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1.发明授权
公开(公告)号：US5703360A
公开(公告)日：1997-12-30
申请号：US706390
申请日：1996-08-30
CPC分类号： H01J49/0431 , H01J49/0009 , G01N2030/027 , G01N30/7233
摘要： An automated calibrant system is provided for use in a liquid separation/mass spectrometry (LS/MS) apparatus. The calibrant system is pneumatically pressurized to forcibly move a reference liquid from the calibrant system to an ion source. The ion source is in fluid communication with a switching valve and with a mass spectrometer. The switching valve communicates effluent from a liquid separation system to the source when the switching valve is in a first position, and communicates one or more reference liquids from the calibrant system to the source when the switching valve is in a second position. The switching valve, and liquid handling valves in the calibrant system, can be individually activated manually or by automated means to alternate between analytical and calibration modes of operation in the LS/MS apparatus. A method is also provided for calibrating a mass spectrometer in a LS/MS apparatus during processing of a liquid sample by the liquid separation system.
摘要翻译： 提供了一种用于液体分离/质谱（LS / MS）装置的自动校准系统。 校准系统被气动加压以将参考液体从校准系统强制移动到离子源。 离子源与切换阀和质谱流体连通。 当切换阀处于第一位置时，切换阀将流体从液体分离系统传递到源，并且当切换阀处于第二位置时，将来自校准系统的一个或多个参考液体连通到源。 校准系统中的切换阀和液体处理阀可以单独地通过手动或通过自动化方式在LS / MS装置中在分析和校准操作模式之间交替。 还提供了一种用于在通过液体分离系统处理液体样品期间校准LS / MS装置中的质谱仪的方法。
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公开(公告)号：US5447553A
公开(公告)日：1995-09-05
申请号：US326060
申请日：1994-10-19
CPC分类号： G01N30/728 , H01J49/04 , G01N30/7273
摘要： Close coupled momentum separator with integral removable source volume for particle beam liquid chromatography/mass spectrometry is provided. The inventive PB LC/MS system comprises a momentum separator wherein the skimmers are designed to accommodate the particle beam conical dispersion so as to minimize the number of particles lost in the separator. In addition, the exit of the momentum separator is closely coupled to the entrance of the MS source volume. The PB LC/MS system demonstrates improved linearity in signal and enhanced sensitivity.
摘要翻译： 提供了用于粒子束液相色谱/质谱的封闭耦合动量分离器和整体可移动源体积。 本发明的PB LC / MS系统包括动量分离器，其中撇渣器被设计成容纳颗粒束锥形分散体，以便最小化在分离器中损失的颗粒的数量。 此外，动量分离器的出口紧密耦合到MS源体积的入口。 PB LC / MS系统显示出信号线性度提高和灵敏度提高。
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3.发明授权
公开(公告)号：US5753910A
公开(公告)日：1998-05-19
申请号：US679481
申请日：1996-07-12
CPC分类号： H01J49/24 , H01J49/145 , H01J49/165 , G01N30/7266
摘要： An atmospheric pressure ionization source is provided which includes an ionization chamber that is formed from the combination of an angled chamber body and a correspondingly angled chamber seal. The ionization chamber is used for electrospray or atmospheric pressure chemical ionization of a liquid sample to provide ionized molecules. The ionized molecules can be passed to an associated analytical device that is capable of detecting and measuring the mass-to-charge ratio and/or the mass and charge of the molecules. A mass spectrometer which includes the present atmospheric pressure ionization source is also provided, as well as a liquid chromatography/mass spectrometry (LC/MS) analysis system which includes an LC/MS interface comprising the present atmospheric pressure ionization source.
摘要翻译： 提供了一种大气压电离源，其包括由倾斜室体和相应成角度的室密封的组合形成的电离室。 电离室用于液体样品的电喷雾或大气压化学电离以提供电离分子。 电离分子可以传递到能够检测和测量分子的质荷比和/或质量和电荷的相关分析装置。 还提供了包括本气氛电离离子源的质谱仪，以及包括包含本气氛电离电离源的LC / MS界面的液相色谱/质谱（LC / MS）分析系统。
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4.发明授权
公开(公告)号：US5331159A
公开(公告)日：1994-07-19
申请号：US7464
申请日：1993-01-22
CPC分类号： H01J49/165 , G01N30/7266 , H01J49/067 , G01N30/7273 , G01N30/7293
摘要： A liquid chromatography-mass spectrometry system that can be configured as either a particle beam or an electrospray interface is provided. The device incorporates structural elements that are common to both interfaces thereby eliminating the need to have two completely separate ES and PB LC/MS systems. The LC/MS device according to the present invention generally comprises a momentum separator, nozzle housing, mass spectrometer, and a vacuum subsystem. A mass spectrometer housing encloses a quadrupole mass analyzer. When used in the ES mode, and ES source module is coupled into the inventive device. Similarly, when used in the PB mode, a PB source module is coupled into the inventive device along with a separate source PB probe. The mass analyzer chamber can accommodate a particle beam source probe for generating ions from analyte particles. In either mode, the modules can consist of commercially available interfaces modified for use with the inventive device.
摘要翻译： 可提供可配置为粒子束或电喷雾界面的液相色谱 - 质谱系统。 该器件包含两个接口共同的结构元件，从而无需使用两个完全独立的ES和PB LC / MS系统。 根据本发明的LC / MS装置通常包括动量分离器，喷嘴壳体，质谱仪和真空子系统。 质谱仪外壳包围四极质量分析仪。 当用于ES模式时，ES源模块耦合到本发明的装置中。 类似地，当以PB模式使用时，PB源模块与单独的源PB探针一起耦合到本发明的装置中。 质量分析器室可以容纳用于从分析物颗粒产生离子的粒子束源探针。 在任一模式中，模块可以由修改用于本发明装置的市售接口组成。
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5.发明授权
公开(公告)号：US5223131A
公开(公告)日：1993-06-29
申请号：US773178
申请日：1991-10-08
CPC分类号： G01N30/728 , H01J49/04 , G01N30/7273
摘要： Close coupled momentum separator with integral removable source volume for particle beam liquid chromatography/mass spectrometry is provided. The inventive PB LC/MS system comprises a momentum separator wherein the skimmers are designed to accommodate the particle beam conical dispersion so as to minimize the number of particles lost in the separator. In addition, the exit of the momentum separator is closely coupled to the entrance of the MS source volume. The PB LC/MS system demonstrates improved linearity in signal and enhanced sensitivity.
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