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公开(公告)号:US20120015355A1
公开(公告)日:2012-01-19
申请号:US13000597
申请日:2009-06-29
CPC分类号: C12Q1/68 , C12Q2565/125 , C12Q2545/101 , C12Q2525/204 , C12Q2537/143
摘要: A size standard, kit includes a size standard, method of defining a size standard and method of analysis using a size standard. The size standard is intended to include size standard elements which have a size greater than and/or less than and/or different from the components of a sample which are to be sized. This means that the same characteristic unit, such as a dye, can be used to label the component and the size standard. A further characteristic unit, from amongst a limited number of such characteristic units is liberated from use only on size standards for use on components. The method is therefore particularly useful in multiplex amplification of STRs.
摘要翻译: 尺寸标准,套件包括尺寸标准,使用尺寸标准定义尺寸标准的方法和分析方法。 尺寸标准旨在包括具有大于和/或小于和/或不同于尺寸的样品的组分的尺寸的尺寸标准元件。 这意味着可以使用相同的特征单元,例如染料来标记组分和尺寸标准。 从有限数量的这种特征单元中的另一个特征单元仅在组件上使用的尺寸标准上被使用。 因此,该方法在STR的多重扩增中特别有用。
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公开(公告)号:US20100221726A1
公开(公告)日:2010-09-02
申请号:US12703046
申请日:2010-02-09
申请人: Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , Matthew Estes , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi
发明人: Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , Matthew Estes , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi
CPC分类号: B01L3/502761 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L7/525 , C12Q1/6806 , C25B9/00 , G01N1/10 , G01N21/01 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44791 , G01N2021/6484 , G01N2201/062 , G01N2201/0846 , Y10T436/143333
摘要: A method of analysis, instrument for analysis and device for use in such an instrument are provided, which perform a number of processes need to reach a useful result in the context of a wide variety of samples. The sequence of those processes being optimised. A device, instrument using the device and method of use are also provided which offer reliable performance of a heating based process, with minimal condensation and/or sample loss issues.
摘要翻译: 提供了一种分析方法,用于分析仪器和用于这种仪器的设备,其执行许多过程需要在各种样品的上下文中获得有用的结果。 这些过程的顺序被优化。 还提供了使用该装置和使用方法的装置,仪器,其具有基于加热的工艺的可靠性能,具有最小的冷凝和/或样品损失问题。
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公开(公告)号:US20100241358A1
公开(公告)日:2010-09-23
申请号:US12558244
申请日:2009-09-11
申请人: Frederic Zenhausern , Ralf Lenigk , Andrew Hopwood , Pieris Koumi
发明人: Frederic Zenhausern , Ralf Lenigk , Andrew Hopwood , Pieris Koumi
CPC分类号: G01N1/28 , B01L3/502753 , B01L2300/024 , C12Q1/68 , C12Q1/6876 , C12Q2600/166 , G01D21/00 , G01N27/44791 , G01N33/487 , G01N33/6803 , G01N2030/045 , G06F17/00
摘要: A method of verifying the performance of a size standard, formed of a plurality of size standard elements, used in a nucleic acid analysis method is provided. The verification is achieved by introducing the size standard to an analysis stage and performing a size based separation on the size standard. The size based separation defines an experimental position for each size standard element. A comparison is made as to whether or not the experimental position for the size standard element corresponds with expected position. The comparison allows a decision to be made on whether or not to use the size standard, which is dependent upon whether or not the experimental position of the size standard element corresponds with the expected position.
