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1.发明申请NEMATODES AS MODEL ORGANISMS FOR THE INVESTIGATION OF NEURODEGENERATIVE DISEASES, IN PARTICULAR PARKINSONS DISEASE, USES AND METHODS FOR THE DISCOVERY OF SUBSTANCES AND GENES WHICH CAN USED IN THE TREATMENT OF THE ABOVE DISEASE STATES AND IDENTIFICATION OF A NEMATODE GENE 失效NEMATODES作为调查神经源性疾病，特别是帕金森病的模型机制，用于发现物质的方法和方法以及可用于治疗上述疾病状态的基因和识别NEMATODE基因公开(公告)号：US20080254475A1
公开(公告)日：2008-10-16
申请号：US12131981
申请日：2008-06-03
Applicant: Marius HOENER , Giuseppe CASSATA , Wolfgang LINK , Ralf BAUMEISTER , Karlheinz TOVAR
Inventor： Marius HOENER , Giuseppe CASSATA , Wolfgang LINK , Ralf BAUMEISTER , Karlheinz TOVAR
IPC: C12Q1/68 , A01K67/033 , C12N15/63 , C12N5/06 , C07K14/435
CPC classification number: C12N9/93 , A01K67/0336 , A01K2217/05 , A01K2217/075 , C07K14/43545 , C07K2319/00
Abstract: The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases, in particular, Parkinsons disease, uses and methods for the discovery of substances and genes which can be used in the treatment of the above disease states and identification of a nematode gene, From C elegans, which is homologous to the human parkin gene associated with Parkinsons disease. The invention further relates to those nematodes which contain an aberrant or missing expression of at least one gene, preferably a parkin gene and/or a α-synucleine gene, which is connected with Parkinsons disease. According to the invention, the above organisms can be used for the identification and characterization of medicaments for the treatment of said disease states.
Abstract translation: 本发明涉及线虫作为用于研究神经变性疾病的模型生物，特别是帕金森病，用于发现可用于治疗上述疾病状态和鉴定线虫基因的物质和基因的用途和方法， 来自线虫，其与与帕金森病相关的人类parkin基因同源。 本发明还涉及含有与帕金森病相关的至少一种基因，优选帕金蛋白基因和/或α-突触核蛋白基因的异常或缺失表达的那些线虫。 根据本发明，上述生物体可用于鉴定和表征用于治疗所述疾病状态的药物。
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公开(公告)号：US20070293450A1
公开(公告)日：2007-12-20
申请号：US11782116
申请日：2007-07-24
Applicant: Ralf BAUMEISTER , Bernard LAKOWSKI , Stefan EIMER
Inventor： Ralf BAUMEISTER , Bernard LAKOWSKI , Stefan EIMER
IPC: A61K31/7052 , A01K67/027 , C07H21/02 , C07H21/04 , C07K14/00 , C07K16/00 , C12N15/63 , C12Q1/02
CPC classification number: C07K14/43545 , A01K2217/05 , A01K2217/075 , A61K38/00
Abstract: The invention relates to isolated nucleic acid molecules coding for SES-3 proteins or muted SES-3 proteins, and vectors and transgenic organisms containing such nucleic acid molecules. The invention also relates to uses of such nucleic acid molecules or others which are functionally similar, for producing pharmaceuticals and for producing model organisms. The invention further relates to the corresponding SES-3 proteins and muted SES-3 proteins, and the antibodies induced thereby. Finally, the invention relates to the use of substances which increase the expression of human presenilin, for the treatment of Alzheimer's disease, in addition to said substances themselves and pharmaceutical compositions containing the same.
