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公开(公告)号：US08725244B2
公开(公告)日：2014-05-13
申请号：US11591286
申请日：2006-10-31
IPC分类号： A61B5/04
CPC分类号： A61N1/36135 , A61B3/113 , A61B5/0031 , A61B5/0205 , A61B5/0476 , A61B5/0816 , A61B5/1116 , A61B5/1118 , A61B5/145 , A61B5/4815 , A61B5/4818 , A61B5/6814 , A61B5/6823 , A61B5/6825 , A61B5/686 , A61B2562/0219 , A61M5/14276 , A61M5/1723 , A61N1/36025 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36082 , A61N1/36521 , A61N1/36542 , A61N1/36557 , A61N1/37247
摘要： A device determines values for one or more metrics that indicate the quality of a patient's sleep based on sensed physiological parameter values. Sleep efficiency, sleep latency, and time spent in deeper sleep states are example sleep quality metrics for which values may be determined. The sleep quality metric values may be used, for example, to evaluate the effectiveness of a therapy delivered to the patient by a medical device. In some embodiments, determined sleep quality metric values are automatically associated with the therapy parameter sets according to which the medical device delivered the therapy when the physiological parameter values were sensed, and used to evaluate the effectiveness of the various therapy parameter sets. The medical device may deliver the therapy to treat a non-respiratory neurological disorder, such as epilepsy, a movement disorder, or a psychological disorder. The therapy may be, for example, deep brain stimulation (DBS) therapy.
摘要翻译： 设备基于感测到的生理参数值来确定指示患者睡眠质量的一个或多个度量的值。 睡眠效率，睡眠延迟和在更深的睡眠状态中花费的时间是可以确定值的示例性睡眠质量度量。 例如，可以使用睡眠质量度量值来评估由医疗装置递送给患者的治疗的有效性。 在一些实施例中，确定的睡眠质量量度值与治疗参数组自动相关联，当感测到生理参数值时医疗设备根据该参数设置递送治疗，并且用于评估各种治疗参数组的有效性。 医疗装置可以递送治疗以治疗非呼吸神经障碍，例如癫痫，运动障碍或心理障碍。 治疗可以是例如深部脑刺激（DBS）治疗。
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2.发明授权公开(公告)号：US08485979B2
公开(公告)日：2013-07-16
申请号：US11741111
申请日：2007-04-27
IPC分类号： A61B8/00
CPC分类号： A61B5/0482 , A61B5/0205 , A61B5/042 , A61B5/08 , A61B5/4094 , A61N1/36082 , A61N1/365
摘要： An implantable neurostimulator device for implantation in a head of a patient includes a housing adapted to be implanted beneath a patient's scalp, and a cardiac monitoring element, a brain monitoring element, and a processor. The processor is configured to receive a cardiac signal from the cardiac monitoring element, identify cardiac events in the cardiac signal, receive a brain signal from the brain monitoring element, identify neurological events in the brain signal, and indicate a relationship between the neurological events and the cardiac events.
摘要翻译： 用于植入患者头部的可植入神经刺激器装置包括适于植入患者头皮下的壳体，以及心脏监测元件，大脑监测元件和处理器。 处理器被配置为从心脏监测元件接收心脏信号，识别心脏信号中的心脏事件，从大脑监测元件接收脑信号，识别脑信号中的神经系统事件，以及指示神经系统事件与 心脏事件。
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公开(公告)号：US08478417B2
公开(公告)日：2013-07-02
申请号：US11264860
申请日：2005-11-02
IPC分类号： A61N1/08
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. An implanted device obtains data and stores the data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.
摘要翻译： 用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。 植入装置获取数据并将数据存储在基于年龄的第一数据结构中的数据记录中。 在最旧的数据记录丢失之前，最早的数据记录可以存储在基于优先级索引的第二数据结构中。 优先权索引可以由严重性级别确定，并且可以由相关因素进一步确定。 植入的装置可以基于相关联的优先级索引来组织，卸载，报告和/或显示多个数据记录。 另外，植入装置可以基于选择标准从可用生理通道中选择生理通道的子集或复合物。
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4.发明申请Implantable Medical Device for Treating Neurological Conditions Including ECG Sensing 有权用于治疗包括ECG感觉的神经病症的植入式医疗装置公开(公告)号：US20120150251A1
公开(公告)日：2012-06-14
申请号：US13158099
申请日：2011-06-10
CPC分类号： A61N1/375 , A61N1/36082 , A61N1/36114 , A61N1/36585 , A61N1/37 , A61N1/3756
摘要： An implantable medical device such as an implantable pulse generator that includes EEG sensing for monitoring and treating neurological conditions, and leadless ECG sensing for monitoring cardiac signals. The device includes a connector block with provisions for cardiac leads which may be used/enabled when needed. If significant co-morbid cardiac events are observed in patients via the leadless ECG monitoring, then cardiac leads may be subsequently connected for therapeutic use.
