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公开(公告)号：US11085018B2
公开(公告)日：2021-08-10
申请号：US16669439
申请日：2019-10-30
IPC分类号： C12N5/00 , B33Y70/00 , B33Y80/00 , C12N5/071 , B29C64/135 , B29L31/00 , B33Y30/00 , B33Y10/00
摘要： Provided herein are methods and systems for forming a three-dimensional object corresponding to an organ or organoid. A method for forming a three-dimensional object corresponding to an organ or organoid may comprise generating a plurality of discrete focal points patterned as a 3D projection corresponding to the organ or organoid in a medium comprising one or more precursors of a polymer, to form at least a portion of the 3D object corresponding to the organ or organoid.
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公开(公告)号：US20220081674A1
公开(公告)日：2022-03-17
申请号：US17354967
申请日：2021-06-22
摘要： Provided herein are methods and systems for bio-printing of three-dimensional organs and organoids. Also provided herein are bio-printed three-dimensional organs and organoids for use in the generation and/or the assessment of immunological products and/or immune responses. Also provided herein are methods and system for bio-printing three-dimensional matrices.
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公开(公告)号：US20220025322A1
公开(公告)日：2022-01-27
申请号：US17318947
申请日：2021-05-12
IPC分类号： C12N5/00 , C12N5/071 , B29C64/124 , B33Y10/00 , B33Y50/00 , B29C64/386
摘要： Provided herein are methods and systems for bio-printing of three-dimensional cell-containing matrixes. Further, provided herein are methods and systems for generating a three-dimensional (3D) structure corresponding to a biological material, such as a kidney or lung comprising either nephron or alveolar structures. Also provided herein are bio-printed three-dimensional matrices for use in the generation nephron and/or alveolar structures.
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公开(公告)号：US20210339465A1
公开(公告)日：2021-11-04
申请号：US17105218
申请日：2020-11-25
发明人： Melanie P. MATHEU
IPC分类号： B29C64/135 , B33Y70/00 , B29C64/277 , B29C64/393 , B33Y50/02 , A61L27/50 , A61L27/26 , A61L27/36 , A61L27/60 , C12N5/00 , C12M3/00 , B33Y10/00 , C12M1/26 , C12N5/071
摘要： The present disclosure provides methods and systems for printing a three-dimensional (3D) material. In some examples, a method for printing a 3D biological material comprises providing a media chamber comprising a medium comprising (i) a plurality of cells and (ii) one or more polymer precursors. Next, at least one energy beam may be directed to the medium in the media chamber along at least one energy beam path that is patterned into a 3D projection wherein the x, y, and z dimensions may be simultaneously accessed in accordance with computer instructions for printing the 3D biological material in computer memory, to form at least a portion of the 3D biological material comprising (i) at least a subset of the plurality of cells, and (ii) a polymer formed from the one or more polymer precursors.
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公开(公告)号：US20220195394A1
公开(公告)日：2022-06-23
申请号：US17694121
申请日：2022-03-14
IPC分类号： C12N5/071 , C12M3/04 , C12N5/077 , C12N5/0775 , C12N5/0781 , C12N5/00 , C12N5/0783 , C12N5/0784 , C07K16/10 , C07K16/00
摘要： Provided herein are methods and systems for bio-printing of three-dimensional organs and organoids. Also provided herein are bio-printed three-dimensional organs and organoids for use in the generation and/or the assessment of immunological products and/or immune responses. Also provided herein are methods and system for bio-printing three-dimensional matrices.
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公开(公告)号：US20210394437A1
公开(公告)日：2021-12-23
申请号：US17163089
申请日：2021-01-29
发明人： Melanie P. MATHEU , Erik BUSBY , Karl Johan Torbjorn BORGLIN , Christopher ROGERS , Hershel SHAH
IPC分类号： B29C64/153 , B29C64/393 , B29C64/268
摘要： The present disclosure provides methods and systems for the three-dimensional (3D) printing of 3D objects. Methods and systems provided herein may comprise 3D holographic lithography which may enable the 3D printing of various shapes. Methods and systems provided herein may enable high efficiency 3D holographic printing and may avoid, for example, problems zero-order defects. Methods and systems provided herein comprise methods for printing 3D objects with reduced or minimal inconsistency.