Abstract translation: 本发明涉及编码SES-3蛋白或微卫星SES-3蛋白的分离的核酸分子以及含有这种核酸分子的载体和转基因生物。 本发明还涉及功能上类似的核酸分子或其它用于生产药物和用于产生模型生物体的用途。 本发明还涉及相应的SES-3蛋白和SST-3蛋白，以及由此诱导的抗体。 最后，本发明涉及除了所述物质本身和含有它们的药物组合物外，本发明涉及增加人类早老素表达的物质用于治疗阿尔茨海默病的用途。
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公开(公告)号：US20090053196A1
公开(公告)日：2009-02-26
申请号：US11632186
申请日：2005-07-29
Applicant: Ralf Baumeister , Thorsten Hoppe , Britta Spanier , Hanns Lochmuller , Rolf Stucka
Inventor： Ralf Baumeister , Thorsten Hoppe , Britta Spanier , Hanns Lochmuller , Rolf Stucka
IPC: A61K31/70 , A01K67/00 , A61K38/00 , A61K39/395 , C12Q1/20
CPC classification number: C12Q1/25 , A01K67/0339 , A01K2217/075 , A01K2227/706 , A01K2267/0306 , A61K38/00 , C07K14/43545 , C07K14/4703 , C07K14/4707 , C12N15/113 , C12N15/8509 , C12N2310/14 , G01N33/573 , G01N2333/9015 , G01N2500/00 , G01N2800/10
Abstract: The present invention relates to a pharmaceutical composition comprising an inhibitor/negative regulator/antagonist of the mammalian ortholog of Caenorhabditis elegans CHN-1 and/or of the human CHIP (carboxyl-terminus of Hsc70 interacting protein). Furthermore, the use of said inhibitor/negative regulator/antagonist in medical and pharmaceutical settings is described. In addition, screening methods and tools for the identification of CHIP/CHN-1 inhibitors/antagonists are provided.
Abstract translation: 本发明涉及含有秀丽隐杆线虫CHN-1和/或人CHIP（Hsc70相互作用蛋白的羧基末端）的哺乳动物直系同源物的抑制剂/阴性调节剂/拮抗剂的药物组合物。 此外，描述了在医疗和药物设置中使用所述抑制剂/阴性调节剂/拮抗剂。 此外，还提供了用于鉴定CHIP / CHN-1抑制剂/拮抗剂的筛选方法和工具。
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公开(公告)号：US20050054592A1
公开(公告)日：2005-03-10
申请号：US10481582
申请日：2002-06-24
Applicant: Ralf Baumeister , Bernard Lakowski
Inventor： Ralf Baumeister , Bernard Lakowski
IPC: A01K67/033 , A61K31/7088 , A61K35/76 , A61K45/00 , A61K48/00 , A61P25/00 , A61P25/28 , A61P43/00 , C07K14/435 , C07K14/44 , C07K16/20 , C12N15/09 , C12N15/12 , G01N33/15 , G01N33/50 , C07H21/04 , C12N9/64
CPC classification number: A01K67/0336 , C07K14/43545
Abstract: The invention relates to isolated nucleic acid molecules coding for SES-1 proteins or muted SES-1 proteins, and vectors and transgenic organisms containing such nucleic acid molecules. The invention also relates to uses of such nucleic acid molecules for producing pharmaceuticals and for producing model organisms. The invention further relates to the corresponding SES-1 proteins and muted SES-1 proteins, and the antibodies induced thereby. Finally, the invention relates to the use of substances which increase the expression of human presenilin, for the treatment of Alzheimer's disease, in addition to said substances themselves and pharmaceutical compositions containing the same.
Abstract translation: 本发明涉及编码SES-1蛋白或SES-1蛋白的分离的核酸分子，以及含有此类核酸分子的载体和转基因生物。 本发明还涉及这种核酸分子用于制备药物和用于产生模型生物体的用途。 本发明进一步涉及相应的SES-1蛋白和静止的SES-1蛋白，以及由此诱导的抗体。 最后，本发明涉及除了所述物质本身和含有它们的药物组合物外，本发明涉及增加人类早老素表达的物质用于治疗阿尔茨海默病的用途。
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公开(公告)号：US06702996B1
公开(公告)日：2004-03-09
申请号：US09980007
申请日：2001-11-30
Applicant: Ralf Baumeister , Nicole Wittenburg
Inventor： Ralf Baumeister , Nicole Wittenburg
IPC: A61K5100
CPC classification number: G01N33/5085 , G01N2333/43534
Abstract: A method of investigating the suitability of a material as a medicament is disclosed. The method according to the invention uses a nematode which has been brought into contact with the test substance and which is then exposed to a local thermal stimulus.