摘要翻译： 可植入的医疗装置，例如植入式脉冲发生器，其包括用于监测和治疗神经病症的脑电图感测，以及用于监测心脏信号的无引导心电图感测。 该装置包括具有用于心脏引线的装置的连接器块，其可以在需要时使用/启用。 如果通过无引导心电图监测在患者中观察到显着的并发心脏事件，则心脏引线可以随后连接用于治疗用途。
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5.发明授权System and method for monitoring cardiac signal activity in patients with nervous system disorders 有权用于监测神经系统疾病患者心脏信号活动的系统和方法公开(公告)号：US08112148B2
公开(公告)日：2012-02-07
申请号：US11767054
申请日：2007-06-22
申请人： Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Nina M. Graves , Mark Turner Rise , Kevin L Bright , Chark Stanford
发明人： Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Nina M. Graves , Mark Turner Rise , Kevin L Bright , Chark Stanford
IPC分类号： A61B5/00
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/02 , A61B5/0205 , A61B5/0245 , A61B5/0402 , A61B5/0476 , A61B5/053 , A61B5/08 , A61B5/0816 , A61B5/1135 , A61B5/4094 , A61N1/36064 , A61N1/36082 , A61N1/3611 , A61N1/365 , A61N1/36521 , A61N1/36585 , A61N1/36592 , A61N1/37288 , A61N1/3962
摘要： A medical device system and method for monitoring cardiac signal activity in patients with nervous system disorders. In some embodiments, a brain signal and a cardiac signal are received by a processor, brain events are identified in the brain signal, and the brain events are used to identify portions of the cardiac signal. In some embodiments, Event portions of the cardiac signal are identified corresponding to brain event time periods, and Inter-event portions are identified corresponding to time periods between brain events. An Inter-event heart-rate variability (HRV) calculation is performed using Inter-event portions of the cardiac signal, and an output of the medical device system is modified based upon the calculated Inter-event HRV according to certain embodiments of the invention. An Event HRV may also be calculated according to certain embodiments, and an output modified based on comparisons of the Event HRV to the Inter-event HRV, for example.
摘要翻译： 用于监测患有神经系统疾病的患者的心脏信号活动的医疗装置系统和方法。 在一些实施例中，脑信号和心脏信号由处理器接收，在脑信号中识别脑事件，并且使用脑事件来识别心脏信号的部分。 在一些实施例中，心脏信号的事件部分被识别为对应于脑事件时间段，并且事件部分被识别为对应于大脑事件之间的时间段。 使用心脏信号的事件间部分来执行事件间心率变异性（HRV）计算，并且基于根据本发明的某些实施例的所计算的事件间HRV来修改医疗装置系统的输出。 还可以根据某些实施例来计算事件HRV，并且例如基于事件HRV与事件间HRV的比较来修改输出。
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6.发明授权Techniques for user-activated data retention in an implantable medical device 有权在可植入医疗设备中用户激活的数据保留技术公开(公告)号：US08024029B2
公开(公告)日：2011-09-20
申请号：US11264915
申请日：2005-11-02
CPC分类号： A61B5/0031 , A61B5/04325 , A61B5/0476 , A61B5/113 , A61B5/4094 , A61B5/7232 , A61N1/36082 , A61N1/3702 , A61N1/37252 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： Apparatus for storing data records associated with a medical monitoring event in a data structure. Upon indication by a patient of a possible manifestation of a neurological event, the implanted device obtains and stores data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.
摘要翻译： 用于存储与数据结构中的医疗监视事件相关联的数据记录的装置。 在由患者指示神经系统事件的可能表现的情况下，植入装置以数据记录的形式获取并存储数据为基于年龄的第一数据结构。 在最旧的数据记录丢失之前，最早的数据记录可以存储在基于优先级索引的第二数据结构中。 优先权索引可以由严重性级别确定，并且可以由相关因素进一步确定。 植入的装置可以基于相关联的优先级索引来组织，卸载，报告和/或显示多个数据记录。 另外，植入装置可以基于选择标准从可用生理通道中选择生理通道的子集或复合物。
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7.发明授权Implantable medical device for treating neurological conditions including ECG sensing 有权用于治疗包括ECG感觉在内的神经病症的植入式医疗装置公开(公告)号：US08000788B2
公开(公告)日：2011-08-16
申请号：US11796382
申请日：2007-04-27
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61N1/36082 , A61N1/36114 , A61N1/36585 , A61N1/37 , A61N1/3756
摘要： An implantable medical device such as an implantable pulse generator that includes EEG sensing for monitoring and treating neurological conditions, and leadless ECG sensing for monitoring cardiac signals. The device includes a connector block with provisions for cardiac leads which may be used/enabled when needed. If significant co-morbid cardiac events are observed in patients via the leadless ECG monitoring, then cardiac leads may be subsequently connected for therapeutic use.
