利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

11 records (took 0.014 seconds)

    Multiplexing capillary array for atmospheric pressure ionization-mass spectrometry
    1.
    发明授权
    Multiplexing capillary array for atmospheric pressure ionization-mass spectrometry 有权
    用于大气压电离质谱的多重毛细管阵列

    公开(公告)号：US06649908B2

    公开(公告)日：2003-11-18

    申请号：US09960890

    申请日：2001-09-20

    Applicant: James A. Apffel, Jr. ,  Hongfeng Yin ,  Thomas P. Doherty

    Inventor： James A. Apffel, Jr. ,  Hongfeng Yin ,  Thomas P. Doherty

    IPC: H01J4904

    CPC classification number: H01J49/107 ,  G01N30/466 ,  G01N30/7266 ,  G01N2030/628 ,  G01N2030/8411 ,  H01J49/04 ,  G01N2030/162 ,  G01N2030/202

    Abstract: A transfer capillary and interface are provided that allow samples from multiple fluid streams to be introduced into a single mass analyzer. The transfer capillary has two or more channels and is placed between a first chamber, in which ions from the multiple fluid streams are generated, and a second chamber that is in fluid communication with a mass analyzer. The interface includes ionizers that generate ionized sample from each fluid stream and that direct the ionized sample toward the channels of the transfer capillary. The transfer capillary includes a multiplex selector that allows ions to flow through a selected subset of channels and sequentially changes which of the channels are included in the subset of channels through which ions flow.

    Abstract translation: 提供了一种转移毛细管和界面，可将来自多个流体流的样品引入单个质量分析仪。 转移毛细管具有两个或更多个通道并且放置在其中产生来自多个流体流的离子的第一室和与质量分析器流体连通的第二室。 该界面包括从每个流体流产生离子化样品并将离子化样品导向转移毛细管的通道的电离器。 转移毛细管包括多路复用选择器，其允许离子流过选定的通道子集，并且顺序地改变哪些通道包括在离子流过的通道子集中。

    Orthogonal ion sampling for electrospray .[.LC/MS.]. mass spectrometry
    2.
    再颁专利
    Orthogonal ion sampling for electrospray .[.LC/MS.]. mass spectrometry 失效
    电喷雾正交离子采样[LC / MS]质谱

    公开(公告)号：USRE36892E

    公开(公告)日：2000-10-03

    申请号：US792303

    申请日：1997-01-31

    Applicant: James A. Apffel, Jr. ,  Mark H. Werlich ,  James L. Bertsch ,  Paul C. Goodley ,  Kent D. Henry

    Inventor： James A. Apffel, Jr. ,  Mark H. Werlich ,  James L. Bertsch ,  Paul C. Goodley ,  Kent D. Henry

    IPC: G01N27/62 ,  G01N30/72 ,  H01J49/04 ,  B01D59/46 ,  H01J49/00

    CPC classification number: H01J49/165 ,  G01N30/7253 ,  H01J49/04

    Abstract: .[.The invention teaches the uses of a plurality of electric fields and of orthogonal spray configurations of vaporized analyte which combine so as to operate to enhance the efficiency of analyte detection and mass analysis with a mass spectrometer by reducing vapor in the vacuum system and concomitant noise. Several embodiments of the invention are described for purposes of illustration..]. .Iadd.The invention relates to a method and apparatus for improving signal relative to noise without loss of ion collection efficiency in electrospray mass spectrometry, including liquid chromatography/mass spectrometry..Iaddend.

    Abstract translation: [本发明教导了多个电场和汽化分析物的正交喷雾构型的使用，其结合起来以便通过减少真空系统中的蒸气和伴随的噪声来提高分析物检测和质谱分析的效率 。 为了说明的目的，描述了本发明的几个实施例。]本发明涉及一种用于在电喷雾质谱（包括液相色谱/质谱）中改善相对于噪声的信号而不损失离子收集效率的方法和装置。

    Combined electrospray/particle beam liquid chromatography/mass spectrometer
    4.
    发明授权
    Combined electrospray/particle beam liquid chromatography/mass spectrometer 失效
    组合电喷雾/粒子束液相色谱/质谱仪

    公开(公告)号：US5331159A

    公开(公告)日：1994-07-19

    申请号：US7464

    申请日：1993-01-22

    Applicant: James A. Apffel, Jr. ,  Robert G. Nordman

    Inventor： James A. Apffel, Jr. ,  Robert G. Nordman

    IPC: G01N27/62 ,  G01N30/72 ,  H01J49/04 ,  H01J49/10

    CPC classification number: H01J49/165 ,  G01N30/7266 ,  H01J49/067 ,  G01N30/7273 ,  G01N30/7293

    Abstract: A liquid chromatography-mass spectrometry system that can be configured as either a particle beam or an electrospray interface is provided. The device incorporates structural elements that are common to both interfaces thereby eliminating the need to have two completely separate ES and PB LC/MS systems. The LC/MS device according to the present invention generally comprises a momentum separator, nozzle housing, mass spectrometer, and a vacuum subsystem. A mass spectrometer housing encloses a quadrupole mass analyzer. When used in the ES mode, and ES source module is coupled into the inventive device. Similarly, when used in the PB mode, a PB source module is coupled into the inventive device along with a separate source PB probe. The mass analyzer chamber can accommodate a particle beam source probe for generating ions from analyte particles. In either mode, the modules can consist of commercially available interfaces modified for use with the inventive device.

