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公开(公告)号：US20110052495A1
公开(公告)日：2011-03-03
申请号：US12740884
申请日：2008-10-31
申请人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
发明人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
CPC分类号： A61K49/00 , A61B5/0095 , A61B8/00 , G01N21/1702 , G01N2021/1787 , Y10S977/734 , Y10S977/842 , Y10S977/927 , Y10S977/953
摘要： Fullerenes, when irradiated with electromagnetic radiation, generate acoustic waves. A photoacoustic tomography method using a material comprising fullerenes is disclosed that includes irradiating the material with a radiation beam such as a laser. The resultant photoacoustic effect produced by the material is detected by at least one detector. A photoacoustic tomography system using a material comprising fullerenes is also described.
摘要翻译： 富勒烯当用电磁辐射照射时产生声波。 公开了一种使用包含富勒烯的材料的光声层析成像方法，其包括用辐射束如激光照射材料。 由材料产生的所得光声效应由至少一个检测器检测。 还描述了使用包含富勒烯的材料的光声层析成像系统。
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公开(公告)号：US08883124B2
公开(公告)日：2014-11-11
申请号：US12740884
申请日：2008-10-31
申请人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
发明人： Vijay Krishna , Brij M. Moudgil , Benjamin L. Koopman , Stephen Grobmyer , Iwakuma Nobutaka , Qiang Wang , Qizhi Zhang , Huabei Jiang , Parvesh Sharma , Amit Kumar Singh
CPC分类号： A61K49/00 , A61B5/0095 , A61B8/00 , G01N21/1702 , G01N2021/1787 , Y10S977/734 , Y10S977/842 , Y10S977/927 , Y10S977/953
摘要： Fullerenes, when irradiated with electromagnetic radiation, generate acoustic waves. A photoacoustic tomography method using a material comprising fullerenes is disclosed that includes irradiating the material with a radiation beam such as a laser. The resultant photoacoustic effect produced by the material is detected by at least one detector. A photoacoustic tomography system using a material comprising fullerenes is also described.
摘要翻译： 富勒烯当用电磁辐射照射时产生声波。 公开了一种使用包含富勒烯的材料的光声层析成像方法，其包括用辐射束如激光照射材料。 由材料产生的所得光声效应由至少一个检测器检测。 还描述了使用包含富勒烯的材料的光声层析成像系统。
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公开(公告)号：US20100254911A1
公开(公告)日：2010-10-07
申请号：US12675633
申请日：2008-08-28
申请人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
发明人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
CPC分类号： A61K49/222 , A61B5/0035 , A61B5/0059 , A61B5/0095 , A61B5/055 , A61B6/00 , A61K41/0052 , A61K49/0002 , A61K49/0093 , A61K49/0423 , A61K49/1806 , A61K49/1881 , A61M31/005 , A61N5/10 , B82Y5/00
摘要： Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.
摘要翻译： 多峰纳米颗粒是含有PAT造影剂和发光成像，X射线成像和/或MRI中的一种或多种的纳米颗粒。 多峰纳米颗粒可以具有包含在芯上具有金属涂层的氧化物的介电芯。 颗粒可以是金属斑点。 多模式纳米颗粒可用于治疗目的，例如肿瘤的消融或中子捕获以及用作成像的造影剂。
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公开(公告)号：US08361437B2
公开(公告)日：2013-01-29
申请号：US12675633
申请日：2008-08-28
申请人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
发明人： Parvesh Sharma , Brij M. Moudgil , Glenn A. Walter , Stephen R. Grobmyer , Swadeshmukul Santra , Huabei Jiang , Scott Chang Brown , Edward W. Scott , Qizhi Zhang , Niclas Bengtsson
CPC分类号： A61K49/222 , A61B5/0035 , A61B5/0059 , A61B5/0095 , A61B5/055 , A61B6/00 , A61K41/0052 , A61K49/0002 , A61K49/0093 , A61K49/0423 , A61K49/1806 , A61K49/1881 , A61M31/005 , A61N5/10 , B82Y5/00
摘要： Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.