摘要翻译： 可植入的医疗装置，例如植入式脉冲发生器，其包括用于监测和治疗神经病症的脑电图感测，以及用于监测心脏信号的无引导心电图感测。 该装置包括具有用于心脏引线的装置的连接器块，其可以在需要时使用/启用。 如果通过无引导心电图监测在患者中观察到显着的并发心脏事件，则心脏引线可以随后连接用于治疗用途。
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8.发明授权System and method for regulating cardiopulmonary triggered therapy to the brain 失效将心肺触发治疗调整到大脑的系统和方法公开(公告)号：US07865244B2
公开(公告)日：2011-01-04
申请号：US11311043
申请日：2005-12-19
IPC分类号： A61N1/36
CPC分类号： A61B5/0476 , A61B5/0031 , A61B5/02 , A61B5/0245 , A61B5/0402 , A61B5/0452 , A61B5/0478 , A61B5/053 , A61B5/08 , A61B5/0816 , A61B5/1135 , A61B5/4094 , A61N1/05 , A61N1/3601 , A61N1/36082 , A61N1/36135 , A61N1/362 , A61N1/36521 , A61N1/36585 , A61N1/37 , A61N1/37247 , A61N1/37282 , A61N1/37288 , A61N1/3962
摘要： A medical device system includes a brain monitoring element, cardiopulmonary monitoring element, therapy module and a processor. The processor is configured to activate the therapy module upon detection of a cardiopulmonary event in the cardiopulmonary signal. The processor is further configured to monitor the brain signal and communicate to the therapy module to change the cardiopulmonary triggered therapeutic output to the brain based upon the brain monitoring. Methods of treating a person with a neurological disorder are also provided.
摘要翻译： 医疗装置系统包括脑监测元件，心肺监测元件，治疗模块和处理器。 处理器被配置为在心肺信号中检测到心肺事件时激活治疗模块。 处理器进一步被配置为基于大脑监测来监测大脑信号并与治疗模块通信，以将心肺触发的治疗输出改变到大脑。 还提供了治疗患有神经障碍的人的方法。
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公开(公告)号：US07787944B2
公开(公告)日：2010-08-31
申请号：US11311200
申请日：2005-12-19
IPC分类号： A61B5/00
摘要： A medical device system includes a brain monitoring element, cardiac monitoring element, therapy module and a processor. The processor is configured to activate the therapy module upon detection of a cardiac event in the cardiac signal. The processor is further configured to monitor the brain signal and communicate to the therapy module to change the cardiac triggered therapeutic output to the brain based upon the brain monitoring. A method of treating a person with a neurological disorder is also provided.
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公开(公告)号：US20090082641A1
公开(公告)日：2009-03-26
申请号：US12236316
申请日：2008-09-23
IPC分类号： A61B5/00
CPC分类号： G06F19/3456 , A61N1/36082 , A61N1/36132 , A61N1/37247 , A61N1/37258 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： An indication that a patient event occurred may be used to evaluate the efficacy of at least one therapy program and/or adjust therapy delivery to the patient. In some examples, the patient event indication includes patient input that may be received via an event indication button of a programming device. In addition to or instead of the patient input, the patient event indication may be generated based on a physiological parameter of the patient. In some examples, therapy delivery may be adjusted by adjusting at least one therapy parameter value, switching therapy programs or therapy program groups or restarting a therapy cycle of a medical device. The patient input via an event indication button may also help evaluate whether a therapy system is useful for the patient.
摘要翻译： 发生患者事件的指示可用于评估至少一个治疗程序的功效和/或调整对患者的治疗递送。 在一些示例中，患者事件指示包括可经由编程设备的事件指示按钮接收的患者输入。 除了或代替患者输入之外，可以基于患者的生理参数生成患者事件指示。 在一些实例中，可以通过调整至少一个治疗参数值，切换治疗程序或治疗程序组或重新启动医疗装置的治疗周期来调整治疗递送。 通过事件指示按钮的患者输入也可以帮助评估治疗系统是否对患者有用。
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