    Abstract translation: 可提供可配置为粒子束或电喷雾界面的液相色谱 - 质谱系统。 该器件包含两个接口共同的结构元件，从而无需使用两个完全独立的ES和PB LC / MS系统。 根据本发明的LC / MS装置通常包括动量分离器，喷嘴壳体，质谱仪和真空子系统。 质谱仪外壳包围四极质量分析仪。 当用于ES模式时，ES源模块耦合到本发明的装置中。 类似地，当以PB模式使用时，PB源模块与单独的源PB探针一起耦合到本发明的装置中。 质量分析器室可以容纳用于从分析物颗粒产生离子的粒子束源探针。 在任一模式中，模块可以由修改用于本发明装置的市售接口组成。

    Microanalytical device containing a membrane for molecular identification
    8.
    发明授权
    Microanalytical device containing a membrane for molecular identification 有权
    含有分子鉴定膜的微量分析装置

    公开(公告)号：US06607644B1

    公开(公告)日：2003-08-19

    申请号：US09703431

    申请日：2000-10-31

    Applicant: James A. Apffel, Jr.

    Inventor： James A. Apffel, Jr.

    IPC: G01N27447

    CPC classification number: G01N33/521

    Abstract: The invention provides a microanalytical device for analyzing a fluid sample containing at least one analyte molecule. The device is constructed from a substrate and a cover plate each having a substantially planar surface and a microchannel formed therein. The cover plate is placed over the substrate such that the cover plate microchannel is arranged in opposing relationship with the substrate microchannel. A membrane is interposed between the substrate and the cover and has at least one pore sized to allow passage of the analyte molecule from the substrate microchannel to the cover plate microchannel. An analyte altering moiety is attached to an interior surface of the pore and is capable of chemically altering the analyte molecule. Also disclosed are a method for chemically altering and transporting an analyte molecule in a fluid and a method for identifying a plurality of biomolecules.

    Abstract translation: 本发明提供了一种用于分析含有至少一种分析物分子的流体样品的微量分析装置。 该装置由基板和盖板构成，每个基板具有形成在其中的基本平坦的表面和微通道。 盖板放置在基板上，使得盖板微通道以与基板微通道相对的关系布置。 膜位于基底和盖子之间，并且具有至少一个孔，其尺寸允许分析物分子从基底微通道通向盖板微通道。 分析物改变部分连接到孔的内表面并且能够化学地改变分析物分子。 还公开了用于化学改变和输送流体中的分析物分子的方法和用于鉴定多个生物分子的方法。

    Mixture of amino acid derivatives, process of producing the mixture and use of the mixture for quantitative determination of the amino acids
    9.
    发明授权
    Mixture of amino acid derivatives, process of producing the mixture and use of the mixture for quantitative determination of the amino acids 失效
    氨基酸衍生物的混合物，生产混合物的方法和混合物的使用用于定量测定氨基酸

    公开(公告)号：US4784962A

    公开(公告)日：1988-11-15

    申请号：US18890

    申请日：1987-02-25

    Applicant: James A. Apffel, Jr. ,  Rainer Schuster

    Inventor： James A. Apffel, Jr. ,  Rainer Schuster

    IPC: G01N30/84 ,  B01D15/08 ,  C07C67/00 ,  C07C239/00 ,  C07C271/10 ,  C07C271/22 ,  C07D209/44 ,  G01N30/74 ,  G01N30/88 ,  G01N33/68 ,  G01N21/77

    CPC classification number: G01N33/6809 ,  Y10T436/173845

    Abstract: A mixture of fluorescently-excitable amino acid derivatives suitable for use in quantitative amino acid analysis is provided in which primary amino acids are present as derivatives of a first reagent and secondary amino acids are present as derivatives of a second different reagent. The process for preparing the mixture comprises the steps of derivatization of the primary amino acids of an amino acid sample with ortho-phthalaldehyde (OPA) and of derivatization of the secondary amino acids of the sample with fluorenylmethylchloroformate (FMOC) in the presence of acetonitrile. The mixture can be obtained automatically and is highly suitable for fast analysis by reversed-phase liquid chromatography.

    Abstract translation: 提供适用于定量氨基酸分析的荧光可兴奋氨基酸衍生物的混合物，其中一次氨基酸作为第一试剂的衍生物存在，并且仲氨基酸作为第二不同试剂的衍生物存在。 制备混合物的方法包括以下步骤：用邻苯二甲醛（OPA）衍生氨基酸样品的伯氨基酸，并在乙腈存在下用氯甲酸芴基甲酯（FMOC）衍生样品的仲氨基酸。 该混合物可以自动获得，非常适合通过反相液相色谱快速分析。

Patent Agency Ranking