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1.发明授权Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoprotein sites 失效靶向多个核糖核蛋白位点的抗菌氰基（取代） - 亚甲基哌啶基苯基恶唑烷酮公开(公告)号：US07405228B2
公开(公告)日：2008-07-29
申请号：US10616888
申请日：2003-07-10
Applicant: Mahesh V Patel , Prasad K Deshpande , Milind D Sindkhedkar , Shrikant V Gupte , Yati Chugh , Nitin Shetty , Milind C Shukla , Ravindra D Yeole , Noel J De Souza
Inventor： Mahesh V Patel , Prasad K Deshpande , Milind D Sindkhedkar , Shrikant V Gupte , Yati Chugh , Nitin Shetty , Milind C Shukla , Ravindra D Yeole , Noel J De Souza
IPC: A61K31/421 , A61K31/454 , C07D413/10 , C07D401/10
CPC classification number: C07D413/10 , C07D413/14 , C07D417/14
Abstract: The present invention provides agents having high antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel cyano-(substituted)-methylenepiperidinophenyl oxazolidinone derivatives, processes for making the compounds, as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.
Abstract translation: 本发明提供了用于预防和治疗感染性疾病的高抗微生物活性的试剂。 因此，本发明提供新的氰基 - （取代） - 亚甲基哌啶基苯基恶唑烷酮衍生物，制备该化合物的方法，以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。
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2.发明授权公开(公告)号：US07247642B2
公开(公告)日：2007-07-24
申请号：US09566875
申请日：2000-05-08
Applicant: Mahesh Vithalbhai Patel , Shivkumar Agarwal , Sreenivas Kandepu , Nitin Shetty , Dilip Jatashankar Upadhyay , Nishith Chandra Chaturvedi , Abraham Thomas , Noel John De Souza , Habil Fakhruddin Khorakiwala
Inventor： Mahesh Vithalbhai Patel , Shivkumar Agarwal , Sreenivas Kandepu , Nitin Shetty , Dilip Jatashankar Upadhyay , Nishith Chandra Chaturvedi , Abraham Thomas , Noel John De Souza , Habil Fakhruddin Khorakiwala
IPC: A61K31/4375 , C07D487/12
CPC classification number: C07C279/14 , A61K31/4745 , C07B2200/07 , C07D455/04 , Y02A50/473
Abstract: The present invention relates to optically pure S-(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(+)-isomers, to processes for preparation of the optically pure S-(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof substantially free of their R-(+)-isomers, and to pharmaceutical compositions comprising the S(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof.
Abstract translation: 本发明涉及基本上不含其R - （+） - 异构体的光学纯的S - （ - ） - 苯并喹嗪羧酸，其衍生物，盐，假多晶型物，多晶型物和水合物，用于制备光学纯S - （ - ） - 苯并喹嗪羧酸，它们的衍生物，盐，假多晶型物，基本上不含其R - （+） - 异构体的多晶型物和水合物，以及包含S（ - ） - 苯醌喹唑啉羧酸的衍生物， 盐，假多晶型物，多晶型物及其水合物。
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3.发明申请Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy 失效具有抗菌活性并具有改善的体内功效的取代的哌啶子基苯基恶唑烷酮公开(公告)号：US20050143421A1
公开(公告)日：2005-06-30
申请号：US10935708
申请日：2004-09-07
Applicant: Prasad Deshpande , Milind Sindkhedkar , Mahesh Phansalkar , Ravindra Yeole , Shrikant Gupte , Yati Chugh , Nitin Shetty , Sachin Bhagwat , Milind Shukla , Noel De Souza , Mahesh Patel
Inventor： Prasad Deshpande , Milind Sindkhedkar , Mahesh Phansalkar , Ravindra Yeole , Shrikant Gupte , Yati Chugh , Nitin Shetty , Sachin Bhagwat , Milind Shukla , Noel De Souza , Mahesh Patel
IPC: C07D413/10 , C07D413/14 , C07D491/10 , C07D495/10 , C07D497/10 , C07D498/10 , C07D513/10 , C07D413/02 , A61K31/422 , A61K31/454
CPC classification number: C07D491/10 , C07D413/10 , C07D413/14 , C07D495/10 , C07D497/10 , C07D513/10
Abstract: The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.
Abstract translation: 本发明提供具有预防和治疗感染性疾病的抗微生物活性的试剂。 因此，本发明提供新的取代的哌啶子基苯基恶唑烷酮衍生物，制备化合物的方法以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。
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公开(公告)号：US06514986B2
公开(公告)日：2003-02-04
申请号：US09802793
申请日：2001-03-09
Applicant: Noel J. de Souza , Shivkumar Agarwal , Mahesh V. Patel , Satish B. Bhawsar , Rupinder K. Beri , Ravindra D. Yeole , Nitin Shetty
Inventor： Noel J. de Souza , Shivkumar Agarwal , Mahesh V. Patel , Satish B. Bhawsar , Rupinder K. Beri , Ravindra D. Yeole , Nitin Shetty
IPC: C07D45506
CPC classification number: C07D215/233 , A61K31/4745 , A61K45/06 , C07B2200/07 , C07C279/14 , C07D401/04 , C07D401/14 , C07D455/04 , C07D471/04 , C07D471/08
Abstract: The invention relates to the new arginine salt forms of S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, a process for their preparation and pharmaceutical formulations which comprise those arginine salt forms as the active ingredient for its use in treating antimicrobial infections.
