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公开(公告)号：US20100028944A1
公开(公告)日：2010-02-04
申请号：US12520075
申请日：2007-12-19
Applicant: Randy Berka , Michelle Maranta , Maria Tang , Barbara Cherry
Inventor： Randy Berka , Michelle Maranta , Maria Tang , Barbara Cherry
Abstract: The present invention relates to methods of obtaining genetic competence in non-competent Bacillus cells for their transformation with exogenous DNA.
Abstract translation: 本发明涉及在非感受态芽孢杆菌细胞中获得外源DNA转化的遗传能力的方法。
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公开(公告)号：US07494798B2
公开(公告)日：2009-02-24
申请号：US10983128
申请日：2004-11-05
Applicant: Randy Berka , Michael Rey , Preethi Ramaiya , Jens Tønne Andersen , Michael Dolberg Rasmussen , Peter Bjarke Olsen
Inventor： Randy Berka , Michael Rey , Preethi Ramaiya , Jens Tønne Andersen , Michael Dolberg Rasmussen , Peter Bjarke Olsen
Abstract: The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis. The present invention also relates to isolated genes of the chromosome of Bacillus licheniformis which encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the genes as well as methods for producing biologically active substances encoded by the genes and to methods of using the isolated genes of the complete chromosome of Bacillus licheniformis.
Abstract translation: 本发明涉及地衣芽孢杆菌的完整染色体的分离的多核苷酸。 本发明还涉及编码生物活性物质的地衣芽孢杆菌染色体和包含该基因的核酸构建体，载体和宿主细胞的分离基因以及用于产生由该基因编码的生物活性物质的方法和 使用地衣芽孢杆菌完整染色体的分离基因。
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公开(公告)号：US06951749B1
公开(公告)日：2005-10-04
申请号：US09712338
申请日：2000-11-13
Applicant: Alexander Blinkovsky , Randy Berka , Michael Rey , Elizabeth Golightly , Alan Klotz , Thomas Erik Mathisen , Claus Dambmann
Inventor： Alexander Blinkovsky , Randy Berka , Michael Rey , Elizabeth Golightly , Alan Klotz , Thomas Erik Mathisen , Claus Dambmann
Abstract: The present invention relates to polypeptides having carboxypeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to methods of obtaining protein hydrolysates useful as flavor improving agents.
Abstract translation: 本发明涉及具有羧肽酶活性的多肽和分离的编码多肽的核酸序列。 本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及用于产生多肽的方法。 本发明还涉及获得可用作风味改善剂的蛋白质水解产物的方法。
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公开(公告)号：US08389283B2
公开(公告)日：2013-03-05
申请号：US12520075
申请日：2007-12-19
Applicant: Randy Berka , Michelle Maranta , Maria Tang , Barbara Cherry
Inventor： Randy Berka , Michelle Maranta , Maria Tang , Barbara Cherry
Abstract: The present invention relates to methods of obtaining genetic competence in non-competent Bacillus cells for their transformation with exogenous DNA.
Abstract translation: 本发明涉及在非感受态芽孢杆菌细胞中获得外源DNA转化的遗传能力的方法。
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公开(公告)号：US20110086407A1
公开(公告)日：2011-04-14
申请号：US12972306
申请日：2010-12-17
Applicant: Randy Berka , Michael Rey , Preethi Ramaiya , Jens Tønne Andersen , Michael Dolberg Rasmussen , Peter Bjarke Olsen
Inventor： Randy Berka , Michael Rey , Preethi Ramaiya , Jens Tønne Andersen , Michael Dolberg Rasmussen , Peter Bjarke Olsen
IPC: C12N9/12 , C12N9/90 , C07K14/32 , C12N9/00 , C12N9/56 , C12N9/16 , C12N9/10 , C12N9/88 , C12N9/78 , C07K14/195
Abstract: The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis. The present invention also relates to isolated genes of the chromosome of Bacillus licheniformis which encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the genes as well as methods for producing biologically active substances encoded by the genes and to methods of using the isolated genes of the complete chromosome of Bacillus licheniformis.
Abstract translation: 本发明涉及地衣芽孢杆菌的完整染色体的分离的多核苷酸。 本发明还涉及编码生物活性物质的地衣芽孢杆菌染色体和包含该基因的核酸构建体，载体和宿主细胞的分离基因以及用于产生由该基因编码的生物活性物质的方法和 使用地衣芽孢杆菌完整染色体的分离基因。
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Patent Agency Ranking
公开(公告)号：US20070015168A1
公开(公告)日：2007-01-18
申请号：US11203606
申请日：2005-08-12
Applicant: Alexandre Bolotine , Alexei Sorokine , Alla Lapidus , Randy Berka , Ib Clausen
Inventor： Alexandre Bolotine , Alexei Sorokine , Alla Lapidus , Randy Berka , Ib Clausen
IPC: C12Q1/68
CPC classification number: C12Q1/6809 , C12Q1/689 , C12Q2600/158 , C12Q2565/501 , C12Q2565/102
Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus genomic sequenced tags. The present invention also relates to computer readable media and computer-based systems. The present invention further relates to substrates containing an array of Bacillus licheniformis or Bacillus clausii GSTs.
