摘要:
Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the β-chemokines RANTES, MIP-1α, and MIP-1β.
摘要:
Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the &bgr;-chemokines RANTES, MIP-1&agr;, and MIP-1&bgr;.
摘要:
Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the .beta.-chemokines RANTES, MIP-1.alpha., and MIP-1.beta..
摘要:
Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the .beta.-chemokines RANTES, MIP-1.alpha., and MIP-1.beta.. It has also been found that individuals who are homozygous for a mutation of the CKR-5 receptor are resistent to HIV infection; in vitro infection requires a 1000-fold higher dose of HIV than normal cells. The mutation results in complete suppression of CKR-5 expression.
摘要:
A semiconductor component and methods for manufacturing the semiconductor component that includes a monolithically integrated common mode choke. In accordance with embodiments, a transient voltage suppression device may be coupled to the monolithically integrated common mode choke.
摘要:
A compact hybrid imaging lens assembly captures return light from a target over a field of view of a linear array of image sensors of a solid-state imager, and projects the captured return light onto the array during electro-optical reading of the target. The assembly includes a plastic lens for optical aberration correction, a glass lens spaced away from the plastic lens along an optical axis, and an aperture stop between the lenses and having an asymmetrical aperture through which the optical axis extends. The glass lens has substantially all the optical power of the imaging lens assembly for thermal stability, and the plastic lens has substantially no optical power. A holder holds the lenses and the aperture stop away from the array. Alignment elements on the plastic lens align the asymmetrical aperture relative to the linear array.
摘要:
A method and imaging assembly (10) are disclosed adapted for reading a target object comprising a scan engine (48) having a sensor (46), focusing optics (44), and an imager (48). The scan engine includes a field-of-view defining an area to be imaged by the imaging assembly (10). A housing (80) internally lodges the scan engine (48) and an illumination source (36). The illumination source (36) is adapted to project illumination from the housing (80). A boot (30) extends from the housing (80) for shaping the illumination as it passes through the boot to form an illumination pattern from the illumination. The illumination pattern substantially conforms to a geometrical shape of the boot (30) and is adapted to envelope the scan engine field-of-view.
摘要:
A semiconductor component and methods for manufacturing the semiconductor component that includes a three dimensional helically shaped common mode choke. In accordance with embodiments, a transient voltage suppression device may be coupled to the monolithically integrated common mode choke.
摘要:
A method and a device for realizing dynamic adjustment of data bandwidth of the invention are disclosed. The method comprises adding a control channel in a PCM trunk link to describe occupancy condition of time slots for current services. The device comprises a control word process circuit, a time slot distribution circuit and a CPU interface circuit, wherein the control word process circuit is designed to complete abstraction and insertion of control information in a control channel of E1/T1 link, the time slot distribution circuit completes separating voice time slots from Ethernet data time slots and rebuilding the data, and the CPU interface circuit implements time slot distribution control. The method and the device can implement dynamic adjustment of Ethernet data bandwidth while ensuring voice services, to make effective use of trunk bandwidth and enhance user's data service bandwidth, without error code and interruption of data service during bandwidth adjustment.
摘要:
A module and an arrangement for, as well as a method of, generating a generally uniform distributed line pattern of light on a symbol to be read by image capture, include a light source for generating light along an optical axis in a distribution having different extents along intersecting directions generally perpendicular to the axis, and an optical component for receiving, and for optically modifying, the light from the light source to generate the gene rally uniform distributed line pattern of light on the symbol. The optical component includes a plurality of compound conic elements spaced apart from one another along one of the directions. Each compound conic element has a pair of conic segments for modifying the light along the one direction. A collimating lens modifies the light along the other of the directions. A solid-state imager has an array of image sensors for capturing return light from the symbol over a field of view having different extents along the intersecting directions.