-
1.发明授权Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoprotein sites 失效靶向多个核糖核蛋白位点的抗菌氰基（取代） - 亚甲基哌啶基苯基恶唑烷酮公开(公告)号：US07405228B2
公开(公告)日：2008-07-29
申请号：US10616888
申请日：2003-07-10
申请人： Mahesh V Patel , Prasad K Deshpande , Milind D Sindkhedkar , Shrikant V Gupte , Yati Chugh , Nitin Shetty , Milind C Shukla , Ravindra D Yeole , Noel J De Souza
发明人： Mahesh V Patel , Prasad K Deshpande , Milind D Sindkhedkar , Shrikant V Gupte , Yati Chugh , Nitin Shetty , Milind C Shukla , Ravindra D Yeole , Noel J De Souza
IPC分类号： A61K31/421 , A61K31/454 , C07D413/10 , C07D401/10
CPC分类号： C07D413/10 , C07D413/14 , C07D417/14
摘要： The present invention provides agents having high antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel cyano-(substituted)-methylenepiperidinophenyl oxazolidinone derivatives, processes for making the compounds, as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.
摘要翻译： 本发明提供了用于预防和治疗感染性疾病的高抗微生物活性的试剂。 因此，本发明提供新的氰基 - （取代） - 亚甲基哌啶基苯基恶唑烷酮衍生物，制备该化合物的方法，以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。
-
公开(公告)号：US07164023B2
公开(公告)日：2007-01-16
申请号：US10749932
申请日：2003-12-31
申请人： Prasad K. Deshpande , Vijaya N. Desai , Ravindra D. Yeole , Shrikant V. Gupte , Mahesh V. Patel , Noel J. de Souza
发明人： Prasad K. Deshpande , Vijaya N. Desai , Ravindra D. Yeole , Shrikant V. Gupte , Mahesh V. Patel , Noel J. de Souza
IPC分类号： C07D401/04 , C07D401/14
CPC分类号： C07D471/06
摘要： The invention relates to crystalline S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid L-arginine salt tetrahydrate, a process for its preparation and pharmaceutical formulations incorporating it as the active ingredient for use in treating microbial infections.
-
公开(公告)号：US07132541B2
公开(公告)日：2006-11-07
申请号：US10671040
申请日：2003-09-25
申请人： Noel J. de Souza , Prasad K Deshpande , Milind C. Shukla , Siddiqui M Jaweed Mukarram , Dilip Ganesh Kulkarni , Ansari Azizur Rahman , Ravindra D Yeole , Mahesh V Patel , Shrikant V Gupte
发明人： Noel J. de Souza , Prasad K Deshpande , Milind C. Shukla , Siddiqui M Jaweed Mukarram , Dilip Ganesh Kulkarni , Ansari Azizur Rahman , Ravindra D Yeole , Mahesh V Patel , Shrikant V Gupte
IPC分类号： C07D451/00 , C07D453/00 , C07D455/00
CPC分类号： C07D455/04
摘要： The invention relates to the new arginine salt forms of RS-(±)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, R-(+)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, a process for their preparation and pharmaceutical formulations which comprise those arginine salt forms as the active ingredient for its use in treating microbial infections.
-
公开(公告)号：US4603137A
公开(公告)日：1986-07-29
申请号：US639312
申请日：1984-08-10
申请人： Sujata V. Bhat , Virbala Shah , Alihussein N. Dohadwalla , Sadashiv M. Mandrekar , Noel J. de Souza , Gerhard Dickneite , Roland Kurrle , Hans-Ulrich Schorlemmer , Hans-Harald Sedlacek
发明人： Sujata V. Bhat , Virbala Shah , Alihussein N. Dohadwalla , Sadashiv M. Mandrekar , Noel J. de Souza , Gerhard Dickneite , Roland Kurrle , Hans-Ulrich Schorlemmer , Hans-Harald Sedlacek
IPC分类号： A61K31/443 , A61K31/445 , A61K36/00 , A61K36/18 , A61P25/04 , A61P29/00 , A61P37/06 , C07D405/04
CPC分类号： C07D405/04
摘要： The present invention relates to a compound of the formula ##STR1## and to a process for its isolation from plants of the family comprising the meliaceae. The compound has, in particular, immunosuppressive properties, and can therefore be used as a medicament.
摘要翻译： 本发明涉及式IMA的化合物及其与包含i科的家族植物分离的方法。 该化合物尤其具有免疫抑制性质，因此可用作药物。
-
公开(公告)号：US4482556A
公开(公告)日：1984-11-13
申请号：US134080
申请日：1980-03-26
申请人： Bansi Lal , Horst Dornauer , Bani K. Bhattacharya , Alihussein N. Dohadwalla , Noel J. de Souza
发明人： Bansi Lal , Horst Dornauer , Bani K. Bhattacharya , Alihussein N. Dohadwalla , Noel J. de Souza
IPC分类号： A61K31/505 , A61K31/535 , A61P9/12 , A61P11/08 , A61P37/08 , C07D217/14 , C07D471/04 , C07D491/14 , C07D491/147 , C07F9/60 , C07F9/6509 , C07F9/6561
CPC分类号： C07D471/04 , C07D217/14 , C07D491/14 , C07F9/650911 , C07F9/6561
摘要： What are disclosed are pyrimido (6,1-a)isoquinolin-4-one compounds useful as hypotensive agents, bronchodilators, and anti-allergenics, intermediates useful in their preparation, and methods for making the compounds and intermediates.
