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    Stacks of coaligned nanopores and fabrication and uses thereof
    4.
    发明申请
    Stacks of coaligned nanopores and fabrication and uses thereof 审中-公开

    公开(公告)号：US20180328909A1

    公开(公告)日：2018-11-15

    申请号：US15975764

    申请日：2018-05-09

    申请人： Stanley Kent Kemmish, JR.

    发明人： Stanley Kent Kemmish, JR.

    IPC分类号： G01N33/487 ,  C12Q1/6869 ,  B01D67/00

    CPC分类号： G01N33/48721 ,  B01D67/0062 ,  B82Y15/00 ,  B82Y35/00 ,  B82Y40/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/6428 ,  G01N27/49

    摘要： Disclosed is an improved form of nanopore-based molecular sensor: a stack of coaligned nanopores in an equivalent number of directly stacked membranes. One or more of the membranes is moved laterally, altering the volumetric shape and thus the sensing characteristics of the passage. This allows at least three major improvements over existing nanopore sensors: 1) volumetrically tunable sensors allow sensing over a wider range of analyte sizes, 2) volumetric shape changes allow a a novel form of translocation control over transiting molecules, enabling more information to be derived from single molecules through interactions with the walls of the passage and controllable alterations in the local electrostratic and hydrodynamic environment, and 3) volumetric shape changes allow regeneration of an appropriate sensor geometry in the event of corrosion or clogging, greatly extending the useful lifetime of individual sensors

    SINGLE-CELL INTRACELLULAR NANO-PH PROBES
    6.
    发明申请
    SINGLE-CELL INTRACELLULAR NANO-PH PROBES 审中-公开

    公开(公告)号：US20180045675A1

    公开(公告)日：2018-02-15

    申请号：US15552685

    申请日：2016-02-24

    申请人： The Regents of the University of California

    发明人： Rifat Emrah OZEL ,  Nader POURMAND

    IPC分类号： G01N27/416 ,  G01N27/49 ,  G01N33/487 ,  G01N21/80

    CPC分类号： G01N27/4167 ,  G01N21/80 ,  G01N27/49 ,  G01N33/48728

    摘要： Disclosed is a method and device for sensing pH in a single living cell. The device is constructed for directing a nano-sized probe to pierce a single cell and extract accurate pH measurements in real time therefrom. A nanopipette, containing an electrode, is prepared through physisorption of chitosan, a biocompatible pH-responsive polymer, onto highly hydroxylated quartz nanopipettes with extremely small pore size (−97 nm). Changes of pH alter the surface charge of chitosan, which can be measured as a change in ionic current at the nanopore. The dynamic pH range of the nano-pH probe was from 2.6 to 10.7 with a sensitivity of 0.09 pH units. The present device can be used for single-cell intracellular pH measurements using, for example, non-cancerous and cancerous human cells, including human fibroblasts and model cells such as HeLa (epithelial cervix).

    Device for measuring the free chloride content of water
    10.
    发明授权
    Device for measuring the free chloride content of water 有权
    测量水中游离氯含量的装置

    公开(公告)号：US09513255B2

    公开(公告)日：2016-12-06

    申请号：US14234921

    申请日：2012-07-25

    申请人： Carine Beriet ,  Yves De Coulon ,  Cyrille Lemoine

    发明人： Carine Beriet ,  Yves De Coulon ,  Cyrille Lemoine

    IPC分类号： G01N27/49 ,  G01N27/404 ,  G01N27/416

    CPC分类号： G01N27/49 ,  G01N27/4045 ,  G01N27/4168

    摘要： An amperometric sensor circuit for measuring chlorine concentration in water. The circuit includes first and second working electrodes coated with a hydrophilic membrane. A power supply and biasing circuit is configured to deliver a generally constant voltage between the first working electrode and a reference electrode and to generally deliver a constant current between the second working electrode and a counter electrode. A measurement circuit measures the current between the counter electrode and the first working electrode. A processing circuit is provided for determining the chlorine concentration based on the current measured by the measurement circuit.

    摘要翻译： 用于测量水中氯浓度的电流传感器电路。 该电路包括涂覆有亲水膜的第一和第二工作电极。 电源和偏置电路被配置为在第一工作电极和参考电极之间传送大致恒定的电压，并且通常在第二工作电极和对电极之间传递恒定的电流。 测量电路测量对电极和第一工作电极之间的电流。 提供了一种基于由测量电路测量的电流来确定氯浓度的处理电路。