摘要翻译: 提供了一种验证在核酸分析方法中使用的由多个尺寸标准元素形成的尺寸标准的性能的方法。 通过将尺寸标准引入分析阶段并根据尺寸标准执行基于尺寸的分离来实现验证。 基于尺寸的分离定义了每个尺寸标准元素的实验位置。 比较尺寸标准元件的实验位置是否对应于预期位置。 该比较允许决定是否使用尺寸标准,这取决于尺寸标准件的实验位置是否与预期位置相对应。
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公开(公告)号:US20160187293A1
公开(公告)日:2016-06-30
申请号:US14124986
申请日:2012-06-11
申请人: Frederic ZENHAUSERN , Alan NORDQUIST , Ralf LENIGK , Cedric HURTH , Jianing YANG , Xiaojia CHEN , Matthew ESTES , John LEE-EDGHILL , Nina MORAN , Andrew HOPWOOD , Pieris KOUMI
发明人: Frederic ZENHAUSERN , Alan NORDQUIST , Ralf LENIGK , Cedric HURTH , Jianing YANG , Xiaojia CHEN , Matthew ESTES , John LEE-EDGHILL , Nina MORAN , Andrew HOPWOOD , Pieris KOUMI
IPC分类号: G01N27/447
CPC分类号: G01N27/44756
摘要: An electrophoresis device where the end of the electrophoresis channel has a part that extends vertically. The electrophoresis channel includes a first access port at one end of the channel and a second port at the other end of the channel, which are in the same horizontal plane. In this way, there is a less than 0.1% hydrostatic pressure differential between two ports and the performance of the device is improved.
摘要翻译: 一种电泳装置,其中电泳通道的末端具有垂直延伸的部分。 电泳通道包括在通道的一端的第一进入口和处于相同水平面的通道的另一端的第二端口。 以这种方式,两个端口之间的静水压差小于0.1%,提高了设备的性能。
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公开(公告)号:US08883412B2
公开(公告)日:2014-11-11
申请号:US13000597
申请日:2009-06-29
CPC分类号: C12Q1/68 , C12Q2565/125 , C12Q2545/101 , C12Q2525/204 , C12Q2537/143
摘要: A size standard, kit includes a size standard, method of defining a size standard and method of analysis using a size standard. The size standard is intended to include size standard elements which have a size greater than and/or less than and/or different from the components of a sample which are to be sized. This means that the same characteristic unit, such as a dye, can be used to label the component and the size standard. A further characteristic unit, from amongst a limited number of such characteristic units is liberated from use only on size standards for use on components. The method is therefore particularly useful in multiplex amplification of STRs.
摘要翻译: 尺寸标准,套件包括尺寸标准,使用尺寸标准定义尺寸标准的方法和分析方法。 尺寸标准旨在包括尺寸标准元件,其尺寸大于和/或小于和/或不同于尺寸的样品的组分。 这意味着可以使用相同的特征单元,例如染料来标记组分和尺寸标准。 从有限数量的这种特征单元中的另一个特征单元仅在组件上使用的尺寸标准上被使用。 因此,该方法在STR的多重扩增中特别有用。
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公开(公告)号:US20060046263A1
公开(公告)日:2006-03-02
申请号:US11212370
申请日:2005-08-25
申请人: Peter Gill , Lindsey Dixon , Pieris Koumi
发明人: Peter Gill , Lindsey Dixon , Pieris Koumi
CPC分类号: G16B20/00
摘要: A method for processing results, particularly from, the method comprising: obtaining from the results information concerning the single nucleotide polymorphisms implied for one or more loci, the information including identity information on the single nucleotide polymorphism or polymorphisms of a locus and a value related to the level detected for each identity; comparing each value with a first threshold and a second threshold, the comparison for the value or values for a locus determining the single nucleotide polymorphism identities considered to be possible for that locus.
摘要翻译: 一种处理结果的方法,特别是包括:从结果获得关于一个或多个基因座所暗示的单核苷酸多态性的信息,所述信息包括单核苷酸多态性或基因座多态性的身份信息以及与 检测每个身份的级别; 将每个值与第一阈值和第二阈值进行比较,确定被认为是该基因座可能的单核苷酸多态性身份的基因座的值或值的比较。
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公开(公告)号:US20130130365A1
公开(公告)日:2013-05-23
申请号:US13649852
申请日:2012-10-11
申请人: Frederic ZENHAUSERN , Alan NORDQUIST , Ralf LENIGK , Cedric HURTH , Jianing YANG , Xiaojia CHEN , Matthew ESTES , John LEE-EDGHILL , Nina MORAN , Andrew HOPWOOD , Pieris KOUMI
发明人: Frederic ZENHAUSERN , Alan NORDQUIST , Ralf LENIGK , Cedric HURTH , Jianing YANG , Xiaojia CHEN , Matthew ESTES , John LEE-EDGHILL , Nina MORAN , Andrew HOPWOOD , Pieris KOUMI
CPC分类号: B01L3/502761 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L7/525 , C12Q1/6806 , C25B9/00 , G01N1/10 , G01N21/01 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44791 , G01N2021/6484 , G01N2201/062 , G01N2201/0846 , Y10T436/143333
摘要: A method of analysis, instrument for analysis and device for use in such an instrument are provided, which perform a number of processes need to reach a useful result in the context of a wide variety of samples. The sequence of those processes being optimised. A device, instrument using the device and method of use are also provided which offer reliable performance of a heating based process, with minimal condensation and/or sample loss issues.