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公开(公告)号：US08105754B2
公开(公告)日：2012-01-31
申请号：US12810241
申请日：2009-01-05
IPC分类号： G03C5/00
CPC分类号： G03F7/039 , G03F7/2059 , H01L21/0277 , Y10S430/143
摘要： A method for electron beam nanolithography without the need for development step involves depositing a film of a resist comprising functionalized fullerenes on a substrate, and writing features by exposure to an electron beam with an accelerating voltage and dose rate sufficient to promote heating or thermal degradation of the functionalized fullerene in the irradiated volume such that a pattern is generated without a subsequent development step or with an aqueous developer. Lithographic features of about 1 nm or greater can be formed.
摘要翻译： 一种不需要显影步骤的电子束纳米光刻的方法包括将包含官能化富勒烯的抗蚀剂膜沉积在基底上，并通过暴露于电子束的加速电压和剂量率来写入特征，该加速电压和剂量率足以促进加热或热降解 在照射的体积中的官能化富勒烯，使得在没有随后的显影步骤的情况下产生图案或用水性显影剂。 可以形成约1nm或更大的光刻特征。
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公开(公告)号：US20110003252A1
公开(公告)日：2011-01-06
申请号：US12810241
申请日：2009-01-05
IPC分类号： G03F7/20
CPC分类号： G03F7/039 , G03F7/2059 , H01L21/0277 , Y10S430/143
摘要： A method for electron beam nanolithography without the need for development step involves depositing a film of a resist comprising functionalized fullerenes on a substrate, and writing features by exposure to an electron beam with an accelerating voltage and dose rate sufficient to promote heating or thermal degradation of the functionalized fullerene in the irradiated volume such that a pattern is generated without a subsequent development step or with an aqueous developer. Lithographic features of about 1 nm or greater can be formed.
摘要翻译： 一种不需要显影步骤的电子束纳米光刻的方法包括将包含官能化富勒烯的抗蚀剂膜沉积在基底上，并通过暴露于电子束的加速电压和剂量率来写入特征，所述加速电压和剂量率足以促进加热或热降解 在照射的体积中的官能化富勒烯，使得在没有随后的显影步骤的情况下产生图案或用水性显影剂。 可以形成约1nm或更大的光刻特征。
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公开(公告)号：US20130039858A1
公开(公告)日：2013-02-14
申请号：US13582242
申请日：2011-02-24
IPC分类号： C07D487/22 , A61K49/22 , A61K49/10 , G01N21/64 , C01B33/18 , A61K49/00 , A61K49/04 , B82Y40/00 , B82Y15/00
CPC分类号： G01N33/54346 , A61K49/0032 , A61K49/0093 , C09B23/0041 , C09B23/0066 , C09B23/086 , C09B69/008 , G01N33/582
摘要： Novel fluorescent dye comprising metal oxide nanoparticles are prepared where the nanoparticles are as small as 3 nm or up to 7000 nm in diameter and where the dye is bound within the metal oxide matrix. In some embodiments the invention, novel dyes are covalently attached to the matrix and in other embodiments of the invention a dye is coordinate or ionic bound within the metal oxide matrix. A method for preparing the novel covalently bondable modified fluorescent dyes is presented. A method to prepare silica comprising nanoparticles that are 3 to 8 nm in diameter is presented. In some embodiments, the fluorescent dye comprising metal oxide nanoparticles are further decorated with functionality for use as multimodal in vitro or in vivo imaging agents. In other embodiments of the invention, the fluorescent dye comprising metal oxide nanoparticles provide therapeutic activity and incorporated therapeutic temperature monitoring.
摘要翻译： 制备包含金属氧化物纳米颗粒的新型荧光染料，其中纳米颗粒直径小至3nm或至多7000nm，并且其中染料结合在金属氧化物基质内。 在一些实施方案中，新颖的染料共价连接到基质上，在本发明的其它实施方案中，染料在金属氧化物基质内是配位或离子键合的。 提出了一种制备新型共价键合修饰荧光染料的方法。 提出了制备直径为3至8nm的纳米颗粒的制备二氧化硅的方法。 在一些实施方案中，包含金属氧化物纳米颗粒的荧光染料进一步用功能性装饰用作多峰体外或体内成像剂。 在本发明的其它实施方案中，包含金属氧化物纳米颗粒的荧光染料提供治疗活性并掺入治疗温度监测。
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8.发明申请FUNCTIONALIZED FULLERENES AS A BIOMASS STIMULANT AND A LIFE EXTENSION AGENT 有权作为生物传感器和生命延伸剂的功能丰富的富勒烯公开(公告)号：US20130035398A1
公开(公告)日：2013-02-07
申请号：US13638054
申请日：2011-04-07
申请人： Jie Gao , Vijay Krishna , Wei Bai , Benjamin L. Koopman , Brij M. Moudgil , Paul Anthony Indeglia , Kevin Michael Folta , Angelina Tsenova Georgieva
发明人： Jie Gao , Vijay Krishna , Wei Bai , Benjamin L. Koopman , Brij M. Moudgil , Paul Anthony Indeglia , Kevin Michael Folta , Angelina Tsenova Georgieva
摘要： Methods of stimulating an increase in biomass by stimulating the growth, lifespan and/or reproduction of organisms such as fungi, algae, plants, and other aquatic organisms are provided by applying an effective amount of functionalized fullerenes. For example, polyhydroxy fullerenes are effective at low levels of promoting the increase in biomass.
