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公开(公告)号：US20110052495A1
公开(公告)日：2011-03-03
申请号：US12740884
申请日：2008-10-31
申请人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
发明人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
CPC分类号： A61K49/00 , A61B5/0095 , A61B8/00 , G01N21/1702 , G01N2021/1787 , Y10S977/734 , Y10S977/842 , Y10S977/927 , Y10S977/953
摘要： Fullerenes, when irradiated with electromagnetic radiation, generate acoustic waves. A photoacoustic tomography method using a material comprising fullerenes is disclosed that includes irradiating the material with a radiation beam such as a laser. The resultant photoacoustic effect produced by the material is detected by at least one detector. A photoacoustic tomography system using a material comprising fullerenes is also described.
摘要翻译： 富勒烯当用电磁辐射照射时产生声波。 公开了一种使用包含富勒烯的材料的光声层析成像方法，其包括用辐射束如激光照射材料。 由材料产生的所得光声效应由至少一个检测器检测。 还描述了使用包含富勒烯的材料的光声层析成像系统。
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公开(公告)号：US08883124B2
公开(公告)日：2014-11-11
申请号：US12740884
申请日：2008-10-31
申请人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
发明人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
CPC分类号： A61K49/00 , A61B5/0095 , A61B8/00 , G01N21/1702 , G01N2021/1787 , Y10S977/734 , Y10S977/842 , Y10S977/927 , Y10S977/953
摘要： Fullerenes, when irradiated with electromagnetic radiation, generate acoustic waves. A photoacoustic tomography method using a material comprising fullerenes is disclosed that includes irradiating the material with a radiation beam such as a laser. The resultant photoacoustic effect produced by the material is detected by at least one detector. A photoacoustic tomography system using a material comprising fullerenes is also described.
摘要翻译： 富勒烯当用电磁辐射照射时产生声波。 公开了一种使用包含富勒烯的材料的光声层析成像方法，其包括用辐射束如激光照射材料。 由材料产生的所得光声效应由至少一个检测器检测。 还描述了使用包含富勒烯的材料的光声层析成像系统。
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公开(公告)号：US20100254911A1
公开(公告)日：2010-10-07
申请号：US12675633
申请日：2008-08-28
申请人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
发明人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
CPC分类号： A61K49/222 , A61B5/0035 , A61B5/0059 , A61B5/0095 , A61B5/055 , A61B6/00 , A61K41/0052 , A61K49/0002 , A61K49/0093 , A61K49/0423 , A61K49/1806 , A61K49/1881 , A61M31/005 , A61N5/10 , B82Y5/00
摘要： Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.
摘要翻译： 多峰纳米颗粒是含有PAT造影剂和发光成像，X射线成像和/或MRI中的一种或多种的纳米颗粒。 多峰纳米颗粒可以具有包含在芯上具有金属涂层的氧化物的介电芯。 颗粒可以是金属斑点。 多模式纳米颗粒可用于治疗目的，例如肿瘤的消融或中子捕获以及用作成像的造影剂。
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公开(公告)号：US08361437B2
公开(公告)日：2013-01-29
申请号：US12675633
申请日：2008-08-28
申请人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
发明人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
CPC分类号： A61K49/222 , A61B5/0035 , A61B5/0059 , A61B5/0095 , A61B5/055 , A61B6/00 , A61K41/0052 , A61K49/0002 , A61K49/0093 , A61K49/0423 , A61K49/1806 , A61K49/1881 , A61M31/005 , A61N5/10 , B82Y5/00
摘要： Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.
