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1.发明授权
公开(公告)号：US5223131A
公开(公告)日：1993-06-29
申请号：US773178
申请日：1991-10-08
CPC分类号： G01N30/728 , H01J49/04 , G01N30/7273
摘要： Close coupled momentum separator with integral removable source volume for particle beam liquid chromatography/mass spectrometry is provided. The inventive PB LC/MS system comprises a momentum separator wherein the skimmers are designed to accommodate the particle beam conical dispersion so as to minimize the number of particles lost in the separator. In addition, the exit of the momentum separator is closely coupled to the entrance of the MS source volume. The PB LC/MS system demonstrates improved linearity in signal and enhanced sensitivity.
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公开(公告)号：US5447553A
公开(公告)日：1995-09-05
申请号：US326060
申请日：1994-10-19
CPC分类号： G01N30/728 , H01J49/04 , G01N30/7273
摘要： Close coupled momentum separator with integral removable source volume for particle beam liquid chromatography/mass spectrometry is provided. The inventive PB LC/MS system comprises a momentum separator wherein the skimmers are designed to accommodate the particle beam conical dispersion so as to minimize the number of particles lost in the separator. In addition, the exit of the momentum separator is closely coupled to the entrance of the MS source volume. The PB LC/MS system demonstrates improved linearity in signal and enhanced sensitivity.
摘要翻译： 提供了用于粒子束液相色谱/质谱的封闭耦合动量分离器和整体可移动源体积。 本发明的PB LC / MS系统包括动量分离器，其中撇渣器被设计成容纳颗粒束锥形分散体，以便最小化在分离器中损失的颗粒的数量。 此外，动量分离器的出口紧密耦合到MS源体积的入口。 PB LC / MS系统显示出信号线性度提高和灵敏度提高。
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3.发明授权
公开(公告)号：US5331159A
公开(公告)日：1994-07-19
申请号：US7464
申请日：1993-01-22
CPC分类号： H01J49/165 , G01N30/7266 , H01J49/067 , G01N30/7273 , G01N30/7293
摘要： A liquid chromatography-mass spectrometry system that can be configured as either a particle beam or an electrospray interface is provided. The device incorporates structural elements that are common to both interfaces thereby eliminating the need to have two completely separate ES and PB LC/MS systems. The LC/MS device according to the present invention generally comprises a momentum separator, nozzle housing, mass spectrometer, and a vacuum subsystem. A mass spectrometer housing encloses a quadrupole mass analyzer. When used in the ES mode, and ES source module is coupled into the inventive device. Similarly, when used in the PB mode, a PB source module is coupled into the inventive device along with a separate source PB probe. The mass analyzer chamber can accommodate a particle beam source probe for generating ions from analyte particles. In either mode, the modules can consist of commercially available interfaces modified for use with the inventive device.
摘要翻译： 可提供可配置为粒子束或电喷雾界面的液相色谱 - 质谱系统。 该器件包含两个接口共同的结构元件，从而无需使用两个完全独立的ES和PB LC / MS系统。 根据本发明的LC / MS装置通常包括动量分离器，喷嘴壳体，质谱仪和真空子系统。 质谱仪外壳包围四极质量分析仪。 当用于ES模式时，ES源模块耦合到本发明的装置中。 类似地，当以PB模式使用时，PB源模块与单独的源PB探针一起耦合到本发明的装置中。 质量分析器室可以容纳用于从分析物颗粒产生离子的粒子束源探针。 在任一模式中，模块可以由修改用于本发明装置的市售接口组成。
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4.发明授权Multiplexing capillary array for atmospheric pressure ionization-mass spectrometry 有权用于大气压电离质谱的多重毛细管阵列公开(公告)号：US06649908B2
公开(公告)日：2003-11-18
申请号：US09960890
申请日：2001-09-20
IPC分类号： H01J4904
CPC分类号： H01J49/107 , G01N30/466 , G01N30/7266 , G01N2030/628 , G01N2030/8411 , H01J49/04 , G01N2030/162 , G01N2030/202
摘要： A transfer capillary and interface are provided that allow samples from multiple fluid streams to be introduced into a single mass analyzer. The transfer capillary has two or more channels and is placed between a first chamber, in which ions from the multiple fluid streams are generated, and a second chamber that is in fluid communication with a mass analyzer. The interface includes ionizers that generate ionized sample from each fluid stream and that direct the ionized sample toward the channels of the transfer capillary. The transfer capillary includes a multiplex selector that allows ions to flow through a selected subset of channels and sequentially changes which of the channels are included in the subset of channels through which ions flow.
摘要翻译： 提供了一种转移毛细管和界面，可将来自多个流体流的样品引入单个质量分析仪。 转移毛细管具有两个或更多个通道并且放置在其中产生来自多个流体流的离子的第一室和与质量分析器流体连通的第二室。 该界面包括从每个流体流产生离子化样品并将离子化样品导向转移毛细管的通道的电离器。 转移毛细管包括多路复用选择器，其允许离子流过选定的通道子集，并且顺序地改变哪些通道包括在离子流过的通道子集中。
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5.再颁专利
公开(公告)号：USRE36892E
公开(公告)日：2000-10-03
申请号：US792303
申请日：1997-01-31
CPC分类号： H01J49/165 , G01N30/7253 , H01J49/04
摘要： .[.The invention teaches the uses of a plurality of electric fields and of orthogonal spray configurations of vaporized analyte which combine so as to operate to enhance the efficiency of analyte detection and mass analysis with a mass spectrometer by reducing vapor in the vacuum system and concomitant noise. Several embodiments of the invention are described for purposes of illustration..]. .Iadd.The invention relates to a method and apparatus for improving signal relative to noise without loss of ion collection efficiency in electrospray mass spectrometry, including liquid chromatography/mass spectrometry..Iaddend.
