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公开(公告)号：US09376422B2
公开(公告)日：2016-06-28
申请号：US14110873
申请日：2012-04-13
申请人： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah K. Knutson , Timothy James Nelson Wigle , Masashi Seki
发明人： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah K. Knutson , Timothy James Nelson Wigle , Masashi Seki
IPC分类号： C07D213/64 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D491/10 , C07D491/113
CPC分类号： C07D213/64 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D491/048 , C07D491/08 , C07D491/10 , C07D491/113
摘要： The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
摘要翻译： 本发明涉及取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US09029343B2
公开(公告)日：2015-05-12
申请号：US13991321
申请日：2011-12-05
IPC分类号： C07H19/16 , C07H19/167 , C07D473/34
CPC分类号： C07H19/16 , C07D473/34 , C07H19/167
摘要： Disclosed are compounds, pharmaceutical compositions containing the compounds, and the uses of the compounds and compositions as modulators of histone methyltransferases, and for treating diseases influenced by modulation of histone methyltransferase activity.
摘要翻译： 公开了化合物，含有这些化合物的药物组合物，以及化合物和组合物作为组蛋白甲基转移酶调节剂的用途，以及用于治疗受组蛋白甲基转移酶活性调节影响的疾病。
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公开(公告)号：US08580762B2
公开(公告)日：2013-11-12
申请号：US13310157
申请日：2011-12-02
申请人： Edward James Olhava , Richard Chesworth , Kevin Wayne Kuntz , Victoria M. Richon , Roy Macfarlane Pollock , Scott Richard Daigle
发明人： Edward James Olhava , Richard Chesworth , Kevin Wayne Kuntz , Victoria M. Richon , Roy Macfarlane Pollock , Scott Richard Daigle
CPC分类号： A61K31/7076 , A61K31/519 , A61K31/52 , A61K31/7064 , C07D473/34 , C07D487/04 , C07H19/14 , C07H19/16
摘要： The present invention relates to substituted purine and 7-deazapurine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
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公开(公告)号：US20120295981A1
公开(公告)日：2012-11-22
申请号：US13486201
申请日：2012-06-01
申请人： Gideon SHAPIRO , Richard CHESWORTH
发明人： Gideon SHAPIRO , Richard CHESWORTH
IPC分类号： A61K31/192 , A61P25/28
CPC分类号： C07C51/09 , C07C51/42 , C07C59/72 , C07C67/343 , C07C67/48 , C07C69/734 , C07C69/757 , C07C205/37 , C07C205/55 , C07C205/56 , C07C229/42 , C07C255/57 , C07C323/18 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D271/12 , C07D277/64 , C07D285/14 , C07D309/08
摘要： Tetrasubstituted benzenes that act as modulators of gamma secretase and their use in the treatment of one or more symptoms of treating neurodegenerative disorders, e.g., Alzheimer's disease, are described.
摘要翻译： 描述了作为γ分泌酶的调节剂的四氮取代的苯及其在治疗治疗神经变性疾病例如阿尔茨海默病的一种或多种症状中的用途。
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公开(公告)号：US08217064B2
公开(公告)日：2012-07-10
申请号：US12341201
申请日：2008-12-22
申请人： Gideon Shapiro , Richard Chesworth
发明人： Gideon Shapiro , Richard Chesworth
IPC分类号： A61K31/4245 , A61K31/433 , A61K31/192 , C07D498/00 , C07C59/48
CPC分类号： C07C51/09 , C07C51/42 , C07C59/72 , C07C67/343 , C07C67/48 , C07C69/734 , C07C69/757 , C07C205/37 , C07C205/55 , C07C205/56 , C07C229/42 , C07C255/57 , C07C323/18 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D271/12 , C07D277/64 , C07D285/14 , C07D309/08
摘要： Tetrasubstituted benzenes that act as modulators of gamma secretase and their use in the treatment of one or more symptoms of treating neurodegenerative disorders, e.g., Alzheimer's disease, are described.