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5.发明申请SUBSTITUTED PIPERIDINO PHENYLOXAZOLIDINONES HAVING ANTIMICROBIAL ACTIVITY WITH IMPROVED IN VIVO EFFICACY 有权具有改善活体功效的抗微生物活性的替代哌啶苯并噻唑啉酮公开(公告)号：US20100144735A1
公开(公告)日：2010-06-10
申请号：US12705258
申请日：2010-02-12
Applicant: Prasad Keshav Deshpande , Milind Dattatraya Sindkhedkar , Mahesh Shriram Phansalkar , Ravindra Dattatraya Yeole , Shrikant Vinayak Gupte , Yati Chugil , Nitin Shetty , Sachin Subhash Bhagwat , Milind Chintaman Shukla , Noel John De Souza , Mahesh Vithalbhai Patel
Inventor： Prasad Keshav Deshpande , Milind Dattatraya Sindkhedkar , Mahesh Shriram Phansalkar , Ravindra Dattatraya Yeole , Shrikant Vinayak Gupte , Yati Chugil , Nitin Shetty , Sachin Subhash Bhagwat , Milind Chintaman Shukla , Noel John De Souza , Mahesh Vithalbhai Patel
IPC: A61K31/5377 , A61K31/496 , A61K31/438 , A61K31/4545 , A61K31/454 , C07D498/10 , C07D495/10 , C07D491/113 , C07D413/10 , A61P31/04 , C07D491/107 , C07D413/14 , C07D513/10
CPC classification number: C07D491/10 , C07D413/10 , C07D413/14 , C07D495/10 , C07D497/10 , C07D513/10
Abstract: The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.
Abstract translation: 本发明提供具有预防和治疗感染性疾病的抗微生物活性的试剂。 因此，本发明提供新的取代的哌啶子基苯基恶唑烷酮衍生物，制备化合物的方法以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。
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Patent Agency Ranking
6.发明申请Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment 审中-公开抗菌光学纯苯喹啉羧酸，方法，组合物和治疗方法公开(公告)号：US20080108646A1
公开(公告)日：2008-05-08
申请号：US11880645
申请日：2007-07-23
Applicant: Mahesh Patel , Shivkumar Agarwal , Sreenivas Kandepu , Nitin Shetty , Dilip Upadhyay , Nishith Chaturvedi , Abraham Thomas , Noel De Souza , Habil Khorakiwala
Inventor： Mahesh Patel , Shivkumar Agarwal , Sreenivas Kandepu , Nitin Shetty , Dilip Upadhyay , Nishith Chaturvedi , Abraham Thomas , Noel De Souza , Habil Khorakiwala
IPC: A61K31/473 , C07D455/04 , A61P31/04
CPC classification number: C07C279/14 , A61K31/4745 , C07B2200/07 , C07D455/04 , Y02A50/473
Abstract: The present invention relates to optically pure S-(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(+)-isomers, to processes for preparation of the optically pure S-(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof substantially free of their R-(+)-isomers, and to pharmaceutical compositions comprising the S(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof.
Abstract translation: 本发明涉及基本上不含其R - （+） - 异构体的光学纯的S - （ - ） - 苯并喹嗪羧酸，其衍生物，盐，假多晶型物，多晶型物和水合物，用于制备光学纯S - （ - ） - 苯并喹嗪羧酸，它们的衍生物，盐，假多晶型物，基本上不含其R - （+） - 异构体的多晶型物和水合物，以及包含S（ - ） - 苯醌喹唑啉羧酸的衍生物， 盐，假多晶型物，多晶型物及其水合物。
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7.发明授权Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments 失效产生三重靶向，手性，广谱抗微生物剂7-取代哌啶子基 - 喹诺酮羧酸衍生物，其制备，组合物和作为药物的用途公开(公告)号：US06964966B2
公开(公告)日：2005-11-15
申请号：US10128996
申请日：2002-04-23
Applicant: Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Shrikant V. Gupte , Dilip J. Upadhyay , Satish B. Bhawsar , Rupinder K. Beri , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Milind Chintaman Shukla , Yati Chugh , Nitin Shetty , Ravindra D. Yeole , M. Madhav Reddy
Inventor： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Shrikant V. Gupte , Dilip J. Upadhyay , Satish B. Bhawsar , Rupinder K. Beri , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Milind Chintaman Shukla , Yati Chugh , Nitin Shetty , Ravindra D. Yeole , M. Madhav Reddy
IPC: A61K31/095 , A61K31/191 , A61K31/47 , A61K31/4709 , A61K45/06 , A61P3/04 , A61P11/00 , A61P13/10 , A61P13/12 , A61P19/02 , A61P27/16 , A61P29/00 , A61P31/00 , A61P31/04 , C07D215/22 , C07D215/233 , C07D401/04 , C07D401/14 , C07D413/12 , C07D455/04 , C07D471/04 , C07D471/08 , C07D519/00 , A61K31/497 , C07D215/36 , C07D279/12 , C07D401/00 , C07F5/02
CPC classification number: C07D215/233 , A61K31/47 , A61K45/06 , C07D401/04 , C07D401/14 , C07D413/12 , C07D455/04 , C07D471/04 , C07D471/08
Abstract: This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.
