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1.发明授权Lipoprotein lipase and lipoprotein lipase activators in the treatment of inflammatory conditions 失效脂蛋白脂肪酶和脂蛋白脂肪酶激活剂治疗炎症状态公开(公告)号：US06869603B2
公开(公告)日：2005-03-22
申请号：US10289203
申请日：2002-11-07
申请人： Jorge Plutzky , Ouliana Ziouzenkova
发明人： Jorge Plutzky , Ouliana Ziouzenkova
IPC分类号： A61K31/11 , A61K31/216 , A61K38/46
CPC分类号： A61K8/375 , A61K8/66 , A61K31/11 , A61K31/216 , A61K38/465 , A61Q5/006 , A61Q7/00 , A61Q19/005 , A61Q19/007 , C12Y301/01034 , A61K2300/00
摘要： The present invention is directed to compositions which include the enzyme lipoprotein lipase. These compositions may be applied topically to the skin of a person to prevent dryness or treat inflammation. In addition, the invention is directed to the use of fibrates to enhance the activity of lipoprotein lipase. The fibrates may be used orally to treat inflammation or enhance metabolic energy production.
摘要翻译： 本发明涉及包含酶脂蛋白脂肪酶的组合物。 这些组合物可以局部施用于人的皮肤，以防止干燥或治疗炎症。 此外，本发明涉及使用贝特类以提高脂蛋白脂肪酶的活性。 贝特类可以口服用于治疗炎症或增强代谢能量的产生。
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2.发明申请公开(公告)号：US20050129724A1
公开(公告)日：2005-06-16
申请号：US11049649
申请日：2005-02-04
申请人： Jorge Plutzky , Ouliana Ziouzenkova
发明人： Jorge Plutzky , Ouliana Ziouzenkova
CPC分类号： A61K8/375 , A61K8/66 , A61K31/11 , A61K31/216 , A61K38/465 , A61Q5/006 , A61Q7/00 , A61Q19/005 , A61Q19/007 , C12Y301/01034 , A61K2300/00
摘要： The present invention is directed to compositions which include the enzyme lipoprotein lipase. These compositions may be applied topically to the skin of a person to prevent dryness or treat inflammation. In addition, the invention is directed to the use of fibrates to enhance the activity of lipoprotein lipase. The fibrates may be used orally to treat inflammation or enhance metabolic energy production.
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公开(公告)号：US08858990B2
公开(公告)日：2014-10-14
申请号：US12884587
申请日：2010-09-17
申请人： Ouliana Ziouzenkova
发明人： Ouliana Ziouzenkova
IPC分类号： A61K9/48 , A01N63/00 , A61K48/00 , C12N15/00 , C12N5/077 , A61K9/50 , C12N5/0775 , A61K9/00 , C07K14/245 , A61K35/12
CPC分类号： A61K9/0024 , A61K9/5031 , A61K9/5036 , A61K2035/126 , C07K14/245 , C12N5/0653 , C12N5/0667 , C12N2501/70 , C12N2510/00 , C12N2533/32 , C12N2533/74
摘要： Described herein are methods and devices for treating a metabolic disease that involve implanting a micro-device into a tissue of a subject having a metabolic disease. The micro-device includes a plurality of thermogenic cells encapsulated in a biocompatible capsule. The capsule includes a core to accommodate the plurality of thermogenic cells and a porous immunoprotective membrane that allows for metabolic interaction between the plurality of thermogenic cells and the tissue.
摘要翻译： 本文描述了用于治疗代谢疾病的方法和装置，其涉及将微型装置植入具有代谢性疾病的受试者的组织中。 微型装置包括封装在生物相容性胶囊中的多个生热细胞。 胶囊包括容纳多个生热细胞的核心和允许多个生热细胞与组织之间的代谢相互作用的多孔免疫保护膜。
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公开(公告)号：US09078852B2
公开(公告)日：2015-07-14
申请号：US12919716
申请日：2009-02-27
申请人： Jorge Plutzky , Ouliana Ziouzenkova
发明人： Jorge Plutzky , Ouliana Ziouzenkova
CPC分类号： A61K31/11
摘要： The present invention is directed to methods of treating a patient for a disease or condition associated with adipogenesis or insulin resistance by administering a retinaldehyde compound to the patient or a compound that increases endogenous retinaldehyde levels by inhibiting the enzyme retinaldehyde dehydrogenase 1.
摘要翻译： 本发明涉及通过向患者施用视黄醛化合物或通过抑制视网膜醛脱氢酶1增加内源性视黄醛水平的化合物来治疗患者与脂肪形成或胰岛素抵抗相关的疾病或病症的方法。
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公开(公告)号：US20110064797A1
公开(公告)日：2011-03-17
申请号：US12884587
申请日：2010-09-17
申请人： Ouliana Ziouzenkova
发明人： Ouliana Ziouzenkova
CPC分类号： A61K9/0024 , A61K9/5031 , A61K9/5036 , A61K2035/126 , C07K14/245 , C12N5/0653 , C12N5/0667 , C12N2501/70 , C12N2510/00 , C12N2533/32 , C12N2533/74
摘要： Described herein are methods and devices for treating a metabolic disease that involve implanting a micro-device into a tissue of a subject having a metabolic disease. The micro-device includes a plurality of thermogenic cells encapsulated in a biocompatible capsule. The capsule includes a core to accommodate the plurality of thermogenic cells and a porous immunoprotective membrane that allows for metabolic interaction between the plurality of thermogenic cells and the tissue.
摘要翻译： 本文描述了用于治疗代谢疾病的方法和装置，其涉及将微型装置植入具有代谢性疾病的受试者的组织中。 微型装置包括封装在生物相容性胶囊中的多个生热细胞。 胶囊包括容纳多个生热细胞的核心和允许多个生热细胞与组织之间的代谢相互作用的多孔免疫保护膜。
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6.发明申请公开(公告)号：US20110046234A1
公开(公告)日：2011-02-24
申请号：US12919716
申请日：2009-02-27
申请人： Jorge Plutzky , Ouliana Ziouzenkova
发明人： Jorge Plutzky , Ouliana Ziouzenkova
CPC分类号： A61K31/11
摘要： The present invention is directed to methods of treating a patient for a disease or condition associated with adipogenesis or insulin resistance by administering a retinaldehyde compound to the patient or a compound that increases endogenous retinaldehyde levels by inhibiting the enzyme retinaldehyde dehydrogenase 1.
摘要翻译： 本发明涉及通过向患者施用视黄醛化合物或通过抑制视网膜醛脱氢酶1增加内源性视黄醛水平的化合物来治疗患者与脂肪形成或胰岛素抵抗相关的疾病或病症的方法。
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