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公开(公告)号：US20130039858A1
公开(公告)日：2013-02-14
申请号：US13582242
申请日：2011-02-24
IPC分类号： C07D487/22 , A61K49/22 , A61K49/10 , G01N21/64 , C01B33/18 , A61K49/00 , A61K49/04 , B82Y40/00 , B82Y15/00
CPC分类号： G01N33/54346 , A61K49/0032 , A61K49/0093 , C09B23/0041 , C09B23/0066 , C09B23/086 , C09B69/008 , G01N33/582
摘要： Novel fluorescent dye comprising metal oxide nanoparticles are prepared where the nanoparticles are as small as 3 nm or up to 7000 nm in diameter and where the dye is bound within the metal oxide matrix. In some embodiments the invention, novel dyes are covalently attached to the matrix and in other embodiments of the invention a dye is coordinate or ionic bound within the metal oxide matrix. A method for preparing the novel covalently bondable modified fluorescent dyes is presented. A method to prepare silica comprising nanoparticles that are 3 to 8 nm in diameter is presented. In some embodiments, the fluorescent dye comprising metal oxide nanoparticles are further decorated with functionality for use as multimodal in vitro or in vivo imaging agents. In other embodiments of the invention, the fluorescent dye comprising metal oxide nanoparticles provide therapeutic activity and incorporated therapeutic temperature monitoring.
摘要翻译： 制备包含金属氧化物纳米颗粒的新型荧光染料，其中纳米颗粒直径小至3nm或至多7000nm，并且其中染料结合在金属氧化物基质内。 在一些实施方案中，新颖的染料共价连接到基质上，在本发明的其它实施方案中，染料在金属氧化物基质内是配位或离子键合的。 提出了一种制备新型共价键合修饰荧光染料的方法。 提出了制备直径为3至8nm的纳米颗粒的制备二氧化硅的方法。 在一些实施方案中，包含金属氧化物纳米颗粒的荧光染料进一步用功能性装饰用作多峰体外或体内成像剂。 在本发明的其它实施方案中，包含金属氧化物纳米颗粒的荧光染料提供治疗活性并掺入治疗温度监测。
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6.发明申请NEAR-IR INDOCYANINE GREEN DOPED MULTIMODAL SILICA NANOPARTICLES AND METHODS FOR MAKING THE SAME 审中-公开近红外吲哚啉绿色多糖多元二氧化硅纳米颗粒及其制备方法公开(公告)号：US20130108552A1
公开(公告)日：2013-05-02
申请号：US13582226
申请日：2011-02-24
申请人： Parvesh Sharma , Scott Chang Brown , Niclas Bengtsson , Glenn A. Walter , Nobutaka Iwakuma , Edward W. Scott , Stephen R. Grobmyer , Swadeshmukul Santra , Brij M. Moudgil
发明人： Parvesh Sharma , Scott Chang Brown , Niclas Bengtsson , Glenn A. Walter , Nobutaka Iwakuma , Edward W. Scott , Stephen R. Grobmyer , Swadeshmukul Santra , Brij M. Moudgil
CPC分类号： A61N5/062 , A61K49/001 , B82Y5/00 , B82Y15/00 , C09K11/02 , C09K11/06 , G01N21/6486
摘要： The subject invention provides novel fluorescent core-shell nanoparticles comprising an encapsulated fluorescent core comprising an ionically bound fluorescent dye and a metal oxide shell. In one exemplary embodiment of the invention a core containing indocyanine green (ICG) with a silica shell that displays excellent photostability for generation of a near infrared fluorescence signal. The fluorescent core-shell nanoparticle can be further modified to act as an MRI, x-ray, or PAT contrast agent. The ICG nanoparticles can also be used as photodynamic therapeutic agent. Other embodiments of the invention directed to methods of making the novel core-shell nanoparticles and to the use of the core-shell nanoparticles for in vitro or in vivo imaging.
摘要翻译： 本发明提供了新颖的荧光核 - 壳纳米颗粒，其包含包含离子键的荧光染料和金属氧化物壳的包封的荧光核心。 在本发明的一个示例性实施方案中，含有具有二氧化硅壳的吲哚菁绿（ICG）的核心，其显示出用于产生近红外荧光信号的优异的光稳定性。 荧光核 - 壳纳米颗粒可进一步修饰为MRI，X射线或PAT造影剂。 ICG纳米颗粒也可以用作光动力治疗剂。 本发明的其它实施方案涉及制备新型核 - 壳纳米颗粒的方法以及使用核 - 壳纳米颗粒进行体外或体内成像。
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