Abstract translation: 本发明涉及新一代三靶向，手性，广谱抗微生物7-取代的哌啶子基 - 喹诺酮羧酸衍生物，其旋光异构体，非对映异构体或对映异构体，以及其药学上可接受的盐，水合物，前药，多晶型物和假多晶型物 ，准备，组合和使用。
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公开(公告)号：US06753333B2
公开(公告)日：2004-06-22
申请号：US10303692
申请日：2002-11-22
Applicant: Noel J. De Souza , Shivkumar Agarwal , Mahesh V. Patel , Satish B. Bhawsar , Rupinder K. Beri , Ravindra D. Yeole , Nitin Shetty
Inventor： Noel J. De Souza , Shivkumar Agarwal , Mahesh V. Patel , Satish B. Bhawsar , Rupinder K. Beri , Ravindra D. Yeole , Nitin Shetty
IPC: A61K314375
CPC classification number: C07D215/233 , A61K31/4745 , A61K45/06 , C07B2200/07 , C07C279/14 , C07D401/04 , C07D401/14 , C07D455/04 , C07D471/04 , C07D471/08
Abstract: The invention relates to the new arginine salt forms of S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, a process for their preparation and pharmaceutical formulations which comprise those arginine salt forms as the active ingredient for its use in treating antimicrobial infections.
Abstract translation: 本发明涉及新的精氨酸盐形式的S - （ - ） - 9-氟-6,7-二氢-8-（4-羟基哌啶-1-基）-5-甲基-1-氧代-1H，5H- 苯并[i，j]喹嗪-2-羧酸，其制备方法和药物制剂，其包含这些精氨酸盐形式作为其用于治疗抗微生物感染的活性成分。
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9.发明授权Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy 有权具有抗菌活性并具有改善的体内功效的取代的哌啶子基苯基恶唑烷酮公开(公告)号：US08729269B2
公开(公告)日：2014-05-20
申请号：US12705258
申请日：2010-02-12
Applicant: Prasad Keshav Deshpande , Milind Dattatraya Sindkhedkar , Mahesh Shriram Phansalkar , Ravindra Dattatraya Yeole , Shrikant Vinayak Gupte , Yati Chugh , Nitin Shetty , Sachin Subhash Bhagwat , Milind Chintaman Shukla , Noel John De Souza , Mahesh Vithalbhai Patel
Inventor： Prasad Keshav Deshpande , Milind Dattatraya Sindkhedkar , Mahesh Shriram Phansalkar , Ravindra Dattatraya Yeole , Shrikant Vinayak Gupte , Yati Chugh , Nitin Shetty , Sachin Subhash Bhagwat , Milind Chintaman Shukla , Noel John De Souza , Mahesh Vithalbhai Patel
IPC: C07D411/06 , A61K31/454
CPC classification number: C07D491/10 , C07D413/10 , C07D413/14 , C07D495/10 , C07D497/10 , C07D513/10
Abstract: The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.
Abstract translation: 本发明提供具有预防和治疗感染性疾病的抗微生物活性的试剂。 因此，本发明提供新的取代的哌啶子基苯基恶唑烷酮衍生物，制备化合物的方法以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。
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10.发明授权Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy 失效具有抗菌活性并具有改善的体内功效的取代的哌啶子基苯基恶唑烷酮公开(公告)号：US07687627B2
公开(公告)日：2010-03-30
申请号：US10935708
申请日：2004-09-07
Applicant: Prasad Keshav Deshpande , Milind Dattatraya Sindkhedkar , Mahesh Shriram Phansalkar , Ravindra Dattatraya Yeole , Shrikant Vinayak Gupte , Yati Chugh , Nitin Shetty , Sachin Subhash Bhagwat , Milind Chintaman Shukla , Noel John De Souza , Mahesh Vithalbhai Patel
Inventor： Prasad Keshav Deshpande , Milind Dattatraya Sindkhedkar , Mahesh Shriram Phansalkar , Ravindra Dattatraya Yeole , Shrikant Vinayak Gupte , Yati Chugh , Nitin Shetty , Sachin Subhash Bhagwat , Milind Chintaman Shukla , Noel John De Souza , Mahesh Vithalbhai Patel
IPC: C07D491/113 , A61K31/438
CPC classification number: C07D491/10 , C07D413/10 , C07D413/14 , C07D495/10 , C07D497/10 , C07D513/10
Abstract: The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.
Abstract translation: 本发明提供具有预防和治疗感染性疾病的抗微生物活性的试剂。 因此，本发明提供新的取代的哌啶子基苯基恶唑烷酮衍生物，制备化合物的方法以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。
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