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公开(公告)号：US20210361584A1
公开(公告)日：2021-11-25
申请号：US17163091
申请日：2021-01-29
摘要： The present disclosure provides methods and systems for optically-induced auto-encapsulation. A method of the present disclosure comprises providing a media chamber comprising a medium comprising (i) a three-dimensional (3D) object comprising a photo-emitter, (ii) at least one polymeric precursor, and (iii) a photoinitiator, and subjecting the medium in the media chamber to a stimulus (e.g., an energy beam or a chemical stimulus) to induce photo-emission from the photo-emitter to trigger the formation of a polymer matrix from the at least one polymeric precursor, which polymer matrix at least partially encapsulates the 3D object.
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公开(公告)号：US20200080060A1
公开(公告)日：2020-03-12
申请号：US16669453
申请日：2019-10-30
IPC分类号： C12N5/071 , C07K16/00 , C07K16/10 , C12N5/0784 , C12N5/0783 , C12N5/00 , C12N5/0781 , C12N5/0775 , C12N5/077 , C12M3/04
摘要： Provided herein are methods and systems for bio-printing of three-dimensional organs and organoids. Also provided herein are bio-printed three-dimensional organs and organoids for use in the generation and/or the assessment of immunological products and/or immune responses. Also provided herein are methods and system for bio-printing three-dimensional matrices.
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公开(公告)号：US20190010463A1
公开(公告)日：2019-01-10
申请号：US16044413
申请日：2018-07-24
IPC分类号： C12N5/071 , C12M3/04 , C12N5/077 , C12N5/0775 , C12N5/0781 , C12N5/00 , C12N5/0783 , C12N5/0784
CPC分类号： C12N5/0671 , C07K16/00 , C07K16/1081 , C07K2317/21 , C07K2317/76 , C12M3/04 , C12N5/0018 , C12N5/0062 , C12N5/0635 , C12N5/0637 , C12N5/0638 , C12N5/064 , C12N5/0667 , C12N5/0669 , C12N5/0691 , C12N5/0697 , C12N5/0698 , C12N2502/09 , C12N2502/094 , C12N2502/1114 , C12N2502/1121 , C12N2502/1323 , C12N2502/45 , C12N2506/1384 , C12N2506/28 , C12N2510/02 , C12N2513/00 , C12N2527/00 , C12N2533/30 , C12N2533/54 , C12N2533/74 , C12N2533/76 , C12N2533/80 , C12N2539/10
摘要： Provided herein are methods and systems for bio-printing of three-dimensional organs and organoids. Also provided herein are bio-printed three-dimensional organs and organoids for use in the generation and/or the assessment of immunological products and/or immune responses. Also provided herein are methods and system for bio-printing three-dimensional matrices.
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公开(公告)号：US20180257297A1
公开(公告)日：2018-09-13
申请号：US15925582
申请日：2018-03-19
发明人： Melanie P. MATHEU
IPC分类号： B29C64/135 , B33Y10/00 , B33Y70/00 , B29C64/277 , B29C64/393 , B33Y50/02 , A61L27/50 , A61L27/26 , A61L27/36 , A61L27/60 , C12N5/00 , C12M3/00
CPC分类号： B29C64/135 , A61L27/26 , A61L27/3604 , A61L27/3612 , A61L27/362 , A61L27/3625 , A61L27/3633 , A61L27/3683 , A61L27/50 , A61L27/507 , A61L27/60 , B29C64/277 , B29C64/393 , B29K2033/08 , B29K2105/0035 , B33Y10/00 , B33Y50/02 , B33Y70/00 , B33Y80/00 , C12M21/08 , C12M33/00 , C12N5/0062 , C12N5/0697
摘要： The present disclosure provides methods and systems for printing a three-dimensional (3D) material. In some examples, a method for printing a 3D biological material comprises providing a media chamber comprising a medium comprising (i) a plurality of cells and (ii) one or more polymer precursors. Next, at least one energy beam may be directed to the medium in the media chamber along at least one energy beam path that is patterned into a 3D projection wherein the x, y, and z dimensions may be simultaneously accessed in accordance with computer instructions for printing the 3D biological material in computer memory, to form at least a portion of the 3D biological material comprising (i) at least a subset of the plurality of cells, and (ii) a polymer formed from the one or more polymer precursors.
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