Abstract translation: 公开了研究材料作为药物的适用性的方法。 根据本发明的方法使用已经与测试物质接触并然后暴露于局部热刺激的线虫。
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Patent Agency Ranking
6.发明授权Nematodes as model organisms for the investigation of neurodegenerative diseases, in particular parkinsons disease, uses and methods for the discovery of substances and genes which can used in the treatment of the above disease states and identification of a nematode gene 失效线虫作为用于调查神经变性疾病，特别是帕金森病的模型生物体，用于发现可用于治疗上述疾病状态和鉴定线虫基因的物质和基因的用途和方法公开(公告)号：US08193408B2
公开(公告)日：2012-06-05
申请号：US12131981
申请日：2008-06-03
Applicant: Marius Hoener , Giuseppe Cassata , Wolfgang Link , Ralf Baumeister , Karlheiniz Tovar
Inventor： Marius Hoener , Giuseppe Cassata , Wolfgang Link , Ralf Baumeister , Karlheiniz Tovar
IPC: A01K67/00 , A01K67/033 , C12N15/00 , C12N5/00
CPC classification number: C12N9/93 , A01K67/0336 , A01K2217/05 , A01K2217/075 , C07K14/43545 , C07K2319/00
Abstract: The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases, in particular, Parkinsons disease, uses and methods for the discovery of substances and genes which can be used in the treatment of the above disease states and identification of a nematode gene, From C elegans, which is homologous to the human parkin gene associated with Parkinsons disease. The invention further relates to those nematodes which contain an aberrant or missing expression of at least one gene, preferably a parkin gene and/or a α-synucleine gene, which is connected with Parkinsons disease. According to the invention, the above organisms can be used for the identification and characterization of medicaments for the treatment of said disease states.
Abstract translation: 本发明涉及线虫作为用于研究神经变性疾病的模型生物，特别是帕金森病，用于发现可用于治疗上述疾病状态和鉴定线虫基因的物质和基因的用途和方法， 来自线虫，其与与帕金森病相关的人类parkin基因同源。 本发明还涉及含有与帕金森病相关的至少一种基因，优选parkin基因和/或α-突触核蛋白基因的异常或缺失表达的线虫。 根据本发明，上述生物体可用于鉴定和表征用于治疗所述疾病状态的药物。
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7.发明授权Nematodes as model organisms for the investigation of neurodegenerative diseases, in particular parkinsons disease, uses and methods for the discovery of substances and genes which can used in the treatment of the above disease states and identification of anematode gene 失效线虫作为用于研究神经变性疾病，特别是帕金森病的模型生物体，用于发现可用于治疗上述疾病状态和鉴定线虫基因的物质和基因的用途和方法公开(公告)号：US07399900B2
公开(公告)日：2008-07-15
申请号：US10239249
申请日：2001-03-21
Applicant: Marius Hoener , Giuseppe Cassata , Wolfgang Link , Ralf Baumeister , Karlheinz Tovar
Inventor： Marius Hoener , Giuseppe Cassata , Wolfgang Link , Ralf Baumeister , Karlheinz Tovar
IPC: A01K67/00 , A01K67/033 , C12N15/00 , C12N5/00
CPC classification number: C12N9/93 , A01K67/0336 , A01K2217/05 , A01K2217/075 , C07K14/43545 , C07K2319/00
Abstract: The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases in particular. Parkinsons disease, uses and methods for the discovery of substances and genes which can be used in the treatment of the above disease states and identification of a nematode gene, from C. elegans, which is homologous to the human parkin gene associated with Parkinsons disease. The invention further relates to those nematodes which contain an aberrant or missing expression of at least one gene, preferably a parkin gene and/or a α-synuclein gene, which is connected with Parkinsons disease. According to the invention, the above organisms can be used for the identification and characterisation of medicaments for the treatment of said disease states.
