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公开(公告)号：US11280799B2
公开(公告)日：2022-03-22
申请号：US17001425
申请日：2020-08-24
发明人： Brett Holmquist , Nigel Clarke
摘要： The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
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公开(公告)号：US20200158688A1
公开(公告)日：2020-05-21
申请号：US16748234
申请日：2020-01-21
摘要： Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
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公开(公告)号：US10191065B2
公开(公告)日：2019-01-29
申请号：US15939030
申请日：2018-03-28
发明人： Nigel Clarke , Zhaohui Chen
IPC分类号： G01N33/68 , G01N33/487 , G01N30/72 , G01N33/74 , G01N30/02 , H01J49/00 , H01J49/16 , H01J49/40
摘要： Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
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公开(公告)号：US09835606B2
公开(公告)日：2017-12-05
申请号：US15284248
申请日：2016-10-03
发明人： Nigel Clarke
CPC分类号： G01N33/15 , G01N30/7233 , G01N33/48 , G01N33/49 , G01N33/94 , H01J49/00 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/10 , Y10T436/17 , Y10T436/24 , Y10T436/25125 , Y10T436/25375
摘要： Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of norendoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites.
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公开(公告)号：US09506937B2
公开(公告)日：2016-11-29
申请号：US14715153
申请日：2015-05-18
发明人： Brett Holmquist , Nigel Clarke
CPC分类号： G01N33/82 , G01N33/6848 , G01N33/6851 , G01N2560/00 , H01J49/00 , H01J49/0027 , Y10T436/212
摘要： The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.
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公开(公告)号：US20230375575A1
公开(公告)日：2023-11-23
申请号：US18364356
申请日：2023-08-02
发明人： Brett Holmquist , Nigel Clarke
CPC分类号： G01N33/82 , G01N33/6848 , G01N33/6851 , H01J49/0027 , Y10T436/212 , H01J49/00 , G01N2560/00
摘要： The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.
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公开(公告)号：US20230039315A1
公开(公告)日：2023-02-09
申请号：US17949863
申请日：2022-09-21
发明人： Cory Bystrom , Shijun Sheng , Nigel Clarke , Richard Reitz
摘要： Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.
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公开(公告)号：US11454637B2
公开(公告)日：2022-09-27
申请号：US16857628
申请日：2020-04-24
发明人： Cory Bystrom , Shijun Sheng , Nigel Clarke , Richard E. Reitz
摘要： Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.
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公开(公告)号：US11346845B2
公开(公告)日：2022-05-31
申请号：US17027267
申请日：2020-09-21
发明人： Nigel Clarke , Zhaohui Chen
IPC分类号： G01N33/68 , G01N33/487 , G01N30/72 , G01N33/74 , H01J49/04 , C07K14/625 , C07K1/16 , B01D15/08 , C07K1/14 , C07K14/62 , G01N33/543 , G01N30/02 , G01N30/06 , G01N30/00 , G01N35/10 , H01J49/00 , H01J49/16 , H01J49/40
摘要： Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
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公开(公告)号：US10830746B2
公开(公告)日：2020-11-10
申请号：US15830812
申请日：2017-12-04
发明人： Nigel Clarke
摘要： Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of norendoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites.
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