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公开(公告)号：US09958421B2
公开(公告)日：2018-05-01
申请号：US13518029
申请日：2010-12-20
Applicant: Klaus Gebauer , Elisabeth Hallgren , Raf Lemmens , Ola Lind , Bjorn Lundgren , Jamil Shanagar , Kajsa Stridsberg-Friden , Helena Widegren
Inventor： Klaus Gebauer , Elisabeth Hallgren , Raf Lemmens , Ola Lind , Bjorn Lundgren , Jamil Shanagar , Kajsa Stridsberg-Friden , Helena Widegren
IPC: G01N30/56 , B01D15/20 , G01N30/28 , B01J20/28 , B01D15/32 , B01J20/22 , B01D15/36 , B01J20/281 , B01J20/30 , B01D15/38 , B01J20/285
CPC classification number: G01N30/56 , B01D15/206 , B01D15/32 , B01D15/361 , B01D15/3804 , B01J20/22 , B01J20/28 , B01J20/28011 , B01J20/28016 , B01J20/285 , B01J20/3092 , G01N30/28 , G01N30/482
Abstract: The invention provides a packing method for high efficiency chromatography columns starting from dry swellable particles, as well as columns packed by the method and the use of the columns in separation of biomolecules. In the packing method, an amount of dry swellable particles sufficient to give a swollen volume in a liquid of about 105-120% of the column chamber volume is transferred to the column, the column is closed and the liquid is provided to the column.
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公开(公告)号：US08277649B2
公开(公告)日：2012-10-02
申请号：US12636833
申请日：2009-12-14
Applicant: Patrick Roland Lucien Malenfant , Cathryn Ellen Olsen , Vincent Francis Pizzi , Gary William Yeager , Robert Scott Duthie , Per Ola Lind , Stina Elisabeth Hallgren , Annika Morrison
Inventor： Patrick Roland Lucien Malenfant , Cathryn Ellen Olsen , Vincent Francis Pizzi , Gary William Yeager , Robert Scott Duthie , Per Ola Lind , Stina Elisabeth Hallgren , Annika Morrison
IPC: B01D15/08
CPC classification number: B01D15/3847 , B01J20/28097 , B01J20/3282 , B01J41/20 , C07K1/165 , C07K16/00 , G01N33/6854
Abstract: The invention relates to a device for separating unwanted compounds from an antibody containing biological sample. The device comprises a porous support and a polymeric resin disposed within the pores of the porous support. The device may further comprise a viral clearance membrane upstream or downstream from the polymeric resin. Methods of use are also provided.
Abstract translation: 本发明涉及用于从含有抗体的生物样品中分离不想要的化合物的装置。 该装置包括多孔载体和设置在多孔载体的孔内的聚合物树脂。 该装置还可包含聚合物树脂上游或下游的病毒清除膜。 还提供了使用方法。
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公开(公告)号：US20110178271A1
公开(公告)日：2011-07-21
申请号：US12674169
申请日：2008-08-27
Applicant: Ingrid Drevin , Hamid Houshmand , Ola Lind
Inventor： Ingrid Drevin , Hamid Houshmand , Ola Lind
CPC classification number: A61L2/07 , B01D15/20 , B01J20/286 , B01J20/3274 , B01J20/3466
Abstract: The present invention relates to a method for sterilization of different materials, especially sensitive material, such as chromatographic media with sensitive ligands. The method for sterilization of a chromatographic separation medium comprises exposing the separation medium to pressurized steam at a temperature of between about 121° C. and about 135° C.
Abstract translation: 本发明涉及不同材料，特别是敏感材料如具有敏感性配体的色谱介质的灭菌方法。 灭菌色谱分离介质的方法包括将分离介质暴露于约121℃至约135℃的加压蒸汽中。
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公开(公告)号：US08999157B2
公开(公告)日：2015-04-07
申请号：US12665950
申请日：2008-07-07
Applicant: Lars C. Andersson , Anna Arefalk , Ola Lind , Bjorn Noren
Inventor： Lars C. Andersson , Anna Arefalk , Ola Lind , Bjorn Noren
IPC: B01J20/32 , B01D15/38 , B01J20/289
CPC classification number: B01J20/3242 , B01D15/3828 , B01J20/289 , B01J20/3219 , B01J20/3251 , B01J20/3265
Abstract: The present invention is relates to method for production of a biomolecule adsorbent with a pentadentate ligand with very strong chelating properties, and to methods for use thereof for, for example, protein purification, detection or binding. The biomolecule adsorbent comprises the formula: wherein Q is a carrier, S is a spacer, L is an amide linkage, X is COOH, and n=2 or 3.
