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1.发明授权公开(公告)号：US10189961B2
公开(公告)日：2019-01-29
申请号：US12676379
申请日：2008-09-04
摘要： The invention provides creep resistant, highly lubricious, tough and ionic hydrogels, creep resistant, lubricious, tough ionic hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the creep resistant, highly lubricious, tough and ionic hydrogels including ionic PVA-hydrogels, ionic PVA-PAAMPS-hydrogels, or the ionic hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled ionic hydrogels and making cross-linked ionic hydrogels and cross-linked ionic hydrogel-containing compositions also are disclosed herein.
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公开(公告)号：US09962463B2
公开(公告)日：2018-05-08
申请号：US15184228
申请日：2016-06-16
IPC分类号： A61L27/16 , A61L27/44 , A61L27/50 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , C08J3/22 , C08J3/28 , C08J3/24 , C08K5/1545
CPC分类号： A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L2430/02 , C08J3/226 , C08J3/247 , C08J3/28 , C08J2323/06 , C08J2423/00 , C08K5/1545 , C08K2201/012 , C08L23/06 , C08L2666/02 , C08K5/005
摘要： The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.
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3.发明授权Methods and devices for knee joint replacement with anterior cruciate ligament substitution 有权用膝关节置换前交叉韧带替代术的方法和装置公开(公告)号：US09005299B2
公开(公告)日：2015-04-14
申请号：US13547383
申请日：2012-07-12
CPC分类号： A61F2/3836 , A61F2/08 , A61F2/0811 , A61F2/3886 , A61F2002/30688
摘要： Methods and devices are provided for knee joint replacement with anterior cruciate ligament (ACL) substitution. Generally, the methods and devices can allow a knee joint to be partially or totally replaced in conjunction with substitution of the knee joint's ACL. In one embodiment, a knee replacement prosthesis can include a medial or lateral femoral implant, a femoral intercondylar notch structure, a medial or lateral tibial insert, and an ACL-substitution member. The ACL-substitution member can be configured to engage with the femoral intercondylar notch structure during a full range of knee motion and/or during only early knee flexion.
摘要翻译： 方法和装置用于膝关节置换前交叉韧带（ACL）替代。 通常，所述方法和装置可以允许膝关节部分地或完全地被替换为膝关节的ACL。 在一个实施例中，膝关节置换假体可以包括内侧或外侧股骨植入物，股骨髁间隙结构，内侧或外侧胫骨插入物和ACL取代构件。 ACL取代构件可以被构造成在全膝关节运动范围和/或仅在早期膝关节屈曲期间与股骨髁间隙结构接合。
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公开(公告)号：US08968628B2
公开(公告)日：2015-03-03
申请号：US12987399
申请日：2011-01-10
IPC分类号： B29C35/08 , A61L27/16 , A61L27/50 , B29C43/00 , C08K5/00 , C08K5/1545 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , C08J3/28 , C08L23/06
CPC分类号： B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
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公开(公告)号：US08569395B2
公开(公告)日：2013-10-29
申请号：US13562867
申请日：2012-07-31
申请人： Orhun K. Muratoglu , Edward T. Kopesky , Ebru Oral
发明人： Orhun K. Muratoglu , Edward T. Kopesky , Ebru Oral
CPC分类号： A61L27/505 , A61L27/16 , B29C43/003 , B29C43/18 , B29C71/04 , B29K2023/0683 , B29K2105/20 , B29K2995/0056 , B29L2031/753 , C08F10/02 , C08F110/02 , C08J3/24 , C08J3/28 , C08J2323/06 , C08K5/1545 , C08K2201/012 , C08F2/46 , C08F2500/01
摘要： The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (α-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (α-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
摘要翻译： 本发明涉及制备交联抗氧化聚合物材料并防止或最小化抗氧化剂的聚合物材料中的抗氧化剂体内洗脱的方法。 本发明还提供了掺杂具有交联和抗氧化分布的空间控制的聚合材料的方法，例如维生素E（α-生育酚），以及用于提取/洗脱抗氧化剂的方法，例如维生素E（α-生育酚 ），来自含抗氧化剂的聚合物材料的表面区域，以及与其一起使用的材料。
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公开(公告)号：US08318065B2
公开(公告)日：2012-11-27
申请号：US12904481
申请日：2010-10-14
IPC分类号： C08J3/28
CPC分类号： A61L27/16 , A61L27/505 , C08L23/06 , C08L23/10 , C08L27/06 , C08L67/00 , C08L77/00 , C08L2312/06
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.