摘要翻译: 提供了一种分析方法,用于分析仪器和用于这种仪器的设备,其执行许多过程需要在各种样品的上下文中获得有用的结果。 这些过程的顺序被优化。 还提供了使用该装置和使用方法的装置,仪器,其具有基于加热的工艺的可靠性能,具有最小的冷凝和/或样品损失问题。
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公开(公告)号:US20110100101A1
公开(公告)日:2011-05-05
申请号:US12703025
申请日:2010-02-09
申请人: Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi
发明人: Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi
IPC分类号: G01N1/00
CPC分类号: B01L3/502761 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L7/525 , C12Q1/6806 , C25B9/00 , G01N1/10 , G01N21/01 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44791 , G01N2021/6484 , G01N2201/062 , G01N2201/0846 , Y10T436/143333
摘要: Instruments, devices and methods of analysis are provided which fully integrate a significant number of process steps in a continuous operation. Accurate positioning and full contact between components is also provided by the relative movement the designs allow. An effect interface between a low cost disposable cartridge or device and the instrument to process it is also detailed.
摘要翻译: 提供了仪器,设备和分析方法,它们在连续操作中充分整合了大量的工艺步骤。 组件之间的精确定位和完全接触也可以通过设计允许的相对运动来提供。 低成本的一次性盒式磁盘或装置与处理它的仪器之间的效果接口也是详细的。
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公开(公告)号:US20090203022A1
公开(公告)日:2009-08-13
申请号:US12368031
申请日:2009-02-09
申请人: Frederic ZENHAUSERN , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Andrew Hopwood , Pieris Koumi , Gill Tully
发明人: Frederic ZENHAUSERN , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Andrew Hopwood , Pieris Koumi , Gill Tully
CPC分类号: C12Q1/686 , C12Q1/6848 , C12Q2545/113
摘要: A method of analysing a sample includes providing a first part of the sample and a second part of the sample. A first analysis is conducted on the first part of the sample and the results of the first analysis are considered. A second analysis is conducted on the second part of the sample, the second analysis being conducted according to a procedure using a value for each of one or more characteristics of the procedure. The consideration of the results of the first analysis is used to determine whether the value for one or more of the characteristics of the procedure is changed to a different value. The second analysis is started before the results of the first analysis are obtained.
摘要翻译: 分析样品的方法包括提供样品的第一部分和样品的第二部分。 对样本的第一部分进行了第一次分析,并考虑了第一次分析的结果。 对样品的第二部分进行第二次分析,根据使用该程序的一个或多个特征中的每一个的值的程序进行第二次分析。 使用第一次分析的结果的考虑来确定该过程的一个或多个特征的值是否被改变为不同的值。 第二次分析是在获得第一次分析结果之前开始的。
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公开(公告)号:US08640555B2
公开(公告)日:2014-02-04
申请号:US12703025
申请日:2010-02-09
申请人: Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi
发明人: Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi
IPC分类号: G01N1/22
CPC分类号: B01L3/502761 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L7/525 , C12Q1/6806 , C25B9/00 , G01N1/10 , G01N21/01 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44791 , G01N2021/6484 , G01N2201/062 , G01N2201/0846 , Y10T436/143333
摘要: Instruments, devices and methods of analysis are provided which fully integrate a significant number of process steps in a continuous operation. Accurate positioning and full contact between components is also provided by the relative movement the designs allow. An effect interface between a low cost disposable cartridge or device and the instrument to process it is also detailed.
摘要翻译: 提供了仪器,设备和分析方法,它们在连续操作中充分整合了大量的工艺步骤。 组件之间的精确定位和完全接触也可以通过设计允许的相对运动来提供。 低成本的一次性盒式磁盘或装置与处理它的仪器之间的效果接口也是详细的。
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