摘要翻译： 描述了作为γ分泌酶的调节剂的四氮取代的苯及其在治疗治疗神经变性疾病例如阿尔茨海默病的一种或多种症状中的用途。
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公开(公告)号：US20110183976A1
公开(公告)日：2011-07-28
申请号：US13001359
申请日：2009-06-25
申请人： Amy Ripka , Gideon Shapiro , Richard Chesworth
发明人： Amy Ripka , Gideon Shapiro , Richard Chesworth
IPC分类号： A61K31/5377 , C07D401/12 , C07D413/14 , C07D401/14 , C07D405/14 , C07D405/12 , C07D471/04 , A61K31/4709 , A61K31/498 , A61K31/4375 , A61K31/517 , A61K31/501 , A61K31/53 , A61P25/00 , A61P3/04 , A61P15/00 , A61P25/34 , A61P25/18 , A61P25/14
CPC分类号： A61K31/53 , A61K31/4375 , A61K31/4439 , A61K31/4709 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/517 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： 5- and 6-membered heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described as are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) for central nervous system (CNS) disorders and other disorders which may affect CNS function. Also described is the treatment of neurological, neurodegenerative and psychiatric disorders including but not limited to those comprising cognitive deficits or schizophrenic symptoms.
摘要翻译： 作为磷酸二酯酶10的抑制剂的5-和6-元杂环化合物被描述为方法，药物组合物，药物制剂和化合物在治疗哺乳动物（包括中枢神经系统（CNS）病症的人）中的药物用途 和其他可能影响CNS功能的疾病。 还描述了治疗神经系统，神经变性和精神病学障碍，包括但不限于包括认知缺陷或精神分裂症状的那些。
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7.发明申请Method of treating neurological disorders using clotrimazole and derivatives thereof 审中-公开使用克霉唑及其衍生物治疗神经障碍的方法公开(公告)号：US20070037800A1
公开(公告)日：2007-02-15
申请号：US11473479
申请日：2006-06-23
IPC分类号： A61K31/5375 , A61K31/4196 , A61K31/4192 , A61K31/415 , A61K31/41
CPC分类号： A61K31/415 , A61K31/41 , A61K31/4192 , A61K31/4196 , A61K31/5375
摘要： Methods and pharmaceutical compositions are disclosed for treating neurological disorders, such as Huntington's disease or Alzheimer's disease. The methods involve the administration of a triarylmethane compound, such as clotrimazole, or a salt thereof.
摘要翻译： 公开了用于治疗诸如亨廷顿病或阿尔茨海默氏病之类的神经障碍的方法和药物组合物。 所述方法包括施用三芳基甲烷化合物，例如克霉唑或其盐。
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公开(公告)号：US20190083482A1
公开(公告)日：2019-03-21
申请号：US15707678
申请日：2017-09-18
申请人： Kenneth W. Duncan , Richard Chesworth , Paula Ann Boriack-Sjodin , Michael John Munchhof , Lei Jin
发明人： Kenneth W. Duncan , Richard Chesworth , Paula Ann Boriack-Sjodin , Michael John Munchhof , Lei Jin
IPC分类号： A61K31/472 , A61K31/4725 , A61K31/5377 , A61K31/538
摘要： Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.
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9.发明申请7-Deazapurine Modulators of Histone Methyltransferase, and Methods of Use Thereof 有权组氨酸甲基转移酶的7-脱氮嘌呤调节剂及其使用方法公开(公告)号：US20130310334A1
公开(公告)日：2013-11-21
申请号：US13991328
申请日：2011-12-05
IPC分类号： C07H19/14
CPC分类号： C07H19/14 , C07D487/04
摘要： Disclosed are compounds, pharmaceutical compositions containing the compounds, uses of the compounds and compositions as modulators of histone methyltransferases, and methods for treating diseases influenced by modulation of histone methyltransferase activity.
摘要翻译： 公开了化合物，含有这些化合物的药物组合物，化合物和组合物用作组蛋白甲基转移酶的调节剂，以及治疗受组蛋白甲基转移酶活性调节影响的疾病的方法。
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公开(公告)号：US20130310333A1
公开(公告)日：2013-11-21
申请号：US13991321
申请日：2011-12-05
IPC分类号： C07H19/16
CPC分类号： C07H19/16 , C07D473/34 , C07H19/167
摘要： Disclosed are compounds, pharmaceutical compositions containing the compounds, and the uses of the compounds and compositions as modulators of histone methyltransferases, and for treating diseases influenced by modulation of histone methyltransferase activity.
摘要翻译： 公开了化合物，含有这些化合物的药物组合物，以及化合物和组合物作为组蛋白甲基转移酶调节剂的用途，以及用于治疗受组蛋白甲基转移酶活性调节影响的疾病。
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