摘要翻译： 本发明涉及制备抗氧化医疗器械的方法，其包括聚合材料，例如超高分子量聚乙烯（UHMWPE）。 本发明还提供了制备抗氧化剂掺杂医疗植入物的方法，例如，通过扩散掺杂含有交联的UHMWPE与维生素E的医疗装置，后掺杂退火和其中使用的材料。
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公开(公告)号：US20120292816A1
公开(公告)日：2012-11-22
申请号：US13562867
申请日：2012-07-31
申请人： Orhun K. Muratoglu , Edward T. Kopesky , Ebru Oral
发明人： Orhun K. Muratoglu , Edward T. Kopesky , Ebru Oral
CPC分类号： A61L27/505 , A61L27/16 , B29C43/003 , B29C43/18 , B29C71/04 , B29K2023/0683 , B29K2105/20 , B29K2995/0056 , B29L2031/753 , C08F10/02 , C08F110/02 , C08J3/24 , C08J3/28 , C08J2323/06 , C08K5/1545 , C08K2201/012 , C08F2/46 , C08F2500/01
摘要： The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (α-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (α-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
摘要翻译： 本发明涉及制备交联抗氧化聚合物材料并防止或最小化抗氧化剂的聚合物材料中的抗氧化剂体内洗脱的方法。 本发明还提供了掺杂具有交联和抗氧化分布的空间控制的聚合材料的方法，例如维生素E（α-生育酚），以及用于提取/洗脱抗氧化剂的方法，例如维生素E（α-生育酚 ），来自含抗氧化剂的聚合物材料的表面区域，以及与其一起使用的材料。
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8.发明申请High Modulus Crosslinked Polyethylene with Reduced Residual Free Radical Concentration Prepared Below the Melt 审中-公开高模量交联聚乙烯，在熔体下方制备残留的自由基浓度降低公开(公告)号：US20120082860A1
公开(公告)日：2012-04-05
申请号：US13314586
申请日：2011-12-08
IPC分类号： B32B15/08 , C08J3/28 , B32B27/08 , C08F110/02
CPC分类号： C08J3/28 , A61F2/3094 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/4202 , A61L27/16 , B29B13/08 , B29C71/04 , B29C2035/085 , B29C2035/0877 , B29K2023/06 , B29K2023/0683 , B29K2995/0087 , B29L2031/7532 , C08J3/24 , C08J7/12 , C08J2323/06 , C08L23/06 , C08L23/0815 , C08L2312/06 , Y10T428/31692 , Y10T428/31909
摘要： The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.
摘要翻译： 本发明提供一种包含还原自由基的辐照交联聚乙烯，优选基本上不含残留的自由基。 公开了通过在低于熔点的高温下照射聚乙烯与感光环境接触来制造照射的交联聚乙烯的方法，以便将残余自由基的浓度降低至不可检测的水平。 本文还公开了通过在低于聚乙烯熔点的温度（任选在敏化环境中）使聚乙烯机械变形来制备具有降低的自由基含量的辐照交联聚乙烯组合物，优选基本上不含残余自由基的方法。 。
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公开(公告)号：US07906064B2
公开(公告)日：2011-03-15
申请号：US11564594
申请日：2006-11-29
IPC分类号： B29B13/08
CPC分类号： B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
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10.发明申请CREEP RESISTANT, HIGHLY LUBRICIOUS, TOUGH, AND IONIC HYDROGELS INCLUDING PVA-PAAMPS HYDROGELS 审中-公开耐腐蚀性，高润滑性，韧性和离子水合物，包括PVA-PAAMPS水凝胶公开(公告)号：US20110054622A1
公开(公告)日：2011-03-03
申请号：US12676379
申请日：2008-09-04
CPC分类号： C08J3/28 , C08J3/075 , C08J3/246 , C08J2329/04
摘要： The invention provides creep resistant, highly lubricious, tough and ionic hydrogels, creep resistant, lubricious, tough ionic hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the creep resistant, highly lubricious, tough and ionic hydrogels including ionic PVA-hydrogels, ionic PVA-PAAMPS-hydrogels, or the ionic hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled ionic hydrogels and making cross-linked ionic hydrogels and cross-linked ionic hydrogel-containing compositions also are disclosed herein.
摘要翻译： 本发明提供抗蠕变性，高光滑性，坚韧和离子水凝胶，抗蠕变性，光滑，坚韧的含离子水凝胶组合物及其制备方法。 本发明还提供植入或施用耐蠕变，高度光滑，韧性和离子水凝胶的方法，包括离子PVA-水凝胶，离子PVA-PAAMPS-水凝胶或含有离子水凝胶的组合物以治疗需要的受试者。 交联预固化或预胶凝的离子水凝胶和制备交联的离子水凝胶和交联的含离子水凝胶的组合物的方法也在本文中公开。
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