Abstract translation: 本发明涉及使用含有芽孢杆菌基因组测序标签的微阵列来监测第一个芽孢杆菌细胞中多个基因的差异表达相对于一个或多个第二个芽孢杆菌细胞中相同基因表达的差异表达的方法。 本发明还涉及计算机可读介质和基于计算机的系统。 本发明还涉及含有地衣芽孢杆菌或克劳氏杆菌GST阵列的底物。
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公开(公告)号：US06187578B1
公开(公告)日：2001-02-13
申请号：US08943714
申请日：1997-10-03
Applicant: Alexander Blinkovsky , Randy Berka , Michael Rey , Elizabeth Golightly , Alan Klotz , Thomas Erik Mathisen , Claus Dambmann , Kimberly M. Brown
Inventor： Alexander Blinkovsky , Randy Berka , Michael Rey , Elizabeth Golightly , Alan Klotz , Thomas Erik Mathisen , Claus Dambmann , Kimberly M. Brown
IPC: G12N948
CPC classification number: A23J3/341 , A23J3/346 , A23K20/147 , A23L27/21 , A23L27/22 , A23L27/24 , A23V2002/00 , C12N9/48 , C12N9/62 , C12Y304/11001 , C12Y304/11004 , C12Y304/15001 , C12Y304/15005 , C12Y304/16002 , C12Y304/16005 , C12Y304/16006 , C12Y304/17001 , C12Y304/17002 , C12Y304/17003 , C12Y304/17004 , C12Y304/17006 , C12Y304/17011 , C12Y304/21004 , C12Y304/21019 , C12Y304/21026 , C12Y304/2105 , C12Y304/21057 , C12Y304/22025 , C12Y304/24033 , C12Y305/01043 , C12Y305/01044 , A23V2300/06
Abstract: The present invention relates to polypeptides having carboxypeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to methods of obtaining protein hydrolysates useful as flavor improving agents.
Abstract translation: 本发明涉及具有羧肽酶活性的多肽和分离的编码多肽的核酸序列。 本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及用于产生多肽的方法。 本发明还涉及获得可用作风味改善剂的蛋白质水解产物的方法。
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公开(公告)号：US08548746B2
公开(公告)日：2013-10-01
申请号：US13439547
申请日：2012-04-04
Applicant: Randy Berka , Elena Bachkirova , Michael Rey
Inventor： Randy Berka , Elena Bachkirova , Michael Rey
CPC classification number: C12Q1/6895 , C12Q2600/158
Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing Trichoderma reesei ESTs or SSH clones, or a combination thereof. The present invention also relates to computer readable media and substrates containing such array features for monitoring expression of a plurality of genes in filamentous fungal cells.
Abstract translation: 本发明涉及使用含有里氏木霉EST或SSH克隆的微阵列来监测第一丝状真菌细胞中多个基因的差异表达相对于一个或多个第二丝状真菌细胞中相同基因表达的方法，或其组合 。 本发明还涉及包含用于监测丝状真菌细胞中多个基因的表达的这种阵列特征的计算机可读介质和底物。
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公开(公告)号：US20120196773A1
公开(公告)日：2012-08-02
申请号：US13439547
申请日：2012-04-04
Applicant: Randy Berka , Elena Bashkirova , Michael Rey
Inventor： Randy Berka , Elena Bashkirova , Michael Rey
IPC: C40B40/06
CPC classification number: C12Q1/6895 , C12Q2600/158
Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing Trichoderma reesei ESTs or SSH clones, or a combination thereof. The present invention also relates to computer readable media and substrates containing such array features for monitoring expression of a plurality of genes in filamentous fungal cells.
Abstract translation: 本发明涉及使用含有里氏木霉EST或SSH克隆的微阵列来监测第一丝状真菌细胞中多个基因的差异表达相对于一个或多个第二丝状真菌细胞中相同基因表达的方法，或其组合 。 本发明还涉及包含用于监测丝状真菌细胞中多个基因的表达的这种阵列特征的计算机可读介质和底物。
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公开(公告)号：US08168768B2
公开(公告)日：2012-05-01
申请号：US12133642
申请日：2008-06-05
Applicant: Randy Berka , Elena Bachkirova , Michael Rey
Inventor： Randy Berka , Elena Bachkirova , Michael Rey
CPC classification number: C12Q1/6895 , C12Q2600/158
Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing Trichoderma reesei ESTs or SSH clones, or a combination thereof. The present invention also relates to computer readable media and substrates containing such array features for monitoring expression of a plurality of genes in filamentous fungal cells.
Abstract translation: 本发明涉及使用含有里氏木霉EST或SSH克隆的微阵列来监测第一丝状真菌细胞中多个基因的差异表达相对于一个或多个第二丝状真菌细胞中相同基因表达的方法，或其组合 。 本发明还涉及包含用于监测丝状真菌细胞中多个基因的表达的这种阵列特征的计算机可读介质和底物。
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