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    Member of the TNF family useful for treatment and diagnosis of disease
    6.
    发明授权
    Member of the TNF family useful for treatment and diagnosis of disease 失效
    TNF家族成员可用于治疗和诊断疾病

    公开(公告)号：US06207642B1

    公开(公告)日：2001-03-27

    申请号：US09105343

    申请日：1998-06-26

    申请人： Steven R. Wiley

    发明人： Steven R. Wiley

    IPC分类号： A61K3818

    CPC分类号： G01N33/5091 ,  A61K2039/51 ,  C07K14/70575 ,  C07K16/2875 ,  C07K2317/34 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5064 ,  G01N33/566 ,  G01N2333/705

    摘要： An isolated clone consisting of sequences transcribed from the TREPA gene. Also provided are human polypeptides translated from said TREPA sequences and a procedure for producing such polypeptide by recombinant techniques. Also provided are a procedure for producing soluble biologically active TREPA, which may be used to treat deficiencies of TREPA and diseases conditions ameliorated by TREPA. Antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat TREPA-associated diseases, tumors or metastastases are disclosed. Also disclosed is the use of said antibodies, agonists and inhibitors as well as the nucleic acid sequences to screen for, diagnose, prognosticate, stage and monitor conditions and diseases attributable to TREPA, especially inflammation. The use of said partial sequence to provide antibodies, agonists and inhibitors as well as partial nucleic acid sequences to screen for, diagnose, stage and monitor diseases associated with TREPA, including but not limited to inflammation. Illustrative sequences and clone designations for TREPA are provided.

    摘要翻译： 由TREPA基因转录的序列组成的分离克隆。 还提供了从所述TREPA序列翻译的人多肽和通过重组技术产生此类多肽的方法。 还提供了用于产生可溶性生物活性TREPA的方法，其可用于治疗TREPA的缺陷和由TREPA改善的疾病状态。 公开了可用于预防这种多肽作用的这种多肽的抗体，拮抗剂和抑制剂，因此可用于治疗性治疗TREPA相关疾病，肿瘤或转移酶。 还公开了所述抗体，激动剂和抑制剂以及核酸序列用于筛选，诊断，预测，分期和监测归因于TREPA，特别是炎症的病症和疾病的用途。 使用所述部分序列提供抗体，激动剂和抑制剂以及部分核酸序列来筛选，诊断，分期和监测与TREPA相关的疾病，包括但不限于炎症。 提供了TREPA的说明性序列和克隆名称。

    Use of TRAIL polypeptides to induce apoptosis
    8.
    发明授权
    Use of TRAIL polypeptides to induce apoptosis 失效
    使用TRAIL多肽诱导细胞凋亡

    公开(公告)号：US07736637B2

    公开(公告)日：2010-06-15

    申请号：US12195564

    申请日：2008-08-21

    申请人： Steven R. Wiley ,  Raymond G. Goodwin

    发明人： Steven R. Wiley ,  Raymond G. Goodwin

    IPC分类号： A61K38/19

    CPC分类号： C07K14/70575 ,  C07K16/24 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/74

    摘要： A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.

    摘要翻译： 称为TRAIL的新型细胞因子诱导某些靶细胞的凋亡，包括癌细胞和病毒感染的细胞。 公开了编码TRAIL的分离的DNA序列，以及可用于产生TRAIL多肽的表达载体和转化的宿主细胞。 还提供了特异性结合TRAIL的抗体。

    Compositions and methods relating to multimeric and oligomeric soluble fragments of the TWEAK receptor
    9.
    发明授权
    Compositions and methods relating to multimeric and oligomeric soluble fragments of the TWEAK receptor 失效
    与TWEAK受体的多聚和低聚可溶性片段相关的组合物和方法

    公开(公告)号：US07482430B2

    公开(公告)日：2009-01-27

    申请号：US10898575

    申请日：2004-07-23

    申请人： Steven R. Wiley

    发明人： Steven R. Wiley

    IPC分类号： A61J38/00 ,  A61K39/00 ,  C07K14/00

    CPC分类号： C07K14/70578 ,  C07K2319/30 ,  C07K2319/70 ,  C07K2319/73

    摘要： The present invention provides methods and compositions relating to fusion proteins comprising multimeric soluble TWEAK receptor fragments and an oligomerization domain. Such fusion proteins are useful for antagonizing the TWEAK receptor and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and inflammatory conditions.

    摘要翻译： 本发明提供了涉及包含多聚可溶性TWEAK受体片段和寡聚化结构域的融合蛋白质的方法和组合物。 这种融合蛋白可用于拮抗TWEAK受体和用于治疗由血管生成介导的疾病或病症，例如实体瘤和炎性病症。