摘要翻译： [本发明教导了多个电场和汽化分析物的正交喷雾构型的使用，其结合起来以便通过减少真空系统中的蒸气和伴随的噪声来提高分析物检测和质谱分析的效率 。 为了说明的目的，描述了本发明的几个实施例。]本发明涉及一种用于在电喷雾质谱（包括液相色谱/质谱）中改善相对于噪声的信号而不损失离子收集效率的方法和装置。
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公开(公告)号：US5495108A
公开(公告)日：1996-02-27
申请号：US273250
申请日：1994-07-11
CPC分类号： H01J49/165 , G01N30/7253 , H01J49/04
摘要： The invention teaches the uses of a plurality of electric fields and of orthogonal spray configurations of vaporized analyte which combine so as to operate to enhance the efficiency of analyte detection and mass analysis with a mass spectrometer by reducing vapor in the vacuum system and concomitant noise. Several embodiments of the invention are described for purposes of illustration.
摘要翻译： 本发明教导了多个电场和蒸发分析物的正交喷雾构型的使用，其结合以便通过减少真空系统中的蒸气和伴随的噪声，通过质谱仪来提高分析物检测和质量分析的效率。 为了说明的目的描述了本发明的若干实施例。
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7.发明授权公开(公告)号：US06379889B1
公开(公告)日：2002-04-30
申请号：US09434035
申请日：1999-11-04
IPC分类号： C12Q168
CPC分类号： C12Q1/6827 , Y10S436/80 , Y10S436/805 , Y10T436/143333 , C12Q2565/137 , C12Q2565/102 , C12Q2527/107
摘要： A method is provided for the separation of nucleic acid samples. The method includes: providing a test mixture of a plurality of nucleic acid samples, wherein each sample is labeled with a spectrally detectable tag; applying the test mixture to a reversed phase solid support; eluting the mixture under partially denaturing conditions; and detecting spectrally resolved signals produced by the nucleic acid samples labeled with the detectable tags.
摘要翻译： 提供了用于分离核酸样品的方法。 该方法包括：提供多个核酸样品的测试混合物，其中每个样品用光谱可检测标签标记; 将测试混合物施加到反相固相支持物上; 在部分变性条件下洗脱混合物; 以及检测由可检测标签标记的核酸样品产生的光谱解析信号。
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公开(公告)号：US06797946B2
公开(公告)日：2004-09-28
申请号：US10640138
申请日：2003-08-13
IPC分类号： H01J4926
CPC分类号： H01J49/145 , G01N30/7253 , H01J49/0431 , H01J49/165 , H01J49/168
摘要： A method and apparatus are disclosed wherein a plurality of electric fields and of orthogonal spray configurations of vaporized analyte are so combined as to enhance the efficiency of analyte detection and mass analysis. The invention provides reduced noise and increased signal sensitivity in both API electrospray and APCI operating modes.
摘要翻译： 公开了一种方法和装置，其中将多个电场和蒸发的分析物的正交喷雾构型组合，以提高分析物检测和质量分析的效率。 本发明在API电喷雾和APCI操作模式中提供降低的噪声和增加的信号灵敏度。
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公开(公告)号：US06639216B2
公开(公告)日：2003-10-28
申请号：US10265943
申请日：2002-10-07
IPC分类号： H01J4926
CPC分类号： H01J49/145 , G01N30/7253 , H01J49/0431 , H01J49/165 , H01J49/168
摘要： A method and apparatus are disclosed wherein a plurality of electric fields and of orthogonal spray configurations of vaporized analyte are so combined as to enhance the efficiency of analyte detection and mass analysis. The invention provides reduced noise and increased signal sensitivity in both API electrospray and APCI operating modes.
摘要翻译： 公开了一种方法和装置，其中将多个电场和蒸发的分析物的正交喷雾构型组合，以提高分析物检测和质量分析的效率。 本发明在API电喷雾和APCI操作模式中提供降低的噪声和增加的信号灵敏度。
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10.发明授权公开(公告)号：US06607644B1
公开(公告)日：2003-08-19
申请号：US09703431
申请日：2000-10-31
申请人： James A. Apffel, Jr.
发明人： James A. Apffel, Jr.
IPC分类号： G01N27447
CPC分类号： G01N33/521
摘要： The invention provides a microanalytical device for analyzing a fluid sample containing at least one analyte molecule. The device is constructed from a substrate and a cover plate each having a substantially planar surface and a microchannel formed therein. The cover plate is placed over the substrate such that the cover plate microchannel is arranged in opposing relationship with the substrate microchannel. A membrane is interposed between the substrate and the cover and has at least one pore sized to allow passage of the analyte molecule from the substrate microchannel to the cover plate microchannel. An analyte altering moiety is attached to an interior surface of the pore and is capable of chemically altering the analyte molecule. Also disclosed are a method for chemically altering and transporting an analyte molecule in a fluid and a method for identifying a plurality of biomolecules.
摘要翻译： 本发明提供了一种用于分析含有至少一种分析物分子的流体样品的微量分析装置。 该装置由基板和盖板构成，每个基板具有形成在其中的基本平坦的表面和微通道。 盖板放置在基板上，使得盖板微通道以与基板微通道相对的关系布置。 膜位于基底和盖子之间，并且具有至少一个孔，其尺寸允许分析物分子从基底微通道通向盖板微通道。 分析物改变部分连接到孔的内表面并且能够化学地改变分析物分子。 还公开了用于化学改变和输送流体中的分析物分子的方法和用于鉴定多个生物分子的方法。
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