Abstract translation: 本发明涉及生产具有非常强螯合性的五齿配体的生物分子吸附剂的方法及其用于例如蛋白质纯化，检测或结合的方法。 生物分子吸附剂包括下式：其中Q是载体，S是间隔基，L是酰胺键，X是COOH，n = 2或3。
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公开(公告)号：US08137559B2
公开(公告)日：2012-03-20
申请号：US12523322
申请日：2008-01-28
Applicant: Michael Katzke , Ola Lind , Tobias Soderman , James Van Alstine
Inventor： Michael Katzke , Ola Lind , Tobias Soderman , James Van Alstine
IPC: B01D15/08
CPC classification number: A23L2/80 , A23L2/02 , B01D15/00 , B01J20/26 , B01J20/264 , B01J20/265 , C12H1/0424
Abstract: The present invention relates to liquid clarification. More closely, the invention relates to beverage clarification, such as reduction of colloidal (not microbial) haze-causing substances in beer or related beverages such as wine, juices, flavorings etc. The method of the invention uses a hydrophilic surface for adsorption of haze-forming substances by hydrogen bonding interaction properties between the surface and the haze-forming substances.
Abstract translation: 本发明涉及液体澄清。 更具体地，本发明涉及饮料澄清，例如在啤酒或相关饮料如葡萄酒，果汁，调味料等中减少胶体（非微生物）雾状物质。本发明的方法使用亲水表面吸附雾度 通过表面和雾状物质之间的氢键相互作用特性形成物质。
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Patent Agency Ranking
公开(公告)号：US20110139717A1
公开(公告)日：2011-06-16
申请号：US12636833
申请日：2009-12-14
Applicant: Patrick Roland Lucien Malenfant , Cathryn Ellen Olsen , Vincent Francis Pizzi , Gary William Yeager , Robert Scott Duthie , Per Ola Lind , Stina Elisabeth Hallgren , Annika Morrison
Inventor： Patrick Roland Lucien Malenfant , Cathryn Ellen Olsen , Vincent Francis Pizzi , Gary William Yeager , Robert Scott Duthie , Per Ola Lind , Stina Elisabeth Hallgren , Annika Morrison
CPC classification number: B01D15/3847 , B01J20/28097 , B01J20/3282 , B01J41/20 , C07K1/165 , C07K16/00 , G01N33/6854
Abstract: The invention relates to a device for separating unwanted compounds from an antibody containing biological sample. The device comprises a porous support and a polymeric resin disposed within the pores of the porous support. The device may further comprise a viral clearance membrane upstream or downstream from the polymeric resin. Methods of use are also provided.
Abstract translation: 本发明涉及用于从含有抗体的生物样品中分离不想要的化合物的装置。 该装置包括多孔载体和设置在多孔载体的孔内的聚合物树脂。 该装置还可包含聚合物树脂上游或下游的病毒清除膜。 还提供了使用方法。
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公开(公告)号：US20080142439A1
公开(公告)日：2008-06-19
申请号：US11817268
申请日：2006-03-06
Applicant: Jan Berglof , Ingrid Drevin , Ola Lind , Ulf Segerbo
Inventor： Jan Berglof , Ingrid Drevin , Ola Lind , Ulf Segerbo
Abstract: The present invention relates to a method of sterilizing a chromatography column which is packed with a separation matrix, which method comprises passing a superheated aqueous liquid through the packing of the column to obtain at least one substantially sterile packed chromatography column. The method may also comprise a preceding heating. In the most advantageous embodiment, the superheated aqueous liquid is passed in a substantially uniform flow through the packing of the column, resulting in a sterility of the packed column.
