细胞系中适应生长的病毒感染所需的辅因子，并命名为fusin。 然而，Fusin不促进被认为是体内关键致病菌株的巨噬细胞 - 嗜性病毒的进入。 现在已经确定，由HIV-1的初级巨噬细胞 - 嗜热菌株的包膜糖蛋白介导的进入的主要辅助因子是CC-CKR5，β-趋化因子RANTES，MIP-1α和MIP-1β的受体。
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6.发明授权Chimeric human immunodeficiency virus type 1 (HIV-1) with enhanced dendritic cell and macrophage tropism comprising the simian immunodeficiency virus (SIV) minimal Vpx packaging domain 有权嵌合人类免疫缺陷病毒1型（HIV-1）具有增强的树突状细胞和巨噬细胞向性，包括猿猴免疫缺陷病毒（SIV）最小Vpx包装域公开(公告)号：US09149519B2
公开(公告)日：2015-10-06
申请号：US13743877
申请日：2013-01-17
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , C12N7/00 , C12N15/86 , C12N2740/16034 , C12N2740/16041 , C12N2740/16045 , C12N2740/16052 , C12N2740/16134 , C12N2740/16234
摘要： The compositions and methods described herein relate to lentiviral vectors that can be used to generate virions/viruses that exhibit enhanced infectivity with respect to monocyte-derived macrophages (MDM) and dendritic cells (MDDC). Such compositions and methods further relate to production of virions/viruses that can be used as components of vaccines that effectively stimulate innate immune responses. In a particular embodiment, compositions and methods described herein relate to production of virions/viruses that can be used as components of human immunodeficiency-1 (HIV-1) vaccines administered to stimulate innate immune responses to HIV-1.
摘要翻译： 本文所述的组合物和方法涉及可用于产生相对于单核细胞衍生的巨噬细胞（MDM）和树突状细胞（MDDC）表现出增强的感染性的病毒粒子/病毒的慢病毒载体。 这样的组合物和方法还涉及可用作有效刺激先天免疫应答的疫苗的组分的病毒粒子/病毒的产生。 在一个具体实施方案中，本文所述的组合物和方法涉及可用作被用于刺激对HIV-1的先天免疫应答的人类免疫缺陷-1（HIV-1）疫苗的组分的病毒粒子/病毒的产生。
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