摘要翻译： 公开的是嘧啶（6,1-a）异喹啉-4-酮化合物，其可用作降压剂，支气管扩张剂和抗过敏原，可用于其制备的中间体，以及制备化合物和中间体的方法。
-
6.发明授权Triazino(2,1-a)isoquinoline derivatives, compositions and their use as medicaments 失效三嗪（2,1-a）异喹啉衍生物，组合物及其用作药物
公开(公告)号：US4479948A
公开(公告)日：1984-10-30
申请号：US396393
申请日：1982-07-08
IPC分类号： A61K31/53 , A61K31/535 , A61P9/00 , A61P9/12 , C07D471/04 , C07D491/147
CPC分类号： C07D471/04
摘要： Hypotensively active triazino-(2,1-a)isoquinoline compounds having the ring system ##STR1## and methods of making and using such compounds.
摘要翻译： 具有环系的低活性三嗪 - （2,1-a）异喹啉化合物及其制备和使用方法。
-
公开(公告)号：US4400506A
公开(公告)日：1983-08-23
申请号：US314994
申请日：1981-10-26
申请人： Bansi Lal , Adolf D'Sa , Horst Dornauer , Noel J. de Souza
发明人： Bansi Lal , Adolf D'Sa , Horst Dornauer , Noel J. de Souza
IPC分类号： A61K31/505 , A61P9/12 , A61P11/08 , A61P37/08 , C07D471/04 , C07D491/14 , C07D491/147 , C07F9/6561
CPC分类号： C07D471/04 , C07D491/14 , C07F9/6561
摘要： What are disclosed are compounds of the formula ##STR1## wherein, X is oxygen, sulfur, or halogen, useful as intermediates in the preparation of certain pyrimido(6,1-a)isoquinolin-4-ones having pharmaceutical utilities, and methods for making said intermediates.
摘要翻译： 所公开的是下式的化合物，其中X是氧，硫或卤素，可用作制备具有药物效用的某些嘧啶（6,1-a）异喹啉-4-酮的中间体，以及用于 制造中间体。
-
公开(公告)号：US06664267B1
公开(公告)日：2003-12-16
申请号：US10156685
申请日：2002-05-28
申请人： Noel J. de Souza , Prasad K Deshpande , Milind C. Shukla , Siddiqui M Jaweed Mukarram , Dilip Ganesh Kulkarni , Ansari Azizur Rahman , Ravindra D Yeole , Mahesh V Patel , Shrikant V Gupte
发明人： Noel J. de Souza , Prasad K Deshpande , Milind C. Shukla , Siddiqui M Jaweed Mukarram , Dilip Ganesh Kulkarni , Ansari Azizur Rahman , Ravindra D Yeole , Mahesh V Patel , Shrikant V Gupte
IPC分类号： C07D45504
CPC分类号： C07D455/04
摘要： The invention relates to the new arginine salt forms of RS-(±)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, R-(+)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, a process for their preparation and pharmaceutical formulations which comprise those arginine salt forms as the active ingredient for its use in treating microbial infections.
摘要翻译： 本发明涉及新的精氨酸盐形式的RS-（±）-9-氟-6,7-二氢-8-（4-羟基哌啶-1-基）-5-甲基-1-氧代-1H，5H- 苯并[i，j]喹嗪-2羧酸，S - （ - ） - 9-氟-6,7-二氢-8-（4-羟基哌啶-1-基）-5-甲基-1-氧代-1H- ，5H-苯并[i，j]喹嗪-2-羧酸，R - （+） - 9-氟-6,7-二氢-8-（4-羟基哌啶-1-基）-5-甲基-1- 氧代-1H，5H-苯并[i，j]喹嗪-2-羧酸，其制备方法和包含这些精氨酸盐形式的药物制剂作为其用于治疗微生物感染的活性成分。
-
公开(公告)号：US06514986B2
公开(公告)日：2003-02-04
申请号：US09802793
申请日：2001-03-09
申请人： Noel J. de Souza , Shivkumar Agarwal , Mahesh V. Patel , Satish B. Bhawsar , Rupinder K. Beri , Ravindra D. Yeole , Nitin Shetty
发明人： Noel J. de Souza , Shivkumar Agarwal , Mahesh V. Patel , Satish B. Bhawsar , Rupinder K. Beri , Ravindra D. Yeole , Nitin Shetty
IPC分类号： C07D45506
CPC分类号： C07D215/233 , A61K31/4745 , A61K45/06 , C07B2200/07 , C07C279/14 , C07D401/04 , C07D401/14 , C07D455/04 , C07D471/04 , C07D471/08
摘要： The invention relates to the new arginine salt forms of S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, a process for their preparation and pharmaceutical formulations which comprise those arginine salt forms as the active ingredient for its use in treating antimicrobial infections.
-
10.发明授权Process for the preparation of 6-acyl, 7-acyl, and 6,7-diacyl analogues of forskolin and intermediates thereof 失效毛喉素的6-酰基，7-酰基和6,7-二酰基类似物的制备方法及其中间体
公开(公告)号：US5268471A
公开(公告)日：1993-12-07
申请号：US5163
申请日：1993-01-15
IPC分类号： C07D311/92 , C07D405/12
CPC分类号： C07D311/92
摘要： Process for the preparation of 6-acyl-, 7-acyl- or 6,7-diacyl analogues of forskolin of the general formula ##STR1##
摘要翻译： 用于制备通式为“IMAGE”的福斯克林的6-酰基，7-酰基或6,7-二酰基类似物的方法，
-
-
-
-
-
-
-
-
-
搜索结果
24 条记录 (耗时 0.021 秒)