Abstract translation: 本发明涉及对填充有分离基质的色谱柱进行灭菌的方法，该方法包括使过热水性液体通过柱的填充物，以获得至少一个基本无菌的填充色谱柱。 该方法还可以包括前面的加热。 在最有利的实施方案中，过热水性液体以基本均匀的流动通过柱的填料，导致填充柱的无菌性。
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公开(公告)号：US20120267299A1
公开(公告)日：2012-10-25
申请号：US13518029
申请日：2010-12-20
Applicant: Klaus Gebauer , Elisabeth Hallgren , Raf Lemmens , Ola Lind , Bjorn Lundgren , Jamil Shanagar , Kajsa Stridsberg-Friden , Helena Widegren
Inventor： Klaus Gebauer , Elisabeth Hallgren , Raf Lemmens , Ola Lind , Bjorn Lundgren , Jamil Shanagar , Kajsa Stridsberg-Friden , Helena Widegren
CPC classification number: G01N30/56 , B01D15/206 , B01D15/32 , B01D15/361 , B01D15/3804 , B01J20/22 , B01J20/28 , B01J20/28011 , B01J20/28016 , B01J20/285 , B01J20/3092 , G01N30/28 , G01N30/482
Abstract: The invention provides a packing method for high efficiency chromatography columns starting from dry swellable particles, as well as columns packed by the method and the use of the columns in separation of biomolecules. In the packing method, an amount of dry swellable particles sufficient to give a swollen volume in a liquid of about 105-120% of the column chamber volume is transferred to the column, the column is closed and the liquid is provided to the column.
Abstract translation: 本发明提供了一种从干燥可溶胀颗粒开始的高效色谱柱的包装方法，以及通过该方法包装的色谱柱和分离生物分子中色谱柱的用途。 在包装方法中，足以使柱体积体积的约105-120％的液体中的溶胀体积的干燥可溶胀颗粒的量转移到柱中，将柱关闭并将液体提供给塔。
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公开(公告)号：US20110097464A1
公开(公告)日：2011-04-28
申请号：US12909120
申请日：2010-10-21
Applicant: MARIA HOLM , OLA LIND , JAMES VAN ALSTINE
Inventor： MARIA HOLM , OLA LIND , JAMES VAN ALSTINE
CPC classification number: A23L2/80 , A23L2/74 , C12H1/0424
Abstract: The present invention relates to liquid clarification and stabilization. More closely, the invention relates to both clarification by removal of suspended particles, as well as stabilization against formation of non-microbial haze via reduction of haze forming substances in various liquids. The haze forming substances are proteins and polyphenol tannins which occur in various plant related fluids such as beer wine, juices, flavorings, plant extracts, and even bioprocess streams. The method of the invention accomplishes both size based removal of colloidal non-haze related particles as well as adsorption based removal of haze forming substances without a need for added flocculants. The to method of the invention utilizes hydrophilic surfaces for adsorption of haze forming substances with such surfaces presented by materials arranged in manner so that size based exclusion of suspended particles is also achieved.
Abstract translation: 本发明涉及液体澄清和稳定化。 更为详细地，本发明涉及通过除去悬浮颗粒进行澄清，以及通过减少各种液体中的雾状物质而形成非微生物雾度的稳定性。 烟雾形成物质是发生在各种植物相关液体中的蛋白质和多酚单宁，例如啤酒，果汁，调味剂，植物提取物，甚至生物过程流。 本发明的方法完成了胶体非雾度相关颗粒的基于尺寸的去除以及基于吸附的去除雾状形成物质而不需要添加的絮凝剂。 本发明的方法利用亲水表面吸附具有这种表面的雾状形成物质，所述表面由以下方式排列：材料排列方式使悬浮颗粒的尺寸排除也得以实现。
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公开(公告)号：US20110003941A1
公开(公告)日：2011-01-06
申请号：US12665950
申请日：2008-07-07
Applicant: Lars C. Andersson , Anna Arefalk , Ola Lind , Bjorn Noren
Inventor： Lars C. Andersson , Anna Arefalk , Ola Lind , Bjorn Noren
CPC classification number: B01J20/3242 , B01D15/3828 , B01J20/289 , B01J20/3219 , B01J20/3251 , B01J20/3265
Abstract: The present invention is relates to method for production of a biomolecule adsorbent with a pentadentate ligand with very strong chelating properties, and to methods for use thereof for, for example, protein purification, detection or binding. The biomolecule adsorbent comprises the formula: wherein Q is a carrier, S is a spacer, L is an amide linkage, X is COOH, and n=2 or 3.
Abstract translation: 本发明涉及生产具有非常强螯合性的五齿配体的生物分子吸附剂的方法及其用于例如蛋白质纯化，检测或结合的方法。 生物分子吸附剂包括下式：其中Q是载体，S是间隔基，L是酰胺键，X是COOH，n = 2或3。
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