摘要翻译： 通过施用有效量的官能化富勒烯来提供刺激生物体如真菌，藻类，植物和其它水生生物的生长，寿命和/或繁殖来刺激生物量增加的方法。 例如，多羟基富勒烯在促进生物量增加的低水平方面是有效的。
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公开(公告)号：US09314027B2
公开(公告)日：2016-04-19
申请号：US13258649
申请日：2010-04-01
CPC分类号： A01N45/00 , C01B32/152 , A01N25/00 , A01N59/00 , A01N59/16 , A01N2300/00
摘要： Functionalized fullerenes are used in a method of combating fungal growth on surfaces and treating fungal diseases of patients. Surfaces that can be treated by the materials comprising an effective amount of functionalized fullerenes include those of fruits, vegetables, harvested grains, plants, or plant seeds. The method of combating fungal growth on a surface can be augmented but is not dependent on irradiation of the surface by light. Functional fullerenes are employed in various dosage forms such as topical, ingestible or administration.
摘要翻译： 功能性富勒烯用于对抗表面真菌生长并治疗患者真菌病的方法。 可以由包含有效量的官能化富勒烯的材料处理的表面包括水果，蔬菜，收获的谷物，植物或植物种子的表面。 可以增强在表面上对抗真菌生长的方法，但不依赖于光的照射。 功能性富勒烯以各种剂型使用，例如局部，可食用或给药。
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10.发明授权Optical luminescence of functionalized fullerenes in an oxygen free environment 有权功能化富勒烯在无氧环境中的光学发光公开(公告)号：US08373139B2
公开(公告)日：2013-02-12
申请号：US12810248
申请日：2009-01-05
IPC分类号： G01N21/64
CPC分类号： C09K11/06 , C09K2211/1011 , C09K2211/1416 , G01N2021/6432
摘要： Functionalized fullerenes, when excited at any of a broad range of wavelengths in an oxygen free environment, undergo luminescence. The oxygen sensitive luminescence of functionalized fullerenes is used for numerous applications including oxygen detection; irradiation induced healing of polymeric materials; and phosphors for optical location and display applications. The degradation of the functionalized fullerenes allows for the detection of oxygen by diminished luminescence when the fullerenes are exposed to an irradiation source, such as a laser beam, in the presence of oxygen. The luminescence from a portion of a surface of a material with functionalized fullerenes allows for the location of the surface containing a functionalized fullerene target in the absence of oxygen or to heat the object in the area irradiated that is exposed to oxygen. The localized heating can be used to repair defects to a material containing the functionalized fullerenes. Materials containing functionalized fullerenes can be used as phosphors in display applications.
摘要翻译： 当无氧环境中的任何波长激发时，官能化的富勒烯经受发光。 官能化富勒烯的氧敏感发光用于许多应用，包括氧气检测; 辐射诱导的聚合材料愈合; 和用于光学位置和显示应用的荧光体。 官能化富勒烯的降解允许当富氧存在下，当富勒烯暴露于照射源（例如激光束）时，通过减少的发光来检测氧。 具有官能化富勒烯的材料的表面的一部分的发光允许在不存在氧的情况下包含官能化的富勒烯靶的表面的位置或者在暴露于氧的被照射区域中加热物体。 局部加热可用于将缺陷修复到含有官能化富勒烯的材料上。 含有官能化富勒烯的材料可用作显示应用中的荧光体。
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