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    Innate Immune Receptor Directed Biocides
    1.
    发明申请
    Innate Immune Receptor Directed Biocides 审中-公开
    先天免疫受体导向杀生物剂

    公开(公告)号：US20080267943A1

    公开(公告)日：2008-10-30

    申请号：US11875343

    申请日：2007-10-19

    申请人： Michael Imboden ,  Jane Homan ,  Robert D. Bremel

    发明人： Michael Imboden ,  Jane Homan ,  Robert D. Bremel

    IPC分类号： A61K38/43 ,  A61K38/00 ,  C12N5/06 ,  C12N15/00 ,  A01K67/027 ,  A61P31/00 ,  A23L3/3463

    CPC分类号： A01N63/04 ,  A01N63/00 ,  A01N63/02 ,  A01N65/00 ,  C07K16/00 ,  C07K16/20 ,  C07K2317/52 ,  C07K2319/01 ,  C07K2319/035 ,  C07K2319/33 ,  C07K2319/55 ,  C07K2319/735

    摘要： The present invention relates to retroviral constructs that encode novel monoclonal antibodies, novel fusion proteins, and chimeric monoclonal antibodies and to methods of using and producing the same. In particular, the present invention relates to methods of producing a fusion protein comprising a microorganism targeting molecule (e.g., immunoglobulin or innate immune system receptor molecule) and a biocide (e.g., bactericidal enzymes) in transgenic animals (e.g., bovines) and in cell cultures. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in health care (e.g., human and veterinary), agriculture (e.g., animal and plant production), and food processing (e.g., beef carcass processing). The present invention also relates to methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in various diagnostic applications in number of diverse fields such as agriculture, medicine, and national defense.

    摘要翻译： 本发明涉及编码新单克隆抗体，新型融合蛋白和嵌合单克隆抗体的逆转录病毒构建体及其使用和生产方法。 特别地，本发明涉及在转基因动物（例如牛）和细胞中产生包含微生物靶向分子（例如，免疫球蛋白或先天免疫系统受体分子）和杀生物剂（例如杀菌酶）的融合蛋白的方法。 文化。 本发明还涉及在医疗保健（例如人类和兽医），农业（例如动物和植物生产）和食品加工（例如，动物和植物生产）中使用包含微生物靶向分子和杀生物剂的融合蛋白的治疗和预防方法， 牛肉屠体处理）。 本发明还涉及在农业，医药，国防等不同领域的多种诊断应用中使用包含微生物靶向分子和杀生物剂的融合蛋白的方法。

    Bioinformatic processes for determination of peptide binding
    4.
    发明授权
    Bioinformatic processes for determination of peptide binding 有权

    公开(公告)号：US10706955B2

    公开(公告)日：2020-07-07

    申请号：US13052733

    申请日：2011-03-21

    申请人： Robert D. Bremel ,  Jane Homan

    发明人： Robert D. Bremel ,  Jane Homan

    IPC分类号： G16B20/00 ,  G16B40/00

    摘要： This invention relates to processes for identifying peptide and polypeptide ligands for a binding partner by using principal component analysis of amino acids to derive vectors describing amino acid subsets corresponding to peptides with known binding affinities and then using this information in a neural network modeling process to derive binding prediction equations. These binding prediction equations are then used in the analysis of subsets of amino acids from a target source to identify peptides or polypeptides ligands in the target source that have affinity for a binding partner.

    Antimicrobial Peptide Biocides
    6.
    发明申请
    Antimicrobial Peptide Biocides 审中-公开
    抗微生物肽杀菌剂

    公开(公告)号：US20080269122A1

    公开(公告)日：2008-10-30

    申请号：US11875349

    申请日：2007-10-19

    申请人： Michael Imboden ,  Jane Homan ,  Robert D. Bremel

    发明人： Michael Imboden ,  Jane Homan ,  Robert D. Bremel

    IPC分类号： A61K38/00 ,  C12N15/00 ,  C12N5/06 ,  A61P31/00 ,  A23L3/3463

    CPC分类号： A01N63/04 ,  A01N63/00 ,  A01N63/02 ,  A01N65/00 ,  C07K16/00 ,  C07K16/20 ,  C07K2317/52 ,  C07K2319/01 ,  C07K2319/035 ,  C07K2319/33 ,  C07K2319/55 ,  C07K2319/735

    摘要： The present invention relates to retroviral constructs that encode novel monoclonal antibodies, novel fusion proteins, and chimeric monoclonal antibodies and to methods of using and producing the same. In particular, the present invention relates to methods of producing a fusion protein comprising a microorganism targeting molecule (e.g., immunoglobulin or innate immune system receptor molecule) and a biocide (e.g., bactericidal enzymes) in transgenic animals (e.g., bovines) and in cell cultures. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in health care (e.g., human and veterinary), agriculture (e.g., animal and plant production), and food processing (e.g., beef carcass processing). The present invention also relates to methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in various diagnostic applications in number of diverse fields such as agriculture, medicine, and national defense.

    摘要翻译： 本发明涉及编码新单克隆抗体，新型融合蛋白和嵌合单克隆抗体的逆转录病毒构建体及其使用和生产方法。 特别地，本发明涉及在转基因动物（例如牛）和细胞中产生包含微生物靶向分子（例如，免疫球蛋白或先天免疫系统受体分子）和杀生物剂（例如杀菌酶）的融合蛋白的方法。 文化。 本发明还涉及在医疗保健（例如人类和兽医），农业（例如动物和植物生产）和食品加工（例如，动物和植物生产）中使用包含微生物靶向分子和杀生物剂的融合蛋白的治疗和预防方法， 牛肉屠体处理）。 本发明还涉及在农业，医药，国防等不同领域的多种诊断应用中使用包含微生物靶向分子和杀生物剂的融合蛋白的方法。

    Antibody libraries
    9.
    发明授权
    Antibody libraries 有权
    抗体库

    公开(公告)号：US08222188B2

    公开(公告)日：2012-07-17

    申请号：US12493851

    申请日：2009-06-29

    申请人： Robert D. Bremel ,  Kurt Eakle ,  Michael Imboden

    发明人： Robert D. Bremel ,  Kurt Eakle ,  Michael Imboden

    IPC分类号： C40B40/02 ,  C12Q1/70

    CPC分类号： C07K16/00 ,  C07K2317/21 ,  C12N2799/027

    摘要： The present invention relates to the production of antibody libraries. In particular, the present invention relates to the use of integrating retroviral vectors to generate libraries comprising a plurality of combinations of antibody light chains and heavy chains. The present invention thus provides improved methods of generating and screening antibody libraries comprising large numbers of unique antibodies.

    摘要翻译： 本发明涉及抗体文库的生产。 特别地，本发明涉及整合逆转录病毒载体以产生包含抗体轻链和重链的多种组合的文库的用途。 因此，本发明提供了产生和筛选包含大量独特抗体的抗体文库的改进方法。