Abstract translation: 本发明涉及线虫作为模型生物体，特别用于研究神经变性疾病。 帕金森病，用于发现可用于治疗上述疾病状态的物质和基因的用途和方法，以及来自线虫的线虫基因，其与与帕金森病相关的人类parkin基因同源。 本发明还涉及含有与帕金森病相关的至少一种基因，优选parkin基因和/或α-突触核蛋白基因的异常或缺失表达的线虫。 根据本发明，上述生物体可用于鉴定和表征用于治疗所述疾病状态的药物。
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公开(公告)号：US20050059586A1
公开(公告)日：2005-03-17
申请号：US10481581
申请日：2002-06-24
Applicant: Ralf Baumeister , Bernard Lakowski , Stefan Eimer
Inventor： Ralf Baumeister , Bernard Lakowski , Stefan Eimer
IPC: A01K67/027 , A61K31/7088 , A61K38/00 , A61K45/00 , A61K48/00 , A61P25/28 , C07K14/435 , C07K16/18 , C12N15/09 , C12N15/12 , C12P21/08 , G01N33/15 , G01N33/50 , C12Q1/68 , A61K38/17 , C07H21/04 , C07K14/47
CPC classification number: C07K14/43545 , A01K2217/05 , A01K2217/075 , A61K38/00
Abstract: The invention relates to isolated nucleic acid molecules coding for SES-3 proteins or muted SES-3 proteins, and vectors and transgenic organisms containing such nucleic acid molecules. The invention also relates to uses of such nucleic acid molecules or others which are functionally similar, for producing pharmaceuticals and for producing model organisms. The invention further relates to the corresponding SES-3 proteins and muted SES-3 proteins, and the antibodies induced thereby. Finally, the invention relates to the use of substances which increase the expression of human presenilin, for the treatment of Alzheimer's disease, in addition to said substances themselves and pharmaceutical compositions containing the same.
Abstract translation: 本发明涉及编码SES-3蛋白或微卫星SES-3蛋白的分离的核酸分子以及含有这种核酸分子的载体和转基因生物。 本发明还涉及功能上类似的核酸分子或其它用于生产药物和用于产生模型生物体的用途。 本发明还涉及相应的SES-3蛋白和SST-3蛋白，以及由此引起的抗体。 最后，本发明涉及除了所述物质本身和含有它们的药物组合物外，本发明涉及增加人类早老素表达的物质用于治疗阿尔茨海默病的用途。
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公开(公告)号：US20080168573A1
公开(公告)日：2008-07-10
申请号：US12036338
申请日：2008-02-25
Applicant: Ralf BAUMEISTER , Bernard LAKOWSKI
Inventor： Ralf BAUMEISTER , Bernard LAKOWSKI
IPC: A01K67/00
CPC classification number: A01K67/0336 , C07K14/43545
Abstract: The invention relates to isolated nucleic acid molecules coding for SES-1 proteins or muted SES-1 proteins, and vectors and transgenic organisms containing such nucleic acid molecules. The invention also relates to uses of such nucleic acid molecules for producing pharmaceuticals and for producing model organisms. The invention further relates to the corresponding SES-1 proteins and muted SES-1 proteins, and the antibodies induced thereby. Finally, the invention relates to the use of substances which increase the expression of human presenilin, for the treatment of Alzheimer's disease, in addition to said substances themselves and pharmaceutical compositions containing the same.
Abstract translation: 本发明涉及编码SES-1蛋白或SES-1蛋白的分离的核酸分子，以及含有此类核酸分子的载体和转基因生物。 本发明还涉及这种核酸分子用于制备药物和用于产生模型生物体的用途。 本发明进一步涉及相应的SES-1蛋白和静止的SES-1蛋白，以及由此诱导的抗体。 最后，本发明涉及除了所述物质本身和含有它们的药物组合物外，本发明涉及增加人类早老素表达的物质用于治疗阿尔茨海默病的用途。
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10.发明授权Transgenic C. elegans as a model organism for investigations on Alzheimer's disease 失效转基因秀丽隐杆线虫作为阿尔茨海默病调查的模型生物公开(公告)号：US06673600B2
公开(公告)日：2004-01-06
申请号：US09422569
申请日：1999-10-21
Applicant: Gisela Peraus , Edmund Hoppe , Ralf Baumeister
Inventor： Gisela Peraus , Edmund Hoppe , Ralf Baumeister
IPC: C12N1500
CPC classification number: A01K67/0336 , A01K2217/05 , C07K14/4711 , C07K2319/00
Abstract: The present invention relates to a transgenic C. elegans which expresses an amyloid precursor protein (APP) or a part thereof, to the transgene itself, to the protein encoded by the transgene, and also to a process for preparing the transgenic C. elegans and to its use.
Abstract translation: 本发明涉及向转基因本身表达淀粉样蛋白前体蛋白（APP）或其部分转基因的转基因秀丽隐杆线虫，以及用于制备转基因秀丽隐杆线虫的方法，以及 使用它。
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