公开(公告)号：US20100080856A1

公开(公告)日：2010-04-01

申请号：US12284966

申请日：2008-09-26

申请人： Peter D. Costantino

发明人： Peter D. Costantino

IPC分类号： A61K33/34 ,  C07C229/02 ,  A61K31/225 ,  A61K31/375 ,  A61K31/593 ,  A61K31/51 ,  A61K31/525 ,  A61K33/04 ,  A61P17/02 ,  A61K33/32 ,  A61K31/455 ,  A61K31/44 ,  A61K33/06 ,  A61K33/26 ,  A61K33/30

CPC分类号： A61K31/198 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A61K31/194 ,  A61K31/232 ,  A61K31/355 ,  A61K31/375 ,  A61K31/44 ,  A61K31/455 ,  A61K31/51 ,  A61K31/525 ,  A61K31/593 ,  A61K45/06 ,  C07C229/26 ,  A61K2300/00

摘要： A composition and a method for administering the composition to a patient in order to accelerate wound healing, particularly postoperative wound healing. The composition, which essentially comprises ornithine α-ketoglutarate, is water-soluble and formulated for oral administration in single-dose packets. The method for using the composition for promoting wound healing includes the step of administering the composition to a patient preoperatively as well as-postoperatively in accordance with a prescribed protocol. The composition may be customized to include one or more additional agents that are effective for promoting nutritional health and/or treating a particular medical problem. The composition may also be taken daily by athletes to minimize the healing time of closed wounds such as muscle or tendon tears that occur during participation in sports, even when the symptoms of such injury are subclinical.

摘要翻译： 用于给患者施用组合物的组合物和方法，以加速伤口愈合，特别是术后伤口愈合。 基本上包含鸟氨酸α-酮戊二酸的组合物是水溶性的并配制成用于单次剂量包装中的口服给药。 用于促进伤口愈合的组合物的方法包括根据规定的方案在术前和术后对患者施用组合物的步骤。 组合物可以被定制为包括一种或多种有效促进营养健康和/或治疗特定医学问题的另外的试剂。 运动员也可以每天服用组合物，以尽量减少在参与运动期间发生的闭合性伤口（例如肌肉或腱撕裂）的愈合时间，即使这种损伤的症状是亚临床的。

公开(公告)号：US20100249913A1

公开(公告)日：2010-09-30

申请号：US12814214

申请日：2010-06-11

申请人： Arindam Datta ,  Craig Friedman ,  Peter D. Costantino ,  Ian N. Askill ,  Daniel Klempner ,  Arthur H. Tinkelenberg ,  Aisa Sendijarevic

发明人： Arindam Datta ,  Craig Friedman ,  Peter D. Costantino ,  Ian N. Askill ,  Daniel Klempner ,  Arthur H. Tinkelenberg ,  Aisa Sendijarevic

IPC分类号： A61F2/06 ,  B29C41/00 ,  B29C41/42 ,  B29C44/00 ,  B05D7/02 ,  C08G18/08 ,  A61F2/00

CPC分类号： A61F2/0077 ,  A61L27/18 ,  A61L27/50 ,  A61L27/56 ,  C08L75/04

摘要： This invention relates to biodurable, reticulated elastomeric matrices that are resiliently-compressible, their manufacture and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for therapeutic, nutritional, or other useful purposes.

公开(公告)号：US20100211110A1

公开(公告)日：2010-08-19

申请号：US12370785

申请日：2009-02-13

申请人： Peter D. Costantino

发明人： Peter D. Costantino

IPC分类号： A61B17/80 ,  A61B17/88

CPC分类号： A61B17/80 ,  A61B17/688 ,  A61B17/808 ,  A61B17/809 ,  A61B17/8875 ,  A61B2017/8655

摘要： A craniofacial plating member comprises a fastening member configured and dimensioned to extend over two portions of bone to be mended together. The fastening member defines a plurality of plate holes, at least a first of the plate holes being positioned to be placed over a first bone hole defined or to be defined in one of the bone portions and a second of the plate holes being positioned to overlie a suitable place for a second bone hole defined or to be defined in the other of said bone portions. They first plate hole overlies the first bone hole, and an attachment member is securely positioned in the first plate hole. In accordance with the preferred embodiment, the attachment member is a pin. That pin further comprises a retention member secured to and integral with the pin. The retention member may also further include a barb.

摘要翻译： 颅面电镀构件包括紧固构件，所述紧固构件构造和尺寸设置成在待修补的骨的两部分上延伸。 紧固构件限定多个板孔，至少第一个板孔被定位成放置在限定或限定在其中一个骨部分中的第一骨孔上，并且第二板孔被定位成覆盖 用于在所述骨部分中的另一个中限定或限定的第二骨孔的合适位置。 它们的第一板孔位于第一骨孔之上，并且附接构件牢固地定位在第一板孔中。 根据优选实施例，附接构件是销。 该销还包括固定到销上并与销一体的保持构件。 保持构件还可以包括倒钩。

公开(公告)号：US06436061B1

公开(公告)日：2002-08-20

申请号：US09474334

申请日：1999-12-29

申请人： Peter D. Costantino

发明人： Peter D. Costantino

IPC分类号： A61B500

CPC分类号： A61N7/00 ,  A61B2017/00747 ,  A61B2090/378

摘要： A method and apparatus for the non-invasive treatment of varicose veins. The vibrational energy in acoustic waves emanating from one or more source of ultrasonic energy is focused beneath the skin to cause localized heating and tissue disruption and/or destruction in and around the varicosed segment of the vein, particularly the venous endothelium. The localized tissue destruction is followed by localized fibrosis in and around the dilated portion of the varicosed vessel. The ultrasound-induced fibrosis includes thickening and loss of elasticity of the vascular wall. If a sufficiently high dosage of ultrasound energy is delivered to the vein, the varicosed portion of the vessel will be obliterated, providing a therapeutic result similar to that obtained by injection sclerotherapy or vein stripping. Alternatively, focused ultrasound may be used to induce fibrosis in the tissue overlying the varicosed vessel thereby providing a relatively inelastic barrier which resists unsightly deformation of the skin overlying the varicose vein due to venous dilation.

摘要翻译： 静脉曲张非侵入性治疗方法和装置。 从一个或多个超声能量源发出的声波中的振动能量集中在皮肤下方，导致静脉静脉曲张段，特别是静脉内皮内和周围的局部加热和组织破坏和/或破坏。 局部组织破坏之后是静脉曲张血管扩张部分内和周围的局部纤维化。 超声引起的纤维化包括血管壁的增厚和弹性丧失。 如果足够高剂量的超声能量被输送到静脉，血管的静脉曲张部分将被消除，提供类似于通过注射硬化疗法或静脉剥离获得的治疗结果。 或者，可以使用聚焦超声来在覆盖静脉曲张血管的组织中诱导纤维化，从而提供相对无弹性的屏障，其阻止由于静脉扩张而覆盖在静脉曲张上的皮肤的难看的变形。